Enhancing deep learning methods for brain metastasis detection through cross-technique annotations on SPACE MRI by Tassilo Wald, Benjamin Hamm, Julius C. Holzschuh, Rami El Shafie, Andreas Kudak, Balint Kovacs, Irada Pflüger, Bastian von Nettelbladt, Constantin Ulrich, Michael Anton Baumgartner, Philipp Vollmuth, Jürgen Debus, Klaus H. Maier-Hein, Thomas Welzel

“…This MRI cross-technique transfer learning is a promising way to increase diagnostic performance. Key Points Delineating small BMs on SPACE MRI sequence results in higher quality annotations than on MPRAGE sequence due to enhanced conspicuity. …”
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Tumor mutational burden and survival on immune checkpoint inhibition in >8000 patients across 24 cancer types by Vivek Subbiah, Samuel J Klempner, Neeraj Agarwal, David P Carbone, Amit Mahipal, Shilpa Gupta, David Fabrizio, Jeffrey S Ross, Gerald Li, David R Gandara, Miles C Andrews, Jonathan W Riess, Ramez N Eskander, Ryon P Graf, Geoffrey R Oxnard, Sarah Sammons, Jeremy Snider, Lilia Bouzit, Cheryl Cho-Phan, Megan Price, Julia C F Quintanilha, Richard Sheng Poe Huang

“…The KEYNOTE 158 trial supported United States Food and Drug Administration (FDA) approval of the Foundation Medicine test (FoundationOneCDx) at TMB≥10 mut/Mb as a companion diagnostic (CDx) for single-agent pembrolizumab in second+line. …”
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Effet de l'illumination proche infra-rouge intracérébrale chez des primates MPTP by Fannie Darlot, Cécile Moro, Napoléon Torres‑Martinez, Claude Chabrol, Florian Reinhart, Diane Agay, Thomas Costecalde, John Mitrofanis, Alim‑Louis Benabid

“…La maladie de Parkinson (MP) est une maladie neurodégénérative chronique affectant le système dopaminergique et se traduisant par une perte des neurones dopaminergiques (DA) de la substance noire compacta (SNc) et des faisceaux nigro-striés. Le diagnostic précoce de la MP est difficile car 70 % des neurones dopaminergiques de la substance noire sont détruits, avec une dysfonction mitochondriale, quand les premiers signes moteurs apparaissent. …”
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The “prostate-pelvic syndrome” theory used in patients with type-III prostatitis and its correlation with prostate volume by Xiao-Ma Zhang, Wei-Yi Li, Zong-Yao Hao, Lei Zhou, Cheng Yang, He-Xi Du, Chao-Zhao Liang

“…The patients were diagnosed retrospectively again by using PPS diagnostic criteria in this retrospective cohort study. …”
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The Effect of Chewing Simulation on Flexural Strength of Different Lithium Disilicate Ceramics by Alsulimani O, Yousief SA, Al-Dabbagh RA, Attar EA, Bukhary DM, Algamaiah H, Musawa K, Subahi A, Abuzinadah SH, Alhaddad AJ, Alqahtani WMS, Emam ANM, Alqhtani MA, Elmarakby AM

