Modulating delirium through stimulation (MoDeSt): study protocol for a randomized, double-blind, sham-controlled trial assessing the effect of postoperative transcranial electrical... by Sophie Leroy, Viktor Bublitz, Ulrike Grittner, Robert Fleischmann, Falk von Dincklage, Daria Antonenko

“…Delirium will be screened twice daily with the 3-min diagnostic interview Confusion Assessment Method (3D-CAM) in the 5 days following surgery. …”
Get full text

Rapid Identification of Clinically Relevant <i>Candida</i> spp. by I-dOne Software Using Attenuated Total Reflectance Fourier Transform Infrared (ATR-FTIR) Spectroscopy by Iacopo Franconi, Roberta Fais, Cesira Giordano, Benedetta Tuvo, Chiaramaria Stani, Arianna Tavanti, Simona Barnini, Antonella Lupetti

“…The present study highlights the potential diagnostic performance of the I-dOne software with ATR-FTIR spectroscopic technique referral spectral database as a real alternative for routine identification of the most frequently isolated <i>Candida</i> spp.…”
Get full text

Reducing neonatal Fc receptor binding enhances clearance and brain-to-blood ratio of TfR-delivered bispecific amyloid-β antibody by Eva Schlein, Ken G. Andersson, Tiffany Dallas, Stina Syvänen, Dag Sehlin

“…Recent development of amyloid-β (Aβ)-targeted immunotherapies for Alzheimer’s disease (AD) have highlighted the need for accurate diagnostic methods. Antibody-based positron emission tomography (PET) ligands are well suited for this purpose as they can be directed toward the same target as the therapeutic antibody. …”
Get full text

Analysis of factors affecting the clinical management of infection in culture-negative patients following percutaneous endoscopic decompression: a retrospective study by Changpeng Qu, Haixin Wei, Hao Zhang, Zheng Lian, Hui Lu, Shuo Han

“…BackgroundCulture-negative spinal infections after prophylactic antibiotic use in percutaneous endoscopic decompression are rare, and diagnostic difficulties and the risk of antibiotic-resistant infections complicate treatment. …”
Get full text

Clusters explaining the relation between menopause and self-reported periodontal disease: a cross-sectional study by Hani T. Fadel, Lujain A. Qarah, Manal O. Alharbi, Alla Al-Sharif, Doaa S. Al-Harkan, Saba Kassim, Osama Abu-Hammad, Najla Dar-Odeh

Get full text

Relationship between Maternal Central Obesity and the Risk of Gestational Diabetes Mellitus: A Systematic Review and Meta-Analysis of Cohort Studies by Da Yao, Qing Chang, Qi-Jun Wu, Shan-Yan Gao, Huan Zhao, Ya-Shu Liu, Yu-Ting Jiang, Yu-Hong Zhao

“…Abdominal subcutaneous fat thickness, waist circumference, waist-hip ratio or body fat distribution were elected as measures of maternal central obesity, and all diagnostic criteria for GDM were accepted. The random effect meta-analysis was performed to evaluate the relationship between central obesity and the risk of GDM. …”
Get full text

Alström syndrome: the journey to diagnosis by Akshat Sinha, Kerry Leeson-Beevers, Catherine Lewis, Elizabeth Loughery, Tarekegn Geberhiwot

“…Insufficient research and treatment advances can further impede the diagnostic process and limit access to therapies or clinical trials, ultimately impacting patient outcomes. …”
Get full text

Digital health technologies and innovation patterns in diabetes ecosystems by Odile-Florence Giger, Estelle Pfitzer, Wasu Mekniran, Hannes Gebhardt, Elgar Fleisch, Mia Jovanova, Tobias Kowatsch

“…Results Our analyses revealed the emergence of eight organization segments in digital diabetes ecosystems: real-world evidence analytics, healthcare management platforms, clinical decision support, diagnostic and monitoring, digital therapeutics, wellness, online community, and online pharmacy (RQ1). …”
Get full text

CircWDR78 inhibits the development of colorectal cancer by regulating the miR-653-3p/RGS4 axis by Chu Hao, Yunju Pu, Jiunian Li, Zhi Zhong, Zhaohui Huang, Xue Wang

“…Abstract Background Colorectal cancer (CRC) stands as one of the most serious threats to human health, with its mortality rate increase during the past years. Low diagnostic accuracy, poor prognosis, and high recurrence rates attributed to the high mortality rate of CRC. …”
Get full text

Diagnosis of Obstructive Sleep Apnea in Parkinson’s Disease Patients: Is Unattended Portable Monitoring a Suitable Tool? by Priti Gros, Victoria P. Mery, Anne-Louise Lafontaine, Ann Robinson, Andrea Benedetti, R. John Kimoff, Marta Kaminska

“…We assessed feasibility and diagnostic accuracy in PD. Methods. Selected PD patients without known OSA underwent home PM and laboratory PSG. …”
Get full text

