Dysfunction in mitochondrial electron transport chain drives the pathogenesis of pulmonary arterial hypertension: insights from a multi-omics investigation by Xin Zhang, Jieling Li, Minyi Fu, Xijie Geng, Junjie Hu, Ke-Jing Tang, Pan Chen, Jianyong Zou, Xiaoman Liu, Bo Zeng

“…Conclusions Down-regulation of electron transport from cytochrome c to oxygen in mitochondrial ETC and disruption of the citric acid cycle homeostasis may contribute to PAH pathogenesis. 3-phenyllactic acid emerges as a potential novel diagnostic biomarker for PAH. These findings offer insights for developing novel PAH therapies and diagnostics.…”
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Association of Hematological and Biochemical Parameters with Serological Markers of Acute Dengue Infection during the 2022 Dengue Outbreak in Nepal by Bibek Raj Bhattarai, Abhishek Mishra, Suraj Aryal, Mandira Chhusyabaga, Rajshree Bhujel

“…The majority of hospitals and laboratories had limited resources for dengue confirmation and had to rely on rapid dengue diagnostic tests. The purpose of the study is to find the predictive hematological and biochemical parameters in each serological phase of dengue infection (NS1 and IgM) that may assist in dengue diagnosis, severity assessment, and patient management via the use of rapid serological tests. …”
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Development of a Machine‐Learning Model for Diagnosis of Pancreatic Cancer from Serum Samples Analyzed by Thermal Liquid Biopsy by Sonia Hermoso‐Durán, Nicolas Fraunhoffer, Judith Millastre‐Bocos, Oscar Sanchez‐Gracia, Pablo F. Garrido, Sonia Vega, Ángel Lanas, Juan Iovanna, Adrián Velázquez‐Campoy, Olga Abian

“…Pancreatic ductal adenocarcinoma (PDAC) poses a considerable diagnostic and therapeutic challenge due to the lack of specific biomarkers and late diagnosis. …”
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Soft wheat cultivars grown in the Saratov region and their resistance to Septoria blotch by Yu. V. Zeleneva, E. A. Konkova

“…The tested cultivars were characterized using the Xfcp623 molecular marker, diagnostic for Tsn1/ tsn1 genes, which controls sensitivity to the fungal toxin of PtrToxA. …”
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Combining a Risk Factor Score Designed From Electronic Health Records With a Digital Cytology Image Scoring System to Improve Bladder Cancer Detection: Proof-of-Concept Study by Sandie Cabon, Sarra Brihi, Riadh Fezzani, Morgane Pierre-Jean, Marc Cuggia, Guillaume Bouzillé

“…Strong risk factors (eg, smoking status, age, professional exposure) have been identified, and some diagnostic tools (eg, by way of cystoscopy) have been proposed. …”
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Correlation of clinically significant prostate cancer sites across multiparametric MRI, prostate biopsy, and whole-mount pathology for optimal prostate biopsy strategy by Matteo Pacini, Alessandro Zucchi, Riccardo Morganti, Filippo Dazzi, Antonio Luigi Pastore, Fabio Maria Valenzi, Andrea Fuschi, Yazan al Salhi, Gianluca Giannarini, Vincenzo Ficarra, Alchiede Simonato, Petar Antonov, Pinuccia Faviana, Riccardo Bartoletti

“…A paired Student’s t-test and Pearson correlation analysis were performed to evaluate the agreement between these diagnostic methods. A total of 106 patients were included in the TSB group and 95 in the TB group. …”
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Lymphoadenopathies caused by Bartonella henselae by V.S. Zhukovskiy, O.V. Prokopiv, I.R. Trutyak, M.V. Pankiv

