C3AR1 as a target for preeclampsia: from bioinformatics and network pharmacology to experimental validation by Yongfeng Hu, Shaoqiang Li, Yunhui Hong, Dongxian Peng

“…Reduced C3AR1 in preeclamptic placentas correlated with maternal blood pressure, and showed high diagnostic potential (AUC = 0.95). C3AR1’s involvement in preeclampsia was linked to Jak-STAT, TGF-β, and HIF-1 pathways, and associated with NK cell and M1 macrophage activity. …”
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Determining anatomically-safe corridors for placement of lateral mass screws in the first cervical vertebra of the Emirati population – a CT study by Dineshwary Suresh, Nerissa Naidoo, Rashid AlSharhan, Usama Al Bastaki, Jeyaseelan Lakshmanan, Baylis Vivek Joseph, Ivan James Prithishkumar

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Patterns of colonic dismotility and visceral hypersensitivity at various clinical variants of irritable bowel syndrome by Ekaterina A. Bubnova, O. Yu. Fomenko, I. L. Khalif, V. V. Pavlenko

“…The diagnosis is verified by modern instrumental and laboratory diagnostic methods (colonoscopy with biopsy, abdominal ultrasonography etc.), and complied to Rome-III criteria. …”
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Hereditary transthyretin amyloidosis incidentally diagnosed by video-associated lung surgery for lung cancer: A case report by Katsuhiro Itogawa, Shintaro Sato, Hideaki Yamakawa, Keiichi Akasaka, Masako Amano, Akiko Adachi, Hidekazu Matsushima

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Economic Burden of Contraception Management in Spain by Inmaculada Parra Ribes, Juan José Rascón Poza, Ezequiel Pérez Campos, Ignacio Bugella Yudice, Maria Jesús Rodríguez Domingo

“…The costs included in the analysis were diagnostic tests, initial and follow-up consultations, methods acquisition costs, and UP derived from therapy failure. …”
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Investigating the relationship between thought interference, somatic passivity and outcomes in patients with psychosis: a natural language processing approach using a clinical reco... by Robert Stewart, Anna Kolliakou, Jyoti Sanyal, Rashmi Patel, Thibault Thierry Magrangeas

“…Objectives We aimed to apply natural language processing algorithms in routine healthcare records to identify reported somatic passivity (external control of sensations, actions and impulses) and thought interference symptoms (thought broadcasting, insertion, withdrawal), first-rank symptoms traditionally central to diagnosing schizophrenia, and determine associations with prognosis by analysing routine outcomes.Design Four algorithms were developed on deidentified mental healthcare data and applied to ascertain recorded symptoms over the 3 months following first presentation to a mental healthcare provider in a cohort of patients with a primary schizophreniform disorder (ICD-10 F20-F29) diagnosis.Setting and participants From the electronic health records of a large secondary mental healthcare provider in south London, 9323 patients were ascertained from 2007 to the data extraction date (25 February 2020).Outcomes The primary binary dependent variable for logistic regression analyses was any negative outcome (Mental Health Act section, >2 antipsychotics prescribed, >22 days spent in crisis care) over the subsequent 2 years.Results Final adjusted models indicated significant associations of this composite outcome with baseline somatic passivity (prevalence 4.9%; adjusted OR 1.61, 95% CI 1.37 to 1.88), thought insertion (10.7%; 1.24, 95% CI 1.15 to 1.55) and thought withdrawal (4.9%; 1.36, 95% CI 1.10 to 1.69), but not independently with thought broadcast (10.3%; 1.05, 95% CI 0.91 to 1.22).Conclusions Symptoms traditionally central to the diagnosis of schizophrenia, but under-represented in current diagnostic frameworks, were thus identified as important predictors of short-term to medium-term prognosis in schizophreniform disorders.…”
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Lipid Metabolism-Related Gene Signature Predicts Prognosis and Indicates Immune Microenvironment Infiltration in Advanced Gastric Cancer by Lijian He, Qiange Ye, Yanmei Zhu, Wenqi Zhong, Guifang Xu, Lei Wang, Zhangding Wang, Xiaoping Zou

“…We then used consensus cluster analysis to classify AGC patients into molecular subtypes based on lipid metabolism and constructed a diagnostic model using least absolute shrinkage and selection operator- (LASSO-) Cox regression analysis and Gene Set Enrichment Analysis (GSEA). …”
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Voice analysis and deep learning for detecting mental disorders in pregnant women: a cross-sectional study by Hikaru Ooba, Jota Maki, Hisashi Masuyama

“…The model’s performance was compared to that of the EPDS in terms of sensitivity, specificity, and other diagnostic metrics. Results Of the 172 participants analyzed (149 without mental disorders and 23 with mental disorders), the voice-based model demonstrated a sensitivity of 1.00 and a recall of 0.82, outperforming the EPDS in these areas. …”
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Visual and Auditory fMRI Paradigms for Presurgical Language Mapping: Convergent Validity and Relationship to Individual Variables by Antonina Omisade, Christopher B. O’Grady, Matthias H. Schmidt, John D. Fisk

