NCK2 Is Significantly Associated with Opiates Addiction in African-Origin Men by Zhifa Liu, Xiaobo Guo, Yuan Jiang, Heping Zhang

“…Most of the GWAS discoveries were only based on single nucleotide polymorphisms (SNPs) and a single dichotomized outcome. By employing both SNP- and gene-based methods of analysis, we identified a strong (odds ratio = 13.87) and significant (P value = 1.33E−11) association of an SNP in the NCK2 gene on chromosome 2 with opiates addiction in African-origin men. …”
Get full text

Endoplasmic Reticulum Stress: Its Role in Disease and Novel Prospects for Therapy by Axel H. Schönthal

“…In recent years, this dichotomic stress response system has been linked to several human diseases, and efforts are underway to develop approaches to exploit ER stress mechanisms for therapy. …”
Get full text

Limitations of Separating Athletes into High or Low-Risk Groups based on a Cut-Off. A Clinical Commentary by Justin M. Losciale, Linda K. Truong, Patrick Ward, Gary S. Collins, Garrett S. Bullock

“…When a cut-off is used in analyses, information is lost, leading to potentially misleading results and less accurate injury risk prediction. Dichotomizing a continuous variable using a cut-off should be avoided. …”
Get full text

Postpartum Visit Attendance Increases the Use of Modern Contraceptives by Saba W. Masho, Susan Cha, RaShel Charles, Elizabeth McGee, Nicole Karjane, Linda Hines, Susan G. Kornstein

“…Routine PPCV (yes, no) and modern contraceptive use were both dichotomized. Descriptive analyses provided percentages, frequencies, and means. …”
Get full text

Understanding the role of nerves in head and neck cancers - a review by Krzysztof Rutkowski, Michał Gola, Michał Gola, Janusz Godlewski, Janusz Godlewski, Anna Starzyńska, Anna Starzyńska, Giulia Marvaso, Giulia Marvaso, Federico Mastroleo, Federico Mastroleo, Maria Giulia Vincini, Maria Giulia Vincini, Alice Porazzi, Mattia Zaffaroni, Barbara Alicja Jereczek-Fossa, Barbara Alicja Jereczek-Fossa

“…However, its prognostic value remains debated due to inconsistent results when classified dichotomously (present/absent). Emerging evidence suggests that quantitative and qualitative descriptions of PNI may better reflect its clinical usefulness. …”
Get full text

Patterns of Antimicrobial Resistance in the Causative Organisms of Spontaneous Bacterial Peritonitis: A Single Centre, Six-Year Experience of 1981 Samples by Sara Sheikhbahaei, Alireza Abdollahi, Nima Hafezi-Nejad, Elham Zare

“…In a cross-sectional, single center, hospital based study, 1981 consecutive ascitic fluid samples were recruited from 2005 to 2011. Samples were dichotomized into three-year periods, in order to assess the trend of resistance to the first-line empirical antibiotics. …”
Get full text

White Blood Cell and Granulocyte Counts Are Independent Predictive Factors for Prognosis of Advanced Pancreatic Caner by Lanyun Feng, Shihui Gu, Peng Wang, Hao Chen, Zhen Chen, Zhiqiang Meng, Luming Liu

“…Blood test results for white blood cell (WBC), granulocyte, neutrophil, lymphocyte, platelet count, neutrophil-to-lymphocyte ratio (NLR), and platelet-to-lymphocyte ratio (PLR) were dichotomized on the basis of median values. This was followed by univariate and multivariate analyses between groups. …”
Get full text

Danish mothers of young children adhere less to international physical activity guidelines compared with mothers of older children by Solvej Videbæk Bueno, Sebastian Deisting Skejø, Rasmus Oestergaard Nielsen, Knud Ryom, Per Kallestrup, Peter Elsborg, Christina Bjørk Petersen, Julie Sandell Jacobsen

“…The primary outcome was weekly hours of moderate-to-vigorous physical activity, dichotomized into adherers or non-adherers to WHO guidelines. …”
Get full text

Association between DNA methylation levels of thioredoxin-interacting protein (TXNIP) and changes in glycemic traits: a longitudinal population-based study by Keisuke Maeda, Ryosuke Fujii, Hiroya Yamada, Eiji Munetsuna, Mirai Yamazaki, Yoshitaka Ando, Genki Mizuno, Hiroaki Ishikawa, Koji Ohashi, Yoshiki Tsuboi, Yuji Hattori, Yuya Ishihara, Nobuyuki Hamajima, Shuji Hashimoto, Koji Suzuki

“…Logistic regression analyses were performed to assess the associations between dichotomized TXNIP DNAm levels and marked increases in glycemic traits. …”
Get full text

Fibrinogen and Albumin Score Changes during Preoperative Treatment Can Predict Prognosis in Patients with Locally Advanced Rectal Cancer by Meng-Jun Tang, Shu-Bo Ding, Wang-Yuan Hu

“…FA scores were calculated based on the Fib and Alb levels dichotomized by clinical reference values. Patients were classified into two groups based on the changes in FA scores during NCRT: in group A, FA scores decreased or remained unchanged (n=84), and in group B, FA scores increased (n=22). …”
Get full text

