PDE4B promotes ferroptosis in nucleus pulposus cells and is involved in intervertebral disc degeneration by Weixing Xu, Rana Dhar, Danyang Zheng, Qi Peng, Yue Li, Sheng Mei, Huifang Tang

“…Abstract Intervertebral Disc degeneration (IDD) is one of the leading causes of disability, and current therapies are ineffective. Phosphodiesterase 4B (PDE4B) plays an essential role in regulating the activation of nuclear factor E2-related factor 2 (Nrf2), while Nrf2 regulates ferroptosis. …”
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FASILITAS KHUSUS PENYANDANG DISABILITAS DAN LANSIA PADA MASJID RAYA MAKASSAR by Irma Rahayu

“…This study aimed to determine the extent of accessible facilities for the disabilities and the elderly people at the Makassar Raya Mosque. …”
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Global burden and trends of the Clostridioides difficile infection-associated diseases from 1990 to 2021: an observational trend study by Jun Xia, Tan Liu, Rui Wan, Jing Zhang, Quanzhu Fu

“…The burden of CDI was assessed using the age-standardized rates of disability-adjusted life years (ASR-DALYs) and deaths (ASDRs). …”
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Ipsilateral concomitant fractures of the clavicle and coracoid process of the scapula: incidence, characteristics, and outcomes by Nan Zhang, Guoyang Bai, Xiaomin Kang, Yangjun Zhu, Dongxu Feng

“…Radiographs assessed bone union and implant integrity, while clinical evaluations included the Constant–Murley score for shoulder function; disability of the arm, shoulder, and hand (DASH) questionnaire for upper limb function; and visual analog scale score for pain. …”
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A comparative analysis of global and Chinese trends in the burden of kidney cancer from 1990 to 2021 by Zhongli Qiao, Jun Xiong, Shenyu Zhang, Lin Chen, Jialin Wang, Runze Chen

“…Utilizing GBD(Global Burden of Disease)2021 data, our study examined the standardized incidence, mortality, prevalence, and DALYs(Disability Adjusted Life Years) rate of renal cancer. …”
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Equality, Diversity and Inclusion characteristics measured or reported in randomised trials of intrapartum interventions: A Scoping Review [version 1; peer review: 2 approved] by Aoife Smith, John Gilmore, Susan Hannon, Valerie Smith

“…Ninety RCTs limited inclusion to nulliparous participants only, six RCTs required participants to have a minimum educational level, 127 RCTs had inclusion age cut-offs although 23 different variations of this were noted and 15 RCTs excluded participants on the grounds of disability. Conclusions This scoping review highlights EDI characteristic measurement and reporting deficits in intrapartum RCTs. …”
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自发性脑出血术后早期使用阿司匹林的可能性：来自中国学者的首个脑出血围手术期管理高级别循证依据 Possibility of Early Use of Aspirin after Spontaneous Intracerebral Hemorrhage Surgery: The First High-Level Evidence-Based Evidenc... by 周航，陈高(ZHOU Hang, CHEN Gao)

“…Abstract: Spontaneous intracerebral hemorrhage is one of the important diseases causing death and disability worldwide. Although surgical treatment has become increasingly mature, the corresponding postoperative management strategies remain poorly defined. …”
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Assessing inflammatory protein factors in inflammatory bowel Disease using multivariable mendelian randomization by Qiang Su, Yun Lu, Song He, Jiang Liang, Song Huang, Yuanli He, Zhenxiang An

“…Abstract Inflammatory bowel disease (IBD), including ulcerative colitis (UC) and Crohn’s disease (CD), decreases quality of life and causes disability. The underlying processes are not fully understood. …”
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Analysis of Risk Factors for Hemorrhagic Transformation of Cerebral Infarction and Recurrence of Cerebral Infarction: A Retrospective Study on Cerebral Infarction Patients with or... by Bao P, Ling L, Xiang L, Liu X, Zhang J, Yue W

“…Pengnan Bao,1 Ling Ling,2 Lei Xiang,2 Xueqing Liu,1 Jinwei Zhang,1 Wei Yue1,2 1Clinical College of Neurology, Neurosurgery and Neurorehabilitation, Tianjin Medical University, Tianjin, 300000, People’s Republic of China; 2Department of Neurology, Tianjin Huanhu Hospital, Tianjin, 300000, People’s Republic of ChinaCorrespondence: Wei Yue, Department of Neurology, Tianjin Huanhu Hospital, Jizhao Road No. 6, Jinnan District, Tianjin, 300000, People’s Republic of China, Tel +86-13752686958, Email hhyuewei2008@163.comBackground: Acute ischemic stroke, especially hemorrhage cerebral infarction (HCI), resulted in the leading causes of mortality and long-term disability across populations. However, fewer researches have focused on the risk factors of first admission and recurrence of HCI.Methods: The study included 1857 patients who underwent cerebral infarction with or without hemorrhagic transformation. …”
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Meta-analysis of minimally invasive transforaminal lumbar interbody fusion versus oblique lumbar interbody fusion for treating lumbar degenerative diseases by Dun Liu, Xinyu Huang, Chongyang Zhang, Qin Wang, Hua Jiang

“…Indicators extracted included operative time, intraoperative blood loss, hospital stay, visual analog scale (VAS) scores, Oswestry Disability Index (ODI), disc height (DH), segmental lordotic angle (SLA), lumbar lordosis angle (LLA), postoperative JOA scores, patient satisfaction, complication rates, and fusion rates. …”
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The Global Burden and Trends of Legionella spp. Infection-Associated Diseases from 1990 to 2021: An Observational Study by Yonghong Zhong, Linfeng Shen, Yan Zhou, Yibo Sun, Xiaofang Fu, Huaqiong Huang

