Hyperglycemia and Correlated High Levels of Inflammation Have a Positive Relationship with the Severity of Coronavirus Disease 2019 by Wen Zhang, Chuanwei Li, Yu Xu, Binfeng He, Mingdong Hu, Guoqiang Cao, Li Li, Shuang Wu, Xia Wang, Chun Zhang, Jianping Zhao, Jungang Xie, Zihui Xu, Qi Li, Guansong Wang

“…The severity of COVID-19 in all patients was determined according to the diagnostic and treatment guidelines issued by the Chinese National Health Committee (7th edition). …”
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Impacts of Sandstorms on Chemistries of Ambient PAHs in a Small City in North China by Zhiyong Li, Zhen Zhai, Jixiang Liu, Lan Chen, Zhuangzhuang Ren, Chen Liu, Ziyi Zhan, Ziyuan Yue, Wenjia Zhu, Jihong Wei, Huiying Gao, Songtao Guo

“…Potential source contribution function (PSCF) indicated that OLC partly came from sandstorm origin area–Inner Mongolia. Low diagnostic ratios of FA/(FA + PY) in the SSP also indicated OLC was more important. …”
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Oral behaviors in Chinese temporomandibular disorder patients: insights from exploratory and confirmatory factor analyses by Tiqian Liu, Tiqian Liu, Adrian Ujin Yap, Adrian Ujin Yap, Adrian Ujin Yap, Yanyu Sun, Yanyu Sun, Yunhao Zheng, Yunhao Zheng, Tianqi Wang, Tianqi Wang, Shiya Zeng, Shiya Zeng, Zhen Liu, Xin Xiong, Xin Xiong

“…This was followed by a clinical examination and diagnosis based on the Diagnostic Criteria for TMDs (DC/TMDs). Exploratory factor analysis, along with confirmatory factor analysis, was applied to waking-state oral behaviors, revealing two key factors: Chinese non-functional (C-NFA) and functional (C-FA) oral activities. …”
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Provocation of brachial plexus and systemic symptoms during the elevated arm stress test in individuals with myalgic encephalomyelitis/chronic fatigue syndrome or idiopathic chroni... by Charles C. Edwards, Julia M. Byrnes, Camille A. Broussard, Alba M. Azola, Meghan E. Swope, Colleen L. Marden, Renee L. Swope, Ying Wei Lum, Richard L. Violand, Peter C. Rowe

“…In the TOS literature, diagnostic maneuvers focus on the provocation of upper limb symptoms (arm fatigue and heaviness, paresthesias, neck and upper back pain), but not on elicitation of systemic symptoms. …”
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Harnessing deep learning to detect bronchiolitis obliterans syndrome from chest CT by Mateusz Koziński, Doruk Oner, Jakub Gwizdała, Catherine Beigelman-Aubry, Pascal Fua, Angela Koutsokera, Alessio Casutt, Argyro Vraka, Michele De Palma, John-David Aubert, Horst Bischof, Christophe von Garnier, Sahand Jamal Rahi, Martin Urschler, Nahal Mansouri

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High fructose rewires gut glucose sensing via glucagon-like peptide 2 to impair metabolic regulation in mice by Eya Sellami, Paulo Henrique Evangelista-Silva, Caio Jordão Teixeira, Khoudia Diop, Patricia Mitchell, Fernando Forato Anhê

“…Our findings are positioned to inform novel early diagnostic tools and treatments tailored to counter high fructose-induced metabolic derangements predisposing to T2D and MASLD.…”
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Programmed cell death-related gene IL20RA facilitates tumor progression and remodels tumor microenvironment in thyroid cancer by Yuqi Wang, Yunlong Zhang, Min Liu, Yu Liu, Yu Zeng, Wei Zhang, Shuping Wu, Linfei Hu, Xianhui Ruan, Xiangqian Zheng, Ming Gao, Jingzhu Zhao

“…The function of IL20RA which could potentially provide a foundation for additional investigations into diagnostic markers and treatment targets for THCA.…”
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Development of a clinical prediction model for benign and malignant pulmonary nodules with a CTR ≥ 50% utilizing artificial intelligence-driven radiomics analysis by Wensong Shi, Yuzhui Hu, Guotao Chang, He Qian, Yulun Yang, Yinsen Song, Zhengpan Wei, Liang Gao, Hang Yi, Sikai Wu, Kun Wang, Huandong Huo, Shuaibo Wang, Yousheng Mao, Siyuan Ai, Liang Zhao, Xiangnan Li, Huiyu Zheng

“…This study aims to develop and validate an AI-driven radiomics prediction model for such nodules to enhance diagnostic accuracy. Methods Data of 2,591 pulmonary nodules from five medical centers (Zhengzhou People’s Hospital, etc.) were collected. …”
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Clinical Practice Guidelines of the Scientific Society for the Clinical Study of Human Microbiome, of the Russian Gastroenterological Association and the Russian Society for the Pr... by V. T. Ivashkin, O. S. Lyashenko, O. M. Drapkina, O. P. Alexeeva, S. A. Alekseenko, D. N. Andreev, A. Yu. Baranovsky, O. V. Goloshchapov, N. V. Zheleznova, O. Yu. Zolnikova, I. L. Kliaritskaia, N. V. Korochanskaya, T. L. Lapina, I. V. Maev, R. V. Maslennikov, R. G. Myazin, P. V. Pavlov, M. V. Perekalina, N. A. Pisarenko, A. V. Povtoreyko, E. A. Poluektova, L. A. Sekretareva, A. V. Tkachev, Yu. M. Troshkina, A. S. Trukhmanov, A. I. Ulyanin, S. G. Filatova, V. V. Tsukanov, O. S. Shifrin

