Hepatitis B care cascade among people with HIV/HBV coinfection in the North American AIDS Cohort Collaboration on Research and Design, 2012-2016. by Jessica Kim, Craig W Newcomb, Dean Carbonari, Jessie Torgersen, Keri N Althoff, Mari M Kitahata, Marina B Klein, Richard D Moore, K Rajender Reddy, Michael J Silverberg, Angel M Mayor, Michael A Horberg, Edward R Cachay, Joseph K Lim, M John Gill, Kara Chew, Timothy R Sterling, Mark Hull, Eric C Seaberg, Gregory D Kirk, Sally B Coburn, Raynell Lang, Kathleen A McGinnis, Kelly A Gebo, Sonia Napravnik, H Nina Kim, Vincent Lo Re, North American AIDS Cohort Collaboration on Research and Design of IeDEA

“…A care cascade is a critical tool for evaluating delivery of care for chronic infections across sequential stages, starting with diagnosis and ending with viral suppression. However, there have been few data describing the hepatitis B virus (HBV) care cascade among people living with HIV infection who have HBV coinfection. …”
Get full text

A novel de novo GABRA2 gene missense variant causing developmental epileptic encephalopathy in a Chinese patient by Li Yang, Xingyu Wan, Ran Hua, Junhong Jiang, Baotian Wang, Rui Tao, De Wu

“…This study presents the clinical presentation and genetic analysis of a Chinese family with a child diagnosed with DEE78, due to a novel GABRA2 variant. Methods Genetic diagnosis was performed using trio‐whole exome sequencing, followed by bioinformatics predictions of pathogenicity. …”
Get full text

Acute portal vein thrombosis in an isolated, blunt, minor liver injury near the porta hepatis by Onchuda Wongweerakit, Osaree Akaraborworn, Burapat Sangthong, Komet Thongkhao

“…If the thrombosis is left untreated, serious morbidity and mortality can ensue. However, its diagnosis in asymptomatic patients is still challenging. …”
Get full text

Magnetic resonance imaging does not distinguish Kallmann syndrome from normosmic isolated hypogonadotropic hypogonadism by Małgorzata Kałużna, Katarzyna Katulska, Katarzyna Ziemnicka, Pola Kompf, Bartłomiej Budny, Paweł Komarnicki, Michał Rabijewski, Jerzy Moczko, Jarosław Kałużny, Marek Ruchała

“…Results were compared with age- and sex-matched healthy controls. Genetic diagnosis was conducted in all IHH patients based on next-generation sequencing. …”
Get full text

Bioinformatic identification of important roles of COL1A1 and TNFRSF12A in cartilage injury and osteoporosis by Muzi Liu, Shiguo Gong, Xin Sheng, Zihong Zhang, Xichun Wang

“…Objective The aim of this study was to identify the key regulatory mechanisms of cartilage injury and osteoporosis through bioinformatics methods, and to provide a new theoretical basis and molecular targets for the diagnosis and treatment of the disease.Methods Microarray data for cartilage injury (GSE129147) and osteoporosis (GSE230665) were first downloaded from the GEO database. …”
Get full text

Effect of folic acid supplementation on diminished ovarian reserve: study protocol of a single-centre, open-label, randomised, placebo-controlled clinical trial by Yan Wang, Ling Zheng, Kaijun Liao, Dongli Lu, Jiaxin Wu, Binjin Wu, Zhaochun Wu, Zhenghua Jiang

“…Introduction The prevalence of diminished ovarian reserve (DOR), a common gynaecological disorder, is approximately 10% across the world. Failure in early diagnosis and treatment may result in continuous decreases in ovarian function and the resultant loss in an opportunity of pregnancy, which greatly affects the happiness of the women’s family and women’s physical and mental health. …”
Get full text

Characterization of diabetic kidney disease in 235 patients: clinical and pathological insights with or without concurrent non-diabetic kidney disease by Mengjie Jiang, Hongyu Chen, Jing Luo, Jinhan Chen, Li Gao, Qin Zhu

“…These patients underwent renal biopsy and received a pathology-based diagnosis of DKD. They were categorized into the DKD alone group (93 cases) and the DKD + NDKD group (142 cases). …”
Get full text

Evaluation of the immunological functions of placental alkaline phosphatase in vivo using ALPP transgenic mice by Tse-Ching Chen, Kwai-Fong Ng, Ning Chen, Yi-Ling Pan, Chun-An Cheng, Hsiao-Chun Wu, Yi-Jen Hsueh, Nien-Yi Chiang, Hsi-Hsien Lin, Hsi-Hsien Lin, Hsi-Hsien Lin, Hsi-Hsien Lin

“…Alkaline phosphatase (ALP) is a ubiquitously expressed dephosphorylating enzyme and its level in blood is widely used as a diagnosis marker of liver damage or bone disorders in human patients. …”
Get full text

Association of dopamine receptor D2 -141C insertion/deletion and dopamine beta-hydroxylase 19 bp insertion/deletion polymorphisms with schizophrenia: A case-control study in the ea... by Boukhenaf Yasmina, Sariyah Ayachi Ouarda, Achou Rayene, Iness Bernou Amina, Zohra Madoui Fatima, Sifi Karima, Larbi Rezgoun Mohamed

Get full text

Hantavirus Cardiopulmonary Syndrome and Diffuse Alveolar Hemorrhage in the Era of COVID-19 by Khizar Hamid, Swaminathan Perinkulam Sathyanarayanan, Touba Naim, Muhammad Hamza, Mirza Omer Mahmood Baig, Emad Abu Sitta

“…The cardiopulmonary phase occurs from increased permeability of pulmonary capillaries and in severe cases can progress to cardiogenic shock. Diagnosis is based on the presence of IgM and IgG Hantavirus antibodies. …”
Get full text

