Preoperative liquid biopsy transcriptomic panel for risk assessment of lymph node metastasis in T1 gastric cancer by Ping’an Ding, Jiaxiang Wu, Haotian Wu, Wenqian Ma, Tongkun Li, Peigang Yang, Honghai Guo, Yuan Tian, Jiaxuan Yang, Limian Er, Renjun Gu, Lilong Zhang, Ning Meng, Xiaolong Li, Zhenjiang Guo, Lingjiao Meng, Qun Zhao

Get full text

Factors influencing the kinetics of MSU crystal depletion measured with dual-energy CT in patients with gout by Tristan Pascart, Victor Laurent, Charlotte Jauffret, Aurore Pacaud, Vincent Ducoulombier, Julie Legrand, Stéphane Verdun, Laurène Norberciak, Jean-François Budzik

“…Objective To examine factors influencing the kinetics of monosodium urate (MSU) crystal dissolution measured with dual-energy computed tomography (DECT) during follow-up of patients with gout.Methods Patients with a diagnosis of gout with baseline knees and feet DECT scans exhibiting MSU crystal volumes ≥0.1 cm3 and at least one follow-up DECT were included. …”
Get full text

Computerised cognitive training tools and online nutritional group counselling for people with mild cognitive impairment: study protocol of a completely digital, randomised, contro... by Stephanie Book, Elmar Graessel, Julia Schneider, Michael Jeitler, Petra Scheerbaum, Michael Jank, Etienne Hanslian, Melanie DellO’ro, Julia-Sophia Scheuermann, Sophia Bösl, Christian Kessler

“…The aim of this study is to investigate the effects of the two interventions on cognition in people with MCI in a 2×2 randomised controlled trial with German participants.Methods and analysis Participants will be community-dwelling individuals with a psychometric diagnosis of MCI based on the Montreal Cognitive Assessment (MoCA) and Mini-Mental State Examination. …”
Get full text

Industry of employment and occupational class in relation to cardiovascular health by race/ethnicity, sex/gender, age and income among adults in the USA: a cross-sectional study by Symielle A Gaston, Chandra L Jackson, Jamie A Murkey, Dana M Alhasan, W Braxton Jackson

“…Yet, few studies have included racially/ethnically diverse samples.Methods Using 2004–2018 National Health Interview Survey cross-sectional data, we investigated standardised occupational classifications in relation to ‘ideal’ CVH using a modified ‘ideal’ CVH (mICVH) metric among US adults (n=230 196) by race/ethnicity, sex/gender, age, and income. mICVH was defined as a report of ‘yes’ to the following: never smoked/former smoker; body mass index (≥18.5–25 kg/m2); physical activity (≥150–300 min/week moderate or ≥75–150 min/week vigorous); sleep duration (7–9 hours/night); and no prior diagnosis of dyslipidaemia, hypertension, or diabetes/pre-diabetes. …”
Get full text

Medium term health and quality of life outcomes in a cohort of children with MIS-C in Cape Town, South Africa by Frank Phoya, Claire Butters, Timothy F. Spracklen, Timothy F. Spracklen, Hanna L. Kassa, Hamza van der Ross, Chris Scott, Kate Webb, Kate Webb

“…This score was used to evaluate the School Functioning, Social, Emotional, and Physical QOL domains.ResultsAll participants with previous MIS-C made a full recovery, with no medical complaints, and normal physical examinations after a median of 705 days post acute diagnosis. The PedsQL inventory revealed that 16.7% of the children with previous MIS-C showed a deficit in the physical domain compared to 60% of the children with JIA (p < 0.001). 12.5% of the children with previous MIS-C had a deficit in their psychosocial domain which included emotional, social, and educational scores, compared to 40% of the children with JIA (p = 0.035).ConclusionsIn a cohort of 24 South African children with previous MIS-C, no medical complications were reported. …”
Get full text

A rare splice site mutation in the gene encoding glucokinase/hexokinase 4 in a patient with MODY type 2 by D. E. Ivanoshchuk, E. V. Shakhtshneider, A. K. Ovsyannikova, S. V. Mikhailova, O. D. Rymar, V. I. Oblaukhova, A. A. Yurchenko, M. I. Voevoda

“…When nonclassical diabetes mellitus is being diagnosed in young people and pregnant women, genetic testing is needed to verify the diagnosis and to select the optimal treatment method.…”
Get full text

Targeted Transition Readiness Workshops for Pediatric Brain Tumor Survivors: Feasibility, Acceptability, and Preliminary Effects by Julie Carrier, Tziona Lugasi, Nathalie Labonté, Carole Provost, Andrea Saragosti, Claire Longpré, Bénédicte Koukoui, Émilie Régnier-Trudeau, Serge Sultan, Hallie Coltin, Sébastien Perreault, Marco Bonanno, Leandra Desjardins