Circulating MicroRNAs in Elderly Type 2 Diabetic Patients by Giuseppina Catanzaro, Zein Mersini Besharat, Martina Chiacchiarini, Luana Abballe, Claudia Sabato, Alessandra Vacca, Paola Borgiani, Francesco Dotta, Manfredi Tesauro, Agnese Po, Elisabetta Ferretti

“…The translational implications are as immediate as evident, with the possibility to develop noninvasive diagnostic tools to predict drug response and development of chronic complications.…”
Get full text

The Videofluorographic Swallowing Study in Rheumatologic Diseases: A Comprehensive Review by Ambra Di Piazza, Federica Vernuccio, Massimo Costanzo, Laura Scopelliti, Dario Picone, Federico Midiri, Francesco Salvaggi, Francesco Cupido, Massimo Galia, Sergio Salerno, Antonio Lo Casto, Massimo Midiri, Giuseppe Lo Re, Roberto Lagalla

“…The videofluorographic swallowing study is a key diagnostic tool in the detection of swallowing disorders, allowing to make an early diagnosis and to reduce the risk of gastrointestinal and pulmonary complications. …”
Get full text

Primary cardiac lymphoma: a clinicopathological study of 121 cases by Shuhui Zhuang, Liudi Chang, Liudi Chang, Xiaoxi Feng, Xiaoxi Feng, Weiwen Hu, Weiwen Hu, Zhaobo Yang, Yuanyuan Zhang

“…Echocardiography served as the primary diagnostic method in 92.6% of cases, while a definitive diagnosis was achieved through pathological examination in all cases (100%). …”
Get full text

CHST1 as a prognostic-related biomarker in gastric cancer correlating with immune infiltration by Long Gui, Jin-hao Yu, Jia-nan Tan, Guang-yu Zhong, Yong-xue Wang, Lin Zhong, Jiao-jiao Su, Dong Hou, Bin Yang, Fang-hai Han, Sheng-ning Zhou

“…Carbohydrate sulfotransferase (CHST) is a Golgi membrane-associated enzyme with potential as a cancer diagnostic marker. In this study, we obtained the transcriptional profile and corresponding clinical information of CHST1 in gastric cancer (GC) tissues and normal tissues from The Cancer Genome Atlas database. …”
Get full text

Using Information Extraction to Normalize the Training Data for Automatic Radiology Report Generation by Yuxiang Liao, Haishan Xiang, Hantao Liu, Irena Spasic

“…High lexico-syntactic variation across radiology reports even when they convey the same diagnostic information complicates evaluation and hence the training of deep learning models for Automatic Radiology Report Generation. …”
Get full text

The Impact of Psoriasis and Metabolic Syndrome on the Systemic Inflammation and Oxidative Damage to Nucleic Acids by Drahomira Holmannova, Lenka Borska, Ctirad Andrys, Pavel Borsky, Jan Kremlacek, Kvetoslava Hamakova, Vit Rehacek, Andrea Malkova, Tereza Svadlakova, Vladimir Palicka, Jan Krejsek, Zdenek Fiala

“…The applicability of serum levels of calprotectin and ANGPTL8 for monitoring of the activity of psoriasis (diagnostic markers) is also evaluated. Methods. Clinical examination (PASI score, MetS), enzyme-linked immunosorbent assay (ELISA), and Enzyme Immunoassay (EIA). …”
Get full text

CT Imaging Findings after Stereotactic Radiotherapy for Liver Tumors by Olga R. Brook, Eavan Thornton, Mishal Mendiratta-Lala, Anand Mahadevan, Vassilious Raptopoulos, Alexander Brook, Robert Najarian, Robert Sheiman, Bettina Siewert

Get full text

Clinical significance of PCT, CRP, IL-6, NLR, and TyG Index in early diagnosis and severity assessment of acute pancreatitis: A retrospective analysis by Xu Xinyu, Zhou Jiang, Ai Qing, Li Lihua, Liu Xiehong, Zhou Lin

“…Combining multiple biomarkers enhances diagnostic precision and provides guidance for personalized treatment strategies in AP.…”
Get full text

Changes in the Parietal Lobe Subregion Volume at Various Stages of Alzheimer’s Disease and the Role in Cognitively Normal and Mild Cognitive Impairment Conversion by Fang Lu, Qing Ma, Cailing Shi, Wenjun Yue

“…Finally, we examined the relationship between the cognitive scores and parietal subregion volume in the diagnostic groups. …”
Get full text

An X-Linked Hyper-IgM Patient Followed Successfully for 23 Years without Hematopoietic Stem Cell Transplantation by Necil Kutukculer, Neslihan Edeer Karaca, Guzide Aksu, Ayca Aykut, Erhan Pariltay, Ozgur Cogulu

“…Flow cytometric analysis for CD40LG expression on activated T cells showed highly decreased, but not absent, CD40LG expression. In conclusion, diagnostic delay is a clinical problem for patients with CD40LG deficiency, because of low or normal IgM levels, showing that all the hypogammaglobulinemic patients, not only with high serum IgM levels, but also with normal to low IgM levels, have to be examined for CD40LG expression on activated T lymphocytes. …”
Get full text