The Difference in Translaminar Pressure Gradient and Neuroretinal Rim Area in Glaucoma and Healthy Subjects by Lina Siaudvytyte, Ingrida Januleviciene, Arminas Ragauskas, Laimonas Bartusis, Indre Meiliuniene, Brent Siesky, Alon Harris

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Single domain antibody-scFv conjugate targeting amyloid β and TfR penetrates the blood–brain barrier and interacts with amyloid β by Rebecca Faresjö, Elisabet O. Sjöström, Tiffany Dallas, Magnus M. Berglund, Jonas Eriksson, Dag Sehlin, Stina Syvänen

“…Our findings suggest that these novel VHH-based FPs hold potential for therapeutic and diagnostic applications in AD, providing a strategy to overcome BBB limitations and enhance brain targeting of antibody-based treatments. …”
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Usefulness of Double-Balloon Endoscopy in the Postoperative Gastrointestinal Tract by Masaki Endo, Yukito Abiko, Syuhei Oana, Norihiko Kudara, Takashi Kosaka, Toshimi Chiba, Yasuhiro Takikawa, Kazuyuki Suzuki, Tamotsu Sugai

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A Single‐Center Retrospective Cohort Study of Biopterin Metabolism Disorders in the United Arab Emirates by Omar Jarrah, Mahmood Nouri, Aisha Al Shamsi

“…It describes new genetic variants and addresses diagnostic challenges to enhance the patient's diagnosis and treatment.…”
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Enhancing pediatric congenital heart disease detection using customized 1D CNN algorithm and phonocardiogram signals by Ihtisham Ul Haq, Ghassan Husnain, Yazeed Yasin Ghadi, Nisreen Innab, Masoud Alajmi, Hanan Aljuaid

“…Early detection is crucial, however constrained by the intricacies of conventional diagnostic techniques such as auscultation and echocardiography. …”
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Circulating fibroblast growth factor 21 levels in gestational diabetes mellitus and preeclampsia: a systematic review and meta-analysis by Zhen Cao, Zhiming Deng, Jieyi Lu, Ying Yuan

“…Conclusions Our study found that FGF21 has the potential to serve as a diagnostic marker for GDM or PE. However, due to the limited number of studies and the fact that most data were from the second and third trimesters of pregnancy, more large-scale prospective studies are needed to validate these conclusions, investigate the potential of FGF21 in enabling early diagnosis, and further examine the role of FGF21 in the development and progression of GDM/PE. …”
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C3AR1 as a target for preeclampsia: from bioinformatics and network pharmacology to experimental validation by Yongfeng Hu, Shaoqiang Li, Yunhui Hong, Dongxian Peng

“…Reduced C3AR1 in preeclamptic placentas correlated with maternal blood pressure, and showed high diagnostic potential (AUC = 0.95). C3AR1’s involvement in preeclampsia was linked to Jak-STAT, TGF-β, and HIF-1 pathways, and associated with NK cell and M1 macrophage activity. …”
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Determining anatomically-safe corridors for placement of lateral mass screws in the first cervical vertebra of the Emirati population – a CT study by Dineshwary Suresh, Nerissa Naidoo, Rashid AlSharhan, Usama Al Bastaki, Jeyaseelan Lakshmanan, Baylis Vivek Joseph, Ivan James Prithishkumar

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Patterns of colonic dismotility and visceral hypersensitivity at various clinical variants of irritable bowel syndrome by Ekaterina A. Bubnova, O. Yu. Fomenko, I. L. Khalif, V. V. Pavlenko

“…The diagnosis is verified by modern instrumental and laboratory diagnostic methods (colonoscopy with biopsy, abdominal ultrasonography etc.), and complied to Rome-III criteria. …”
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Association of dietary decanoic acid intake with diabetes or prediabetes: an analysis from NHANES 2005–2016 by Huangxin Zhu, Huangxin Zhu, Qingan Fu, Ruxin Chen, Linfei Luo, Miao Yu, Yue Zhou

“…DDA intake was assessed through two 24-h dietary recalls and participants were grouped according to the diagnostic criteria for diabetes and prediabetes. Multivariate regression models were applied to analyze the relationship between DDA intake and diabetes and prediabetes, with subgroup analyses conducted to explore potential interactions.ResultsDietary decanoic acid intake was significantly negatively associated with the risk of diabetes. …”
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Hereditary transthyretin amyloidosis incidentally diagnosed by video-associated lung surgery for lung cancer: A case report by Katsuhiro Itogawa, Shintaro Sato, Hideaki Yamakawa, Keiichi Akasaka, Masako Amano, Akiko Adachi, Hidekazu Matsushima

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Economic Burden of Contraception Management in Spain by Inmaculada Parra Ribes, Juan José Rascón Poza, Ezequiel Pérez Campos, Ignacio Bugella Yudice, Maria Jesús Rodríguez Domingo

“…The costs included in the analysis were diagnostic tests, initial and follow-up consultations, methods acquisition costs, and UP derived from therapy failure. …”
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Exploring the role of artificial intelligence in chemotherapy development, cancer diagnosis, and treatment: present achievements and future outlook by Bassam Abdul Rasool Hassan, Ali Haider Mohammed, Souheil Hallit, Souheil Hallit, Souheil Hallit, Diana Malaeb, Hassan Hosseini, Hassan Hosseini

