Significance of Linked Color Imaging for Predicting the Risk of Clinical Relapse in Ulcerative Colitis by Shuji Kanmura, Akihito Tanaka, Kazuki Yutsudou, Kosuke Kuwazuru, Fukiko Komaki, Yuga Komaki, Hiromichi Iwaya, Shiho Arima, Fumisato Sasaki, Shiroh Tanoue, Shinichi Hashimoto, Akio Ido

“…LCI findings, including an orange-like color lesion, have diagnostic implications for predicting the risk of clinical relapse in UC during the 1-year follow-up period.…”
Get full text

Advancing the understanding of Naegleria fowleri: Global epidemiology, phylogenetic analysis, and strategies to combat a deadly pathogen by Awadh Alanazi, Sonia Younas, Hasan Ejaz, Muharib Alruwaili, Yasir Alruwaili, Bi Bi Zainab Mazhari, Muhammad Atif, Kashaf Junaid

“…This review provides a detailed overview of N. fowleri epidemiology, transmission dynamics, phylogenetic diversity, state-of-the-art diagnostic techniques, therapeutic approaches, and preventive measures. …”
Get full text

Tiny clue reveals the general trend: a bibliometric and visualized analysis of renal microcirculation by Bing Wang, Mengting Xu, Sunjing Fu, Yingyu Wang, Hao Ling, Yuan Li, Bingwei Li, Xueting Liu, Qin Ouyang, Xiaoyan Zhang, Ailing Li, Xu Zhang, Mingming Liu

“…While the trends discerned from the literature emerging opportunities in diagnostic innovation, renal microcirculation research, and precision medicine interventions, their translation to clinical practice is anticipated to be a deliberate process.…”
Get full text

Are Saudi Radiological Sciences Students Prepared for Emergencies? Exploring Knowledge, and Attitudes Towards Basic Life Support and Cardiopulmonary Resuscitation by Alshamrani KM, Alkhayyat AA, Arif RN, Alahmadi AAS, Aldahery ST, Alsharif WM, Qurashi AA

“…Khalid M Alshamrani,1– 3 Alaa A Alkhayyat,1 Rimaz N Arif,1 Adnan AS Alahmadi,4 Shrooq T Aldahery,5 Walaa M Alsharif,6 Abdulaziz A Qurashi6 1College of Applied Medical Sciences, King Saud Bin Abdulaziz University for Health Sciences, Jeddah, Saudi Arabia; 2King Abdullah International Medical Research Center, Jeddah, Saudi Arabia; 3Ministry of the National Guard - Health Affairs, Jeddah, Saudi Arabia; 4Radiologic Sciences Department, Faculty of Applied Medical Sciences, King Abdulaziz University, Jeddah, Saudi Arabia; 5Department of Applied Radiologic Technology, College of Applied Medical Sciences, University of Jeddah, Jeddah, Saudi Arabia; 6Diagnostic Radiology Technology Department, College of Applied Medical Sciences, Taibah University, Al Madinah Al Munawwarah, Saudi ArabiaCorrespondence: Khalid M Alshamrani, College of Applied Medical Sciences, King Saud bin Abdulaziz University for Health Sciences Jeddah, Saudi Arabia, P. …”
Get full text

Rapid response electroencephalography decreases time to seizure diagnosis in pediatric acute care patients by Nevedha Rajan, Toni Kavanagh, Maite LaVega‐Talbott, Sandeep Gangadharan

“…TDEA (time to diagnosis of electrographic activity) and setup time were recorded and compared using Welch's T‐test. Diagnostic specificity and sensitivity for SE using the Brain Stethoscope were calculated against the epileptologist's assessment. …”
Get full text

Toward autism spectrum disorders and Williams-Beuren syndrome co-occurrence condition in Tunisian patients: Genetic insights by Rim Khelifi, Afef Jelloul, Houda Ajmi, Wafa Slimani, Sarra Dimassi, Khouloud Rjiba, Manel Dardour, Moez Gribaa, Ali Saad, Soumaya Mougou-Zerelli

“…We underline the utility of array-CGH as a valuable genetic diagnostic tool for characterizing WBS cases, and we shed light on the complex interplay of behavioral disorders in the 7q11.2 region rearrangements.…”
Get full text

