Distinct iPS Cells Show Different Cardiac Differentiation Efficiency by Yohei Ohno, Shinsuke Yuasa, Toru Egashira, Tomohisa Seki, Hisayuki Hashimoto, Shugo Tohyama, Yuki Saito, Akira Kunitomi, Kenichiro Shimoji, Takeshi Onizuka, Toshimi Kageyama, Kojiro Yae, Tomofumi Tanaka, Ruri Kaneda, Fumiyuki Hattori, Mitsushige Murata, Kensuke Kimura, Keiichi Fukuda

“…Because of the different properties of the various iPS cell lines such as cardiac differentiation efficiency and potential safety hazards, newly established iPS cell lines must be characterized prior to their use in cardiac regenerative medicine.…”
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Increased Neuronal Differentiation Efficiency in High Cell Density-Derived Induced Pluripotent Stem Cells by Sumitra Srimasorn, Matthias Kirsch, Susanne Hallmeyer-Ellgner, Dirk Lindemann, Alexander Storch, Andreas Hermann

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Early and non-destructive prediction of the differentiation efficiency of human induced pluripotent stem cells using imaging and machine learning by Miki Arai Hojo, Taku Tsuzuki, Yosuke Ozawa, Toshiyuki Araki, Hidetoshi Sakurai

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Correction: Microglia-secreted TNF-α affects differentiation efficiency and viability of pluripotent stem cell-derived human dopaminergic precursors. by PLOS ONE Staff

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RETRACTED ARTICLE: Strontium doped bioglass incorporated hydrogel-based scaffold for amplified bone tissue regeneration by Hamed Manoochehri, Masoud Ghorbani, Mehrdad Moosazadeh Moghaddam, Mohammad Reza Nourani, Pooyan Makvandi, Esmaeel Sharifi

“…Alg/Cs/Sr-BG scaffolds had higher mechanical stability and more differentiation efficiency in comparison with Alg/Cs and Alg/Cs/BG scaffolds. …”
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Improved Efficiency of Cardiomyocyte-Like Cell Differentiation from Rat Adipose Tissue-Derived Mesenchymal Stem Cells with a Directed Differentiation Protocol by Blanca Rebeca Ibarra-Ibarra, Martha Franco, Araceli Paez, Elvira Varela López, Felipe Massó

“…The percentage of cardiac troponin T- (cTnT-) positive cells was evaluated by flow cytometry to assess the cardiomyocyte differentiation efficiency in a quantitative manner. ASCs treated with the directed cardiomyocyte differentiation protocol obtained a differentiation efficiency of up to 44.03% (39.96%±3.78) at day 15 without any enrichment step. …”
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3D Spheroid Formation Using BMP-Loaded Microparticles Enhances Odontoblastic Differentiation of Human Dental Pulp Stem Cells by Tae-Jun Min, Min Ji Kim, Kyung-Jung Kang, Yeoung Jo Jeoung, Se Heang Oh, Young-Joo Jang

“…However, monolayered cultures have significant drawbacks including inconsistent differentiation efficiency, require a higher BMP concentration than should be necessary, and require periodic treatment with BMPs for weeks to see results. …”
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Time-efficient strategies in human iPS cell-derived pancreatic progenitor differentiation and cryopreservation: advancing towards practical applications by Elena Genova, Paola Rispoli, Yue Fengming, Johkura Kohei, Matteo Bramuzzo, Roberta Bulla, Marianna Lucafò, Rosalba Monica Ferraro, Giuliana Decorti, Gabriele Stocco

“…We confirmed the possibility of shortening the time necessary for obtaining pancreatic cells without losing differentiation efficiency. Pancreatic progenitors and exocrine cells were maintained in culture and cryopreserved. …”
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Regulation of Induced Pluripotent Stem Cells(iPS) Differentiation and Disease Model Establishment by Qi Xinyue

“…Subsequently, we examine several common differentiation induction methods, supported by specific experimental data, and discuss optimization strategies to enhance differentiation efficiency and obtain specific cell types. Finally, we focus on the application of iPS cells in establishing disease models, particularly in neurodegenerative diseases, cardiovascular diseases, and genetic diseases, incorporating the latest research progress and innovative content. …”
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A deep learning approach to predict differentiation outcomes in hypothalamic-pituitary organoids by Tomoyoshi Asano, Hidetaka Suga, Hirohiko Niioka, Hiroshi Yukawa, Mayu Sakakibara, Shiori Taga, Mika Soen, Tsutomu Miwata, Hiroo Sasaki, Tomomi Seki, Saki Hasegawa, Sou Murakami, Masatoshi Abe, Yoshinori Yasuda, Takashi Miyata, Tomoko Kobayashi, Mariko Sugiyama, Takeshi Onoue, Daisuke Hagiwara, Shintaro Iwama, Yoshinobu Baba, Hiroshi Arima

