Alarm sings for primary immunodeficiency diagnosis. A proposal adapted to the Cienfuegos province by Yosvany Castillo Leyva, Alain Alonso Remedios, Grace de Lara García, Daynelis Pardo Martínez, Albert Vera Razumova

“…<br /><strong>Methods:</strong> eleven articles on alarm signs for primary immunodeficiencies diagnosis, published by associations and international organizations dedicated to immunology were reviewed. The sign diagnostic value was determined as a criterion for inclusion in the disease warning signs list. …”
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Neuroleptic Malignant Syndrome (NMS) on Clozapine with a Potential Atypical Interaction with Paliperidone by Paras Agarwal, Adanegbe Omoruyi, Kiara Gascon Perai, Kerenza MacDaid, Andrea Burton

“…While being titrated on clozapine, the patient developed major and minor criteria features of NMS as per the Diagnostic and Statistical Manual of Mental Disorders, Fifth edition (DSM-5) criteria except for fever, a core symptom which created diagnostic uncertainty. …”
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Tropheryma whipplei infection presenting as indolent endophthalmitis by Rami Waked, Jeffrey K. Moore, Brandon Winward, Sophia Ham, Howard W. Hoyt, Leyla Azis

“…This case underscores the diagnostic utility of broad-range bacterial PCR in atypical infections and highlights Whipple infection as a differential diagnosis in ocular presentations. …”
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A Case of Philadelphia Chromosome Positive Myeloproliferative Neoplasm in a Pregnant Woman with Unusual Primary Myelofibrosis Features by Jason Koshy, Jack Alperin, Bagi Jana, Avi Markowitz, You-Wen Qian

“…However, a diagnostic dilemma arises when Philadelphia chromosome-positive MPNs lack the majority of the typical features seen in CML. …”
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IMPROVING PREDICTION ACCURACY OF DEEP LEARNING FOR BRAIN CANCER DIAGNOSIS USING POLYAK-RUPPERT OPTIMIZATION by M Muthulekshmi, Azath Mubarakali, Y M Blessy

“…Recent advancements in deep learning have significantly enhanced diagnostic capabilities, but challenges persist in optimizing model performance for diverse and complex datasets. …”
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Automated Diagnosis of Otitis Media: Vocabulary and Grammar by Anupama Kuruvilla, Nader Shaikh, Alejandro Hoberman, Jelena Kovačević

“…We propose a novel automated algorithm for classifying diagnostic categories of otitis media: acute otitis media, otitis media with effusion, and no effusion. …”
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New Insight into Laboratory Tests and Imaging Modalities for Fast and Accurate Diagnosis of COVID-19: Alternative Suggestions for Routine RT-PCR and CT—A Literature Review by Amir Khorasani, Amir Chegini, Arezoo Mirzaei

“…The globally inimitable and unremitting outbreak of COVID-19 infection confirmed the emergency need for critical detection of human coronavirus infections. Laboratory diagnostic tests and imaging modalities are two test groups used for the detection of COVID-19. …”
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Cancer of the Pancreas: The Best Image for Early Detection – CT, MRI, PET or US? by Anthony E Hanbidge

“…Abdominal ultrasound, computed tomography, magnetic resonance imaging and endoscopic retrograde cholangiopancreatography are the most commonly used radiological techniques for imaging the pancreas. The diagnostic evaluation should be tailored to the individual patient. …”
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Effects of tissue type and season on the detection of regulated sugarcane viruses by high throughput sequencing by Stephen Bolus, Kate Wathen-Dunn, Samuel C. Grinstead, Xiaojun Hu, Martha Malapi, Dimitre Mollov

“…Abstract High throughput sequencing (HTS) can supplement and may replace diagnostic tests for plant pathogens. However, the methodology and processing of HTS data must first be optimized and standardized to ensure the sensitivity and repeatability of the results. …”
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Swift Onset, Swift Recovery: Unusual Nonrheumatic Myocarditis in a Young Adult Post Group A Streptococcal Pharyngitis by Andres Rios, Colby Wood, Ricardo Isaiah Garcia, Emily C. Mitchell, Jacob Nichols

“…The insights from this report contribute to the broader understanding of nonrheumatic myocarditis, emphasizing the significance of tailored diagnostic and therapeutic strategies to ensure optimal patient outcomes.…”
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Adult Bilateral Ureteroceles Presenting with Lower Urinary Tract Symptoms and Acute Urinary Retention by Alexis Rompré-Brodeur, Sero Andonian

