Alpha-1 Antitrypsin as a Regulatory Protease Inhibitor Modulating Inflammation and Shaping the Tumor Microenvironment in Cancer by Siyu Xiang, Liu Yang, Yun He, Feng Ding, Shuangying Qiao, Zonghua Su, Zheng Chen, Aiping Lu, Fangfei Li

“…Therefore, in this review, we have elucidated the pivotal roles of AAT in inflammation and the tumor microenvironment, including the structure and molecular properties of AAT, its molecular functions in the regulation of the inflammatory response and tumor microenvironment, and its clinical implications in cancer including its diagnosis, prognosis, and therapeutic intervention. …”
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Fixed timed artificial insemination in buffalo heifers with fresh and frozen-thawed semen in Argentina by José Luis Konrad, Alexis Bandeo, Natalia Vallejos, Pablo Ponce, Jesús Alfredo Berdugo, Pablo Maldonado-Vargas

“…Fresh semen (30±6.5x10 6 spermatozoa) and frozen semen (40±4.4x10 6 spermatozoa) from two breeders were used. 35 days after insemination, pregnancy diagnosis was performed by ultrasonography. The data obtained were recorded in Excel spread-sheets. …”
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Il "corpo paziente", da oggetto a soggetto della cura: embodiment e caring touch by Anna Restaino, Loredana Cavagnero, Paola Mosca, Mariangela Mazzone, Gabriella Mincione

“…La North American Nursing Diagnosis Association raccomanda, fra gli interventi infermieristici per le diagnosi infermieristiche “Campo energetico sbilanciato” e “Rischio di solitudine”, il caring touch. …”
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Impact of chemoradiotherapy for first primary lung cancer on the prognosis and re-chemoradiotherapy sensitivity of second primary lung cancer by Zhe Chen, Gaoming Wang, Nan Wang, Jiangjiang Liu, Yu Yao, Haitao Ma, Haitao Ma, Jing Luo, Kai Xie

“…Among these, 5,302 FPLC patients developed SPLC within 5 years of their initial diagnosis. We employed the Fine-Gray competitive risk model, Cox proportional hazards model, and restricted mean survival time analysis to assess the effects of FPLC radiotherapy and chemotherapy on SPLC risk and survival differences.ResultsThe competitive risk model indicated that FPLC radiotherapy and chemotherapy did not significantly change the risk of developing SPLC. …”
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Predictors of treatment outcome in higher levels of care among a large sample of adolescents with heterogeneous eating disorders by Erin E. Reilly, Sasha Gorrell, Alan Duffy, Dan V. Blalock, Philip Mehler, Harry Brandt, Susan McClanahan, Kianna Zucker, Naomi Lynch, Simar Singh, Catherine R. Drury, Daniel Le Grange, Renee D. Rienecke

“…Psychiatric comorbidity, primary diagnosis, age, and eating disorder symptoms at admission consistently predicted treatment-related change, although patterns in findings varied across symptoms. …”
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Characterising melanoma diagnostic pathways for patients in routine practice using administrative health data in Ontario, Canada: a population-based study by Frances C Wright, Timothy P Hanna, Patti A Groome, Nicole J Look Hong, Meaghan E Mavor, Yuka Asai, Hugh Langley

“…Indicator variables characterised the patient’s keratinocyte carcinoma and dermatologist history, presentation pattern, procedure types, number of visits and procedures, and the activity on the diagnosis date. χ2 tests and Pearson residuals were used. …”
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Assessing caregiver stress and resource needs in pediatric cancer care by Shaimaa Mohamed Amin, Mahmoud Abdelwahab Khedr, Azza Medhat Aziz Mansy, Ahmed Hashem El-Monshed, Mohamed Gamal Noaman Malek, Ayman Mohamed El-Ashry

“…The number of children, child’s age, and duration since cancer diagnosis also significantly impacted stress levels (p < 0.001). …”
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Deep learning radiomics nomogram for preoperatively identifying moderate-to-severe chronic cholangitis in children with pancreaticobiliary maljunction: a multicenter study by Hui-min Mao, Kai-ge Chen, Bin Zhu, Wan-liang Guo, San-li Shi

“…Consequently, preoperative diagnosis of moderate-to-severe chronic cholangitis is essential for guiding treatment strategies and surgical planning. …”
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Oral Plaque from Type 2 Diabetic Patients Reduces the Clonogenic Capacity of Dental Pulp-Derived Mesenchymal Stem Cells by Antonella Bordin, Francesca Pagano, Eleonora Scaccia, Matteo Saccucci, Iole Vozza, Noemi Incerti, Antonella Polimeni, Elena Cavarretta, Isotta Chimenti, Elena De Falco

“…The multivariate analysis confirmed that the decreased clonogenesis was significantly correlated only with T2D diagnosis. Moreover, the effect of T2D oral plaque was specific to DPSCs. …”
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Role of Aging in Ulcerative Colitis Pathogenesis: A Focus on ETS1 as a Promising Biomarker by Ni M, Peng W, Wang X, Li J

“…In this study, we explored the role of aging-related genes (ARGs) in UC pathogenesis and diagnosis prediction.Methods: Gene expression data were obtained from four independent datasets (GSE75214, GSE87466, GSE94648, and GSE169568) in the GEO database, and ARGs were derived from multiple public databases. …”
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Primary Neuroendocrine Carcinoma of Ocular Adnexa by Daisuke Yamanouchi, Toshiyuki Oshitari, Yosuke Nakamura, Jiro Yotsukura, Kaoru Asanagi, Takayuki Baba, Tomohiro Nizawa, Takashi Kishimoto, Yoko Yonemori, Satoshi Ota, Shuichi Yamamoto

