Chronic Constrictive Pericarditis by Hossein Doustkami, Afshin Hooshyar, Nasrollah Maleki, Zahra Tavosi, Iraj Feizi

“…Constrictive pericarditis (CP) is a rare clinical entity that can pose diagnostic problems. The diagnosis of CP requires a high degree of clinical suspicion. …”
Get full text

Viral Agents of Diarrhea in Young Children in Two Primary Health Centers in Edo State, Nigeria by Paul Erhunmwunse Imade, Nosakhare Odeh Eghafona

“…The most commonly associated clinical symptom of viral diarrhea in this study was vomiting. Viral diagnostic tests are advocated for primary health care facilities in this locality.…”
Get full text

Gubernaculum Sparing Laparoscopic Orchiopexy in Cryptorchidism with Ipsilateral Congenital Absence of the Vas Deferens: Unique Outcome by Ebtehal Althobaiti, Hattan Badr, Maryam Aloqalaa, Raghdah Alsharif, Naif Alqarni

“…Cryptorchidism with congenital ipsilateral absence of the vas deferens and renal agenesis is a rare diagnostic entity. Our case supports the suggested theory that the gubernacular vessels can increase the blood supply to the testis, although further studies are needed to confirm this hypothesis.…”
Get full text

Genotype-phenotype insights of pediatric dilated cardiomyopathy by Ying Dai, Yan Wang, Youfei Fan, Bo Han

“…Clarifying the genotype-phenotype relationship can improve diagnostic accuracy, enhance prognosis, and guide follow-up treatment for genotype-positive and phenotype-negative patients identified through genetic testing, providing new insights for precision medicine. …”
Get full text

Enhancing imputation accuracy for catch-all missing data mechanisms with DFBETAS and leverage by Fares Qeadan, William A. Barbeau

“…The study introduces the use of the regression diagnostic DFBETAS along with Leverage to improve the imputation of categorical data under such conditions. …”
Get full text

Identification of Novel Causal FBN1 Mutations in Pedigrees of Marfan Syndrome by Yueli Wang, Xiaoyan Li, Rongjuan Li, Ya Yang, Jie Du

“…These novel mutations provide important diagnostic and therapeutic insights for precision medicine in MFS, especially regarding the lethal cardiovascular events.…”
Get full text

The Efficiency of Operating Microscope Compared with Unaided Visual Examination, Conventional and Digital Intraoral Radiography for Proximal Caries Detection by Ilkay Peker, Meryem Toraman Alkurt, Oya Bala, Bulent Altunkaynak

“…One way variance of analysis (ANOVA) and Scheffe test were performed for comparison of observers, and the diagnostic accuracies of all systems were assessed from the area under the ROC curve (𝐴𝑧). …”
Get full text

Thanatophoric Dysplasia: A Report of 2 Cases with Antenatal Misdiagnosis by Lamidi Audu, Amina Gambo, Tokan Silas Baduku, Bilkisu Farouk, Anisa Yahaya, Kefas Jacob

“…We present 2 cases of TD seen at Barau Dikko Teaching Hospital (BDTH) between January and August 2021 to highlight the potential difficulty with antenatal diagnosis, its diagnostic features, and associated early postnatal fatality. …”
Get full text

Diagnosis of depression based on facial multimodal data by Nani Jin, Renjia Ye, Peng Li

“…Traditional scale-based depression diagnosis methods often have problems of strong subjectivity and high misdiagnosis rate, so it is particularly important to develop automatic diagnostic tools based on objective indicators.MethodsThis study proposes a deep learning method that fuses multimodal data to automatically diagnose depression using facial video and audio data. …”
Get full text

Challenges and considerations of genetic testing in von Willebrand disease by Omid Seidizadeh, Luciano Baronciani, Flora Peyvandi

“…Genetic testing of VWF has been around for 4 decades following the cloning of VWF, and nowadays, it has been integrated into the diagnostic panel of VWD. With the introduction of next-generation sequencing, genetic analysis of the VWF has become more practical than it was in the past, when Sanger sequencing was used. …”
Get full text

