Cushing’s disease with twin pregnancy and diabetes mellitus: a case report and literature review by Hideyasu Asai, Ikuo Yamamori, Shigeru Hagimoto, Kyoichi Okumura, Koki Sakakibara

“…Therefore, we reported the third case of CD in a twin pregnancy and reviewed the diagnostic and therapeutic challenges associated with CD during pregnancy.…”
Get full text

SARS-CoV-2 Evolution: Implications for Diagnosis, Treatment, Vaccine Effectiveness and Development by Fabrizio Angius, Silvia Puxeddu, Silvio Zaimi, Serena Canton, Sepehr Nematollahzadeh, Andrea Pibiri, Ilenia Delogu, Gualtiero Alvisi, Meng Ling Moi, Aldo Manzin

“…In the past four years, immense research efforts have contributed much to our understanding of the viral pathogenesis mechanism, the COVID-19 syndrome, and the host–microbe interactions, leading to the development of effective vaccines, diagnostic tools, and treatments. The focus of this review is to provide a comprehensive analysis of the functional impact of mutations on diagnosis, treatments, and vaccine effectiveness. …”
Get full text

Combined Klippel-Feil syndrome, Sprengel deformity, and diffuse large B-cell lymphoma: A rare case report by Golnaz Lotfian, MD, Amirmasoud Negarestani, MD, Sarah Gondek, BS, Aleksandr Raskind, DO, William Chen, MD, Emad Allam, MD

“…We hereby present a complex case of a 60-year-old male with the co-occurrence of KFS, Sprengel deformity, and DLBCL. Diagnostic imaging revealed an ill-defined right neck mass on ultrasound which was confirmed on neck CT. …”
Get full text

Groping for Quantitative Digital 3-D Image Analysis: An Approach to Quantitative Fluorescence In Situ Hybridization in Thick Tissue Sections of Prostate Carcinoma by Karsten Rodenacker, Michaela Aubele, Peter Hutzler, P. S. Umesh Adiga

“…The quantitative evaluation of such events is a necessary condition for a prospective use in diagnostic pathology. To avoid occlusions of signals, the cell nucleus has to be analyzed in three dimensions. …”
Get full text

B-Flow Twinkling Sign in Preoperative Evaluation of Cervical Lymph Nodes in Patients with Papillary Thyroid Carcinoma by Giuseppina Napolitano, Antonio Romeo, Andrea Bianco, Maurizio Gasperi, Pio Zeppa, Luca Brunese

“…The ultrasonography (US) is the best diagnostic method for the detection of cervical metastatic LNs. …”
Get full text

PseudoCell: Hard Negative Mining as Pseudo Labeling for Deep Learning-Based Centroblast Cell Detection by Narongrid Seesawad, Piyalitt Ittichaiwong, Thapanun Sudhawiyangkul, Phattarapong Sawangjai, Peti Thuwajit, Paisarn Boonsakan, Supasan Sripodok, Kanyakorn Veerakanjana, Komgrid Charngkaew, Ananya Pongpaibul, Napat Angkathunyakul, Narit Hnoohom, Sumeth Yuenyong, Chanitra Thuwajit, Theerawit Wilaiprasitporn

“…Depending on the confidence threshold, <italic>PseudoCell</italic> can eliminate 58.18-99.35&#x0025; of irrelevant tissue areas on WSI, streamlining the diagnostic process. <italic>Conclusion:</italic> This study presents <italic>PseudoCell</italic> as a practical and efficient prescreening method for centroblast detection, eliminating the need for refined labels from pathologists. …”
Get full text

Calcific Tendinitis of the Supraspinatus Tendon in an Infant by Masanori Wako, Jiro Ichikawa, Kensuke Koyama, Yoshihiro Takayama, Hirotaka Haro

“…Because only four other pediatric cases of calcific tendinitis of the supraspinatus tendon have ever been reported, there is a lack of information on the diagnostic process, management, and treatment of such a condition in young patients. …”
Get full text

Symptom clusters and resting cardiovascular autonomic measures in adolescents: From acute concussion to recovery by Wenjie Ji, Haley M. Chizuk, John J. Leddy, Sue A. Sisto, Mohammad N. Haider

“…Resting cardiovascular ANS function remains unchanged in adolescent athletes acutely after SRC, suggesting it has limited diagnostic and prognostic potential. Although some correlations between individual symptom domains and ANS activity were observed, they were not significantly different from asymptomatic controls, limiting the ability to interpret these findings.…”
Get full text

Brain Abscess and Keratoacanthoma Suggestive of Hyper IgE Syndrome by Soheyla Alyasin, Reza Amin, Alireza Teymoori, Hamidreza Houshmand, Gholamreza Houshmand, Mohammad Bahadoram

“…Laboratory workup for immune deficiency showed high eosinophil count and high level of immunoglobulin-E, due to some diagnostic criteria (NIH sores: 41 in 9-year-olds), he was suggestive of hyper IgE syndrome. …”
Get full text

Developing non-invasive molecular markers for early risk assessment of Alzheimer's disease by Tapas K. Sur, Tanmoy Mondal, Zarish Noreen, Jheannelle Johnson, Gail Nunlee-Bland, Christopher A. Loffredo, Brent E. Korba, Vijay Chandra, Siddhartha S. Jana, Bernard Kwabi-Addo, Sumit Sarkar, Somiranjan Ghosh

