Machine learning-based identification and validation of amino acid metabolism related genes as novel biomarkers in chronic kidney disease by Guoqing Zhang, Hongyan Luo, Xiaohua Lu, Yonghua Liu, Mei Wang, Bo Li, Haixia Lu, Yali Zheng

“…Results: All six genes exhibited promising diagnostic capabilities (AUC:0.7 to 0.9). Immune cells such as Activated CD4+ T cells, Regulatory T cells, Immature B cells and MDSC,etc.infiltrated differentially in the high and low risk groups of CKD. …”
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De Novo Mutation of m.3243A>G together with m.16093T>C Associated with Atypical Clinical Features in a Pedigree with MIDD Syndrome by Zhixin Jiang, Yinan Zhang, Jingbin Yan, Fengwen Li, Xinqian Geng, Huijuan Lu, Xiaoer Wei, Yanmei Feng, Congrong Wang, Weiping Jia

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Genotype Variations and Association between PAI-1 Promoter Region (4G/5G and -844G/A) and Susceptibility to Acute Myocardial Infarction and Chronic Stable Angina by Sunil Kumar, Amit Kumar Verma, Vinay Sagar, Ravi Ranjan, Rahul Sharma, Preeti Tomar, Deepti Bhatt, Yamini Goyal, Mohammed A. Alsahli, Ahmad Almatroudi, Saleh A. Almatroodi, Arshad Husain Rahmani, Faris Alrumaihi, Khursheed Muzammil, Kapil Dev, Rakesh Yadav, Renu Saxena

“…The present study for the first time revealed significant association of 4G/5G allele polymorphism with high risk of AMI in Indian population and will be helpful in identifying the genetic risk factors associated with AMI and CSA and for better management of diagnostic measures.…”
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Circulating tumor DNA for surveillance in high-risk melanoma patients: a study protocol by Magnús P.B. Obinah, Sarah A. Al-Halafi, Karin Dreisig, Tim S. Poulsen, Christoffer Johansen, Thomas Litman, Stig E. Bojesen, Estrid Høgdall, Annette H. Chakera, Lisbet R. Hölmich

“…In case of recurrence, patient-specific mutations are identified through next-generation sequencing (NGS) of formalin and paraffin embedded tissue from diagnostic routine. Detection of mutation-specific ctDNA is performed on blood using digital droplet polymerase chain reaction (ddPCR) or NGS. …”
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Peptide-based vaccine targeting IL17A attenuates experimental spondyloarthritis in HLA-B27 transgenic rats by Tetsuya Tomita, Hiromi Rakugi, Hiroki Hayashi, Ryuichi Morishita, Jiao Sun, Yuka Yanagida, Shota Yoshida, Satoshi Baba, Akiko Tenma, Masayoshi Toyoura, Sotaro Kawabata, Takako Ehara, Ryoko Asaki, Makoto Sakaguchi, Hideki Tomioka, Munehisa Shimamura, Hironori Nakagami

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Clinical Features of Ischemic Enteritis Diagnosed by Double-Balloon Endoscopy by Masanao Nakamura, Takeshi Yamamura, Keiko Maeda, Tsunaki Sawada, Yasuyuki Mizutani, Eri Ishikawa, Naomi Kakushima, Kazuhiro Furukawa, Takuya Ishikawa, Eizaburo Ohno, Takashi Honda, Hiroki Kawashima, Masatoshi Ishigami, Mitsuhiro Fujishiro

“…Ischemic enteritis (IE) is a relatively rare small bowel disease that is diagnosed via double-balloon endoscopy (DBE), although the lack of established diagnostic criteria can make it difficult to confirm the diagnosis. …”
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Surgical resection, radiotherapy and percutaneous thermal ablation for treatment of stage 1 non-small cell lung cancer: protocol for a systematic review and network meta-analysis by Arun Chockalingam, Menelaos Konstantinidis, Brandon Koo, John Timothy Moon, Andrew Tran, Sahar Nourouzpour, Emily Lawson, Kathleen Fox, Peiman Habibollahi, Bruno Odisio, Mohammed Loya, Ali Bassir, Nariman Nezami