“…Pediatric brain tumor survivors (PBTS) are at risk for late effects related to their diagnosis and treatment. Long-term medical follow-ups are deemed essential, implying a transition from pediatric to adult healthcare settings. …”
Get full text

Antibiotic Resistance and Molecular Epidemiological Characteristics of Streptococcus agalactiae Isolated from Pregnant Women in Guangzhou, South China by Zhaomin Cheng, Pinghua Qu, Peifeng Ke, Xiaohan Yang, Qiang Zhou, Kai Lan, Min He, Nannan Cao, Sheng Qin, Xianzhang Huang

Get full text

A predictive risk‐scoring model for survival prognosis of multiple myeloma based on gain/amplification of 1q21: Experience in a tertiary hospital in South‐Western China by Yanqiu Xiong, Shanshan Liang, Wenjiao Tang, Li Zhang, Yuhuan Zheng, Ling Pan, Ting Niu

“…Results Upon initial diagnosis, 159 patients (43.32%) exhibited +1q21, with 94 (59.11%) having three copies, referred to as Gain(1q21), and 65 (40.89%) possessing four or more copies, referred to as Amp (1q21). …”
Get full text

Evaluation and Management of Patients with Hematoma After Gynecologic and Obstetric Surgery by Bekir Kahveci, Mehmet Obut, Serhat Ege, Mete Sucu, Nurullah Peker, Osman Uzundere, Gaye Kahveci, Mehmet Sukru Budak

“…We included the patients who hospitalized with the diagnosis of a postoperative hematoma between June 2017 and April 2019 at Gazi Yasargil Training and Research Hospital of Health Sciences University. …”
Get full text

Implications of hormonal carcinogenesis for transgender and gender-diverse people undergoing gender-affirming hormone therapy: an up-to-date review by Matteo Lambertini, Filippo Pietrantonio, Dario Trapani, Francesco Perrone, Rossana Berardi, Saverio Cinieri, Chiara Cassani, Amelia Barcellini, Filippo Ghelardi, Alberto Giovanni Leone, Stefania Bonadonna, Marianna Sirico, Barbara Tagliaferri, Stefano Maccarone, Davide Dalu, Lorenzo Ruggieri, Simone Nardin, Nicla La Verde

“…Consequently, these factors contribute to poorer clinical outcomes in terms of cancer diagnosis and mortality. A focal point of interest is the potential carcinogenic effect of gender-affirming hormone therapy (GAHT). …”
Get full text

Clinical outcomes of early remdesivir administration in hospitalized patients at high risk for severe COVID-19 during the Omicron wave by Yeon Ju La, Won Sup Oh, Changhyup Kim, Myoung-nam Lim, Yong Duk Jeon

“…We included patients aged ≥ 18 years who had symptom onset within 7 days and had at least one risk factor for disease progression at the time of diagnosis. We compared the clinical outcomes between the early remdesivir administration group and the group not administered early remdesivir. …”
Get full text

Genomic epidemiology and phenotypic characterization of Staphylococcus aureus isolated from atopic dermatitis patients in South China by Chao Yang, Xiaowei Chen, Min Li, Wenchang Yuan, Shunguang Li, Dexing Han, Junhui Feng, Haimin Luo, Minling Zheng, Jiaqi Liang, Cha Chen, Pinghua Qu, Song Li

Get full text

Occupational outcomes of people with multiple sclerosis: a scoping review by Guglielmo Dini, Alfredo Montecucco, Nicoletta Debarbieri, Paolo Durando, Giuliana Buresti, Benedetta Persechino, Matilde Inglese, Bruno Kusznir Vitturi, Alborz Rahmani, Elvira Sbragia, Paolo Bandiera, Michela Ponzio, Mario Alberto Battaglia, Tommaso Manacorda

“…The results were categorised into seven subtopics: ‘Changes in work and occupational status due to MS’, ‘work-related socio-economic consequences of MS’, ‘risk factors for unfavourable occupational outcomes’, ‘reported barriers to employment’, ‘reported job accommodations and vocational rehabilitation strategies’, ‘job satisfaction, stigma, and disclosing the diagnosis in the workplace’ and ‘rating clinical scales’.Conclusions There are several issues that deserve further in-depth study by the scientific community in order to improve the occupational outcomes of people with MS.…”
Get full text

tiRNA-Gln-CTG is Involved in the Regulation of Trophoblast Cell Function in Pre-eclampsia and Serves as a Potent Biomarker by Yixiao Wang, Xiaohong Ji, Hengmei Shi, Sicong Liu, Hong Yu