SLC1A4 Promotes Malignant Transformation of Hepatocellular Carcinoma by Activating the AKT Signaling by Jiaoyun Zheng, Jian Gong

“…The findings in this study suggested that SLC1A4 may be a diagnostic indicator for the early HCC and a therapeutic target for the advanced HCC.…”
Get full text

New frontiers in CRISPR: Addressing antimicrobial resistance with Cas9, Cas12, Cas13, and Cas14 by Ahmed S.A. Ali Agha, Ali Al-Samydai, Talal Aburjai

Get full text

Small Bowel Obstruction due to Intestinal Xanthomatosis by L. E. Barrera-Herrera, F. Arias, P. A. Rodríguez-Urrego, M. A. Palau-Lázaro

“…Radiologic images revealed jejunal loop thickening and inflammatory changes suggestive of foreign body obstruction, diagnostic laparoscopy found two strictures at the jejunum, and a pathologic examination confirmed a segmental small bowel xanthomatosis. …”
Get full text

The Diagnosis Is in the Smear: A Case and Review of Spur Cell Anemia in Cirrhosis by Gabriella A. Raffa, Diana M. Byrnes, John J. Byrnes

“…This case highlights the importance of recognition of spur cell anemia as a cause of anemia in cirrhosis as well as the importance of the peripheral smear in the diagnostic workup. Early recognition can lead to avoidance of unnecessary procedures. …”
Get full text

Nutrition and Reproductive Health: Sperm versus Erythrocyte Lipidomic Profile and ω-3 Intake by Gabriela Ruth Mendeluk, Mariano Isaac Cohen, Carla Ferreri, Chryssostomos Chatgilialoglu

“…This is the first report indicating that membrane lipids of different tissues do not equally metabolize the fatty acid elements upon supplementation. Molecular diagnostic tools are necessary to understand the cell metabolic turnover and monitor the success of nutraceuticals for personalized treatments.…”
Get full text

Preclinical research models for endometrial cancer: development and selection of animal models by Yang Xue, Wei Shi, Bing Lun, Meilin Kan, Mengling Jia, Yuelin Wu, Li Yang, Li Yang

“…Experimental animal models are crucial for studying the pathogenesis, advancing diagnostic methods, and developing new treatments. We review five main EC animal models. …”
Get full text

Clinical and Epidemiological Aspects of Ankylosing Spondylitis Patients in a Single Center in Baghdad by Ali Hussein Al Hafidh

“…Recommendation: more comprehensive assessment with advanced diagnostic and treatment standards. …”
Get full text

Interdisciplinary Management of Cystic Neoplasms of the Pancreas by Linda S. Lee, Thomas Clancy, Vivek Kadiyala, Shadeah Suleiman, Darwin L. Conwell

“…Though reliable biomarkers are lacking, a wide spectrum of diagnostic modalities are available to evaluate pancreatic cystic neoplasms, including radiologic, endoscopic, laboratory, and pathologic analysis. …”
Get full text

Epithelial-Myoepithelial Carcinoma of the Breast with Rhabdoid Features by Karl Grenier, Gulbeyaz Altinel, Zari Dastani, Atilla Omeroglu

“…Myoepithelial cells are known to adopt varied morphologies, including spindle, chondroid, clear cell, and rhabdoid morphologies, and can represent a diagnostic challenge when isolated on biopsy. Rhabdomyosarcoma, phyllodes tumor, metaplastic carcinoma, and myoepithelial carcinoma are primary breast tumors that all have been shown to exhibit rhabdoid features, whether representing true differentiation or morphological mimic. …”
Get full text

Case report: Periorbital pilomatricoma: a rare benign skin tumor misdiagnosed as cellulitis by Rahul Kumar, Jane Z. Spadaro, Jane Z. Spadaro, Alon Kahana, Alon Kahana, Alon Kahana

“…Complete surgical excision is therapeutic and allows for diagnostic confirmation. Histopathology is required to rule out pilomatrix carcinoma, a malignant variant.…”
Get full text