“…Osamah Alsulimani,1 Salah A Yousief,2,3 Raghad A Al-Dabbagh,4 Esraa A Attar,4 Dalea M Bukhary,4 Hamad Algamaiah,5 Khadija Musawa,6 Awatif Subahi,6 Samar H Abuzinadah,7 Abdulrahman J Alhaddad,4 Waleed MS Alqahtani,8 Abdel Naser M Emam,9 Mohammad A Alqhtani,9 Ahmed M Elmarakby2,10 1Department of Oral Diagnostic Sciences, Faculty of Dentistry, King Abdulaziz University, Jeddah, Saudi Arabia; 2Department of Restorative and Prosthetic Dental Sciences, College of Dentistry, Dar Al Uloom University, Riyadh, 13313, Saudi Arabia; 3Department of Crown and Bridge, Faculty of Dental Medicine, Al-Azhar University, Assuit, Egypt; 4Department of Oral and Maxillofacial Prosthodontics, Faculty of Dentistry, King Abdulaziz University, Jeddah, Saudi Arabia; 5Department of Restorative Dental Science, King Saud University, College of Dentistry, Riyadh, Saudi Arabia; 6BDS, General Dentist, Faculty of Dentistry, King Abdulaziz University, Jeddah, Saudi Arabia; 7Department of Restorative Dentistry, Faculty of Dentistry, King Abdulaziz University, Jeddah, Saudi Arabia; 8Department of Prosthetic Dentistry, College of Dentistry, King Khalid University, Abha, Saudi Arabia; 9Department of Prosthetic Dental Science, Faculty of Dentistry, Najran University, Najran, Saudi Arabia; 10Department of Operative Dentistry, Faculty of Dental Medicine, Al-Azhar University, Assuit, EgyptCorrespondence: Salah A Yousief, Department of Restorative and Prosthetic Dental Sciences, College of Dentistry, Dar Al Uloom University, Riyadh, 13313, Saudi Arabia, Tel +966598045800, Email Salah.a@dau.edu.saBackground: Improved Lithium Disilicate Ceramic has been highly valued in dentistry for over two decades, owing to its durability and aesthetic qualities, making it a preferred choice for both anterior and posterior crowns.Objective: This study aimed to evaluate the flexural strength of two types of lithium disilicate blocks post-chewing simulation.Materials and Methods: Seventy-six lithium disilicate specimens were utilized in this study. …”
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Clinical Characteristics and Treatment Options of Peripheral Spondyloarthritis by ZENG Lulu, JI Xiaojian, HU Lidong, HU Jiawen, ZHANG Yinan, ZHANG Jiaxin, LIU Xingkang, YANG Shiwei, HUANG Feng

“…Compared to axSpA patients, pSpA patients had fewer male patients(62.5% vs. 79.7%, P < 0.001), later onset age(33.8 years vs. 22.0 years, P < 0.001), shorter diagnostic delays(6.0 months vs. 14.2 months, P=0.004), more associated peripheral arthritis(71.7% vs. 9.3%, P < 0.001) and dactylitis(6.5% vs. 0.3%, P < 0.001), more cases of psoriasis(52.7% vs. 1.1%, P < 0.001) and a more common family history of psoriasis(11.4% vs. 3.4%, P < 0.001). pSpA patients had higher levels of inflammatory markers but a lower positive rate of human leukocyte antigen(HLA)-B27(43.5% vs. 87.4%, P < 0.001). …”
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Effect of nonsteroidal anti-inflammatory drugs on neonatal calf diarrhea when administered at a disease alert generated by automated milk feeders by A. Welk, M.C. Cantor, H.W. Neave, J.H.C. Costa, J.L. Morrison, C.B. Winder, D.L. Renaud

“…An alert that was previously validated as diagnostically accurate to identify calves at risk for diarrhea was used using automated milk feeder data (≤60% rolling dividends in milk intake or drinking speed over 2 d). …”
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Time Interval for Diagnosis of Tuberculosis and Related Expenditure in Selected Health Centers in Addis Ababa, Ethiopia by Ezra Shimeles, Melaku Tilahun, Tsegaye Hailu, Fikre Enquselassie, Abraham Aseffa, Alemayehu Mekonnen, Getachew Wondimagegn

“…It is recommended to build capacity of health service providers to update them on programmatic approaches and latest diagnostic algorithm. It is important to strengthen public private partnership for TB services.…”
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Evaluation of three novel antigens and costimulatory agents for improvement of M. Tuberculosis specific interferon gamma release assays by Sandra Schwarzlose-Schwarck, Mark Reinwald, Torsten Bauer, Florian Hentschel, Til Kiderlen, Dorinja Zapf, Victor Herbst, Stefan Lüth, David Krieger, Werner Dammermann

