Alpha-2-adrenergic receptor agonists for the prevention of delirium and cognitive decline after open heart surgery (ALPHA2PREVENT): protocol for a multicentre randomised controlled... by Eva Skovlund, Rune Haaverstad, Henrik Zetterberg, Jorunn L Helbostad, Rolf Busund, Johan Raeder, Theis Tønnessen, Torgeir Bruun Wyller, Melanie R Simpson, Nils Kristian Skjærvold, Bjørn Erik Neerland, Svein Aslak Landsverk, Ieva Martinaityte, Hilde Margrethe Norum, Geir Selbaek, Elisabeth Skaar, Arjen JC Slooter, Øyvind Sverre Svendsen, Alexander Wahba

“…The infusion rate will be decreased to 0.2 µg/kg/hour postoperatively and be continued until discharge from the ICU or 24 hours postoperatively, whichever happens first.Primary end point is the 7-day cumulative incidence of postoperative delirium (Diagnostic and Statistical Manual of Mental Disorders, fifth edition). …”
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Morphological and Chemical Changes in the Hemolymph of the Wax Moth <i>Galleria mellonella</i> Infected by the Entomopathogenic Fungus <i>Conidiobolus coronatus</i> by Mieczysława Irena Boguś, Agata Kaczmarek, Anna Katarzyna Wrońska, Mikołaj Drozdowski, Lena Siecińska, Ewelina Mokijewska, Marek Gołębiowski

“…Its composition can provide important information about the physiological state of an insect and can have diagnostic significance, which might be particularly important in the case of harmful insects subjected to biological control. …”
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Pharmacokinetic Evaluation of [C]CEP-32496 in Nude Mice Bearing BRAF Mutation-Induced Melanomas by Cuiping Jiang MMSc, Lin Xie MD, PhD, Yiding Zhang BSc, Masayuki Fujinaga PhD, Wakana Mori MSc, Yusuke Kurihara PhD, Tomoteru Yamasaki PhD, Feng Wang MD, PhD, Ming-Rong Zhang MD, PhD

“…Our results indicate that [ 11 C]CEP-32496 has excellent specificity and affinity for the BRAF V600E mutation in vitro, while its noninvasive personalized diagnostic role needs to be studied further.…”
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CircWDR78 inhibits the development of colorectal cancer by regulating the miR-653-3p/RGS4 axis by Chu Hao, Yunju Pu, Jiunian Li, Zhi Zhong, Zhaohui Huang, Xue Wang

“…Abstract Background Colorectal cancer (CRC) stands as one of the most serious threats to human health, with its mortality rate increase during the past years. Low diagnostic accuracy, poor prognosis, and high recurrence rates attributed to the high mortality rate of CRC. …”
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Establishing a preoperative predictive model for gallbladder adenoma and cholesterol polyps based on machine learning: a multicentre retrospective study by Yubing Wang, Chao Qu, Jiange Zeng, Yumin Jiang, Ruitao Sun, Changlei Li, Jian Li, Chengzhi Xing, Bin Tan, Kui Liu, Qing Liu, Dianpeng Zhao, Jingyu Cao, Weiyu Hu

“…Abstract Background With the rising diagnostic rate of gallbladder polypoid lesions (GPLs), differentiating benign cholesterol polyps from gallbladder adenomas with a higher preoperative malignancy risk is crucial. …”
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Sigmoid Volvulus in Pregnancy Assessed by Contrast-Enhanced Computed Tomography Scanning by Toshiaki Watanabe, Tadatsugu Kinjo, Yoshino Kinjyo, Hayase Nitta, Hitoshi Masamoto, Keiko Mekaru, Yoichi Aoki

“…Second, abdominal contrast-enhanced CT is useful for rapid diagnostic and treatment decisions relative to this pathology.…”
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Unsteady ground: understanding the problem of BPPV in the world of sports by Wojciech Nowak, Mirosław Sawicki, Jagoda Mikołajczyk, Paulina Krzemińska, Maciej Gołębski, Zuzanna Kukla, Sebastian Musialik, Stella Mieruszyńska, Jakub Włosiański, Izabela Sadowska

“…Presenting all at once: the data, diagnostic and treatement strategy, we resume the existing knowledge on the phenomenon of BPPV in physical activity. …”
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A Cause of Diarrhea in a Patient with Selective Immunoglobulin A Deficiency by M. I. Gonik, V. S. Shcherbakha, E. Yu. Yuryeva, I. M. Kartavenko, A. S. Tertychny, P. V. Pavlov, A. E. Leonovich, T. L. Lapina, V. T. Ivashkin

“…Despite the absence of antibodies to parietal cells and intrinsic factor, a diagnosis of autoimmune gastritis was established on the basis of histologically confirmed atrophy of the stomach; decrease in serum pepsinogen I and the ratio of pepsinogen I to pepsinogen II, hypergastrinemia; vitamin B12 deficiency; proven autoimmune thyroiditis (antibodies to thyroglobulin and thyroid peroxidase in the diagnostic titre). Histologically, lymphoid hyperplasia of the stomach was determined. …”
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An assessment of breast cancer HER2, ER, and PR expressions based on mammography using deep learning with convolutional neural networks by Shun Zeng, Hongyu Chen, Rui Jing, Wenzhuo Yang, Ligong He, Tianle Zou, Peng Liu, Bo Liang, Dan Shi, Wenhao Wu, Qiusheng Lin, Zhenyu Ma, Jinhui Zha, Yonghao Zhong, Xianbin Zhang, Guangrui Shao, Peng Gong