“…Transfer ribonucleic acid (tRNA)-derived small RNAs (tsRNAs) are important in the progression and diagnosis of various diseases. However, their role in the development of PE is unclear. …”
Get full text

Prevalence and risk factors of postpartum depression, general depressive symptoms, anxiety and stress (PODSAS) among mothers during their 4-week postnatal follow-up in five public... by Boon How Chew, Subashini Ambigapathy, Saidatul Akmar Mohammad Redzuan, Priyasini Suntharalingam, Thenmoli Palaniyappan, Venotha Ganasan, Puteri Normalina Megat Abu Bakar, Paream Kaur, Lili Zuryani Marmuji, V Paranthaman

“…Non-Malaysians and mothers with known diagnosis of psychotic disorders will be excluded from the study. …”
Get full text

Cryptococcal Meningitis: A Retrospective Cohort of a Brazilian Reference Hospital in the Post-HAART Era of Universal Access by Aline Z. de Azambuja, Gustavo Wissmann Neto, Guilherme Watte, Luciana Antoniolli, Luciano Z. Goldani

“…Detailed data on risk factors, clinical manifestations, diagnosis methods, treatment, and prognosis of patients with meningeal cryptococcosis were evaluated from January 2009 to December 2016. …”
Get full text

Sepsis in Internal Medicine: blood culture-based subtypes, hospital outcomes, and predictive biomarkers by Gaetano Zizzo, Gabriele Guazzardi, Daniela Bompane, Francesco Di Terlizzi, Giorgio Rotola, Ilario Stefani, Michela Medugno, Mario Bucalo, Antonino Mazzone

“…BackgroundSepsis is a challenging condition increasingly managed in medical wards, however literature and clinical evidence in this hospital setting are lacking.MethodsUsing the computational i2b2 framework, we retrospectively analyzed data from patients admitted to internal medicine units of four hospitals in Lombardy (Italy) between January 2012 and December 2023, with a discharge diagnosis of sepsis, septic shock, or septicemia.ResultsA total of 4,375 patients were recruited. …”
Get full text

A novel nomogram to predict all‐cause readmission or death risk in Chinese elderly patients with heart failure by Mengxi Yang, Liyuan Tao, Hui An, Gang Liu, Qiang Tu, Hu Zhang, Li Qin, Zhu Xiao, Yu Wang, Jiaxai Fan, Dongping Feng, Yan Liang, Jingyi Ren

“…The C‐index of the 30 day and 1 year diagnosis prediction model was 0.778 [95% confidence interval (CI) 0.693–0.862] and 0.738 (95% CI 0.640–0.836), respectively. …”
Get full text

Correlation Between the Ratio of Uric Acid to High-Density Lipoprotein Cholesterol (UHR) and Diabetic Retinopathy in Patients with Type 2 Diabetes Mellitus:A Cross-Sectional Study by Wang L, Liu L, Luo H, Wu Y, Zhu L

“…Leran Wang,1 Lei Liu,2 Huilan Luo,3– 5 Yiling Wu,3– 5 Lingyan Zhu3– 5 1Queen Mary School, Jiangxi Medical College, Nanchang University, Nanchang City, People’s Republic of China; 2Department of Endocrinology, Lu’an Hospital of Anhui Medical University, Lu’an City, Anhui Province, People’s Republic of China; 3Department of Endocrinology and Metabolism, the First Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang City, People’s Republic of China; 4Jiangxi Clinical Research Center for Endocrine and Metabolic Disease, the First Affiliated Hospital of Nanchang University, Nanchang City, People’s Republic of China; 5Jiangxi Branch of National Clinical Research Center for Metabolic Disease, Nanchang City, People’s Republic of ChinaCorrespondence: Lingyan Zhu, Jiangxi Branch of National Clinical Research Center for Metabolic Disease, No. 17, Yongwaizheng Street, Nanchang City, Jiangxi Province, People’s Republic of China, Tel +86-13870690788, Email zly982387@126.comBackground/Objective: Considering the uncertain relationship between high-density lipoprotein cholesterol (HDL-C) and uric acid (UA) with diabetic retinopathy (DR),this study investigates the link between Uric Acid to High-Density Lipoprotein Cholesterol (UHR) and DR in T2DM patients, evaluating its potential for DR diagnosis and early prediction.Study Design and Data Collection: This retrospective study analyzed 1450 type 2 diabetes patients, divided into NDR and DR groups by retinal exams. …”
Get full text