Sex-specific anatomical variation of circle of Willis arteries by Phebe J. Groenheide, Iris N. Vos, Robin Bülow, Irene C. van der Schaaf, Birgitta K. Velthuis, Ynte M. Ruigrok

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Sonication: A Valuable Technique for Diagnosis and Treatment of Periprosthetic Joint Infections by D. S. Evangelopoulos, I. P. Stathopoulos, G. P. Morassi, S. Koufos, A. Albarni, P. K. Karampinas, A. Stylianakis, S. Kohl, S. Pneumaticos, J. Vlamis

“…Sonication fluid cultures represent a cheap, easy, accurate, and sensitive diagnostic modality demonstrating increased sensitivity compared to periprosthetic tissue cultures (70.5 versus 47.1%).…”
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Association between retinal markers and cognition in older adults: a systematic review by Gerald Liew, Bamini Gopinath, Joyce Chan, Joyce Siette, Varshanie Jeevakumar, Rebekah Sefton, Tejal M Shah

“…Risk of bias was assessed using the Quality Assessment of Diagnostic Accuracy Studies tool.Data extraction and synthesis Data extraction was conducted by two authors (VJ, RS) and reviewed by another author (JS). …”
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Network characteristics of comorbid symptoms in alcohol use disorder by Xin Yu, Wen Zhang, Can Wang, Guolin Mi, Xiuzhe Chen, Yanhu Wang, Xu Chen

“…Although these are not diagnostic criteria, they may increase dependence risk and complicate treatment. …”
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Clinical Value of Asymmetrical Dimethylarginine Detection in Patients with Connective Tissue Disease-Associated Pulmonary Arterial Hypertension by Juan Liu, Qiang Fu, Lili Jiang, Youlian Wang

“…Using the receiver operating characteristic (ROC) curve analysis, at the cutoff level of 0.810 μmol/L, ADMA showed good diagnostic efficacy as follows: sensitivity was 97.7%, specificity was 75.6%, and the area under the curve (AUC) was 0.947 (P<0.001). …”
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Thermographic Scan of the Thoracolumbar Area in Dogs with Acute Intervertebral Disc Extrusion (IVDE): A Retrospective Study by Cristian Zaha, Liliana Cărpinișan, Larisa Schuszler, Nistor Paula, Tudor Căsălean, Tiana Florea, Văduva Cristina, Bogdan Sicoe, Ciprian Rujescu, Roxana Dascălu

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Case report: an unusual long-term evolution of a diffuse midline glioma, H3K27 altered by Michael Griessmair, Michael Griessmair, Claire Delbridge, Claus Zimmer, Eva Mayr, Arthur Wagner, Julian Canisius, Marie-Christin Metz, Benedikt Wiestler, Benedikt Wiestler

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Hyperandrogenism, Elevated 17-Hydroxyprogesterone and Its Urinary Metabolites in a Young Woman with Ovarian Steroid Cell Tumor, Not Otherwise Specified: Case Report and Review of t... by Felix C. K. Wong, Angela Z. Chan, W. S. Wong, Angel H. W. Kwan, Tracy S. M. Law, Jacqueline P. W. Chung, Jeffrey S. S. Kwok, Angel O. K. Chan

“…Alternatively, USP might be useful in localizing the source of 17-OHP to the ovaries. Its diagnostic performance should be evaluated in further studies.…”
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Utility of Endoscopic Examination in the Diagnosis of Acute Graft-versus-Host Disease in the Lower Gastrointestinal Tract by Kosuke Nomura, Toshiro Iizuka, Daisuke Kaji, Hisashi Yamamoto, Yasutaka Kuribayashi, Masami Tanaka, Tsukasa Furuhata, Satoshi Yamashita, Daisuke Kikuchi, Akira Matsui, Toshifumi Mitani, Yasunori Ota, Shuichi Taniguchi, Shu Hoteya

“…We retrospectively investigated the incidence of acute graft-versus-host disease (GVHD) in the lower gastrointestinal (GI) tract and the diagnostic accuracy of endoscopy. Methods. Of 1231 patients who underwent allogeneic hematopoietic stem cell transplantation between January 2005 and December 2014, 186 of whom underwent colonoscopy and biopsy and had no cytomegalovirus infection. …”
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How spinal GABAergic circuits modulate cerebral processing of postsurgical pain by Bruno Pradier, Daniel Segelcke, Nathalie Just, Mirjam Augustin, Nina Nagelmann, Cornelius Faber, Esther Pogatzki-Zahn

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Clinical evaluation of long-read sequencing-based episignature detection in developmental disorders by Mathilde Geysens, Benjamin Huremagic, Erika Souche, Jeroen Breckpot, Koenraad Devriendt, Hilde Peeters, Griet Van Buggenhout, Hilde Van Esch, Kris Van Den Bogaert, Joris Robert Vermeesch

“…In addition, concurrent haplotyped genomic and epigenomic analyses leverage simultaneous detection of single nucleotide/structural variants, X-inactivation, and imprinting, consolidating a multi-step sequential process into a single diagnostic assay.…”
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Informatics Consideration on the Hierarchical System of Rare Diseases Clinical Care in China by GONG Mengchun, GUO Yanying, ZHENG Xihong, FAN Junkang, LIU Peng, NIU Ling, YANG Yining, ZOU Xiaoguang