Integrative genomic analyses combined with molecular dynamics simulations reveal the impact of deleterious mutations of Bcl-2 gene on the apoptotic machinery and implications in ca... by Ghazi Elamin, Ghazi Elamin, Zhichao Zhang, Depika Dwarka, Kabange Kasumbwe, John Mellem, Nompumelelo P. Mkhwanazi, Paradise Madlala, Paradise Madlala, Mahmoud E. S. Soliman

“…Single nucleotide polymorphisms (SNPs) are considered viable diagnostic and therapeutic biomarkers for various cancers. …”
Get full text

An updated systematic review with meta-analysis and meta-regression of the factors associated with human visceral leishmaniasis in the Americas by Anna Gabryela Sousa Duarte, Guilherme Loureiro Werneck, Sarah de Farias Lelis, Thays Santos Mendonça, Daniela Dias Vasconcelos, Tiago Silveira Gontijo, Álisson Oliveira dos Santos, Lucas Edel Donato, Vinícius Silva Belo

“…Future research should be conducted with greater statistical power and using molecular diagnostic techniques, preferably involving cohort studies in diverse Latin American countries. …”
Get full text

Ocular surface treatment in dry eye patients before corneal refractive surgery by O.A. Klokova, R.O. Damashauskas, M.S. Geidenrich

“…</i> </p> <p> <i><b>Conclusion</b>: a complex diagnostic approach to DED involving specific tests, patient survey, corneal topography, and OCT provides the diagnosis of both manifest and latent DED. …”
Get full text

The impact of endolymphatic hydrops on wideband acoustic immittance and otoacoustic emissions in guinea pigs by Huan Lin, Xuanyi Li, Huiying Zhang, Yi Mu, Xi Wang, Naveena Konduru, Renlong Ji, Wen Liu, Wen Liu, Wen Liu, Zhao Fei, Wen Jiang, Wen Jiang, Wen Jiang, Yuehua Qiao, Yuehua Qiao, Yuehua Qiao

“…DPOAE measures, both magnitude and phase, showed no significant changes (p &gt; 0.05).ConclusionWAI demonstrates greater sensitivity than DPOAE in the early detection of acoustic transmission alterations in EH models, suggesting its utility as a diagnostic tool in early-stage inner ear disorders.…”
Get full text

Profiling the Secretome of Glioblastoma Cells Under Histone Deacetylase Inhibition Using Mass Spectrometry by Aline Menezes, Yara Martins, Fábio Nogueira, Denise De Abreu Pereira, Katia Carneiro

“…The main challenge in GBM research has been to identify novel molecular therapeutic targets and accurate diagnostic/prognostic biomarkers. To better investigate the GBM secretome upon in vitro treatment with histone deacetylase inhibitor (iHDAC), we employed a high-throughput label-free methodology of protein identification and quantification based on mass spectrometry followed by in silico studies. …”
Get full text

Increased aqueous humor levels of endothelin-1 in patients with open angle glaucoma by Adam Hedberg-Buenz, Erin A. Boese, Angela W. Nyunt, Nathan C. Sears, Andrew E. Pouw, Kai Wang, John H. Fingert

“…Patients Open angle glaucoma patients (n=62 total) from the ophthalmology clinics of the University of Iowa Hospitals and Clinics were enrolled in this study and organized into three distinct cohorts based on their diagnostic criteria, including those with primary open angle glaucoma (POAG, n=25 patients), normal tension glaucoma (NTG, n=17 patients), exfoliation glaucoma (XFG, n=8 patients), and normal controls (n=12 patients). …”
Get full text

Repurposing of phosphodiesterase-5 inhibitor sildenafil as a therapeutic agent to prevent gastric cancer growth through suppressing c-MYC stability for IL-6 transcription by Zhenzhan Zhang, Wuqing Huang, Donghua Huang, Zhou Xu, Qingfeng Xie, Xin Tan, Wenjun He, Weihao Yang, Guoxin Li, Jianguang Ji, Hao Liu

“…A total of 161 Swedish GC patients from a nationwide population-based cohort who received post-diagnostic PDE5 inhibitors demonstrated lower cancer-specific mortality compared to the controls (HR = 0.66, 95% CI = 0.47-0.92, P = 0.016). …”
Get full text