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Predictive factors of fibrotic interstitial lung abnormality on high-resolution computed tomography scans: a prospective observational study by Kazuya Ichikado, Hidenori Ichiyasu, Kazuhiro Iyonaga, Kodai Kawamura, Yuko Yasuda, Keisuke Anan, Hiroko Okabayashi, Kimitaka Akaike, Noritaka Higashi, Takeshi Johkoh, Kiminori Fujimoto, Tetsuo Saito, Jun Morinaga, Minoru Yoshida, Katsuhiko Mitsuzaki, Takuro Sakagami

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Comparison of PD-L1 tumor cell expression with 22C3, 28-8, and SP142 IHC assays across multiple tumor types by Jeffrey S Ross, Richard S P Huang, Jake G Maule, Lani K Clinton, Ryon P Graf, Jinpeng Xiao, Geoffrey R Oxnard

“…Background Multiple PD-L1 immunohistochemistry (IHC) assays, including DAKO 22C3, DAKO 28-8, and Ventana SP142 PD-L1 IHC assays, have been approved by the Food and Drug Administration as a companion diagnostic (CDx) for various antiprogrammed death-1 and antiprogrammed death ligand 1 (PD-L1) based cancer immunotherapies. …”
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Effet de l'illumination proche infra-rouge intracérébrale chez des primates MPTP by Fannie Darlot, Cécile Moro, Napoléon Torres‑Martinez, Claude Chabrol, Florian Reinhart, Diane Agay, Thomas Costecalde, John Mitrofanis, Alim‑Louis Benabid

“…La maladie de Parkinson (MP) est une maladie neurodégénérative chronique affectant le système dopaminergique et se traduisant par une perte des neurones dopaminergiques (DA) de la substance noire compacta (SNc) et des faisceaux nigro-striés. Le diagnostic précoce de la MP est difficile car 70 % des neurones dopaminergiques de la substance noire sont détruits, avec une dysfonction mitochondriale, quand les premiers signes moteurs apparaissent. …”
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The “prostate-pelvic syndrome” theory used in patients with type-III prostatitis and its correlation with prostate volume by Xiao-Ma Zhang, Wei-Yi Li, Zong-Yao Hao, Lei Zhou, Cheng Yang, He-Xi Du, Chao-Zhao Liang

“…The patients were diagnosed retrospectively again by using PPS diagnostic criteria in this retrospective cohort study. …”
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Assessment tuberculin skin test specificity in water buffalo using five different antigens by Alessandra Martucciello, Francesco Napolitano, Piera Mazzone, Francesco Grandoni, Maria Beatrice Boniotti, Monica Cagiola, Gabriele Di Vuolo, Felice Gerardo Giglio, Francesco Grippa, Giorgio Galiero, Federica Signorelli, Esterina De Carlo

“… Tuberculosis (TB) control involves “test and cull strategies”. The primary diagnostic test is the tuberculin skin test (TST) which requires intradermal inoculation with specific My cobacterium bovis antigens, bovine tuberculin (PPDB) in the single intradermal reaction test (SIT) and avian tuberculin (PPDA) in the comparative intradermal reaction test (SICT). …”
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Impact of Cordyceps sinensis on coronary computed tomography angiography image quality and renal function in a beagle model of renal impairment by Peiji Song, Peiji Song, Kun Li, Xiaodie Xu, Guifeng Zhang, Zengkun Wang, Linbing Sun, Zekai Zhao, Ting Li, Ximing Wang, Zhangyong Xia, Zhangyong Xia, Zhangyong Xia, Zhangyong Xia

