Role of laparoscopic surgery in blunt abdominal trauma; retrospective analysis in a tertiary trauma center by Rifan Alyami, Ahad E. Alotaibi, Leen Almohayya, Ajyad Al Jawad, Raghad Almukhayzim, Abeer Alhoumedan, Rakan S. Aldusari

“…The laparoscopic approach has gained popularity in trauma care since its inception, becoming increasingly favored for both diagnostic and therapeutic purposes. This study aims to reduce unnecessary laparotomies and assess the effectiveness of laparoscopy in managing patients with blunt abdominal trauma. …”
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Effectiveness of Frequent Point-of-Care Molecular COVID-19 Surveillance in a Rural Workplace: Nonrandomized Controlled Clinical Trial Among Miners by Akshay Sood, William “Cotton” Jarrell, Xin W Shore, Nestor Sosa, Alisha Parada, Nicholas Edwardson, Alexandra V Yingling, Teah Amirkabirian, Qiuying Cheng, Ivy Hurwitz, Linda S Cook, Shuguang Leng, Orrin B Myers, Douglas J Perkins

“…Our second outcome was the rate of cumulative postbaseline seropositivity to SARS-CoV-2 nucleocapsid protein, which was analyzed in the intervention cohort and compared to the control cohort between baseline and 12 months. The diagnostic accuracy of detecting SARS-CoV-2 using rapid antigen testing on NSs was compared to laboratory-based reverse transcriptase polymerase chain reaction (RT-PCR) on nasopharyngeal swabs (NPSs) in a subset of 68 samples. …”
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Immuno-PET Imaging of Siglec-15 Using the Zirconium-89-Labeled Therapeutic Antibody, NC318 by Elaine M. Jagoda, Falguni Basuli, Colleen Olkowski, Ido Weiss, Tim E. Phelps, Karen Wong, Anita Thien Ton, Kelly C. Lane, Steve Adler, Donna Butcher, Elijah F. Edmondson, Sol Langermann, Peter L. Choyke

“…In these preclinical studies, the therapeutic mAb, NC318 (antihuman/murine Siglec-15 mAb), was labeled with zirconium-89 and evaluated in human Siglec-15 expressing cancer cells and mouse xenografts for potential use as a clinical diagnostic imaging agent. Methods. Desferrioxamine-conjugated NC318 was radiolabeled with zirconium-89 to synthesize [89Zr]Zr-DFO-NC318. …”
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Potato mosaic viruses which infect plants of tuber-bearing Solanum spp. growing in the VIR field gene bank by E. V. Rogozina, N. V. Mironenko, N. A. Chalaya, Yu. Matsushita, H. Yanagisawa

“…We examined clonal plants of 137 genotypes representing 31 species of the section Petota of the genus Solanum L. A diagnostic was carried out using ELISA, RT-PCR and indicator plants. …”
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Diagnosis and Treatment of Sepsis in a Fourteen-year-old Patient: A case study of pulmonary inflammatory discharge without typical features of respiratory tract infection by Bartłomiej Żaczek, Jakub Kozłowski, Alicja Kamińska, Wojciech Kupczak, Kinga Bujak, Aleksandra Kocjan, Ismael Alsoubie, Natalie Papachristoforou, Wojciech Kaźmierski, Mateusz Ziomek, Paulina Lis, Marta Czubaj-Kowal

“…In the case of unclear symptoms of high fever and indicators of inflammation, a broad diagnostic spectrum is necessary, including imaging and laboratory tests and specialist consultations. …”
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Enhanced preoperative prediction of breast lesion pathology, prognostic biomarkers, and molecular subtypes using multiple models diffusion-weighted MR imaging by Litong He, Feng Li, Yanjin Qin, Yuling Li, Qilan Hu, Zhiqiang Liu, Yunfei Zhang, Tao Ai

“…All five diffusion models proved valuable for breast cancer diagnosis, with the CTRW model exhibiting the highest diagnostic performance, although the difference was not statistically significant. …”
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Multi-centre comparison between device-independent web-browser perimetry (Melbourne Rapid Fields-web) and SITA-Faster for glaucoma by Joyce Tiang, Algis J. Vingrys, Algis J. Vingrys, Sarah Lin, Selwyn M. Prea, Adam Ahmed Moktar, Allan Bank, Ashish Agar, Ashish Agar, Yu Xiang George Kong, Yu Xiang George Kong, Yu Xiang George Kong