“…The model has the potential to predict HER2, PR, and especially ER expressions, and thus serve as an adjunctive diagnostic tool for breast cancer.…”
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Multiple rare abdominal aortic branch variations in the case of a centenarian woman. Case report and review of the literature by Michela Vincis, Claire Lewis, Denis Barry, Marcello Trucas

“…Background: Anatomical variations of the abdominal aorta are crucial when considering the success of clinical procedures including diagnostic imaging, oncologic resections, organ transplantations, laparoscopic surgeries, management of penetrating abdominal injuries, and interventional radiological procedures. …”
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Clinical characteristics and treatment outcomes of patients with insulinoma–a single center's experience of 76 cases over a 10-year period by Wei Li, Yali Cheng, Qingyong Ma, Zheng Wu, Zheng Wang

“…When CT combined with MRI was used, the diagnostic rate was as high as 96.87 %. Of the 76 patients, 48.68 % of preoperative tumors were in the head/neck, and the remaining 51.32 % were in the body/tail. …”
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Analysis of clinical characteristics and risk factors for patients with heat stroke in western China in 2022: a multicenter retrospective study by Xin Zheng, Yuchun Gao, Qinli Xie, Qiulan Chen, Chuan Guo, Qionglan Dong, Jin Tang, Jun Luo, Ying Ge, Jian He, Xiaolin Hou, Guanghong Zhou, Yuan Chen, Haiquan Cao, Jiujia Xiao, An Lan, Qiu Chen, Yonghong Zeng, Jing Huang, Huaicong Long

“…The AUC values for the combined diagnostic model were 0.848 (95% CI: 0.781–0.914). Male morbidity, the number of patients with combined hypertension, the prognosis, and the APACHE II score and ALT level were all greater (p &lt; 0.05) in the CHS group. …”
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Immune checkpoint inhibitor-induced diabetes mellitus: clinical characteristics and risk factors by Mei Zhan, Mei Zhan, Qinran Long, Qinran Long, Jinhan He, Jinhan He, Jinhan He, Litao Huang, Bin Wu, Bin Wu, Haixia Xu, Li Mo, Ting Xu

“…Among them, 1,077 patients (13.14%) developed ICI-DM according to diagnostic criteria based on guidelines. By excluding patients influenced by glucocorticoids or immunosuppressants, ICI-DM was observed in 713 of 8,199 (8.70%) patients. …”
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M-Mode in grade 3 dyspneic patients assessment by Ravikanti Karthik, Yerramsetty Venu Sashank, Kumar Ranjith K., Haward Raymond

“…To clinically achieve higher accuracy during the diagnostic process, our study uses motion-mode (M-MODE) echo parameters. …”
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Distinctive Gut Microbiota Alteration Is Associated with Poststroke Functional Recovery: Results from a Prospective Cohort Study by Yini Dang, Xintong Zhang, Yu Zheng, Binbin Yu, Dijia Pan, Xiaomin Jiang, Chengjie Yan, Qiuyu Yu, Xiao Lu

“…Random forest and receiver operating characteristic analysis were used to identify potential diagnostic biomarkers. Relationships between discriminant bacteria and poststroke functional outcomes were estimated. …”
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A Multi-Branch Convolution and Dynamic Weighting Method for Bearing Fault Diagnosis Based on Acoustic–Vibration Information Fusion by Xianming Sun, Yuhang Yang, Changzheng Chen, Miao Tian, Shengnan Du, Zhengqi Wang

“…The model achieved over 99% diagnostic accuracy under all signal-to-noise ratio (SNR) conditions, showcasing exceptional robustness and noise resistance in both noisy and high-SNR environments. …”
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The Difference in Translaminar Pressure Gradient and Neuroretinal Rim Area in Glaucoma and Healthy Subjects by Lina Siaudvytyte, Ingrida Januleviciene, Arminas Ragauskas, Laimonas Bartusis, Indre Meiliuniene, Brent Siesky, Alon Harris

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Usefulness of Double-Balloon Endoscopy in the Postoperative Gastrointestinal Tract by Masaki Endo, Yukito Abiko, Syuhei Oana, Norihiko Kudara, Takashi Kosaka, Toshimi Chiba, Yasuhiro Takikawa, Kazuyuki Suzuki, Tamotsu Sugai

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A Single‐Center Retrospective Cohort Study of Biopterin Metabolism Disorders in the United Arab Emirates by Omar Jarrah, Mahmood Nouri, Aisha Al Shamsi

“…It describes new genetic variants and addresses diagnostic challenges to enhance the patient's diagnosis and treatment.…”
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Circulating fibroblast growth factor 21 levels in gestational diabetes mellitus and preeclampsia: a systematic review and meta-analysis by Zhen Cao, Zhiming Deng, Jieyi Lu, Ying Yuan

“…Conclusions Our study found that FGF21 has the potential to serve as a diagnostic marker for GDM or PE. However, due to the limited number of studies and the fact that most data were from the second and third trimesters of pregnancy, more large-scale prospective studies are needed to validate these conclusions, investigate the potential of FGF21 in enabling early diagnosis, and further examine the role of FGF21 in the development and progression of GDM/PE. …”
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