“…The typical course of the disease in one of them at the beginning of the disease, was manifested by symptoms of general intoxication, fever, an increase of lymph nodes in the neck and axillary area, which coincided in time with the previously diagnosed bacterial angina. The diagnostic search ended with the set diagnosis and surgical operation three months after the onset of clinical manifes­tations of the disease. …”
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Development and cross-validation of predictive equations for fat-free mass estimation by bioelectrical impedance analysis in Brazilian subjects with overweight and obesity by Kalina Veruska Da Silva Bezerra Masset, Analiza M. Silva, Analiza M. Silva, Gerson Ferrari, Gerson Ferrari, Breno Guilherme De Araújo Tinoco Cabral, Paulo Moreira Silva Dantas, Roberto Fernandes Da Costa

“…IntroductionObesity is a public health problem worldwide, and body composition assessment is a very important diagnostic tool. Bioelectrical Impedance Analysis (BIA) is a fast, non-invasive, relatively low-cost, and user-friendly technique; however, to obtain greater validity of the estimates, the predictive equations used must be population specific. …”
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DIDADTIC TOOLS FOR THE STUDENTS’ ALGORITHMIC THINKING DEVELOPMENT by T. P. Pushkaryeva, T. A. Stepanova, V. V. Kalitina

“…The research used methods: analysis; modeling of cognitive processes; designing training tools that take into account the mentality and peculiarities of information perception; diagnostic efficiency of the didactic tools. Results. …”
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Detecting Atrial Fibrillation Using Smartwatches by Agnieszka Kulczycka-Rowicka, Julianna Podolec, Silvia Ciraolo, Joanna Wojda, Adam Sobiński, Zuzanna Kościuszko, Katarzyna Kurza, Matylda Czerwonka, Katarzyna Lesiczka-Fedoryj, Anna Walczak

“…Basic results: The findings indicate that the detection of atrial fibrillation (AF) using commercially available smartwatches demonstrates a very high level of diagnostic accuracy but still has room for improvement.   …”
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Factor Analysis Influencing Postoperative Hospital Stay and Medical Costs for Patients with Definite, Suspected, or Unmatched Diagnosis of Acute Cholecystitis according to the Toky... by Aoi Hayasaki, Koji Takahashi, Takehiro Fujii, Koji Kumamoto, Koji Fujii, Eiichi Matsumoto, Shigeki Miyahara, Tsukasa Kusuta, Yoshinori Azumi, Shuji Isaji

“…The 171 patients were classified according to the combination of diagnostic criteria including local signs of inflammation (A), systemic signs of inflammation (B), and imaging findings (C): A+ B+ C (definite diagnosis, n=84), A+ B (suspected diagnosis, n=25), (A or B) + C (n=10), A (n=41), and B (n=11). …”
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Idiopathic pulmonary fibrosis is a risk factor for cardiovascular disease: potential role of KL-6 and systemic inflammation by Mohamed F. AbdelGhany, Waleed GamalEldin Khaleel, Asmaa Omar Ahmed, Ahmad BaheyElden Ahmed, Lamees M. Bakkar

“…Diagnosis of IPF was based on diagnostic radiologic criteria addressed by ATS guidelines. …”
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Decoding MexB efflux pump genes: structural, molecular, and phylogenetic analysis of multidrug-resistant and extensively drug-resistant Pseudomonas aeruginosa by Muhammad Bilal Habib, Naseer Ali Shah, Afreenish Amir, Huda Ahmed Alghamdi, Muhammad Haseeb Tariq, Kiran Nisa, Mariam Ammoun

“…These highly conserved regions could be used for diagnostic purposes of efflux pump MexB genes.ConclusionTo avoid their spread in hospital settings, responsible authorities ought to begin rigorous initiatives in order to reduce the prevalence of multi-drug resistant, extensively drug resistant, and efflux pump carrying isolates in clinical settings.…”
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Prognostic significance of PD‐L2 expression in patients with oral squamous cell carcinoma—A comparison to the PD‐L1 expression profile by Manuel Weber, Falk Wehrhan, Christoph Baran, Abbas Agaimy, Maike Büttner‐Herold, Marco Kesting, Jutta Ries