“…Evidence from recent studies highlights AI’s potential to reduce cancer-related mortality by optimizing diagnostic accuracy, personalizing treatment plans, and improving therapeutic outcomes. …”
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Investigating the relationship between thought interference, somatic passivity and outcomes in patients with psychosis: a natural language processing approach using a clinical reco... by Robert Stewart, Anna Kolliakou, Jyoti Sanyal, Rashmi Patel, Thibault Thierry Magrangeas

“…Objectives We aimed to apply natural language processing algorithms in routine healthcare records to identify reported somatic passivity (external control of sensations, actions and impulses) and thought interference symptoms (thought broadcasting, insertion, withdrawal), first-rank symptoms traditionally central to diagnosing schizophrenia, and determine associations with prognosis by analysing routine outcomes.Design Four algorithms were developed on deidentified mental healthcare data and applied to ascertain recorded symptoms over the 3 months following first presentation to a mental healthcare provider in a cohort of patients with a primary schizophreniform disorder (ICD-10 F20-F29) diagnosis.Setting and participants From the electronic health records of a large secondary mental healthcare provider in south London, 9323 patients were ascertained from 2007 to the data extraction date (25 February 2020).Outcomes The primary binary dependent variable for logistic regression analyses was any negative outcome (Mental Health Act section, >2 antipsychotics prescribed, >22 days spent in crisis care) over the subsequent 2 years.Results Final adjusted models indicated significant associations of this composite outcome with baseline somatic passivity (prevalence 4.9%; adjusted OR 1.61, 95% CI 1.37 to 1.88), thought insertion (10.7%; 1.24, 95% CI 1.15 to 1.55) and thought withdrawal (4.9%; 1.36, 95% CI 1.10 to 1.69), but not independently with thought broadcast (10.3%; 1.05, 95% CI 0.91 to 1.22).Conclusions Symptoms traditionally central to the diagnosis of schizophrenia, but under-represented in current diagnostic frameworks, were thus identified as important predictors of short-term to medium-term prognosis in schizophreniform disorders.…”
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Boosting skin cancer diagnosis accuracy with ensemble approach by Priya Natha, Sivarama Prasad Tera, Ravikumar Chinthaginjala, Safia Obaidur Rab, C. Venkata Narasimhulu, Tae Hoon Kim

“…Better predictive modeling methods are needed since the diagnostic procedures used now frequently produce inaccurate and inconsistent results. …”
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In vivo confocal microscopic study of cornea verticillata and limbus deposits in patients with Fabry disease by Xuecong Zhou, Yawen Zhao, Yingsi Li, Yujing Yuan, Xiaoming Yan, Wei Zhang, Yuan Wu

“…The high prevalence of epithelial deposits observed through IVCM in the cardiac variant highlights the essential ability of IVCM as an effective diagnostic tool.…”
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The Role of Motility Impairment in the Pathogenesis of Functional Disorders of the Gastrointestinal Tract and Modern Possibilities for Their Treatment (Resolution of an Expert Coun... by I. V. Maev, A. S. Trukhmanov, A. A. Sheptulin, V. I. Simanenkov, S. R. Abdulhakov, N. A. Agafonova, V. A. Akhmedov, T. A. Ilchishina, M. G. Ipatova, O. V. Krapivnaya, Yu. A. Kucheryavyi, M. F. Osipenko, O. A. Storonova, G. N. Tarasova, G. Ya. Khismatullina, S. V. Cheryomushkin

“…It is emphasized that, at the stage of a diagnostic search in the absence of “alarm symptoms” in patients with suspected FD, IBS, and BD, these drugs can be prescribed empirically.Conclusions. …”
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Lipid Metabolism-Related Gene Signature Predicts Prognosis and Indicates Immune Microenvironment Infiltration in Advanced Gastric Cancer by Lijian He, Qiange Ye, Yanmei Zhu, Wenqi Zhong, Guifang Xu, Lei Wang, Zhangding Wang, Xiaoping Zou

“…We then used consensus cluster analysis to classify AGC patients into molecular subtypes based on lipid metabolism and constructed a diagnostic model using least absolute shrinkage and selection operator- (LASSO-) Cox regression analysis and Gene Set Enrichment Analysis (GSEA). …”
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Voice analysis and deep learning for detecting mental disorders in pregnant women: a cross-sectional study by Hikaru Ooba, Jota Maki, Hisashi Masuyama

“…The model’s performance was compared to that of the EPDS in terms of sensitivity, specificity, and other diagnostic metrics. Results Of the 172 participants analyzed (149 without mental disorders and 23 with mental disorders), the voice-based model demonstrated a sensitivity of 1.00 and a recall of 0.82, outperforming the EPDS in these areas. …”
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Visual and Auditory fMRI Paradigms for Presurgical Language Mapping: Convergent Validity and Relationship to Individual Variables by Antonina Omisade, Christopher B. O’Grady, Matthias H. Schmidt, John D. Fisk

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