“…The disease severity is determined by clinical symptoms and laboratory findings. Additional diagnostic methods that are used according to indications and contribute to the assessment of severity include endoscopy of the colon and abdominal cavity imaging methods. …”
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Cohort profile: the Viral load Cohort North-East Lesotho (VICONEL) from 2016 to 2023 – cohort description, test volumes, predictors of viraemia and the road ahead by Tracy Glass, Frédérique Chammartin, Jochen Ehmer, Thomas Klimkait, Alain Amstutz, Josephine Muhairwe, Irene Ayakaka, Blaise Lukau, Jennifer Anne Brown, Lipontso Motaboli, Malebanye Lerotholi, Maurus Kohler, Kathrin Haenggi, Moliehi Mokete, Makobefo Gladys Chakela, Mpho Kao, Mathebe Kopo, Moleboheng Mokebe, Lorena Urda, Bienvenu Lengo Nsakala, Anna Klicpera, Nadine Tschumi, Niklaus Daniel Labhardt

“…Sex, age category/ART regimen core agent (combined variable), time since ART initiation and district were independently associated with viraemia.Future plans VICONEL offers potential for (1) further digitalisation and automation of results sharing at the client, facility and district/national level, (2) integration of additional clinical and diagnostic data, including comorbidities and drug resistance and (3) embedding randomised trials.…”
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Identification and preliminary validation of biomarkers associated with mitochondrial and programmed cell death in pre-eclampsia by Rong Lin, Rong Lin, XiaoYing Weng, XiaoYing Weng, Liang Lin, Liang Lin, XuYang Hu, XuYang Hu, ZhiYan Liu, ZhiYan Liu, Jing Zheng, Jing Zheng, FenFang Shen, FenFang Shen, Rui Li, Rui Li

“…Immunofluorescence, RT-qPCR, and Western blot confirmed reduced expression of SLC25A5, MFF, and PMAIP1 in PE, whereas ACSF2 was significantly upregulated.ConclusionThese four mtPCD-related biomarkers may play a pivotal role in PE pathogenesis, offering new perspectives on the disease’s diagnostic and mechanistic pathways.…”
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Unambiguous identification of fungi: where do we stand and how accurate and precise is fungal DNA barcoding? by Robert Lücking, M. Catherine Aime, Barbara Robbertse, Andrew N. Miller, Hiran A. Ariyawansa, Takayuki Aoki, Gianluigi Cardinali, Pedro W. Crous, Irina S. Druzhinina, David M. Geiser, David L. Hawksworth, Kevin D. Hyde, Laszlo Irinyi, Rajesh Jeewon, Peter R. Johnston, Paul M. Kirk, Elaine Malosso, Tom W. May, Wieland Meyer, Maarja Öpik, Vincent Robert, Marc Stadler, Marco Thines, Duong Vu, Andrey M. Yurkov, Ning Zhang, Conrad L. Schoch

“…This allows objective evaluation of diagnostic characters, either phenotypic or molecular or both. …”
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Epidemiology of community-acquired pneumonia among hospitalised children in Indonesia: a multicentre, prospective study by Rina Triasih, Yan Mardian, Dewi Lokida, Helmia Farida, Herman Kosasih, Adhella Menur Naysilla, Arif Budiman, Chakrawati Hayuningsih, Moh Syarofil Anam, Dwi Wastoro, Mujahidah Mujahidah, Setya Dipayana, Amalia Setyati, Abu Tholib Aman, Nurhayati Lukman, Muhammad Karyana, Ahnika Kline, Aaron Neal, Chuen-Yen Lau, Clifford Lane

“…Objective To identify aetiologies of childhood community-acquired pneumonia (CAP) based on a comprehensive diagnostic approach.Design ‘Partnerships for Enhanced Engagement in Research-Pneumonia in Paediatrics (PEER-PePPeS)’ study was an observational prospective cohort study conducted from July 2017 to September 2019.Setting Government referral teaching hospitals and satellite sites in three cities in Indonesia: Semarang, Yogyakarta and Tangerang.Participants Hospitalised children aged 2–59 months who met the criteria for pneumonia were eligible. …”
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Inflammatory Gene Signature Identified by Machine Algorithms Reveals Novel Biomarkers of Coronary Artery Disease by Liu X, Zhang Y, Wang Y, Xu Y, Xia W, Liu R, Xu S