Antiganglioside Antibodies and Inflammatory Response in Cutaneous Melanoma by Corina Daniela Ene, Mircea Tampa, Ilinca Nicolae, Cristina Iulia Mitran, Madalina Irina Mitran, Clara Matei, Ana Caruntu, Constantin Caruntu, Simona Roxana Georgescu

“…Antiganglioside antibodies associated with inflammation markers could be used as diagnostic, monitoring, and treatment tools in patients with cutaneous melanoma.…”
Get full text

MRI to digital medicine diagnosis: integrating deep learning into clinical decision-making for lumbar degenerative diseases by Baoyi Ke, Wenyu Ma, Junbo Xuan, Junbo Xuan, Yinghao Liang, Liguang Zhou, Wenyong Jiang, Jing Lin, Guixiang Li

“…Additionally, the testing time of the deep learning program was significantly shorter than that of manual identification, and the differences were statistically significant (P &lt; 0.05).ConclusionsDeep learning technology based on the PP-YOLOv2 algorithm can be used to identify normal intervertebral discs, lumbar disc herniation, and lumbar spondylolisthesis from lumbar MRI images. Its diagnostic performance is significantly higher than that of most spinal surgeons and can be practically applied in clinical settings.…”
Get full text

Implications of hormonal carcinogenesis for transgender and gender-diverse people undergoing gender-affirming hormone therapy: an up-to-date review by Matteo Lambertini, Filippo Pietrantonio, Dario Trapani, Francesco Perrone, Rossana Berardi, Saverio Cinieri, Chiara Cassani, Amelia Barcellini, Filippo Ghelardi, Alberto Giovanni Leone, Stefania Bonadonna, Marianna Sirico, Barbara Tagliaferri, Stefano Maccarone, Davide Dalu, Lorenzo Ruggieri, Simone Nardin, Nicla La Verde

Get full text

Genomic regions of Solanum tuberosum L. associated with the tuber eye depth by I. V. Totsky, I. V. Rozanova, A. D. Safonova, A. S. Batov, Yu. A. Gureeva, A. V. Kochetov, E. K. Khlestkina

“…Identification of the loci that control tuber eye depth would allow diagnostic markers for the marker-assisted selection to be created. …”
Get full text

tiRNA-Gln-CTG is Involved in the Regulation of Trophoblast Cell Function in Pre-eclampsia and Serves as a Potent Biomarker by Yixiao Wang, Xiaohong Ji, Hengmei Shi, Sicong Liu, Hong Yu

“…Methods: High-throughput sequencing of tsRNA in plasma from PE cases was performed to evaluate its potential as a diagnostic or therapeutic biomarker. The function of tsRNA in trophoblasts was explored using the HTR-8/SVneo cell line. …”
Get full text

A perspective from the National Eye Institute Extracellular Vesicle Workshop: Gaps, needs, and opportunities for studies of extracellular vesicles in vision research by Sun Young Lee, Mikael Klingeborn, Jeff W. M. Bulte, Daniel T. Chiu, Michael Chopp, Christopher W. Cutler, Saumya Das, Charles E. Egwuagu, Christie D. Fowler, Sarah F. Hamm‐Alvarez, Hakho Lee, Yutao Liu, Ben Mead, Tara L. Moore, Sriram Ravindran, Ashok K. Shetty, Johan Skog, Kenneth W. Witwer, Ali R. Djalilian, Alissa M. Weaver

“…Abstract With an evolving understanding and new discoveries in extracellular vesicle (EV) biology and their implications in health and disease, the significant diagnostic and therapeutic potential of EVs for vision research has gained recognition. …”
Get full text

Ultrasound-based radiomics and clinical factors-based nomogram for early intracranial hypertension detection in patients with decompressive craniotomy by Zunfeng Fu, Lin Peng, Laicai Guo, Chao Qin, Yanhong Yu, Jiajun Zhang, Yan Liu

“…A combined nomogram was developed by integrating radiomics features with clinical-ultrasound variables, and its diagnostic performance was evaluated using Receiver Operating Characteristic (ROC) curve analysis and decision curve analysis (DCA). …”
Get full text