“…It integrates and optimizes auxiliary diagnostic tools, promotes the rapid dissemination of rare disease diagnosis and treatment experiences to the grassroots, enhances the information construction level of the hierarchical diagnosis and treatment system, and endeavors to address the practical predicament of weak diagnosis and treatment capabilities of rare diseases in grassroots medical institutions. …”
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Cervical length of preoperative cervical cerclage prognostic impacted the effect of cervical insufficiency by Yayun Zhang, Zihan Zhao, Jiaqi Xu, Fei Wu, Ting Chen, Shunyu Hou, Aifen Wang

“…Abstract Background This study aimed to analyze the impact of preoperative cervical length before cervical cerclage on the extension of gestational days in patients with various diagnostic types of cervical insufficiency, including obstetric history-based diagnosis, ultrasound-based diagnosis, and physical examination-based diagnosis. …”
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Prognostic significance of the logistic regression model for assessing the risk of recurrence in patients with prostate cancer after radical prostatectomy by S. A. Reva, A. V. Arnautov, O. A. Klitsenko, S. B. Petrov

“…The sensitivity of this model was 86.6 %, specificity 81.5 %, diagnostic accuracy 82.7 %.Conclusion. This model makes it possible to obtain the probability of recurrence after radical prostatectomy depending on the severity of a specific set of predictive signs (a positive effect is predicted for y &gt; 0.5, a negative one for y ≤ 0.5) and the degree of influence of one or a group of predictive signs on the likelihood of relapse, such as the ISUP grade group, locally advanced disease, clinically detectable lymph node lesion, positive surgical margin, PSA level of more than 0.09 ng/ml 1 month after surgery, the presence of regional metastases and the time between biopsy and the start of treatment.…”
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Serum drug levels and anti-drug antibodies in the context of dose tapering by interval prolongation of adalimumab, etanercept and ustekinumab in psoriasis patients: results of the... by Selma Atalay, Sophie E. Berends, Hans M. M. Groenewoud, Ron A. A. Mathot, David M. Njoo, Johannes M. Mommers, Paul M. Ossenkoppele, Marjolein I. A. Koetsier, Maartje A. Berends, Annick de Vries, Peter C. M. van de Kerkhof, Alfons A. den Broeder, Elke M. G. J. de Jong, Juul M. P. A. van den Reek

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Ferric Carboxymaltose in the Management of Iron Deficiency Anemia in Pregnancy: A Subgroup Analysis of a Multicenter Real-World Study Involving 1191 Pregnant Women by Prakash Trivedi, S. Chitra, Suma Natarajan, Vandana Amin, Shilpi Sud, Priti Vyas, Meenakshi Singla, Ajinkya Rodge, Onkar C. Swami

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Attention Investigation on Children with Attention Deficit Hyperactivity Disorder in Different Genders at School Age by Jingzhi HUANG, Minghe LIN

“…Objective:To explore the different dimensions of attention in children with attention deficit hyperactivity disorder (ADHD) and normal children of different genders at school age.Methods:A total of 62 children at school age who complied with DSM-V ADHD diagnostic criteria were divided into 32 male ADHD group and 30 female ADHD group, in the meantime, 65 normal children were recruited and divided into 33 male control group and 32 female control group. …”
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The Willingness of Doctors to Adopt Artificial Intelligence–Driven Clinical Decision Support Systems at Different Hospitals in China: Fuzzy Set Qualitative Comparative Analysis of... by Zhongguang Yu, Ning Hu, Qiuyi Zhao, Xiang Hu, Cunbo Jia, Chunyu Zhang, Bing Liu, Yanping Li

“… BackgroundArtificial intelligence–driven clinical decision support systems (AI-CDSSs) are pivotal tools for doctors to improve diagnostic and treatment processes, as well as improve the efficiency and quality of health care services. …”
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Business Venturing in Regulated Markets—Taxonomy and Archetypes of Digital Health Business Models in the European Union: Mixed Methods Descriptive and Exploratory Study by Sascha Noel Weimar, Rahel Sophie Martjan, Orestis Terzidis

“…In addition, 6 archetypes of DHT business models were identified: administration and communication supporter (A1), insurer-to-consumer digital therapeutics and care (A2), diagnostic and treatment enabler (A3), professional monitoring platforms (A4), clinical research and solution accelerators (A5), and direct-to-consumer wellness and lifestyle (A6). …”
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A Rare Case of Severe Congenital RYR1-Associated Myopathy by Nicola Laforgia, Manuela Capozza, Lucrezia De Cosmo, Antonio Di Mauro, Maria Elisabetta Baldassarre, Francesca Mercadante, Anna Laura Torella, Vincenzo Nigro, Nicoletta Resta

“…We report clinical and genetic characteristics of a male preterm newborn, whose phenotype was characterized by severe hypotonia and hyporeactivity, serious respiratory distress syndrome that required mechanical ventilation, clubfoot, and other dysmorphic features. The diagnostic procedure was completed with the complete exome sequencing of the proband and of his parents and his sister, which showed new mutations in the ryanodine receptor gene (RYR1), which maps to chromosome 19q13.2 and encodes the skeletal muscle isoform of a calcium-release channel in the sarcoplasmic reticulum (RyR1). …”
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