The Mycobacterium ulcerans toxin mycolactone causes destructive Sec61-dependent loss of the endothelial glycocalyx and vessel basement membrane to drive skin necrosis by Louise Tzung-Harn Hsieh, Belinda S Hall, Jane Newcombe, Tom A Mendum, Sonia Santana Varela, Yagnesh Umrania, Michael J Deery, Wei Q Shi, Josué Diaz-Delgado, Francisco J Salguero, Rachel E Simmonds

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HCV and HBV genotypes: vital in the progression of HCV/ HBV co-infection by Yasmin Badshah, Maria Shabbir, Khushbukhat Khan, Sameen Zafar, Tayyaba Afsar, Fohad Mabood Husain, Houda Amor, Suhail Razak

“…To determine the liver damage due to viral infection levels of ALT, ALP, and total bilirubin were also determined. Diagnostic history of patients was thoroughly documented through serological tests and liver biopsy reports. …”
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Analyzing special needs reports for children: sociodemographic trends, diagnoses, and support areas over five years (2019–2024) by Semih Canpolat, Mehmet Emin Parlak, Esra Kurt Canpolat, Erdogan Oz

“…ObjectiveThis study aims to evaluate the special needs reports for children (SNRC) in terms of sociodemographic characteristics, diagnoses, and areas of special needs in the five years from 2019, when special health boards for children were established with the new diagnostic and evaluation criteria.MethodsThis descriptive study was conducted by retrospectively reviewing the board evaluation reports of children aged 0–18 years who applied to Batman Training and Research Hospital SNRC Health Board between March 2019 and March 2024. …”
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Systematic review on the compliance of WHO guidelines in the management of patients with advanced HIV disease in Africa: The case of cryptococcal antigen screening. by Zuhura Mbwana Ally, Jackline Vicent Mbishi, Mariam Salim Mbwana, Hafidha Mhando Bakari, Swalehe Mustafa Salim, Zarin Nudar Rodoshi, Muhidin Ibrahim Hundisa, Rebecca Mesfin Sileshi, Biruk Demisse Ayalew, Rahma Musoke, Lynn Moshi, Yousef Elias Fakhoury, Haji Mbwana Ally, Habib Omari Ramadhani

“…Among those who tested positive for CrAg, 84.6% (95% CI: 54.1-99.0) received preemptive antifungal treatment, though nearly 25% did not undergo lumbar puncture, highlighting gaps in diagnostic follow-up. Six studies evaluated CrAg positive patients with lumbar puncture and the overall prevalence of lumbar puncture was 74.9% (48.0-94.8). …”
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Serum and plasma as a good candidates of body fluids for detection lung cancer by FTIR liquid biopsy by Jolanta Smok-Kalwat, Stanisław Góźdź, Paweł Macek, Zuzanna Kalwat, Maryna Khalavka, Wioletta Rzad, Andrzej Stepulak, Joanna Depciuch

“…Abstract Using Fourier Transform Infrared spectroscopy (FTIR), it is possible to show chemical composition of materials and / or profile chemical changes occurring in tissues, cells, and body fluids during onset and progression of diseases. For diagnostic application, the use of blood would be the most appropriate in biospectroscopy studies since, (i) it is easily accessible and, (ii) enables frequent analyses of biochemical changes occurring in pathological states. …”
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Exploring the associations of gut microbiota with inflammatory and the early hematoma expansion in intracerebral hemorrhage: from change to potential therapeutic objectives by Haixiao Jiang, Wei Zeng, Fei Zhu, Xiaoli Zhang, Demao Cao, Aijun Peng, Hongsheng Wang

“…Our comprehensive research revealed the potential of intestinal flora as a potent diagnostic tool, emphasizing its significance as a preventive target for HE.…”
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Percutaneous microwave ablation on management of hereditary renal cell carcinoma in Von Hippel–Lindau disease by Jiye Chen, Lin Zheng, Wei Zhang, Zhen Wang, Jie Yu, Ping Liang

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Influence of symptoms of attention deficit hyperactivity disorder on emotional behavioral problems： parallel mediating effect of different dimensions of executive function by XUE Yiyun, OU Zixin, HONG Danping, DANG Caiping, ZHU Zhihang, CHENG Daomeng, HU Yingzi, LI Guoquan, YANG Chanjuan, YIN Weizhen

“…Methods A total of 102 children with ADHD aged 6-12 years old who met the Diagnostic and Statistical Manual of Mental Disorders 5th edition （DSM-5） criteria were selected as the study subjects. …”
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Clinical code usage in UK general practice: a cohort study exploring 18 conditions over 14 years by Christos Grigoroglou, Darren M Ashcroft, Evangelos Kontopantelis, David Reeves, Salwa S Zghebi, Rosa Parisi, Brian McMillan

“…Objective To assess the diagnostic Read code usage for 18 conditions by examining their frequency and diversity in UK primary care between 2000 and 2013.Design Population-based cohort studySetting 684 UK general practices contributing data to the Clinical Practice Research Datalink (CPRD) GOLD.Participants Patients with clinical codes for at least one of asthma, chronic obstructive pulmonary disease, diabetes, hypertension (HT), coronary heart disease, atrial fibrillation (AF), heart failure, stroke, hypothyroidism, chronic kidney disease, learning disability (LD), depression, dementia, epilepsy, severe mental illness (SMI), osteoarthritis, osteoporosis and cancer.Primary and secondary outcome measures For the frequency ranking of clinical codes, canonical correlation analysis was applied to correlations of clinical code usage of 1, 3 and 5 years. …”
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The “Chopsticks” Method: A Technique for Capsular Retraction During Hip Arthroscopy Utilizing Switching Sticks by Alec E. Winzenried MD, Kyle R. Wagner MD, Lucas McLean MD, Andrea M. Spiker MD