“…From this intersection, 29 DIRGs were identified, of which 14 DIRGs (PTGER1, IL17RC, KLKB1, GPR32, ADM, NUPR1, SCN9A, IL17B, CX3CL1, FFAR3, PYDC2, SYT11, RORA, and GPR31) exhibited high diagnostic efficacy. Four biomarkers (ADM, NUPR1, PTGER1, and PYDC2) were identified using Support Vector Machine (SVM). …”
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Diagnosis and Treatment of Patients with Autoimmune Hepatitis (Experts’ Agreement) by Yu. G. Sandler, E. V. Vinnitskaya, K. L. Raikhelson, K. V. Ivashkin, S. N. Batskikh, E. N. Aleksandrova, D. T. Abdurakhmanov, D. I. Abdulganieva, I. G. Bakulin, A. O. Bueverov, S. L. Vorobyev, O. A. Gerasimova, A. I. Dolgushina, M. S. Zhuravleva, L. Yu. Ilchenko, V. E. Karev, N. V. Korochanskaya, I. L. Kliaritskaia, N. S. Karnaukhov, S. V. Lapin, M. A. Livzan, M. V. Maevskaya, N. V. Marchenko, T. P. Nekrasova, I. G. Nikitin, A. A. Novikov, R. G. Saifutdinov, E. V. Skazyvaeva, V. E. Syutkin, M. K. Prashnova, T. Yu. Khaymenova, S. G. Khomerik

“…In the last decade, the understanding of the pathogenesis of autoimmune hepatitis (AIH) has significantly deepened, based on the results of new clinical studies some diagnostic issues have been revised and immunosuppressive therapy regimens have been optimized.Materials and methods. …”
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Clinical Presentation and Course of Pulmonary Involvement in Chronic Nonbacterial Osteomyelitis by Toni Hospach, Friederike Blankenburg, Anita Heinkele, Kristina Rücklová, Peter Müller‐Abt, Frank Weller‐Heinemann, Laura Buchtala, Jan Maier, Jasmin Kümmerle‐Deschner, Christiane Reiser, Ales Janda, Andreas Urban, Reiner Berendes, Andrea Skrabl‐Baumgartner, Jürgen Brunner, Ralf Trauzeddel, Johannes Peter Haas, Annette Holl‐Wieden, Henner Morbach, Anja Schnabel, Normi Brück, Gabriele Hahn, Wolfgang Emminger, Isabella Valent, Regine Borchers, Christian Klemann, Ilias Tsiflikas, Jens Klotsche, Kirsten Minden, Christian M. Hedrich, Thekla von Kalle

“…Limited awareness results in diagnostic challenges, especially because malignancy or infection needs to be considered. …”
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Phenotypic and Complete Reference Whole Genome Sequence Analyses of Two <i>Paenibacillus</i> spp. Isolates from a Gray Wolf (<i>Canis lupus</i>) Gastrointestinal Tract by Jessika L. Bryant, Jennifer McCabe, C. Cristoph Klews, MiCayla Johnson, Ariel N. Atchley, Thomas W. Cousins, Maya Barnard-Davidson, Kristina M. Smith, Mark R. Ackermann, Michael Netherland, Nur A. Hasan, Peter A. Jordan, Evan S. Forsythe, Patrick N. Ball, Bruce S. Seal

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Prevalence and drivers of malaria infection among asymptomatic and symptomatic community members in five regions with varying transmission intensity in mainland Tanzania by Gervas A. Chacha, Filbert Francis, Salehe S. Mandai, Misago D. Seth, Rashid A. Madebe, Daniel P. Challe, Daniel A. Petro, Dativa Pereus, Ramadhani Moshi, Rule Budodo, Angelina J. Kisambale, Ruth B. Mbwambo, Catherine Bakari, Sijenunu Aaron, Daniel Mbwambo, Stella Kajange, Samuel Lazaro, Ntuli Kapologwe, Celine I. Mandara, Deus S. Ishengoma

“…Participants aged ≥ 6 months were recruited and tested using rapid diagnostic tests (RDTs). Demographic, anthropometric, clinical, parasitological, type of house, and socio-economic status (SES) data were captured using structured questionnaires. …”
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Enhancing deep learning methods for brain metastasis detection through cross-technique annotations on SPACE MRI by Tassilo Wald, Benjamin Hamm, Julius C. Holzschuh, Rami El Shafie, Andreas Kudak, Balint Kovacs, Irada Pflüger, Bastian von Nettelbladt, Constantin Ulrich, Michael Anton Baumgartner, Philipp Vollmuth, Jürgen Debus, Klaus H. Maier-Hein, Thomas Welzel

“…This MRI cross-technique transfer learning is a promising way to increase diagnostic performance. Key Points Delineating small BMs on SPACE MRI sequence results in higher quality annotations than on MPRAGE sequence due to enhanced conspicuity. …”
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Warm and humid environment induces gut microbiota dysbiosis and bacterial translocation leading to inflammatory state and promotes proliferation and biofilm formation of certain ba... by Yinrui Guo, Jianlang He, Shaojie Li, Shiqi Zou, Haiting Zhang, Xin Yang, Jian Wang

“…Thick and greasy tongue fur and sticky feces are characteristic symptoms of “Dampness Syndrome” and serve as crucial diagnostic indicators in TCM for assessing health conditions. …”
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