“…Area Under the Curve of MRF and HFA are similar indicating comparable diagnostic capacity.ConclusionMRF-web produces outcomes comparable to HFA SITA-Faster. …”
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Association between Metrnl and carotid atherosclerosis in patients with type 2 diabetes mellitus by Chunmei Li, Chunmei Li, Qiongzhu Huang, Qiongzhu Huang, Yanqian Zhuang, Yanqian Zhuang, Pin Chen, Pin Chen, Yiyang Lin, Yiyang Lin

“…The ROC curve used to identify the diagnostic accuracy of serum Metrnl level in the predication of T2DM subjects with carotid atherosclerosis revealed an area under the curve (AUC) of 0.742. …”
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Comparative efficacy of conventional pap smear and liquid based cytology for screening of cervical cancer in women of reproductive age group in a tertiary care centre in rural Madh... by Shambhavi, Suresh Kumar Sutrakar, Lokesh Tripathi, Parul Singh Rajpoot, Priyanka Agrawal, Uday Raj Singh, Jagannath Jatav, Deepti Tiwari, Pushpkunjika Sharma

“…Conclusion: LBC demonstrated superior sensitivity, sample adequacy, and diagnostic accuracy, making it the recommended screening tool for high-risk populations.…”
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Acceptance, Safety, and Effect Sizes in Online Dialectical Behavior Therapy for Borderline Personality Disorder: Interventional Pilot Study by Ruben Vonderlin, Tali Boritz, Carola Claus, Büsra Senyüz, Saskia Mahalingam, Rachel Tennenhouse, Stefanie Lis, Christian Schmahl, Jürgen Margraf, Tobias Teismann, Nikolaus Kleindienst, Shelley McMain, Martin Bohus

“…MethodsA total of 39 individuals meeting the DSM-5 (Diagnostic and Statistical Manual of Mental Disorders [Fifth Edition]) criteria for BPD received 1 year of outpatient telehealth DBT at 3 sites in Germany and Canada. …”
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Association between the triglyceride-glucose index and its combined obesity indicators and the risk of hypertension in middle-aged and older Chinese adults: A nationwide cross-sect... by Huoping Zheng, Meiling Xu, Jing Yang, Mingjun Xu

“…The receiver operating characteristic curve indicated that TyG-WC demonstrated the highest diagnostic performance for hypertension, with an area under the curve of 0.642 (95% CI: 0.631-0.654).…”
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Utility of Cand PCR in the Diagnosis of Vulvovaginal Candidiasis in Pregnant Women by Eduardo García-Salazar, Paola Betancourt-Cisneros, Xóchitl Ramírez-Magaña, Hugo Díaz-Huerta, Erick Martínez-Herrera, María Guadalupe Frías-De-León

“…In this work, we evaluated the diagnostic utility of an endpoint PCR assay (Cand PCR) in vaginal swab specimens. …”
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Clinical Laboratory Validation Study of a High Sensitivity Troponin I Assay on a POCT (Point of Care Testing) Device by Fabio Grunspun Pitta, Adriana Caschera Leme, Simone Rodrigues Gomes, Tarsila Perez Mota, Fernanda Vieira Paladino, José Leão de Souza Júnior, Rosemeire de Paula Braz, Thais Cristine Rodrigues Leonel Lamounier, Jéssica Buzin Gomes Ferreira, Carlos Eduardo dos Santos Ferreira

“…Background: In Acute Coronary Syndrome without ST-segment elevation, the use of high-sensitivity troponins in rapid protocols is considered the gold standard for diagnostic exclusion/confirmation, in conjunction with clinical stratification. …”
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Prediction Efficiency of Postoperative Acute Kidney Injury in Acute Stanford Type A Aortic Dissection Patients with Renal Resistive Index and Semiquantitative Color Doppler by Huai Qin, Yaqiong Li, Nan Zhang, Tiezhu Wang, Zhanming Fan

