Propionibacterium acnes Causing Mediastinal Infection following Endobronchial Ultrasound-Guided Transbronchial Needle Aspiration by Katherine Janssen, Joseph Keenan, Roy Cho, Erhan Dincer

“…Endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) is now a standard of care to sample mediastinal lymph nodes and masses with high diagnostic accuracy and low complication rates. However, the procedure has potential complications that might be life-threatening. …”
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Diarrhea in the HIV-Infected Patient by Peter Phillips

“…Considerable progress has been made in recents years regarding our understanding or HIV-related diarrhea, including etiological agents, diagnostic methods and treatment.…”
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Sprain of the Subaxial Cervical Spine in Childhood by Rebecca F. Lyons, Kevin McSorely, Mutaz Jadaan, J. P. McCabe, Colin G. Murphy

“…Presenting with minimal symptoms other than neck pain, this case highlights the diagnostic difficulty and need for further radiological imaging in paediatric patients with neck pain post trauma.…”
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Middle Ear Welding Injury: Case Report and Literature Review by Gabriele Bruno, Elena Carlotto, Fabio Bramardi, Elisa Franco, Alessia Lanzillotta, Walter Lerda, Nertila Naqe, Silvia Ponzo

“…An exhaustive review of the literature is lacking, particularly with regard to clinical presentation, diagnostic-therapeutic work-up, and outcomes. Here we describe the clinical details of an injury caused by the largest welding foreign body ever reported in the ME. …”
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Proteomic profiling of the local and systemic immune response to pediatric respiratory viral infections by Emily Lydon, Christina M. Osborne, Brandie D. Wagner, Lilliam Ambroggio, J. Kirk Harris, Ron Reeder, Todd C. Carpenter, Aline B. Maddux, Matthew K. Leroue, Nadir Yehya, Joseph L. DeRisi, Mark W. Hall, Athena F. Zuppa, Joseph Carcillo, Kathleen Meert, Anil Sapru, Murray M. Pollack, Patrick McQuillen, Daniel A. Notterman, Charles R. Langelier, Peter M. Mourani

“…To address this gap, gain insights into vLRTI pathophysiology, and test a novel diagnostic approach, we assayed 1,305 proteins in tracheal aspirate (TA) and plasma from 62 critically ill children using SomaScan. …”
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Exploring the comorbidity mechanisms between atherosclerosis and hashimoto’s thyroiditis based on microarray and single-cell sequencing analysis by Yirong Ma, Shuguang Wu, Junyu Lai, Qiang Wan, Jingxuan Hu, Yanhong Liu, Ziyi Zhou, Jianguang Wu