Lower Extremity Kinematic Waveform Analysis During a Single Leg Drop Task – Including a Single Subject Design by Nickolai JP Martonick, Youngmin Chun, Lukas Krumpl, Joshua P Bailey

“…Until a method is developed to adequately dichotomize lower extremities during the SLD task, a single subject design strategy be used with group analysis when making bilateral comparisons…”
Get full text

Performance in organic chemistry at either a four-year university or community college predicts academic performance in an accelerated school of pharmacy by Troy J. Smith, Jason Ross, Charles R. Breese, Melissa A. Burmeister

“…Students were then dichotomized into two subcategories based on whether they received an above average (i.e., A or B) or average (i.e., C) grade in organic chemistry I or II. …”
Get full text

Examining the Validity and Reliability of Iranian Women's Sexual Self-Efficacy Questionnaire by Fatemeh Shabani, Rasol Roshan Chesli, Soheila Ghomian

“…Additionally, traditional methods of internal consistency, including Cronbach's alpha and dichotomization, were utilized to evaluate its reliability.Results: Data analysis indicated that premarital education, which focused on risk factors using a cognitive-behavioral approach, positively influenced the resilience and quality of life of the engaged couples. …”
Get full text

Pilot application of an inflammation and physiological dysregulation index based on noninvasive salivary biomarkers by Andrey I. Egorov, William Xue, Jason Kobylanski, Miyu Fuzawa, Shannon M. Griffin, Timothy J. Wade, Michael Nye

“…A composite Inflammation and Physiological Dysregulation Index (IPDI) was calculated as a count of potentially unhealthy values of dichotomized biomarkers. In 20 individuals who completed the survey (average age 46 years, 75% females), allergy to house dust was significantly associated with increased IPDI (adjusted for age) and significantly increased odds of potentially unhealthy values of total IgA, IL-1β, and CRP. …”
Get full text

Continuing exposure to disadvantageous material and perceived economic factors on self-rated health in different life stages: fixed effects analyses with data from the German Socio... by Tobias Rähse, Matthias Richter, Anja Knöchelmann

“…Exposure variables, including loan burdens, housing status and quality (material factors) as well as financial and occupational worries, housing and income satisfaction (perceived economic factors), were analyzed dichotomously. Exposure duration was calculated as observed years in exposure for each of the factors, taking only continuous exposure years into account. …”
Get full text

Self-Movement Screening using the Symmio Application is Reliable and Valid for Identifying Musculoskeletal Risk Factors by Kyle Matsel, Jonathan Kirsch, Tessa Netelbeek, Rolando Rodriguez, Ervin Velic, Kate Schwartzkopf-Phifer

“…The validity of Symmio was determined by comparing self-screen performance dichotomized as pass or fail with the reference standard of pain with movement, failure on the Functional Movement Screen™, and asymmetry on the Y Balance Test-Lower Quarter™ using three separate 2x2 contingency tables…”
Get full text

Risk Factors Associated with Hemoparasites in Dual-Purpose Cattle of Colombia by César A. Murcia-Mono, Sergio Falla-Tapias, Andrés F. Morales Cabrera, Laura C. Navia Álvarez, Leidy Rivera-Sánchez, Yolanda Gómez Vargas, William O. Burgos-Paz

“…In this sense, we conducted a cross-sectional study sampling 360 female cattle older than one year to identify infectious cattle using the PCR technique. We employed a dichotomic questionnaire for association analyses in 150 herds of the southern Andean region of Colombia. …”
Get full text

Utility of Integrated Analysis of Pharmacogenomics and Pharmacometabolomics in Early Phase Clinical Trial: A Case Study of a New Molecular Entity by Jaeseong Oh, Sojeong Yi, Namyi Gu, Dongseong Shin, Kyung-Sang Yu, Seo Hyun Yoon, Joo-Youn Cho, In-Jin Jang

“…During conducting a first-in-human trial for a new molecular entity, we were able to determine the mechanism of dichotomized variability in plasma drug concentrations, which appeared closely related to adverse drug reactions (ADRs) through integrated omics analysis. …”
Get full text

Clinical Oral Health Recommended Care and Oral Health Self-Report, NHANES, 2013-2014 by R. Constance Wiener, Nilanjana Dwibedi, Chan Shen, Patricia A. Findley, Usha Sambamoorthi

“…The assessments were dichotomized to (1) recommendation for immediate care and (2) routine oral health care. …”
Get full text

Xylaria iriomotensis sp. nov. from termite nests and notes on X. angulosa by Izumi Okane, Huei-Mei Hsieh, Yu-Ming Ju, Chun-Ru Lin, Chun-Yun Huang, I-Ching Kuan

“…Cultures of X. angulosa were obtained from two Taiwan specimens, which agree with the holotype from BO and the isotypes from NY and WSP in their stromata being repeatedly dichotomously branched and possessing a black core. In contrast to X. iriomotensis, X. angulosa does not form the teleomorph in culture but a typical Xylaria anamorph with conidiophores densely arranged in palisades. …”
Get full text