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Efficacy of Hymecromone in Post-Cholecystectomy Patients by A V. Okhlobystin, A. К. Ufimtseva, M. A. Tatarkina, O. Z. Okhlobystina, V. T. Ivashkin

“…All patients were diagnosed to have SOD according to Rome IV Diagnostic Criteria for functional biliary sphincter of Oddi disorder (E1b). …”
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Potentials and Limitations of Real-Time Elastography for Prostate Cancer Detection: A Whole-Mount Step Section Analysis by Daniel Junker, Georg Schäfer, Friedrich Aigner, Peter Schullian, Leo Pallwein-Prettner, Jasmin Bektic, Wolfgang Horninger, Ethan J. Halpern, Ferdinand Frauscher

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Personal determinants of vandal behaviour among urban school and student youth from a gender perspective by O. V. Kruzhkova, I. V. Deviatovskaia, M. S. Krivoshchekova

“…The HEXACO Personality Inventory, Dark Triad Personality Test and the questionnaire “Motives of Vandalism” were used as diagnostic tools. Mathematical and statistical processing of the results was carried out using comparative statistics (Student’s t-test) and linear regression analysis.The results of the study confirm the existence of significant differences in the motivational readiness for vandalism among the male and female subsamples. …”
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Epigenetic Biomarkers and the Wnt/β-Catenin Pathway in Opisthorchis viverrini-associated Cholangiocarcinoma: A Scoping Review on Therapeutic Opportunities. by Alok Kafle, Sutas Suttiprapa, Mubarak Muhammad, Jan Clyden B Tenorio, Roshan Kumar Mahato, Norhidayu Sahimin, Shih Keng Loong

“…Promoter hypermethylation of specific genes suggests potential diagnostic biomarkers and dysregulation of Wnt/β-catenin-modulating genes contributes to pathway activation in Ov-CCA progression. …”
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Decision tree-based learning and laboratory data mining: an efficient approach to amebiasis testing by Enas Al-khlifeh, Ahmad S. Tarawneh, Khalid Almohammadi, Malek Alrashidi, Ramadan Hassanat, Ahmad B. Hassanat

“…This is especially evident in developing countries, where infections are more common. The primary diagnostic method in laboratories involves the microscopy of stool samples. …”
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Factors Associated with Malaria Infection among Head Porters in Agbogbloshie Market in the Greater Accra Region of Ghana by Patience Kwofie, John Tetteh, Reindorf Elijah Akakpo, Bismark Sarfo

“…A total of 218 head porters were recruited from the Agbogbloshie market, and blood samples were collected from participants to test for malaria parasite infection using Rapid Diagnostic Test (RDT) and microscopy and were interviewed using a closed-ended questionnaire. …”
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Accuracy of Deep Learning Algorithms for the Diagnosis of Retinopathy of Prematurity by Fundus Images: A Systematic Review and Meta-Analysis by Jingjing Zhang, Yangyang Liu, Toshiharu Mitsuhashi, Toshihiko Matsuo

“…We performed a systematic review and meta-analysis of published evidence to summarize and evaluate the diagnostic accuracy of DL algorithms for ROP by fundus images. …”
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Drawing-Aware Parkinson’s Disease Detection Through Hierarchical Deep Learning Models by Ioannis Kansizoglou, Konstantinos A. Tsintotas, Daniel Bratanov, Antonios Gasteratos

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Sunflower lines originated from varieties with high oil content in their seed by V. A. Gavrilova, I. N. Anisimova, T. G. Stupnikova

“…Lines originated from one and the same variety can differ by the presence of diagnostic markers of the Rf1 gene controlling pollen fertility restoration in forms with cytoplasmic male sterility, and also by allelic variants of storage protein genes and morphological characters.…”
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Association between asymptomatic submicroscopic and microscopic malaria infections and anemia: A study in southern Benin. by Alejandro Rojas Chaves, Yannelle Dossou, Armel Djènontin, Elisée Adimi, Romuald Akoho, Justine Bailly, Aziz Bouraïma, Déborah Matondo, Yolande Sissinto, Dismand Houinato, Achille Massougbodji, Célia Dechavanne, Gilles Cottrell

“…This underscores the importance of employing ultrasensitive diagnostic methods for such infections and acknowledging their potential health implications.…”
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Serum connexin 26 as a potential marker of non-syndromic hearing loss by Hend M. Moness, Noha M. Abdullah, Doaa El Amrousy, Reham Gamal, Hatem A. Mohamed, Mohammed A. Gomaa, Shaimaa Moustafa Hafez, Zamzam Hassan Mohamed

“…Conclusion Serum connexin 26 could be used as a good diagnostic marker to detect NSHL in children. It could be used as a potential marker for NSHL in newborns as it is more rapid and easily available than genetic study, especially in developing countries.…”
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