“…Laboratory renal function markers were measured multiple times before and after the intervention, and their correlation with fMRI parameters was analyzed.ResultsCCTA imaging revealed that the CT values of the major coronary artery branches in all groups met the international diagnostic criteria for coronary arteries. No statistically significant differences in image quality were observed among the four groups (P > 0.05). …”
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Characteristics of the monkeypox virus isolate obtained from the first patient in Russia and its sensitivity to 7-[N-(4-trifluoromethylbenzoyl)-hydrazinocarbonyl]-tricyclo-[3.2.2.0... by Alena S. Ovchinnikova, Dmitrii A. Odnoshevsky, Alexey S. Kabanov, Sergey A. Bodnev, Oleg V. Pyankov, Oksana P. Os'kina, Maria V. Sivay, Andrey V. Bespalov, Tatyana V. Tregubchak, Larisa N. Shishkina, Oleg S. Taranov, Vladimir V. Zolin, Artemiy A. Sergeev, Alexander P. Agafonov

“…The antiviral effectiveness of NIOCH-14 against the new MPXV strain was assessed using an adapted spectrophotometric method. Results. A diagnostic study of the biological samples of a patient who returned from a tourist trip to European countries with complaints of skin rashes all over the body revealed MPXV DNA. …”
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Increased Interleukin-11 Levels Are Correlated with Cardiac Events in Patients with Chronic Heart Failure by Jing Ye, Zhen Wang, Di Ye, Yuan Wang, Menglong Wang, Qingwei Ji, Ying Huang, Ling Liu, Ying Shi, Lei Shi, Tao Zeng, Yao Xu, Jianfang Liu, Huimin Jiang, Yingzhong Lin, Jun Wan

“…Higher plasma IL-11 levels significantly increase the presence of cardiac events and suggest a poor outcome; although the diagnostic value of IL-11 in CHF is not as good as BNP, there is a certain value in predicting cardiac events in CHF.…”
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PseudoCell: Hard Negative Mining as Pseudo Labeling for Deep Learning-Based Centroblast Cell Detection by Narongrid Seesawad, Piyalitt Ittichaiwong, Thapanun Sudhawiyangkul, Phattarapong Sawangjai, Peti Thuwajit, Paisarn Boonsakan, Supasan Sripodok, Kanyakorn Veerakanjana, Komgrid Charngkaew, Ananya Pongpaibul, Napat Angkathunyakul, Narit Hnoohom, Sumeth Yuenyong, Chanitra Thuwajit, Theerawit Wilaiprasitporn

“…Depending on the confidence threshold, <italic>PseudoCell</italic> can eliminate 58.18-99.35&#x0025; of irrelevant tissue areas on WSI, streamlining the diagnostic process. <italic>Conclusion:</italic> This study presents <italic>PseudoCell</italic> as a practical and efficient prescreening method for centroblast detection, eliminating the need for refined labels from pathologists. …”
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The Effect of Chewing Simulation on Flexural Strength of Different Lithium Disilicate Ceramics by Alsulimani O, Yousief SA, Al-Dabbagh RA, Attar EA, Bukhary DM, Algamaiah H, Musawa K, Subahi A, Abuzinadah SH, Alhaddad AJ, Alqahtani WMS, Emam ANM, Alqhtani MA, Elmarakby AM