“…Furthermore, we specifically investigated the potential of the complement factor C5a and the toll like receptor (TLR) agonists CpG ODN as well as Poly(I: C) as costimulators in order to increase diagnostic quality of MT IGRAs. Three MT IGRAs were evaluated, i.e. our in-house IGRA, a prototypic EUROIMMUN Quan-T-Cell TB assay and the gold standard QuantiFERON Tb-Gold Plus assay. …”
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Prevalence and factors associated with childhood malaria and anaemia in Osun state, Nigeria: a baseline household malariometric study by Olusola Ajibaye, Semiu Adebayo Rahman, Oluwagbemiga Olanrewaju Aina, Chinazo Ujuju, Chimere Obiora Agomo, Samuel Akindele, Olakiigbe Abiodun, Tolulope Victoria Uzoka, Nnenna Ogbulafor, Olufemi Oroge, Rufai-Ahmed Garba, Michael Ekholuenetale, Kolawole Maxwell, Ridwan Akorede Awosanya, Mary Abosede Adekola, Benjamin Bukky Ilesanmi, Adekemi Ajayi, Olusola Oresanya, James K. Tibenderana, Adeola Yetunde Olukosi

“…Malaria test positivity was determined by rapid diagnostic test (RDT) and microscopy. In addition, haemoglobin levels were measured using Haemocue® Hb 201. …”
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Volume contracted state, mortality and functional outcomes in patients with acute ischaemic stroke due to large vessel occlusion by Risheng Xu, Max Wintermark, Gregory W Albers, Jeremy J Heit, Adam A Dmytriw, Adrien Guenego, Yasmin Aziz, Kambiz Nael, Benjamin Pulli, Victor Urrutia, Dhairya A Lakhani, Tobias D Faizy, Argye Hillis, Vivek Yedavalli, Dylan Wolman, Licia P Luna, Elisabeth B Marsh, Hamza Adel Salim, Janet Mei, Vaibhav Vagal, Aakanksha Sriwastwa, Raf Llinas, Hanzhang Lu, Mona N Bahouth

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Isomeric Differentiation of Four Triterpene Acids Using Full Collision Energy Ramp-MS2 Analysis by Li-juan WU, Rui-ru NAN, Qian WANG, Xin CHEN, Wen-jing LIU, Yue-lin SONG

“…The four isomers were firstly divided into two groups, designated as group I (ursolic acid and oleanolic acid) and group II (α-boswellic acid and β-boswellic acid) through the existences of the so-called diagnostic fragment ions. Moreover, the two isomers belonging to group I show different OCE and RIImax values for m/z 411 and 439, respectively. …”
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Harnessing deep learning to detect bronchiolitis obliterans syndrome from chest CT by Mateusz Koziński, Doruk Oner, Jakub Gwizdała, Catherine Beigelman-Aubry, Pascal Fua, Angela Koutsokera, Alessio Casutt, Argyro Vraka, Michele De Palma, John-David Aubert, Horst Bischof, Christophe von Garnier, Sahand Jamal Rahi, Martin Urschler, Nahal Mansouri

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Inflammatory Gene Signature Identified by Machine Algorithms Reveals Novel Biomarkers of Coronary Artery Disease by Liu X, Zhang Y, Wang Y, Xu Y, Xia W, Liu R, Xu S

“…From this intersection, 29 DIRGs were identified, of which 14 DIRGs (PTGER1, IL17RC, KLKB1, GPR32, ADM, NUPR1, SCN9A, IL17B, CX3CL1, FFAR3, PYDC2, SYT11, RORA, and GPR31) exhibited high diagnostic efficacy. Four biomarkers (ADM, NUPR1, PTGER1, and PYDC2) were identified using Support Vector Machine (SVM). …”
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Phenotypic and Complete Reference Whole Genome Sequence Analyses of Two <i>Paenibacillus</i> spp. Isolates from a Gray Wolf (<i>Canis lupus</i>) Gastrointestinal Tract by Jessika L. Bryant, Jennifer McCabe, C. Cristoph Klews, MiCayla Johnson, Ariel N. Atchley, Thomas W. Cousins, Maya Barnard-Davidson, Kristina M. Smith, Mark R. Ackermann, Michael Netherland, Nur A. Hasan, Peter A. Jordan, Evan S. Forsythe, Patrick N. Ball, Bruce S. Seal