“…Local PD‐L2 expression in tissue samples might be useful as a diagnostic parameter for malignancy and could contribute to the immunosuppressive local microenvironment in OSCC.…”
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Canine and Human Dirofilariosis in the Rostov Region (Southern Russia) by Vladimir Kartashev, Irina Batashova, Sergey Kartashov, Alexey Ermakov, Anna Mironova, Yulia Kuleshova, Boris Ilyasov, Irina Kolodiy, Alexander Klyuchnikov, Elena Ryabikina, Marina Babicheva, Yulia Levchenko, Raisa Pavlova, Nicola Pantchev, Rodrigo Morchón, Fernando Simón

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The Mycobacterium ulcerans toxin mycolactone causes destructive Sec61-dependent loss of the endothelial glycocalyx and vessel basement membrane to drive skin necrosis by Louise Tzung-Harn Hsieh, Belinda S Hall, Jane Newcombe, Tom A Mendum, Sonia Santana Varela, Yagnesh Umrania, Michael J Deery, Wei Q Shi, Josué Diaz-Delgado, Francisco J Salguero, Rachel E Simmonds

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Analyzing special needs reports for children: sociodemographic trends, diagnoses, and support areas over five years (2019–2024) by Semih Canpolat, Mehmet Emin Parlak, Esra Kurt Canpolat, Erdogan Oz

“…ObjectiveThis study aims to evaluate the special needs reports for children (SNRC) in terms of sociodemographic characteristics, diagnoses, and areas of special needs in the five years from 2019, when special health boards for children were established with the new diagnostic and evaluation criteria.MethodsThis descriptive study was conducted by retrospectively reviewing the board evaluation reports of children aged 0–18 years who applied to Batman Training and Research Hospital SNRC Health Board between March 2019 and March 2024. …”
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Systematic review on the compliance of WHO guidelines in the management of patients with advanced HIV disease in Africa: The case of cryptococcal antigen screening. by Zuhura Mbwana Ally, Jackline Vicent Mbishi, Mariam Salim Mbwana, Hafidha Mhando Bakari, Swalehe Mustafa Salim, Zarin Nudar Rodoshi, Muhidin Ibrahim Hundisa, Rebecca Mesfin Sileshi, Biruk Demisse Ayalew, Rahma Musoke, Lynn Moshi, Yousef Elias Fakhoury, Haji Mbwana Ally, Habib Omari Ramadhani

“…Among those who tested positive for CrAg, 84.6% (95% CI: 54.1-99.0) received preemptive antifungal treatment, though nearly 25% did not undergo lumbar puncture, highlighting gaps in diagnostic follow-up. Six studies evaluated CrAg positive patients with lumbar puncture and the overall prevalence of lumbar puncture was 74.9% (48.0-94.8). …”
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Exploring the associations of gut microbiota with inflammatory and the early hematoma expansion in intracerebral hemorrhage: from change to potential therapeutic objectives by Haixiao Jiang, Wei Zeng, Fei Zhu, Xiaoli Zhang, Demao Cao, Aijun Peng, Hongsheng Wang

“…Our comprehensive research revealed the potential of intestinal flora as a potent diagnostic tool, emphasizing its significance as a preventive target for HE.…”
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Clinical code usage in UK general practice: a cohort study exploring 18 conditions over 14 years by Christos Grigoroglou, Darren M Ashcroft, Evangelos Kontopantelis, David Reeves, Salwa S Zghebi, Rosa Parisi, Brian McMillan

“…Objective To assess the diagnostic Read code usage for 18 conditions by examining their frequency and diversity in UK primary care between 2000 and 2013.Design Population-based cohort studySetting 684 UK general practices contributing data to the Clinical Practice Research Datalink (CPRD) GOLD.Participants Patients with clinical codes for at least one of asthma, chronic obstructive pulmonary disease, diabetes, hypertension (HT), coronary heart disease, atrial fibrillation (AF), heart failure, stroke, hypothyroidism, chronic kidney disease, learning disability (LD), depression, dementia, epilepsy, severe mental illness (SMI), osteoarthritis, osteoporosis and cancer.Primary and secondary outcome measures For the frequency ranking of clinical codes, canonical correlation analysis was applied to correlations of clinical code usage of 1, 3 and 5 years. …”
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