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Diagnosis and Treatment of Gastroesophageal Reflux Disease (Clinical Guidelines of the Russian Gastroenterological Association, Russian Scientific Medical Society of Internal Medic...
Published 2024-12-01“…These recommendations are developed for practitioners in order to familiarize them with modern diagnostic methods, management features and pharmacotherapy of patients with gastroesophageal reflux disease (GERD).General provisions. …”
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Soluble and cell-based markers of immune checkpoint inhibitor-associated nephritis
Published 2023-01-01“…A sIL-2R cut-off point of 1.75-fold ULN was highly diagnostic of ICI-nephritis (area under the curve >96%) when compared with either ICI-treated or hemodynamic AKI controls. …”
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Tumor mutational burden and survival on immune checkpoint inhibition in >8000 patients across 24 cancer types
Published 2025-02-01“…The KEYNOTE 158 trial supported United States Food and Drug Administration (FDA) approval of the Foundation Medicine test (FoundationOneCDx) at TMB≥10 mut/Mb as a companion diagnostic (CDx) for single-agent pembrolizumab in second+line. …”
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The significance of isolated de novo red patches in the bladder in patients referred with suspected urinary tract cancer: Results from the IDENTIFY study
Published 2025-01-01“…Clinicians should consider the patient's age, smoking status and how suspicious‐looking the patch is, before deciding on surveillance versus biopsy to improve cancer diagnostic yield.…”
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Frailty Assessment Tools in Chronic Kidney Disease: A Systematic Review and Meta-analysis
Published 2025-03-01“…In order to make recommendations for frailty tools across measurement domains, future studies should compare the diagnostic accuracy to the clinical standard, geriatric assessment, and examine responsiveness to change.…”
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An assessment of breast cancer HER2, ER, and PR expressions based on mammography using deep learning with convolutional neural networks
Published 2025-02-01“…The model has the potential to predict HER2, PR, and especially ER expressions, and thus serve as an adjunctive diagnostic tool for breast cancer.…”
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Analysis of clinical characteristics and risk factors for patients with heat stroke in western China in 2022: a multicenter retrospective study
Published 2025-01-01“…The AUC values for the combined diagnostic model were 0.848 (95% CI: 0.781–0.914). Male morbidity, the number of patients with combined hypertension, the prognosis, and the APACHE II score and ALT level were all greater (p < 0.05) in the CHS group. …”
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Site-specific immunoglobulin G N-glycosylation is associated with gastric cancer progression
Published 2025-02-01“…Understanding these changes could improve our knowledge of molecular mechanisms, aiding in diagnostic improvements and therapeutic development.…”
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A Bibliometric and Visualised Analysis of Proliferative Verrucous Leucoplakia From 2003 to 2023
Published 2025-02-01“…We found that current publications comprise mainly case reports, there is a significant research need to explore the molecular mechanisms, specific diagnostic criteria, and effective management options for PVL. …”
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Dilated cardiomyopathy signature metabolic marker screening: Machine learning and multi-omics analysis
Published 2025-02-01“…Objects: Our aim was to identify changes in the metabolome in dilated cardiomyopathy (DCM) as well as to construct a metabolic diagnostic model for DCM. Methods: We utilized non-targeted metabolomics with a cross-sectional cohort of age- and sex-matched DCM patients and controls. …”
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The value of sex hormones and sex hormone-binding globulin in metabolic dysfunction-associated fatty liver disease among boys with obesity
Published 2025-02-01“…Utilizing logistic regression analysis to explore the risk factors for developing MAFLD, and through the construction of Receiver Operating Characteristic (ROC) curves, conducting a preliminary assessment of the diagnostic value for MAFLD.ResultsA total of 155 male children with obesity were included in the study, mean age of 11.07 ± 1.53 years. …”
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Understanding experiences of neglected tropical diseases of the skin: a mixed-methods study to inform intervention development in Ethiopia
Published 2025-02-01“…Opportunities for integrated skin NTD service provision were explored through policy document review, interviews with health officials (n=25), and stakeholder meetings.Results Availability of diagnostic supplies and health worker competence to provide skin care was very limited across primary healthcare facilities, particularly for CL. …”
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