“…Methods Age-standardized disability-adjusted life years (ASR-DALYs) and age-standardized death rates (ASDRs) of LSIADs from 1990 to 2021 were accessed from the Global Burden of Disease (GBD) 2021, which utilized the Bayesian hierarchical meta-regression tool and the Cause of Death Ensemble model to estimate these metrics. …”
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Worldwide Research Trends on Diabetic Foot Ulcers (2004–2020): Suggestions for Researchers by Pin Deng, Hongshuo Shi, Xuyue Pan, Huan Liang, Shulong Wang, Junde Wu, Wei Zhang, Fasen Huang, Xiaojie Sun, Hanjie Zhu, Zhaojun Chen

“…It has high mortality and disability rates. The number of research articles on DFUs has increased. …”
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Some Common SNPs of the T-Cell Homeostasis-Related Genes Are Associated with Multiple Sclerosis, but Not with the Clinical Manifestations of the Disease, in the Polish Population by Monika Chorąży, Natalia Wawrusiewicz-Kurylonek, Edyta Adamska-Patruno, Olga Zajkowska, Katarzyna Kapica-Topczewska, Renata Posmyk, Adam Jacek Krętowski, Jan Kochanowicz, Alina Kułakowska

“…The aim of our study was to evaluate the frequencies of alleles and genetic variants of the T-cell homeostasis-related genes, in subjects with MS, as well as to investigate the association with MS clinical manifestations and disability. Methods. 94 subjects with MS and 160 healthy individuals have been genotyped for seven common single-nucleotide variants in IL-2RA, CTLA4, CD40, and PADI4 genes. …”
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The influence of body mass index on efficacy and outcomes of percutaneous transforaminal endoscopic surgery (PTES) for the treatment of lumbar degenerative diseases: a retrospectiv... by Chenyang Zhuang, Yun Xu, Hong Lin, Yutong Gu

“…Visual Analogue Scale (VAS) and Oswestry Disability Index (ODI) were used to evaluate the clinical efficacy and outcomes of the surgery. …”
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Understanding road accident injury dynamics in Iran: a growth mixture modelling perspective by Ziba Zarrin, Kamran Gholamizadeh, Elaheh Talebi-Ghane, Erfan Ayubi, Omid Hamidi

“…In Iran, road accidents have become a leading cause of death and disability, necessitating urgent attention to injury prevention strategies. …”
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The effect of thermoelectric craniocerebral cooling device on protecting brain functions in post-cardiac arrest syndrome by Aydın Nadir, Deniz Kara, Ayda Turkoz

“…In contrast, CPC scores of 3 or higher were observed in 37.5% of patients, reflecting varying degrees of disability. Biochemical analysis revealed significant decreases in sodium, potassium, calcium, and magnesium levels, alongside increased urea and creatinine concentrations. …”
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Gabapentin versus Transdermal Fentanyl Matrix for the Alleviation of Chronic Neuropathic Pain of Radicular Origin: A Randomized Blind Multicentered Parallel-Group Noninferiority Tr... by Chang Ju Hwang, Jae Hyup Lee, Jung-Hoon Kim, Sang Hyuk Min, Kun-Woo Park, Hyoung-Yeon Seo, Kwang-Sup Song

“…Secondary endpoints included pain relief, improvement in functional status (the Korean-Oswestry Disability Index (K-ODI)), improvement in depressive symptoms (Korean-Beck Depression Index (K-BDI)) between the 28th and 56th day, and adverse events (AEs). …”
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DENND5B Gene Expression as a Trigger for the Development of Diabetes Mellitus–Peripheral Artery Disease: Insights from a Univariate and Multivariate Mendelian Randomization Study by Qiaoqiao Li, Fuli Cao, Xueping Gao, Yuan Xu, Bo Li, Tianyang Hu

“…Background: Peripheral artery disease (PAD) is a manifestation of systemic atherosclerosis that can result in limb pain, disability, or mortality. Notably, diabetes mellitus (DM) stands out as one of the most significant risk factors for the development of PAD. …”
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Unravelling the transcriptomic symphony of muscle ageing: key pathways and hub genes altered by ageing and caloric restriction in rat muscle revealed by RNA sequencing by Gulam Altab, Brian J. Merry, Charles W. Beckett, Priyanka Raina, Inês Lopes, Katarzyna Goljanek-Whysall, João Pedro de Magalhães

“…Abstract Age-related muscle wasting, sarcopenia is an extensive loss of muscle mass and strength with age and a major cause of disability and accidents in the elderly. Mechanisms purported to be involved in muscle ageing and sarcopenia are numerous but poorly understood, necessitating deeper study. …”
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Effect of Neck Exercises Combined with Stimulating Baihui and Yongquan Acupoints Based on the Concept of Muscle and Bone Balance on Patients with Cervical Hypertension by CHEN Xiuming, LIN Jian, LIU Jinyong, FANG Yuelong, ZHAN Zhengxuan, HE Zhen, CAI Shuhe

“…The systolic blood pressure (SBP) and diastolic blood pressure (DBP), visual analogue scale (VAS), neck disability index (NDI) score, TCM syndrome score, and the effective rate of antihypertensive were compared between the two groups before and after the treatment.ResultsThe SBP and DBP of both groups decreased significantly after the treatment, VAS score, NDI score and TCM syndrome score of the observation group decreased significantly after the treatment, the difference was statistically significant (<italic>P</italic>&lt;0.05). …”
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