“…Osamah Alsulimani,1 Salah A Yousief,2,3 Raghad A Al-Dabbagh,4 Esraa A Attar,4 Dalea M Bukhary,4 Hamad Algamaiah,5 Khadija Musawa,6 Awatif Subahi,6 Samar H Abuzinadah,7 Abdulrahman J Alhaddad,4 Waleed MS Alqahtani,8 Abdel Naser M Emam,9 Mohammad A Alqhtani,9 Ahmed M Elmarakby2,10 1Department of Oral Diagnostic Sciences, Faculty of Dentistry, King Abdulaziz University, Jeddah, Saudi Arabia; 2Department of Restorative and Prosthetic Dental Sciences, College of Dentistry, Dar Al Uloom University, Riyadh, 13313, Saudi Arabia; 3Department of Crown and Bridge, Faculty of Dental Medicine, Al-Azhar University, Assuit, Egypt; 4Department of Oral and Maxillofacial Prosthodontics, Faculty of Dentistry, King Abdulaziz University, Jeddah, Saudi Arabia; 5Department of Restorative Dental Science, King Saud University, College of Dentistry, Riyadh, Saudi Arabia; 6BDS, General Dentist, Faculty of Dentistry, King Abdulaziz University, Jeddah, Saudi Arabia; 7Department of Restorative Dentistry, Faculty of Dentistry, King Abdulaziz University, Jeddah, Saudi Arabia; 8Department of Prosthetic Dentistry, College of Dentistry, King Khalid University, Abha, Saudi Arabia; 9Department of Prosthetic Dental Science, Faculty of Dentistry, Najran University, Najran, Saudi Arabia; 10Department of Operative Dentistry, Faculty of Dental Medicine, Al-Azhar University, Assuit, EgyptCorrespondence: Salah A Yousief, Department of Restorative and Prosthetic Dental Sciences, College of Dentistry, Dar Al Uloom University, Riyadh, 13313, Saudi Arabia, Tel +966598045800, Email Salah.a@dau.edu.saBackground: Improved Lithium Disilicate Ceramic has been highly valued in dentistry for over two decades, owing to its durability and aesthetic qualities, making it a preferred choice for both anterior and posterior crowns.Objective: This study aimed to evaluate the flexural strength of two types of lithium disilicate blocks post-chewing simulation.Materials and Methods: Seventy-six lithium disilicate specimens were utilized in this study. …”
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Community benefits of mass distribution of three types of dual-active-ingredient long-lasting insecticidal nets against malaria prevalence in Tanzania: evidence from a 3-year clust... by Eliud Andrea Lukole, Jackie Cook, Jacklin F Mosha, Nancy S Matowo, Manisha A Kulkarni, Elizabeth Mallya, Tatu Aziz, Jacklin Martin, Mark Rowland, Immo Kleinschmidt, Alphaxard Manjurano, Franklin W Mosha, Natacha Protopopoff

“…Results A total of 22,479 children from 12,654 households were tested for malaria using rapid diagnostic tests in January 2020, 2021, & 2022 and July 2020 & 2021. …”
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Clinical Characteristics and Treatment Options of Peripheral Spondyloarthritis by ZENG Lulu, JI Xiaojian, HU Lidong, HU Jiawen, ZHANG Yinan, ZHANG Jiaxin, LIU Xingkang, YANG Shiwei, HUANG Feng

“…Compared to axSpA patients, pSpA patients had fewer male patients(62.5% vs. 79.7%, P < 0.001), later onset age(33.8 years vs. 22.0 years, P < 0.001), shorter diagnostic delays(6.0 months vs. 14.2 months, P=0.004), more associated peripheral arthritis(71.7% vs. 9.3%, P < 0.001) and dactylitis(6.5% vs. 0.3%, P < 0.001), more cases of psoriasis(52.7% vs. 1.1%, P < 0.001) and a more common family history of psoriasis(11.4% vs. 3.4%, P < 0.001). pSpA patients had higher levels of inflammatory markers but a lower positive rate of human leukocyte antigen(HLA)-B27(43.5% vs. 87.4%, P < 0.001). …”
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Investigating Elevated E-Selectin and P-Selectin Levels in Non-Arteritic Anterior Ischemic Optic Neuropathy (NAION) Patients: The Stepping Stone to a Future Clinical Approach by Syntia Nusanti, Andhika Rachman, Brigitta Marcia Budihardja, Lourisa Ruth Eldinia, Nadia Delima Andini, Arief Kartasasmita, M Sidik, Seskoati Prayitnaningsih, Alida Roswita Harahap, Aria Kekalih, Tjahjono Darminto Gondhowiardjo

“…Conclusion: This interesting finding opens up the potential for considering the involvement of E-selectin and P-selectin in the diagnostic strategy for NAION. It prompts consideration of whether assessing E-selectin and P-selectin levels should be recommended for all NAION patients. …”
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