Hyperuricemia-induced complications: dysfunctional macrophages serve as a potential bridge by Wenyi Gu, Wenyi Gu, Jiajing Zhao, Yu Xu, Yu Xu, Yu Xu

“…The first mechanism involves direct action on urate transporters, such as URAT1 and ABCG2. …”
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Comparison between Sevoflurane and Isoflurane Effects on Hemodynamic Status by Adel Amen Hama

“… Back ground: Volatile anaesthetics are known to cause hypotension because of its effects on the central nervous system and autonomic nervous system, on the myocardium as well as its direct action on vascular smooth muscle. Aim of study: is to compare between sevoflurane and isoflurane effects on pulse rate and mean blood pressure during general anaesthesia. …”
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COMPONENTES Y DINÁMICA NATURAL DEL AMBIENTE -CIUDAD DE NEUQUÉN- by Olga C. Capua, Elsie M. Jurio

“…Furthermore, the scarse plant covering and soil characteristics favor the direct action of wind on the surface incrementing the processes of erosion-deflation, abrasion and attrition, and build farms. …”
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Endometrial Regenerative Cell-Derived Conditioned Medium Alleviates Experimental Colitis by Chenglu Sun, Jingpeng Hao, Hong Qin, Yanglin Zhu, Xiang Li, Baoren Zhang, Yafei Qin, Guangming Li, Hongda Wang, Hao Wang

“…Endometrial regenerative cells (ERCs) have been shown to exert immunosuppressive effects in different models of inflammation, and stem cell-derived conditioned media (CM) have advantages over cell therapy in terms of easy access and direct action. However, whether ERC-CM could alleviate colitis remains unclear and will be explored in this study. …”
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Timosin alpha-1 immunomodulating properties by M. V. Mayevskaya

“…Timosin alpha1 is 28-base acetylated polypeptide, that effectively modulates human immune system and has direct action on the cells infected by virus that allows to talk of its «double» mechanism of action. …”
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The Videofluorographic Swallowing Study in Rheumatologic Diseases: A Comprehensive Review by Ambra Di Piazza, Federica Vernuccio, Massimo Costanzo, Laura Scopelliti, Dario Picone, Federico Midiri, Francesco Salvaggi, Francesco Cupido, Massimo Galia, Sergio Salerno, Antonio Lo Casto, Massimo Midiri, Giuseppe Lo Re, Roberto Lagalla

“…Gastrointestinal tract involvement in these patients may also due to both a direct action of antibodies against organs and pharmacological therapies. …”
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Endothelial Dysfunction Correlates with Liver Fibrosis in Chronic HCV Infection by Michele Barone, Maria Teresa Viggiani, Annabianca Amoruso, Serafina Schiraldi, Annapaola Zito, Fiorella Devito, Francesca Cortese, Michele Gesualdo, Natale Brunetti, Alfredo Di Leo, Pietro Scicchitano, Marco Matteo Ciccone

“…Hepatitis C virus (HCV) infection can exert proatherogenic activities due to its direct action on vessel walls and/or via the chronic inflammatory process involving the liver. …”
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AIP56, an AB toxin secreted by Photobacterium damselae subsp. piscicida, has tropism for myeloid cells by Inês Lua Freitas, Inês Lua Freitas, Inês Lua Freitas, Maria Fátima Macedo, Maria Fátima Macedo, Liliana Oliveira, Liliana Oliveira, Pedro Oliveira, Ana do Vale, Ana do Vale, Nuno M.S. dos Santos, Nuno M.S. dos Santos

“…The tropism of AIP56 for cells of the sea bass, mouse and human immune system was analyzed by following toxin internalization by flow cytometry and arrival of the toxin in the cytosol by evaluating the cleavage of NF-kB p65 by western blotting.ResultsOnly a small population of sea bass neutrophils internalized AIP56, indicating that most of the neutrophilic destruction during Phdp infection and/or AIP56 intoxication does not result from the direct action of the toxin. Moreover, the cellular tropism of AIP56 for myeloid cells was observed in the three species, including its preference for macrophages. …”
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Maternal exposure to deltamethrin during pregnancy and lactation impairs hippocampal learning and memory function of male offspring by ferroptosis by Shasha Huang, Wanqi Li, Dengke Wang, Huiwen Feng, Bo Wang, Xinyu Dong, Wei Zhao, Dan Liu, Yuan Wang