“…An interportal cut is performed for better visualization and access. A diagnostic arthroscopy of the central compartment is performed, and pathology is addressed as needed, including labral repair, subspine decompression or pincer resection, and chondroplasty. …”
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Could Infectious Agents Play a Role in the Onset of Age-related Macular Degeneration? A Scoping Review by Petra P. Larsen, MD, PhD, Virginie Dinet, PhD, Cécile Delcourt, PhD, Catherine Helmer, MD, PhD, Morgane Linard, MD, PhD

“…All types of study design, infectious agents, AMD diagnostic methods, and AMD stages were considered. …”
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Diagnosis of Malignant Endometrial Lesions from Ultrasound Radiomics Features and Clinical Variables Using Machine Learning Methods by Shanshan Li, Jiali Wang, Li Zhou, Hui Wang, Xiangyu Wang, Jian Hu, Qingxiu Ai

“…This is significant for enhancing early diagnostic accuracy and improving treatment outcomes and long-term management.…”
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The short-, medium-, and long-term prevalence of physical health comorbidities in first-episode psychosis: a systematic review and meta-analysis protocol [version 2; peer review: 3... by Michael Norton, Brian O'Donoghue, Mary Clarke, Karen O'Connor, Jennifer Murphy, Anna Zierotin

“…Potential limitations include the risk of diagnostic heterogeneity across studies and possible underreporting of certain comorbidities. …”
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Exploring therapeutic mechanisms of Chuan Huang Fang-II in the treatment of acute kidney injury on chronic kidney disease patients from the perspective of lipidomics by Ling Chen, Qian Wang, Tonglu Li, Lejia Li, Chen Wang, Bing Xu, Xuezhong Gong

“…Lipid differential metabolites could serve as diagnostic indicators for AKI in patients with CKD. …”
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Biomarkers for Diagnosis and Prediction of Outcomes in Contrast-Induced Nephropathy by Justor Banda, Raquel Duarte, Therese Dix-Peek, Caroline Dickens, Pravin Manga, Saraladevi Naicker

“…Outcomes were biomarker diagnostic discrimination performance for CIN and mortality after generation of area under receiver operating characteristic curves (AUROCs). …”
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The role of long non-coding RNA LINC00839 in oral squamous cell carcinoma based on bioinformatics and experimental research by Ashkan Kalantary-Charvadeh, Saman Morovat, Somayeh Aslani, Nasrin Ziamajidi, Amirnader Emami Razavi, Roghayeh Abbasalipourkabir

“…A Chi-square test was used to determine clinicopathological associations, and ROC analysis estimated diagnostic value. A total of 66 differentially expressed lncRNAs, 80 miRNAs, and 1149 mRNAs were identified in OSCC versus non-tumor samples. …”
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A Cross-Sectional Comparative Study of the Performance of the Widal Test and the Typhidot Immunoassay for Typhoid Fever Diagnosis in the West Region of Cameroon by Karimo Ousenu, Innocent Mbulli Ali, Leonard Fonkeng Sama, Marcel Nsangou Ndam, Thibau Florant Tchouangueu, Christopher Bonglavnyuy Tume

“…We undertook a study to evaluate the diagnostic performance of the Widal test and the Typhidot immunoassay in patients suspected of having typhoid fever in the Menoua division, West Region of Cameroon. …”
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Temperature and repeated catecholamine surges modulate regional wall motion abnormalities in a rodent takotsubo syndrome model by Ermir Zulfaj, AmirAli Nejat, Abdulhussain Haamid, Aaron Espinosa, Ahmed Elmahdy, Tetiana Pylova, Sandeep Jha, Björn Redfors, Elmir Omerovic

“…RWMA analysis offers promise as a diagnostic and prognostic tool in TS, and the delayed adaptive response presents a potential pathway for therapeutic intervention.…”
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Medical students’ attitudes toward AI in education: perception, effectiveness, and its credibility by Abdul Sami, Fateema Tanveer, Khadeejah Sajwani, Nafeesa Kiran, Muhammad Ahsan Javed, Dilber Uzun Ozsahin, Khalid Muhammad, Yasir Waheed

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Population-Level SARS-CoV-2 RT–PCR Cycle Threshold Values and Their Relationships with COVID-19 Transmission and Outcome Metrics: A Time Series Analysis Across Pandemic Years by Judith Carolina De Arcos-Jiménez, Ernestina Quintero-Salgado, Pedro Martínez-Ayala, Gustavo Rosales-Chávez, Roberto Miguel Damian-Negrete, Oscar Francisco Fernández-Diaz, Mariana del Rocio Ruiz-Briseño, Rosendo López-Romo, Patricia Noemi Vargas-Becerra, Ruth Rodríguez-Montaño, Ana María López-Yáñez, Jaime Briseno-Ramirez

“…The study further observed a weakening association in later pandemic stages, likely influenced by the emergence of new variants, hybrid immunity, changes in human behavior, and diagnostic shifts. These findings underscore the value of Ct values as scalable tools for public health surveillance and highlight the importance of contextualizing their analysis within specific epidemiological and temporal frameworks. …”
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