Gut Microbiome Modulation in Hepatocellular Carcinoma: Preventive Role in NAFLD/NASH Progression and Potential Applications in Immunotherapy-Based Strategies by Elisa Monti, Clara Vianello, Ilaria Leoni, Giuseppe Galvani, Annalisa Lippolis, Federica D’Amico, Sara Roggiani, Claudio Stefanelli, Silvia Turroni, Francesca Fornari

“…., short-chain fatty acids and bile acids) occurring in HCC patients and influencing NAFLD progression, emphasizing their potential as early diagnostic biomarkers and prognostic tools. We discuss the weight loss effects of diet-based interventions and healthy lifestyles for the treatment of NAFLD patients, highlighting their impact on the restoration of the intestinal barrier and GM structure. …”
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The emerging role of blood-based biomarkers in early detection of colorectal cancer: A systematic review by Faris Shweikeh, Yuhao Zeng, Abdur Rahman Jabir, Erica Whittenberger, Saurav P. Kadatane, Yuting Huang, Mohamad Mouchli, Dani Ran Castillo

“…For instance, methylation patterns in genes such as MYO1-G and NDRG4 exhibited high diagnostic accuracies with AUCs reaching up to 0.996. …”
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Large Language Models in Dental Licensing Examinations: Systematic Review and Meta-Analysis by Mingxin Liu, Tsuyoshi Okuhara, Wenbo Huang, Atsushi Ogihara, Hikari Sophia Nagao, Hiroko Okada, Takahiro Kiuchi

“…The reliance on image-based diagnostics also presents challenges. As a result, their accuracy in dental exams is lower compared to medical licensing exams. …”
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Exploring the boundaries of anastomotic leak: experience in a high-volume center by Carolina Riscanevo Bobadilla, Gloria Flórez Dussan, Jorge Vargas, Liliana Suarez, German Jimenez, Carlos Gonzalez, Andrea Carolina Córdoba, Wilmar Martín, Diego Olivera, Raúl Guevara

“…The study described patient characteristics, diagnostic methods, and management at Clinica Universitaria Colombia from 2013 to 2023. …”
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A glimpse into the future: Integrating artificial intelligence for precision HER2‐positive breast cancer management by Xinpei Deng, Yixuan Yan, Zekai Zhan, Jindong Xie, Hailin Tang, Yutian Zou, Jian Tu, Peng Liu

“…This study aims to provide a comprehensive review of current diagnostic and predictive models that utilize data obtained from histopathological slides, radiomics, and HER2 binding sites. …”
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A case of Saturday night retinopathy following postoperative orbital compression bandaging: Diagnosis and evaluation using multimodal imaging by Rong Luan, Jinzhi Zhao, Zeying Liu, Limin Zhu, Lingyao Kong, Xiaorong Li, Tingting Lin

“…Multimodal imaging, including diagnostic imaging and angiography, revealed retinal and choroidal ischemia without optic nerve compression, confirming the diagnosis of SNR. …”
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Colorectal cancer detection with enhanced precision using a hybrid supervised and unsupervised learning approach by Akella S. Narasimha Raju, K. Venkatesh, Ranjith Kumar Gatla, Eswara Prasad Konakalla, Marwa M. Eid, Nataliia Titova, Sherif S. M. Ghoneim, Ramy N. R. Ghaly

“…This framework will incorporate both supervised classification and unsupervised clustering methods to present more understandable and accurate diagnostic results. The method entails several steps with CNN models: ADa-22 and AD-22, transformer networks, and an SVM classifier, all inbuilt. …”
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Optimization of In Vivo Studies by Combining Planar Dynamic and Tomographic Imaging: Workflow Evaluation on a Superparamagnetic Nanoparticles System by Maritina Rouchota, Alessio Adamiano, Michele Iafisco, Eirini Fragogeorgi, Irineos Pilatis, Gilles Doumont, Sébastien Boutry, Daniele Catalucci, Argyro Zacharioudaki, George C. Kagadis

“…Thus, such an imaging protocol combines the strengths of both dynamic planar and tomographic imaging, and by using iron-based NPs of high biocompatibility along with the appropriate administration route, a potential diagnostic or therapeutic effect could be attained.…”
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Can the 3rd Hour Value of 100 g Oral Glucose Tolerance Test Be Ignored in the Diagnosis of Gestational Diabetes Mellitus? by Mehmet Metin Altay, Serdinç Özdoğan, Aytaç Tohma, Sertaç Esin, Okyar Erol, Orhan Gelişen, Melih Akkuş, Sinan Karadeniz

“…OGTT, third hour values is of diagnostic value and cannot be ignored. …”
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Three-Dimensional Reconstruction of Oral Tongue Squamous Cell Carcinoma at Invasion Front by Tomoo Kudo, Yoshihito Shimazu, Hisao Yagishita, Toshiyuki Izumo, Yuuichi Soeno, Kaori Sato, Yuji Taya, Takaaki Aoba