“…Deltamethrin (DM), a broad-spectrum insecticide, is widely used in the world. It can exert direct action on the central nervous system to produce neurotoxicity. …”
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Componentes y Dinámica Natural del Ambiente - Ciudad de Neuquén- by Olga Capua, Elsie Marcela Jurio

“…Furthermore, the scarse plant covering and soil characteristics favor the direct action of wind on the surface incrementing the processes of erosion-deflation, abrasion and attrition, and build farms. …”
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Children with autistic spectrum disorder can imagine actions— what can this reveal about the Broken Mirror Hypothesis? by Jessica Galli, Jessica Galli, Laura Dusi, Gioacchino Garofalo, Gioacchino Garofalo, Alessandra Brizzi, Michela Gritti, Federica Polo, Elisa Fazzi, Elisa Fazzi, Giovanni Buccino, Giovanni Buccino

“…ObjectiveThis study investigated whether children with Autistic Spectrum Disorder (ASD) can imagine object directed actions similarly to their typically developed (TD) peers.Study designWe tested the ability to imagine goal directed actions in children with ASD (n = 18) and TD (n = 18) peers by means of VMIQ-2 questionnaire and a novel behavioral task, in which children were requested to imagine some daily actions, after seeing them through videoclips presented on a computer screen. …”
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Strategic Climate Litigation before National Courts: Can European Union Law be used as a Shield? by Christina Eckes

“…However, the EU has very restrictive standing requirements for direct actions against general acts. Therefore, most strategic climate litigation is brought to national courts. …”
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La paradoja del desarrollo: consultas comunitarias en la posguerra guatemalteca by Vaclav Masek

“…Connecting three layers of meaning-making through the collective memory of colonialism, genocide, and extractivism, Maya Q’eqchi community leaders articulate «future-coordination» through collective memory. An array of direct actions also serves to resist the State, implicating scholarly reconceptualizations of indigenous territory, post-conflict development, and the political ambiguities of organizing.…”
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Theoretical-methodological foundations of nursing training aimed at self-care in patients with intellectual disabilities by María del Rosario Melo Muñoz, Ángel Luis Gómez Cardoso, Elizabeth Gómez Núñez, Rolando Rodríguez Puga

“…Patients with intellectual disabilities often show support needs, in response to which nursing professionals must direct actions that allow to improve the life quality. …”
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A New Approach for Resolving Conflicts in Actionable Behavioral Rules by Peng Su, Dan Zhu, Daniel Zeng

“…Knowledge is considered actionable if users can take direct actions based on such knowledge to their advantage. …”
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Decoding the physics of observed actions in the human brain by Moritz F Wurm, Doruk Yiğit Erigüç

“…Recognizing goal-directed actions is a computationally challenging task, requiring not only the visual analysis of body movements, but also analysis of how these movements causally impact, and thereby induce a change in, those objects targeted by an action. …”
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GENDER GENEALOGY OF READING AS CULTURAL PRACTICE by N. Yu. Kryvda, L. V. Osadcha

“…The paper considered the typology of human intellectual conditions according to Kant’s divided into pure and practical reason. The last one directs action-willed individual efforts so as to meet the universal relevance and ethical coherence. …”
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Behavioral and sociodemographic correlates of the body mass index in Brazilian workers by Priscila Cristina Santos, Kelly Samara da Silva, Bruno Gonçalves Galdino da Costa, Gabrielli Thais de Mello, Elusa Santina Antunes de Oliveira, Markus Vinícius Nahas

“…When possible, it is suggested to promote the practice the practice of physical activity during leisure time without directing actions to comply with the recommendation of 150 minutes per week with the understanding that some activity is better than none, as well as stimulate the reduction of TV viewing time among workers. …”
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The Vibrio type VI secretion system induces intestinal macrophage redistribution and enhanced intestinal motility by Julia S. Ngo, Piyush Amitabh, Jonah G. Sokoloff, Calvin Trinh, Travis J. Wiles, Karen Guillemin, Raghuveer Parthasarathy

“…In addition to illuminating host-directed actions of the widespread T6SS protein apparatus, our findings highlight how localized bacteria-induced injury can reshape neuro-immune cellular dynamics to impact whole-organ physiology.IMPORTANCEGut microbes, whether beneficial, harmful, or neutral, can have dramatic effects on host activities. …”
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