“…Current improvements have unveiled the disease's pathophysiology and clinical diagnostic tests, targeting the neurological changes (neurodegeneration, amyloid precursor protein metabolism and tangle pathology) with precise PET/MRI imaging and xMAP/SIMOA (Multiplex simultaneous detection/single molecule array) to identify and quantify β-amyloids (Aβ40, Aβ42), total tau (T-tau) and phosphorylated tau (P-tau) proteins in the brain and cerebrospinal fluid (CSF) of patients. …”
Get full text

Designing a Web Page to Improve Tutors’ Role in Nursing Students Formation by Juan Carlos Alvarado Peruyero, Zulema Bos Rodríguez, Nancy Ester Sosa Botana, Lourdes Montenegro Arias, Ariel Barceló Bos

“…In order to identify tutors’ needs, a questionnaire and a diagnostic test were applied to 33,7 % of active-teaching tutors, randomly selected from a total of 169. …”
Get full text

Posterior Mediastinal Adenomatoid Tumor: A Case Report and Review of the Literature by Vishwas Parekh, Thomas Winokur, Robert J. Cerfolio, Todd M. Stevens

“…The lesional cells expressed cytokeratin, calretinin, and nuclear WT1 but were negative for PAX8, TTF1, p53, chromogranin, CD31, and CD34, and Ki67 showed <2% proliferation rate, diagnostic of adenomatoid tumor. Three years after resection, the patient is in good health without tumor recurrence. …”
Get full text

Safety and effectiveness of laparoscopic renal biopsy: a single-center review and meta-analysis by Lingling Xu, Xueqin Bian, Jian Yang, Hongying Xu, Yi Fang, Junwei Yang, Lei Jiang, Ping Wen

“…Background While renal biopsy remains the preferred diagnostic method for assessing proteinuria, hematuria, or renal failure, laparoscopic renal biopsy (LRB) can serve as an alternative for high-risk patients when percutaneous kidney biopsy (PKB) is not recommended. …”
Get full text

A Comprehensive Review of Artificial Intelligence (AI) Applications in Pulmonary Hypertension (PH) by Sogol Attaripour Esfahani, Nima Baba Ali, Juan M. Farina, Isabel G. Scalia, Milagros Pereyra, Mohammed Tiseer Abbas, Niloofar Javadi, Nadera N. Bismee, Fatmaelzahraa E. Abdelfattah, Kamal Awad, Omar H. Ibrahim, Hesham Sheashaa, Timothy Barry, Robert L. Scott, Chadi Ayoub, Reza Arsanjani

“…<i>Background:</i> Pulmonary hypertension (PH) is a complex condition associated with significant morbidity and mortality. Traditional diagnostic and management approaches for PH often face limitations, leading to delays in diagnosis and potentially suboptimal treatment outcomes. …”
Get full text

Brucella abortus Strain RB51 Vaccine: Immune Response after Calfhood Vaccination and Field Investigation in Italian Cattle Population by Manuela Tittarelli, Barbara Bonfini, Fabrizio De Massis, Armando Giovannini, Mauro Di Ventura, Donatella Nannini, Vincenzo Caporale

“…The design of a more sophisticated diagnostic protocol including an epidemiological investigation, the use of RB51-CFT, and the use of the skin test with RB51 as antigen is deemed more appropriate for the identification of RB51 vaccinated animals.…”
Get full text

MFGE8, ALB, APOB, APOE, SAA1, A2M, and C3 as Novel Biomarkers for Stress Cardiomyopathy by Xiao-Yu Pan, Zai-Wei Zhang

“…Seven hub genes contained APOE, MFGE8, ALB, APOB, SAA1, A2M, and C3 identified as hub genes of SCM, which might be used as diagnostic biomarkers or molecular targets for the treatment of SCM.…”
Get full text

ThyroNet-X4 genesis: an advanced deep learning model for auxiliary diagnosis of thyroid nodules’ malignancy by Xiaoxue Wang, Yupeng Niu, Hongli Liu, Fa Tian, Qiang Zhang, Yimeng Wang, Yeju Wang, Yijia Li

“…This work underscores the growing role of deep learning in thyroid nodule diagnosis and provides a foundation for future research in high-performance medical diagnostic models.…”
Get full text

From Serendipity to Precision: Integrating AI, Multi-Omics, and Human-Specific Models for Personalized Neuropsychiatric Care by Masaru Tanaka

“…This paradigm shift, which combines cutting-edge technologies with systematic frameworks, promises increased diagnostic accuracy, reproducibility, and efficiency, paving the way for tailored treatments and better patient outcomes in neuropsychiatric care.…”
Get full text

Bibliometric analysis of 100 most cited papers on oral proliferative verrucous leukoplakia by Namrata Sengupta, Gargi S. Sarode, Sachin C. Sarode

“…Oral proliferative verrucous leukoplakia (OPVL) is a challenging lesion with no uniform diagnostic criteria. Thus, bibliometric analysis of published papers in this field will help researchers and clinicians to get an overview of the research trends and the research lacunae associated with OPVL. …”
Get full text

miR-370-3p as a Novel Biomarker Promotes Breast Cancer Progression by Targeting FBLN5 by Jiahui Mao, Lingxia Wang, Junying Wu, Yichun Wang, Huiyan Wen, Xueming Zhu, Bo Wang, Huan Yang

“…The purpose of this study was to explore the roles and clinical diagnostic value of miR-370-3p in breast cancer. Our results demonstrated that miR-370-3p significantly promoted proliferation, metastasis, and stemness of breast cancer in vitro and in vivo. …”
Get full text