“…Furthermore, the core genes and their interactions with immune cells could serve as promising targets for future diagnostic and therapeutic strategies.…”
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Early warning systems for identifying severe maternal outcomes: findings from the WHO global maternal sepsis studyResearch in context by Yamikani Chimwaza, Alexandra Hunt, Livia Oliveira-Ciabati, Laura Bonnett, Edgardo Abalos, Cristina Cuesta, João Paulo Souza, Mercedes Bonet, Vanessa Brizuela, David Lissauer, Yamikani Chimwaza, Alexandra Hunt, Livia Oliveira-Ciabati, Laura Bonnett, Edgardo Abalos, Cristina Cuesta, João Paulo Souza, Mercedes Bonet, Vanessa Brizuela, David Lissauer, Mohammad Iqbal Aman, Bashir Noormal, Marisa Espinoza, Julia Pasquale, Charlotte Leroy, Kristien Roelens, Griet Vandenberghe, M. Christian Urlyss Agossou, Sourou Goufodji Keke, Christiane Tshabu Aguemon, Patricia Soledad Apaza Peralta, Víctor Conde Altamirano, Rosalinda Hernández Muñoz, José Guilherme Cecatti, Carolina Ribeiro do Valle, Vincent Batiene, Kadari Cisse, Henri Gautier Ouedraogo, Kannitha Cheang, Phirun Lam, Tung Rathavy, Elie Simo, Pierre-Marie Tebeu, Emah Irene Yakana, Javier Carvajal, María Fernanda Escobar, Paula Fernández, Lotte Berdiin Colmorn, Jens Langhoff-Roos, Wilson Mereci, Paola Vélez, Yasser Salah Eldin, Alaa Sultan, Alula M. Teklu, Dawit Worku, Richard Adanu, Philip Govule, Charles Noora Lwanga, William Enrique Arriaga Romero, María Guadalupe Flores Aceituno, Carolina Bustillo, Bredy Lara, Vijay Kumar, Vanita Suri, Sonia Trikha, Irene Cetin, Serena Donati, Carlo Personeni, Guldana Baimussanova, Saule Kabylova, Balgyn Sagyndykova, George Gwako, Alfred Osoti, Zahida Qureshi, Raisa Asylbasheva, Aigul Boobekova, Damira Seksenbaeva, Saad Eddine Itani, Meilė Minkauskienė, Diana Ramašauskaitė, Owen Chikhwaza, Luis Gadama, Eddie Malunga, Haoua Dembele, Hamadoun Sangho, Fanta Eliane Zerbo, Filiberto Dávila Serapio, Nazarea Herrera Maldonado, Juan I. Islas Castañeda, Tatiana Cauaus, Ala Curteanu, Victor Petrov, Yadamsuren Buyanjargal, Seded Khishgee, Bat-Erdene Lkhagvasuren, Amina Essolbi, Rachid Moulki, Zara Jaze, Arlete Mariano, Nafissa Bique Osman, Hla Mya Thway Einda, Thae Maung Maung, Khaing Nwe Tin, Tara Gurung, Amir Babu Shrestha, Sangeeta Shrestha, Kitty Bloemenkamp, Marcus J. Rijken, Thomas Van Den Akker, María Esther Estrada, Néstor J. Pavón Gómez, Olubukola Adesina, Chris Aimakhu, Bukola Fawole, Rizwana Chaudhri, Saima Hamid, M. Adnan Khan, María del Pilar Huatuco Hernández, Nelly M. Zavaleta Pimentel, Maria Lu Andal, Zenaida Dy Recidoro, Carolina Paula Martin, Mihaela Budianu, Lucian Pușcașiu, Léopold Diouf, Dembo Guirassy, Philippe Marc Moreira, Miroslav Borovsky, Ladislav Kovac, Alexandra Kristufkova, Sylvia Cebekhulu, Laura Cornelissen, Priya Soma-Pillay, Vicenç Cararach, Marta López, María José Vidal Benedé, Hemali Jayakody, Kapila Jayaratne, Dhammica Rowel, Wisal Nabag, Sara Omer, Victoria Tsoy, Urunbish Uzakova, Dilrabo Yunusova, Thitiporn Siriwachirachai, Thumwadee Tangsiriwatthana, Catherine Dunlop, Marian Knight, Jhon Roman, Gerardo Vitureira, Dinh Anh Tuan, Luong Ngoc Truong, Nghiem Thi Xuan Hanh, Mugove Madziyire, Thulani Magwali, Stephen Munjanja, Adama Baguiya, Mónica Chamillard, Bukola Fawole, Marian Knight, Seni Kouanda, Pisake Lumbiganon, Ashraf Nabhan, Ruta Nadisauskiene, Linda Bartlett, Fernando Bellissimo-Rodrigues, Shevin T. Jacob, Sadia Shakoor, Khalid Yunis, Liana Campodónico, Hugo Gamerro, Daniel Giordano, Fernando Althabe, A. Metin Gülmezoglu

“…Machine learning was used to test the diagnostic potential of routine maternal sepsis markers. …”
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The Diagnosis Value of a Novel Model with 5 Circulating miRNAs for Liver Fibrosis in Patients with Chronic Hepatitis B by Qingqing Zhang, Qidi Zhang, Binghang Li, Ying Qu, Zhenghong Li, Lungen Lu, Rongzhou Li, Xiaobo Cai

“…The multivariate logistic regression analysis identified that a model of five miRNAs (miR-5) had a high diagnostic accuracy in discrimination of different stages of liver fibrosis. …”
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Interobserver Agreement in the Diagnosis of Inflammatory Bowel Disease-Associated Neoplasia in China in Comparison to Subspecialized American Gastrointestinal Pathologists by Xian-rui Wu, Hua-shan Liu, Xue-ying Shi, Wei-xun Zhou, Zhi-nong Jiang, Yan Huang, Dipti M. Karamchandani, John R. Goldblum, Shu-yuan Xiao, Hong-fa Zhu, Michael M. Feely, Amy L. Collinsworth, Ashwini Esnakula, Hao Xie, Bo Shen, Ping Lan, Xiu-li Liu

“…Each pathologist evaluated the images and selected the most appropriate diagnostic category for each case (negative, indefinite, low-grade dysplasia [LGD], high-grade dysplasia [HGD], and carcinoma). …”
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Unveiling new therapeutic horizons in rheumatoid arthritis: an In-depth exploration of circular RNAs derived from plasma exosomes by Guoqing Li, Hongyi Chen, Jiacheng Shen, Yimin Ding, Jingqiong Chen, Yongbin Zhang, Mingrui Tang, Nan Xu, Yuxuan Fang

