Nebulised 3% hypertonic saline versus 0.9% saline for treating patients hospitalised with acute bronchiolitis: protocol for a randomised, double-blind, multicentre trial by Sara Szupieńko, Aleksandra Buczek, Henryk Szymański

“…However, non-evidence-based diagnostic and therapeutic approaches, including the use of inhaled bronchodilators, nebulised epinephrine, and nebulised and systemic steroids, are common. …”
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Cardiac Myxoma: Typical Presentation but Unusual Histology by Hassan H. AlAhmadi, Noor Said Alsafwani, Mohamed A. Shawarby, Fayez Ahmed

“…Its presence can complicate the diagnostic process. A 43-year-old Saudi male was referred with a two-month history of progressively increasing shortness of breath. …”
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Nano theranostics involved in bladder cancer treatment by Kunpeng Liu, Qixi Mo, Zhenshan Ding, Shicong Lai, Jian Ren, Qingsong Yu

“…Theranostics, the integration of diagnostic and therapeutic technologies, has emerged as a promising strategy to address these challenges. …”
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Serum chemokine IL-8 acts as a biomarker for identifying COVID-19-associated persistent severe acute kidney injury by Zhi He, Jing-jing Liu, Shao-lei Ma

“…Our study attempted to evaluate the diagnostic value of chemokines for early-stage PS-AKI prediction.Methods According to the KDIGO criteria, 115 COVID-19 patients diagnosed with stage 2/3 AKI were recruited from the intensive care unit between December 2022 and February 2023. …”
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The role of HSPA14 in breast cancer: implications for tumorigenesis, immune response modulation, and personalized therapies by Ruipeng Zhao, Xiaocun Zhu, Wan Wei, Linlin Zhen

“…The mRNA expression of HSPA14 was validated through cell experiments.Results HSPA14 expression is elevated in breast cancer, which is associated with poor overall survival. It can serve as a diagnostic biomarker for breast cancer patients. Pathway analysis revealed that HSPA14-associated differential genes are involved in cell cycle, apoptosis, cellular response to heat stress, and more. …”
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Complications during chest tube drainage for iatrogenic pneumothorax by Birgitte Siem Joensen, Uffe Bodtger, Christian B. Laursen, Rob J Hallifax, Beenish Iqbal, Søren Helbo Skaarup

“…Background Iatrogenic pneumothorax is a common complication of diagnostic and therapeutic pulmonary procedures. New guidelines on primary spontaneous pneumothorax suggest ambulatory approaches may be suitable. …”
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Prevalence of dry eye disease in Russia by O.N. Onufriichuk, A.V. Kuroyedov

“…This issue is further exacerbated by the lack of study coordination in a whole country and, as a result, the use of different methods and diagnostic criteria, samples of unequal age, comorbidities, region, and climatic geographical living conditions. …”
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Evaluating the accuracy of a nutritional screening tool for patients with digestive system tumors: A hierarchical Bayesian latent class meta-analysis. by Menghao Yang, Na Xiao, Le Tang, Yang Zhang, Yuexiu Wen, Xiuqin Yang

“…<h4>Methods</h4>A systematic search of six databases was conducted to identify studies that met predefined inclusion and exclusion criteria. Diagnostic test metrics such as sensitivity, specificity, and likelihood ratios (positive and negative) were estimated using a hierarchical summary receiver operating characteristic model. …”
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Pyrenophora tritici-repentis population structure in the Republic of Kazakhstan and identification of wheat germplasm resistant to tan spot by A. M. Kokhmetova, N. M. Kovalenko, M. T. Kumarbaeva

“…A collection of 30 common wheat accessions, including promising lines and cultivars from Kazakhstan and CIMMYT–ICARDA, was assessed for resistance to P. triticirepentis in a greenhouse and characterized using the Xfcp623 molecular marker, diagnostic for the Tsn1 gene. Monosporic isolates of P. tritici-repentis isolated from the southeastern region were assigned to certain races based on the manifestation of symptoms of necrosis/chlorosis on standard differentials (Glenlea, 6B662, 6B365). …”
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Multi-omics approaches for understanding gene-environment interactions in noncommunicable diseases: techniques, translation, and equity issues by Robel Alemu, Nigussie T. Sharew, Yodit Y. Arsano, Muktar Ahmed, Fasil Tekola-Ayele, Tesfaye B. Mersha, Azmeraw T. Amare

“…These diseases arise from the complex interactions between genetic, behavioral, and environmental factors, necessitating a thorough understanding of these dynamics to identify effective diagnostic strategies and interventions. Although recent advances in multi-omics technologies have greatly enhanced our ability to explore these interactions, several challenges remain. …”
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Infectious and Noninfectious Acute Pericarditis in Children: An 11-Year Experience by Nahed Abdel-Haq, Zeinab Moussa, Mohamed Hani Farhat, Leela Chandrasekar, Basim I. Asmar