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Warm and humid environment induces gut microbiota dysbiosis and bacterial translocation leading to inflammatory state and promotes proliferation and biofilm formation of certain ba... by Yinrui Guo, Jianlang He, Shaojie Li, Shiqi Zou, Haiting Zhang, Xin Yang, Jian Wang

“…Thick and greasy tongue fur and sticky feces are characteristic symptoms of “Dampness Syndrome” and serve as crucial diagnostic indicators in TCM for assessing health conditions. …”
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Comparative analysis of retinal vascular structural parameters in populations with different glucose metabolism status based on color fundus photography and artificial intelligence by Naimei Chen, Naimei Chen, Zhentao Zhu, Di Gong, Xinrong Xu, Xinya Hu, Weihua Yang

“…Receiver Operating Characteristic (ROC) curve analysis demonstrated that length_avg_a, length_avg_v, branch_avg_v, angle_avg_v, asymmetry_avg_v, vessel_length_density, and vessel_density had diagnostic value for mild-to-moderate NPDR (P &lt; 0.05).ConclusionIn individuals diagnosed with T2DM, specific retinal vascular parameters, such as branch_avg_v and vessel_density, demonstrate a significant correlation with mild-to-moderate NPDR. …”
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Functional cognitive disorder: Beyond pseudodementia by D.S. Marín-Medina, P.A. Arenas-Vargas, M. del Pilar Velásquez-Duque, P.M. Bagnati

“…We describe circumstances in which diagnostic support and neuropsychological assessment are required. …”
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Estimation of the incidence of invasive meningococcal disease using a capture–recapture model based on two independent surveillance systems in Catalonia, Spain by Pilar Ciruela, Carmen Munoz-Almagro, Cristina Rius, Tomas Pumarola, Frederic Gomez-Bertomeu, Núria Soldevila, Ángela Domínguez, LAURA RUIZ, Ana Calderon, Ana Martinez, M Ángeles Domínguez, Mercé Garcia, Dionisia Fontanals, Gloria Carmona, Pere Godoy, Goretti Sauca, Jordi Vila, Marta Vilaró, Mireia Jané, Tomás Garcia, Sergi Hernández, Maria Teresa Bastida, Frederic Ballester, Isabel Pujol, Miguel Angel Benítez, Alba Cebollero, Jordi Bosch, Margarida Curriu, Fe Tubau Quintano, Jose Manuel Ramirez, Ma Jose Fusté, Carme Gallés, Pilar Hernandez Pérez, ElisendaCapdevila GildeBernabe, Paula Gassiot, Araceli González-Cuevas, Marius Juanpere, Amaresch Perez Arguello, Carmina Martí, Nuria Margall, Lurdes Matas, Montserrat Giménez, Montserrat Morta, Gloria Trujillo, Silvia Noguer, Montserrat Olsina, Amaia Oteiza Ubanell, Pepa Perez, Mar Olga Pérez-Moreno, Juanjo Gonzales, Xavier Raga, Mercè Ribelles, Esther Sanfeliu, Isabel Sanfeliu, Anna Vilamala, César Arias, Irene Barrabeig, Neus Camps, Mònica Carol, Núria Follia, Sofia Minguell, Ignasi Parron, Ma Rosa Sala-Farré, Ariadna Rovira

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Rapid detection of Vibrio alginolyticus in seafood using the flgL gene and real-time polymerase chain reaction by Muktiningsih Nurjayadi, Gladys Indira Putri, Jefferson Lynford Declan, Ismaya Krisdawati, Dandy Akbar Juliansyah, Maharanianska Azzahra, Irvan Maulana, Irma Ratna Kartika, Fera Kurniadewi, Tiara Fahriza, Adinda Myra Amalia Putri, Ayu Berkahingrum, Atikah Nur Rahmawati, Rosita Gio Anggraeni, Dalia Sukmawati, Sri Rahayu, Vira Saamia, I Made Wiranatha, Bassam Abomoelak, Hesham Ali El-Enshasy

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