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Aptamer-Conjugated Multi-Quantum Dot-Embedded Silica Nanoparticles for Lateral Flow Immunoassay by Kwanghee Yoo, Hye-Seong Cho, Jaehi Kim, Minsup Shin, Jun-Sik Chu, Sohyeon Jang, Han-Joo Bae, Heung Su Jung, Homan Kang, Bong-Hyun Jun

“…These results highlight the potential of QD² and aptamer conjugation technology as a reliable and versatile sensing platform for various diagnostic applications.…”
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Evaluation of pathology resources for cervical cancer detection between 2018 and 2022: a retrospective study at Moi Teaching and Referral Hospital, Western Kenya by Nelson Anangwe, Jon Steimgrimson, Susan Cu-Uvin

“…These findings emphasize the need for continued investment in pathology resources and personnel to enhance diagnostic capacity and address the rising incidence of cervical cancer in Kenya and similar low-resource settings. …”
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Partial weight bearing and long-term survival outcomes in extracapsular hip fractures treated with trochanteric Gamma3 nails by Carlos Hernández-Pascual, José Ángel Santos-Sánchez, Jorge Hernández-Rodríguez, Carlos Fernando Silva-Viamonte, Carmen Pablos-Hernández, Pablo Alonso-Rodríguez, José Antonio Mirón-Canelo

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Pain Measurement through Temperature Changes in Children Undergoing Dental Extractions by Eleazar S. Kolosovas-Machuca, Mario A. Martínez-Jiménez, José L. Ramírez-GarcíaLuna, Francisco J. González, Amaury J. Pozos-Guillen, Nadia P. Campos-Lara, Mauricio Pierdant-Perez

“…Infrared thermography has previously been used as a diagnostic tool for pain detection in animals; therefore, the aim of this study was to assess the presence of temperature changes during dental extractions and to evaluate its correlation with heart rate changes as markers of pain and discomfort. …”
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Comparison of mNGS with conventional methods for diagnosis of cryptococcal meningitis: a retrospective study by Zai-Jie Jiang, Jian-Chen Hong, Bi-Wei Lin, Wei-Qing Zhang, Qi-Chao Fan, Bi-Hui Yang, Xiang-Ping Yao

“…Our study demonstrates that both CrAg and mNGS offer excellent diagnostic accuracy for cryptococcal meningitis, and utilizing both tests can enhance clinical assessment and patient management.…”
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Mirizzi Syndrome: Diagnosis and Management of a Challenging Biliary Disease by Gennaro Clemente, Andrea Tringali, Agostino M. De Rose, Elena Panettieri, Marino Murazio, Gennaro Nuzzo, Felice Giuliante

“…The disease can mimic cancer of the gallbladder, causing considerable diagnostic difficulties. Furthermore, it increases the risk of intraoperative biliary injury during cholecystectomy. …”
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Single-cell sequencing reveals cell heterogeneity and aberrantly activated pathways associated with microvascular invasion in hepatocellular carcinoma by Jianwei Cui, Fanyi Zeng, Ming Tang, Ming Tang, Shiwu Yin, Shiwu Yin

“…The single-cell transcriptome and bioinformatics analyses provided insights into the mechanisms driving MVI, potentially aiding the development of targeted diagnostic and therapeutic strategies. Future research should further validate the role of MARCKSL1 in MVI progression and explore its potential clinical applications.…”
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TERT de novo mutation-associated dyskeratosis congenita and porto-sinusoidal vascular disease: a case report by Ge Yu, Guijie Xin, Xu Liu, Wanyu Li, Chen Shao, Runping Gao

“…“Porto-sinusoidal vascular disease” has been recently proposed, according to new diagnostic criteria, to replace the term “idiopathic non-cirrhotic portal hypertension.” …”
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Unusual Presentation of Recurrent Early Stage Endometrial Carcinoma 28 Years after Primary Surgery by Alessandro Franchello, Gianruggero Fronda, Giacomo Deiro, Alessia Fiore, Davide Cassine, Luca Molinaro, Luigi Chiusa, Sara Galati, Andrea Resegotti, Stefano Silvestri

“…It is important to keep in mind this possibility in order to set a correct diagnostic and therapeutic algorithm, including preoperative immunohistochemical staining, and to plan a prolonged follow-up program.…”
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Black Hole Supernovae, Their Equation of State Dependence, and Ejecta Composition by Oliver Eggenberger Andersen, Evan O’Connor, Haakon Andresen, André da Silva Schneider, Sean M. Couch

“…We investigate why the explosions survive despite the massive overburden and link the shape of the diagnostic energy curve and character of the ejecta evolution to the progenitor structure.…”
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