“…Echocardiography-guided thoracocentesis remains the preferred diagnostic and therapeutic approach. However, pericardiotomy and drainage are needed when appropriate clinical response is not achieved with percutaneous drainage.…”
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Advances in the application of digital technology in orthodontic monitoring by WANG Qi, LUO Ting, LU Wei, ZHAO Tingting, HE Hong, HUA Fang

“…The digitization of diagnostic data and the visualization of dental models make chair-side follow-up monitoring more convenient, accurate, and efficient. …”
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Neurofibroma of bladder: A case report and literature review by Zhipeng Yan, Baoqun Xu, Maokun Sun, Heng Zhang, Xiaolu Sun, Lihua Li, Yulan Gao, Yunji Sun

“…After 6 months of surgery, follow-up examination showed a significant reduction in tumor volume and no recurrence. The successful diagnostic and therapeutic experience of this case can be referenced for clinical practice.…”
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Intelligent imaging technology applications in multidisciplinary hospitals by Ke Fan, Lei Yang, Fei Ren, Xueyuan Zhang, Bo Liu, Ze Zhao, Jianwen Gu, Yuanyuan Ji

“…This advanced technology offers a faster and more precise diagnostic approach, ultimately improving patient care and outcomes. …”
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Do Salivary <i>Cullin7</i> Gene Expression and Protein Levels Provide Advantages over Plasma Levels in Diagnosing Breast Cancer? by Ceren Tilgen Yasasever, Derya Duranyıldız, Süleyman Bademler, Hilal Oğuz Soydinç

“…The role of the Cul7 molecule in breast cancer is still unclear, and understanding its function could have significant implications for identifying novel therapeutic targets or improving diagnostic strategies in breast cancer management. In this study, the levels of the Cul7 molecule in plasma and noninvasive material saliva were investigated, and its possibility as a marker for breast cancer was discussed. …”
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Patient stratification by genetic risk in Alzheimer's disease is only effective in the presence of phenotypic heterogeneity. by Jack Euesden, Muhammad Ali, Chloe Robins, Praveen Surendran, Padhraig Gormley, Alzheimer’s Disease Neuroimaging Initiative (ADNI), David Pulford, Carlos Cruchaga

“…Where clinically relevant biomarkers suggest diagnostic heterogeneity, there is evidence that a priori identified genetic risk factors may have value in patient stratification. …”
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Dickkopf-1 Is a Biomarker for Systemic Lupus Erythematosus and Active Lupus Nephritis by Jing Xue, Jiali Yang, Lijuan Yang, Shaolan Zhou, Chen Ji, Xuemei Wang, Nan Yu, Xiaoming Liu, Shuhong Chi

“…In this study, the concentrations of Wnt-3A, Frizzled-8 (FZD-8), and Dickkopf-1 (DKK-1) of Wnt signaling, as well as their diagnostic values for accessing LN, were evaluated by ELISA in sera and urine of 111 SLE patients (31 with LN and 80 without LN) and 70 healthy cohorts. …”
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Differentiation between 3,4- and 4,15-Epoxyeudesmanolides by Electrospray Ionization Tandem Mass Spectrometry by Herbert Júnior Dias, Ricardo Stefani, José Carlos Tomaz, Ricardo Vessecchi, Antônio Eduardo Miller Crotti

“…The formation of these diagnostic ions was associated with the C(3)–O bond of compound 1, which propitiates the participation of the lone pair of the oxygen epoxide in the formation of B through a Grob-Wharton-type fragmentation, then resulting in an alternative fragmentation pathway. …”
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Serum Levels of Mitochondrial Fission- and Fusion-Related Genes of Coal Workers’ Pneumoconiosis and Risk Factor Analysis Based on a Generalized Linear Model by Xiao-Yu Li, Jing-Lin Wei, Yong-Xin Xie, Ji Zhao, Li-Ya Ma, Na Zhang, Hui-Fang Yang

“…We aimed to explore the risk factors for coal workers’ pneumoconiosis and to further explore the significance of mitochondrial fission and fusion factors in CWP and verify the feasibility of mitochondrial fission and fusion factors as diagnostic and therapeutic targets. Methods. The data of 168 cases were collected, and they were divided into a healthy control group (40 cases), dust exposure control group (61 cases), and CWP group (67 cases) and entered into SPSS 24.0. …”
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Tear matrix metalloproteinases-9 and ocular surface parameters in diabetics: a cross-sectional study in Shenyang, China by Ling Yang, Wei He, Jiayan Chen, Guanghao Qin, Emmanuel Eric Pazo, Zhengpeng Qu

“…The MMP-9 test is a potential diagnostic tool for DDE. It may help follow-up diabetic patients with DED and guide clinicians in deciding on anti-inflammatory treatments for these patients.…”
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