“…Diagnostic performance evaluated via receiver operating characteristic (ROC) curves using pROC for area under the curve (AUC). …”
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Analytic and clinical validity of thyroid nodule mutational profiling using droplet digital polymerase chain reaction by Vincent L. Biron, Ashlee Matkin, Morris Kostiuk, Jordana Williams, David W. Cote, Jeffrey Harris, Hadi Seikaly, Daniel A. O’Connell

“…This study aimed to assess the analytic and clinical validity of RAS and BRAF ddPCR mutational testing as a diagnostic tool for thyroid fine needle aspirate biopsy (FNAB). …”
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Homologous recombination deficiency test validation in patients with high-grade advanced ovarian cancer by Angelica Nogueira Rodrigues, Andreza Karine de Barros Almeida Souto, Diocésio Alves Pinto de Andrade, Larissa Müller Gomes, Sandra Satie Koide, Renata de Godoy e Silva, Bruno Batista de Souza, Juliana Doblas Massaro, Andréia Cristina de Melo, Andrea Morais Borges, Camila Giro, Carlos Augusto Vasconcelos de Andrade, Cesar Martins da Costa, Daniel Luiz Gimenes, Eduardo Caminha Bandeira de Mello, Fernanda Cesar de Oliveira, Frederico Müller de Toledo Lima, Gabriel Lima Lopes, Gustavo de Oliveira Bretas, Gustavo Guerra Jacob, Herika Lucia da Costa Silva, Juliana Ferrari Notaro, Lara Ladislau Alves, Marcos Veloso Moitinho, Mirian Cristina da Silva, Roberto Abramoff, Thais Amaral da Cunha Rauber, Rodrigo Dienstmann, Fernanda Christtanini Koyama

“…Our in-house assay is eligible for diagnostic test approval and market access as per Brazilian regulations.…”
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Point-of-care tests in the emergency medical services: a scoping review by T. H. M. Moore, S. Dawson, K. Kirby, R. Body, A. Thompson, Y. O. Adepoju, R. Perry, H. Nicholson, J. Dinnes, K. Mitchell, J. Savović, S. Voss, J. R. Benger

“…The time-lag from diagnostic accuracy to developing an RCT is considerable. …”
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Can Ethiopia eliminate malaria? Malaria burden: insights from the pre-elimination era, current challenges and perspectives by Dagmawi Woldesenbet, Yalewayker Tegegne, Abdulhakim Mussema, Elias Tamene, Kemal Mohamed, Wagaw Abebe, Melese Mekuria, Kasahun Bogale, Habtamu Geremew, Mufta Muzemil Shifa, Mulugeta Aemero Tegegne

“…Previous developments in vector control, diagnostic capabilities, and treatment protocols have led to notable reductions in malaria morbidity and mortality. …”
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Retroperitoneal Cyst: An Uncommon Presentation of Filariasis by Senthil Ganesan, Saurabh Galodha, Rajan Saxena

“…After surgical resection due to diagnostic uncertainty, at histopathology, it turned out be a filarial cyst. …”
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A New Record for Occurrence of Symphodus bailloni (Osteichthyes: Perciformes: Labridae) in the Western Black Sea Coast of Turkey by Didem Göktürk, F. Saadet Karakulak, Nuran Ünsal, Abdullah E. Kahraman

“…Morphometrics, meristics, and diagnostic characteristics of the species are presented.…”
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A call to the use of the clinical method in the practice of perinatal medicine by Carlos Esteban Zerquera Álvarez

“…A reflection on the appropriateness and current application of the clinical method, defined as the diagnostic process inherent to the practice of human medicine is presented. …”
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Use of LARA-urea Breath Test in diagnosis of Helicobacter pylori Infection in Children and Adolescents: A Preliminary Study by Andrew S Day, Sander Veldhuyzen van Zanten, Anthony R Otley, Linda Best, AnneMarie Griffiths, Philip M Sherman

“…The primary aim of the present study was to prospectively evaluate a novel urea breath testing method in children undergoing diagnostic assessment of dyspeptic symptoms and secondarily to consider the roles of other noninvasive tests in these children.…”
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Small Bowel Obstruction Secondary to Intussuscepted Meckel’s Diverticulum in an Adult by Daniel John Marascia

“…The following is a case report that discusses a 29-year-old female who posed diagnostic uncertainty for the treating surgical team and ultimately underwent emergency surgery for the management of intestinal obstruction. …”
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Sister Mary Joseph's Nodule as a First Manifestation of Primary Peritoneal Cancer by C. Iavazzo, K. Madhuri, S. Essapen, N. Akrivos, A. Tailor, S. Butler-Manuel

“…Through a literature search, we also discuss the pathophysiology, diagnostic approach, management, and prognosis of such a condition.…”
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