“…Receiver operating characteristic (ROC) analysis was performed to compare the diagnostic accuracy between RRI and SQC Doppler grade in early prediction of PAKI by using AKIN classifications as the reference standard. …”
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A conformational change of C-reactive protein drives neutrophil extracellular trap formation in inflammation by Ebru Karasu, Rebecca Halbgebauer, Lena Schütte, Johannes Greven, Felix M. Bläsius, Johannes Zeller, Oscar Winninger, David Braig, David Alexander Christian Messerer, Bettina Berger, Hendrik Feuerstein, Anke Schultze, Karlheinz Peter, Uwe Knippschild, Klemens Horst, Frank Hildebrand, Steffen U. Eisenhardt, Markus Huber-Lang

“…Abstract Background C-reactive protein (CRP) represents a routine diagnostic marker of inflammation. Dissociation of native pentameric CRP (pCRP) into the monomeric structure (mCRP) liberates proinflammatory features, presumably contributing to excessive immune cell activation via unknown molecular mechanisms. …”
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A genomic strategy for precision medicine in rare diseases: integrating customized algorithms into clinical practice by Cristina Méndez-Vidal, Nereida Bravo-Gil, Javier Pérez-Florido, Irene Marcos-Luque, Raquel M. Fernández, José Luis Fernández-Rueda, María González-del Pozo, Marta Martín-Sánchez, Elena Fernández-Suárez, Marcela Mena, Rosario Carmona, Joaquín Dopazo, Salud Borrego, Guillermo Antiñolo

“…Conclusion This strategy has shown promising improvements in the diagnostic rate, facilitating timely diagnosis and gradually expanding our services portfolio for rare diseases. …”
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Expression of Wnt signaling proteins LEF1, β-catenin, GSK3β, DVL1, and N-myc varies across retinoblastoma subtypes and pRb phosphorylation status by Leon Marković, Anja Bukovac, Ana Maria Varošanec, Antonia Jakovčević, Davor Tomas, Zdenko Sonicki, Borna Puljko, Fran Dumančić, Reno Hrašćan, Nives Pećina-Šlaus

“…Our study aimed to analyze the expression levels of key Wnt pathway proteins, GSK3β, LEF1, β-catenin, and DVL1, and associate them to non-phosphorylated active form (pRb) and the phosphorylated inactive form (ppRb) and N-myc expression, in retinoblastoma cells and healthy retinal cells, in order to elucidate their roles in retinoblastoma and identify potential targets that could help to improve diagnostic and therapy. Specimens from 22 retinoblastoma cases (unilateral, bilateral, and trilateral) were analyzed. …”
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Washback of a High-stakes Language Exam on Spanish Teachers' Practice in Brazil by Yasser Abdullah Al Tamimi, Gladys Quevedo-Camargo, Rafael Sena Raposo de Melo

“…The Serial Assessment Program (PAS) is an annual reading test in Spanish, French or English functioning as a diagnostic, summative, and formative assessment tool and offering an entry opportunity for low-income students. …”
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Lipid trajectories improve risk models for Alzheimer’s disease and mild cognitive impairment by Bruce A. Chase, Roberta Frigerio, Chad J. Yucus, Smita Patel, Demetrius Maraganore, Alan R. Sanders, Jubao Duan, Katerina Markopoulou

“…Clinically well-characterized cases were diagnosed using Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition (DSM-IV) criteria; MCI cases had been stable for ≥5 years; and controls were propensity matched to cases at symptom onset (MCI: 116 cases, 435 controls; AD: 215 cases, 483 controls). …”
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Co-Occurrence of Rarest Type of Dysphagia Lusoria (Type N-1) and Eosinophilic Esophagitis in a Cognitively Disabled Individual by Kishore Kumar, Jasbir Makker, Hassan Tariq, Ariyo Ihimoyan, Chime Chukwunonso, Masooma Niazi, Michael Lombino, Muhammad Kamal, Harish K. Patel

“…We present a rare case of co-occurrence of dysphagia lusoria with esophageal eosinophilia in a patient with cognitive disability which portends a case with diagnostic challenge and treatment dilemma. A 31-year-old man with intellectual disability, cerebral palsy, previous history of feeding difficulty, and esophageal food impaction presented with esophageal foreign body impaction. …”
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