Long-term trends in the incidence of male breast cancer and nomogram for predicting survival in male breast cancer patients: a population-based epidemiologic study by Aimin Huang, Daning Li, Zhe Fan, Jingfang Chen, Weidong Zhang, Wentao Wu

“…The high incidence and poor prognosis of MBC in the elderly population emphasize the need for improved screening and early diagnosis in high-risk groups. Our competing risk model, compared to the Cox model, more accurately reflects real-world conditions. …”
Get full text

Management of Psychosis and Schizophrenia by Primary Care GPs: A Cross-Sectional Study in Spain by Jesús Sepúlveda-Muñoz, Casta Quemada González, María M. Hurtado Lara, Ángel Manuel Gutiérrez García, Celia Martí-García, José María García-Herrera Pérez-Bryan, José Miguel Morales-Asencio

“…Often, psychotic episodes go unnoticed for years before a diagnosis is established. Primary care physicians are crucial for early recognition of psychosis and schizophrenia, especially in Spain, where primary care is the main entry point to healthcare services. …”
Get full text

Epidemiological Study of Uveal Melanoma from US Surveillance, Epidemiology, and End Results Program (2010–2015) by Yufeng Xu, Lixia Lou, Yijie Wang, Qi Miao, Kai Jin, Menglu Chen, Juan Ye

“…Determinants of survival included age at diagnosis, AJCC stage, and radiation therapy.…”
Get full text

Serum vitamin C levels and their correlation with chronic kidney disease in adults: a nationwide study by Chunli Wang, Jili Zhao, Qiaoqiao Zhou, Jing Li

“…Participants below 18 years of age, pregnant individuals, those lacking essential data for CKD diagnosis, or individuals with incomplete serum vitamin C data were excluded. …”
Get full text

Highlights of the Fourth Canadian Symposium on Hepatitis C: Moving towards a National Action Plan by Selena M. Sagan, Benoit Dupont, Jason Grebely, Mel Krajden, Sonya A. MacParland, Jennifer F. Raven, Sahar Saeed, Jordan J. Feld, D. Lorne Tyrrell, Joyce A. Wilson

“…Thus, managing treatment costs and improving treatment engagement in those most in need will be a key challenge. Diagnosis and treatment uptake are currently poor in Canada due to financial, geographical, cultural, and social barriers. …”
Get full text

Cyto-histological correlation of salivary gland lesions according to the Milan reporting system by Shireen Hamid, Muhammad Mudassar, Nida Hamid, Muhammad Sarwar Zia, Tariq Mehmood, Sadia Hameed

“…The diagnostic accuracy of FNAC was determined to be 95.2% compared to the final histopathological diagnosis. Correspondingly, the associated risk of malignancy for these categories was 0%, 30%, 0%, 30%, 100%, and 100%, respectively. …”
Get full text

Endoscopic Removal of Gastrointestinal Stromal Tumors in the Stomach: A Single-Center Experience by Yingjie Guo, Xue Jing, Jian Zhang, Xueli Ding, Xiaoyu Li, Tao Mao, Zibin Tian

“…The clinical features, surgical outcomes, complications, pathological diagnosis, and risk classification were evaluated retrospectively. …”
Get full text

Primary and tertiary management of ocular surface lesions in HIV-infected patients in Ehlanzeni, Mpumalanga Province by S Mhlanga, A C Turner, S J Biddulph

“…Sixty-two files were reviewed and 51 (82.2%) of the patients had an HIV-positive diagnosis. Fifty percent had carcinoma-in situ and squamous cell carcinoma of the conjunctiva. …”
Get full text

Prevalence and Determinants of Antenatal Depression Risk Among Urban Women Seeking Antenatal Clinical Care at a District Hospital in Ghana by Opei Kwafo Adarkwa, Douglas Aninng Opoku, Roderick E. Larsen‐Reindorf, Ellis Owusu‐Dabo, Benedicta Boamah, Magdalene Adarkwa, Christian Obirikorang, Yvonne A. Nartey, Timothy Kwabena Adjei, Aliyu Mohammed

“…Also, screening all pregnant women, especially those with risk factors, for the risk of antenatal depression and early diagnosis and treatment of the risk of depression are important for the health of the mother, fetus and newborn.…”
Get full text

Longitudinal association of thyroid-stimulating immunoglobulin levels with clinical characteristics in thyroid eye disease by Kyung In Woo, Suk-Woo Yang, Jeong Kyu Lee, Sang In Khwarg, Jin Sook Yoon, Sehyun Baek, Jae Wook Yang, JaeSang Ko, Koung Hoon Kook, Sang Duck Kim, Jun Hyuk Son, Helen Lew, Sung Bok Lee, Jae Woo Jang, Hee Young Choi, Mi Jung Chi

“…In this study, we evaluated the longitudinal association between changes in serum thyroid-stimulating hormone (TSH) receptor antibody (TRAb) levels and course of disease activity and severity over time.Design This was a multicentre, prospective, observational study.Setting Fifteen tertiary care oculoplastic service centres in Korea.Participants Seventy-six patients with newly diagnosed TED were included and followed up for 12 months.Methods We evaluated clinical characteristics and serum TRAb levels at baseline, 6 and 12 months of TED diagnosis. Additionally, we analysed longitudinal associations between the serum TRAb levels and clinical activity score (CAS), no signs or symptoms, only signs, soft tissue involvement, proptosis, extraocular muscle involvement, corneal involvement, sight loss (NOSPECS) score and proptosis.Results Thyroid-stimulating immunoglobulin (TSI) and TSH-binding inhibitory immunoglobulin (TBII) levels decreased during the 1-year follow-up, whereas disease activity measured using CAS decreased mainly in the first 6 months. …”
Get full text