“…Three-dimensional culture is inherently characterized by its ability to induce heterogeneous cell populations, making it difficult to maintain constant differentiation efficiency. That is why the culture process involves empirical aspects. …”
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PRC2 promotes canalisation during endodermal differentiation. by Jurriaan Jochem Hölzenspies, Dipta Sengupta, Wendy Anne Bickmore, Joshua Mark Brickman, Robert Scott Illingworth

“…Despite this, chemical inhibition of polycomb enhanced endodermal differentiation efficiency, but did so at the cost of lineage fidelity. …”
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MicroRNA-1 Regulates the Differentiation of Adipose-Derived Stem Cells into Cardiomyocyte-Like Cells by Can Chen, Quanxiang Yan, Yiguang Yan, Mudi Ma, Yuan He, Xiaorong Shui, Zhigang Yang, Xiaozhong Lan, Yaoliang Tang, Wei Lei

“…We performed cocultures with ASCs and cardiomyocytes. The differentiation efficiency of ASCs was detected by cell-specific surface antigens. …”
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Serine synthesis pathway regulates cardiac differentiation from human pluripotent stem cells by Tomohiko C. Umei, Shugo Tohyama, Yuika Morita-Umei, Manami Katoh, Seitaro Nomura, Kotaro Haga, Takako Hishiki, Tomomi Matsuura, Hidenori Tani, Yusuke Soma, Otoya Sekine, Masatoshi Ohno, Masashi Nakamura, Taijun Moriwaki, Yoshikazu Kishino, Keiichi Fukuda, Masaki Ieda

“…However, variations in hPSC-CM differentiation efficiency and its poor reproducibility have remained a challenge. …”
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Stem Cell Therapies in Canine Cardiology: Comparative Efficacy, Emerging Trends, and Clinical Integration by Ahmed Farag, Hanan Hendawy, Mahmoud H. Emam, Mizuki Hasegawa, Ahmed S. Mandour, Ryou Tanaka

“…Challenges such as low cell retention, differentiation efficiency, and variability in therapeutic responses are also discussed. …”
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Functional Overload Enhances Satellite Cell Properties in Skeletal Muscle by Shin Fujimaki, Masanao Machida, Tamami Wakabayashi, Makoto Asashima, Tohru Takemasa, Tomoko Kuwabara

“…Although it is well known that the number of satellite cells increases following physical exercise, functional alterations in satellite cells such as proliferative capacity and differentiation efficiency following exercise and their molecular mechanisms remain unclear. …”
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FIST GEOINFORMATION SYSTEM MODEL USING FOG COMPUTING IN DESTABILIZATION by V. V. Gryzunov

“…Based on the model, integral and differential efficiency indicators are proposed. The  integrated indicator characterizes the share of tasks solved over a time  interval; the differential indicator characterizes the "performance margin." …”
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Spermidine Retarded the Senescence of Multipotent Mesenchymal Stromal Cells In Vitro and In Vivo through SIRT3-Mediated Antioxidation by Hua Huang, Wen Zhang, Junjie Su, Bisheng Zhou, Qingjiang Han

“…Thus, MSCs maintain the ability to proliferate and differentiate efficiently in vitro and in vivo, which reflects the potential clinical utilization of MSCs in the future.…”
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Forward programming of hPSCs to neutrophils using chemically defined media by Hayley E. Hall, Xiaoping Bao, Cheng Dong, Xiaojun Lance Lian

“…We analyzed not only their differentiation efficiency but also the transcriptomic profiles and functional capabilities of the resulting PMNs. …”
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Health care system efficiency and life expectancy: A 140-country study. by Virginia Zarulli, Elizaveta Sopina, Veronica Toffolutti, Adam Lenart

“…We then analyzed, with regression analysis stratified by average education level, and by the role of health-related variables in differentiating efficient and inefficient countries from each other. …”
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Alveolar Differentiation Potency of Human Distal Airway Stem Cells Is Associated with Pulmonary Pathological Conditions by Yujia Wang, Yi Lu, Yingchuan Wu, Yufen Sun, Yueqing Zhou, Qiwang Ma, Yawen Zheng, Qianwen Yu, Yujie Cao, Guangdong Chen, Ting Zhang, Xiaotian Dai, Tao Ren, Yu Ma, Wei Zuo

“…More importantly, the alveolar differentiation potency was higher in DASCs derived from patients than from healthy people. The differentiation efficiency of DASCs also correlates with age in patients with bronchiectasis and ILD.…”
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