“…Ureterocele is a well-known pathologic entity in the pediatric urology population but remains a diagnostic and treatment challenge in the adult population. …”
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Contribution of cuproptosis and immune-related genes to idiopathic pulmonary fibrosis disease by Chengji Jin, Jia Li, Qiaoyu Li, Lipeng Zhang, Shaomao Zheng, Qiong Feng, Yongjie Li, Yu Zheng, Qiuli Nie, Jin Liang, Jing Wang, Jing Wang

“…The study aimed to explore the diagnostic value of cuproptosis-related hub genes in patients with IPF. …”
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Comparison of positive BioFire FilmArray meningitis/encephalitis (ME) panels, CSF cultures, CSF parameters, clinical presentation and in-patient mortality among patients with bacte... by Thein Myint, Jaime Soria, Yuanzheng Gao, Marice Ruiz Conejo Castillo, Vaneet Arora, Julie A. Ribes

“…This study highlights the importance of using MEP as a diagnostic tool, especially in patients who have already received antibiotics, where traditional culture-based methods may not be diagnostic. …”
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High-throughput methylation sequencing reveals novel biomarkers for the early detection of renal cell carcinoma by Wenhao Guo, Weiwu Chen, Jie Zhang, Mingzhe Li, Hongyuan Huang, Qian Wang, Xiaoyi Fei, Jian Huang, Tongning Zheng, Haobo Fan, Yunfei Wang, Hongcang Gu, Guoqing Ding, Yicheng Chen

“…Advances in cell-free DNA (cfDNA) methylation profiling using liquid biopsies offer a promising non-invasive diagnostic option, but robust biomarkers for early detection are current not available. …”
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Identification of WDR74 and TNFRSF12A as biomarkers for early osteoarthritis using machine learning and immunohistochemistry by Yiwei Chen, Yiwei Chen, Jiali Lin, Detong Shi, Yu Miao, Yu Miao, Feng Xue, Feng Xue, Kexin Liu, Kexin Liu, Xiaotao Wang, Changqing Zhang, Changqing Zhang

“…Additionally, ML analysis was performed to identify core URGs and construct a diagnostic model. We employed XGBoost, a gradient-boosting ML algorithm, to identify core URGs and construct a diagnostic model. …”
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Development and Evaluation of a Loop-Mediated Isothermal Amplification Assay for Diagnosis of Schistosoma mansoni Infection in Faecal Samples by Ibrahim N. Mwangi, Eric L. Agola, Robert M. Mugambi, Esther A. Shiraho, Gerald M. Mkoji

“…Current diagnostic tools are limited by suboptimal sensitivity, slow turn-around-time, affordability, and inability to distinguish current from past infections. …”
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Advancements in nanosensors for cancer detection by Dinesh Bhatia, Tania Acharjee, Monika Bhatia

“…Developing sophisticated diagnostic instruments like bio-computers and resonant mirrors is made easier by these biosensors, which combine analytes, receptors, and electrical sensors to detect cancer biomarkers in biological samples. …”
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LncRNA HOTAIR: A Novel Biomarker for the Diagnosis of Asymptomatic Carotid Artery Stenosis and Prediction of the Onset of Cerebral Ischemic Events by Pengcheng Feng, Chenguang Tong, Yuan Li, Li Liu

“…The receiver operating characteristic (ROC) curve assessed the diagnostic accuracy of HOTAIR in identifying patients with ACAS. …”
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The significant role of IL-15, IL-22, IL-37, and caspase 9 in polycystic ovary syndrome: A case-control study in a sample of Iraqi women by Noor A. Mohammed, Ghassan M. Sulaiman, Hazima M. Alabassi, Khalil A.A. Khalil, Elsadig M. Ahmed

“…However, the potential diagnostic utility of the Caspase 9 gene expression was not confirmed in this study.…”
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Evaluation of twin-arginine translocation substrate proteins as potential antigen candidates for serodiagnosis of brucellosis by Yao Wu, Yao Wu, Xin Yan, Mingjun Sun, Xiaohan Guo, Jiaqi Li, Xiangxiang Sun, Xiangxiang Sun, Mengda Liu, Mengda Liu, Haobo Zhang, Haobo Zhang, Wenlong Nan, Weixing Shao, Fangkun Wang, Xiaoxu Fan, Xiaoxu Fan, Shufang Sun

“…However, the roles of these Tat substrate proteins in diagnosing brucellosis remain unclear.MethodsIn this study, ErfK, YxeI, and EntF were expressed in prokaryotic cells and utilized as diagnostic antigens. The clinical sera from bovines and sheep diagnosed with brucellosis were analyzed using indirect ELISA with these proteins.ResultsFor bovine serum, the combined protein group (ErfK + YxeI + EntF) and YxeI demonstrated the highest diagnostic accuracy of 94.23% and 93.58%, respectively. …”
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