“…A complete surgical excision of the margins of the tumor was performed with histopathological confirmation of negative margins. The final diagnosis was a primary MCC of the right upper eyelid. …”
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Causal associations of Helicobacter pylori infection and metabolic syndrome: insights from a two-sample Mendelian randomization study by Hongwei Wang, Fangying Tian, Caizheng Yang, Xinyu Cui, Yongxia Ding, Ming Zhao, Xueyu Wang, Shanshan Ge

“…Conclusions Our study suggests that there is a causal effect between Hp infection and Mets diagnosis and its composition, and further studies are needed to understand the mechanism of its influence.…”
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Bladder-sparing therapy in a case report of huge muscle-invasive bladder IMT treated with 1470 nm diode laser en bloc resection followed by laparoscopic partial cystectomy by Junhao Chu, Huisheng Yuan, Zhihui Zhang, Jiajun Kan, Shishuai Duan, Zilong Wang, Zilong Wang, Zilong Wang, Muwen Wang

“…Pathological examination following 1470 nm laser resection confirmed the diagnosis of an IMT with malignant potential, showing anaplastic lymphoma kinase (ALK) positivity, a Ki-67 index of 20% in hotspot regions, and ALK gene rearrangement detected by fluorescence in situ hybridization (FISH). …”
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Does gender influence outcome measures similarly in patients with spondyloarthritis? Results from the ASAS-perSpA study by Sofia Ramiro, Maxime Dougados, Anna Molto, Clementina López-Medina, Victoria Navarro-Compán, Diego Benavent, Dafne Capelusnik

“…Objectives To investigate the influence of gender on disease outcomes in patients with spondyloarthritis (SpA), including across SpA subtypes.Methods Data from 4185 patients of 23 countries with a diagnosis of axial SpA (axSpA), peripheral SpA (pSpA) or psoriatic arthritis (PsA) from the Assessment of SpondyloArthritis International Society (ASAS)-perSpA study were analysed. …”
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Evaluation of two electronic-rehabilitation programmes for persistent knee pain: protocol for a randomised feasibility trial by Philip G Conaghan, Kim L Bennell, Mark Conner, Rana S Hinman, Sarah R Kingsbury, Elizabeth M A Hensor, Gretl A McHugh, Christine Comer, Dawn Groves-Williams, Rachel K Nelligan

“…The trial aims to recruit 90 participants (45 years or older) with a history of persistent knee pain consistent with a clinical diagnosis of knee osteoarthritis. Participants will be randomly assigned in a 1:1:1 allocation ratio. …”
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Isolation and Characterization of Coronavirus and Rotavirus Associated with Calves in Central Part of Oromia, Ethiopia by Umer Seid, Fufa Dawo, Asamino Tesfaye, Munera Ahmednur

“…The four study areas were purposively selected and faecal samples were collected by simple random sampling for diagnosis of coronavirus and rotavirus infection by using the antigen detection enzyme-linked immunosorbent assay (Ag-ELISA) kit. …”
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Noncoding RNAs in sepsis-associated acute liver injury: Roles, mechanisms, and therapeutic applications by Jialian Wang, Xingyu Tao, Zhengyang Liu, Yuan Yan, Peifeng Cheng, Bin Liu, Huimin Du, Bailin Niu

“…By integrating advancements in high-throughput sequencing technologies, this review provides novel insights into the dual potential of ncRNAs as diagnostic biomarkers and therapeutic targets, offers new ideas for SA-ALI diagnosis and treatment research and highlights potential challenges in clinical translation.…”
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Evaluation of indirect indices in the insulin resistance assessment in patients with different body mass index by Lejla Čano Dedić, Arzija Pašalić, Emsel Papić, Emir Begagić, Sabina Šečić Selimović, Mario Gazibarić, Sabina Šegalo

“…The studied group consisted of 91 subjects with a suspected diagnosis of IR who were further categorized according to BMI, while control group consisted from 38 age- and gender-matched subjects. …”
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Factors associated with risk analysis for asymptomatic left ventricular diastolic dysfunction in nondialysis patients with chronic kidney disease by Yajuan Gao, Shengnan Chen, Jiani Fu, Cui Wang, Yali Tang, Yongbai Luo, Xiaozhen Zhuo, Xueying Chen, Yan Shen

“…Therefore, dynamic monitoring of these factors associated with risk, timely diagnosis and treatment of ALVDD can delay the progression to symptomatic HF, which is of great importance for reducing CVD mortality, and improving the prognosis and quality of life in CKD patients.…”
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Inequalities in physical comorbidity: a longitudinal comparative cohort study of people with severe mental illness in the UK by Tim Doran, Darren M Ashcroft, Evangelos Kontopantelis, David Reeves, Siobhan Reilly, Claire Planner, Ivan Olier, Linda Gask

“…We calculated the prevalence of SMI by UK country, English region and deprivation quintile, antipsychotic and antidepressant medication prescription rates for people with SMI, and prevalence rates of common comorbidities in people with SMI compared with people without SMI.Design Retrospective cohort study from 2000 to 2012.Setting 627 general practices contributing to the Clinical Practice Research Datalink, a UK primary care database.Participants Each identified case (346 551) was matched for age, sex and general practice with 5 randomly selected control cases (1 732 755) with no diagnosis of SMI in each yearly time point.Outcome measures Prevalence rates were calculated for 16 conditions.Results SMI rates were highest in Scotland and in more deprived areas. …”
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