Protocol for a first-in-human feasibility study of T regulatory cells (TR004) for inflammatory bowel disease using (ex vivo) Treg expansion (TRIBUTE) by Jennifer Clough, Peter Irving, A Toby Prevost, Graham M Lord, Joana Vasconcelos, James B Canavan, Beverley Rodger, D Macallan

“…Eligible participants are those who are at least 18 years old, have a diagnosis of active moderate to severe CD and have failed to respond to or tolerate at least two prior lines of standard medication. …”
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Barriers and facilitators of loaded self-managed exercises and physical activity in people with patellofemoral pain: understanding the feasibility of delivering a multicentred rand... by Michael Skovdal Rathleff, Phillipa Logan, Marcus Bateman, Benjamin E Smith, Fiona Moffatt, Paul Hendrick, James Selfe, Toby O Smith

“…The trial investigated a loaded self-managed exercise intervention, which included education and advice on physical activity versus usual physiotherapy as the control.Design Qualitative study, embedded within a mixed-methods design, using semi-structured interviews.Setting A UK National Health Service physiotherapy clinic in a large teaching hospital.Participants Purposively sampled 20 participants within a feasibility RCT study; 10 patients with a diagnosis of patellofemoral pain, aged between 18 and 40 years, and 10 physiotherapists delivering the interventions.Results In respect to barriers and facilitators, the five overlapping themes that emerged from the data were: (1) locus of control; (2) belief and attitude to pain; (3) treatment expectations and preference; (4) participants’ engagement with the loaded self-managed exercises and (5) physiotherapists’ clinical development. …”
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Status Epilepticus due to Intraperitoneal Injection of Vehicle Containing Propylene Glycol in Sprague Dawley Rats by Evon S. Ereifej, Seth M. Meade, Cara S. Smith, Keying Chen, Nanette Kleinman, Jeffrey R. Capadona

“…Blood tests from the seizing rat support a diagnosis of hemolysis and lactic acidosis which may have led to the seizures, all of which appeared to be a consequence of the propylene glycol administration. …”
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Comparison between Intestinal Behçet’s Disease and Crohn’s Disease in Characteristics of Symptom, Endoscopy, and Radiology by Tianyu Zhang, Liwen Hong, Zhengting Wang, Rong Fan, Maochen Zhang, Yun Lin, Mengmeng Cheng, Xiaolin Zhou, Peijun Sun, Xiaoyi Lin, Jie Zhong

“…The differentiation model that integrated the various parameters together may yield a high diagnostic efficacy in the differential diagnosis between intestinal BD and CD.…”
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REPEATED THERAPEUTIC LEUKAPHERESIS - A SOLE TREATMENT DURING PREGNANCY AS A BRIDGE BEFORE TYROSINE KINASE INHIBITORS FOR A PREGNANT WOMAN WITH CHRONIC MYELOGENOUS LEUKEMIA – A CASE... by Ivan Tonev, Chavdar Botev, Georgui Balatzenko, Milcho Mincheff

“…Materials and Methods:A 20-year-old female patient, during a routine examination for pregnancy, presented with elevated white blood cells (WBC) count (over 275x109/L) and splenomegaly without any complaints. The diagnosis of Ph-positive CML was confirmed by cytology and PCR [presence of p210 type BCR::ABL1 [e13a2 (b2a2)] transcripts. …”
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Cloning, expression, and purification of fusion antigens MPT83 and ESAT6 from the local strain of Mycobacterium tuberculosis in Escherichia coli as a seed vaccine candidate against... by Rusdina Bte Ladju, Ahyar Ahmad, Abdul Karim, Rugaiyah Arfah, Rosana Agus, Najdah Hidayah, Muhammad Nasrum Massi, Astutiati Nurhasanah, Harningsih Karim, Irda Handayani

“…In conclusion, the purified recombinant fusion protein MPT83 and ESAT6 hold promise for TB diagnosis and show potential as vaccine candidates in the future. [ J Adv Biotechnol Exp Ther 2025; 8(1.000): 91-104]…”
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Clinicopathological study and molecular subtyping of muscle-invasive bladder cancer (MIBC) using dual immunohistochemical (IHC) markers by R. Vaithegi, Kanthilatha Pai, Anuradha Calicut Kini Rao, Vidya Monappa, Swathi Prabhu, Nischitha Suvarna

“…Results The mean age at diagnosis of MIBC was 65.91 years with a male predominance. …”
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Evaluating the impact of ESICM 2023 guidelines and the new global definition of ARDS on clinical outcomes: insights from MIMIC-IV cohort data by Duanhong Song, Qingquan Chen, Shangbin Huang, Shengxun Qiu, Zeshun Chen, Yuanhang Cai, Yifu Zeng, Xiaoyang Chen, Yixiang Zhang

“…Conclusions The new ARDS definition offers advantages in earlier detection, more accurate grading, and more precise diagnosis in resource-limited settings compared with the Berlin definition. …”
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A Prospective Study of Tuberculosis Drug Susceptibility in Sabah, Malaysia, and an Algorithm for Management of Isoniazid Resistance by Muhammad Redzwan S. Rashid Ali, Uma Parameswaran, Timothy William, Elspeth Bird, Christopher S. Wilkes, Wai Khew Lee, Tsin Wen Yeo, Nicholas M. Anstey, Anna P. Ralph

“…However, INH-resistance poses challenges, and NTM is an important differential diagnosis in this setting, where smear microscopy is the usual diagnostic modality. …”
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Intestinal obstruction caused by disseminated mycobacterium avium complex disease following solid organ transplantation: a case report by Akane Mita, Sho Nakakubo, Yusuke Nishimura, Hideki Shima, Masaaki Watanabe, Tsuyoshi Shimamura, Satoshi Konno

“…Awareness and thorough differential diagnosis are essential for timely and accurate management in such complex cases. …”
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Extracellular vesicles display distinct glycosignatures in high-grade serous ovarian carcinoma by Kristina Mae Bienes, Akira Yokoi, Masami Kitagawa, Hiroaki Kajiyama, Morten-Thaysen Andersen, Rebeca Kawahara

“…Aberrant protein N-linked glycosylation has been reported in HGSOC, holding a potential for improving the diagnosis and prognosis of affected patients. Building on our recent observation documenting that HGSOC-derived extracellular vesicles (EVs) exhibit aberrant protein expression patterns, we here explore the protein N-glycosylation displayed by EVs isolated from HGSOC cell lines and patient ascites relative to those from matching controls to unveil candidate markers for HGSOC. …”
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Exploring the predictive power of antinuclear antibodies and Rheumatoid factor correlations in anticipating therapeutic outcomes for female patients with coexisting Sjögren's syndr... by Anitha Krishnan Pandarathodiyil, Hema Shree K, Pratibha Ramani, B. Sivapathasundharam, Ramya Ramadoss

“…Biomarkers such as antinuclear antibodies (ANA) and rheumatoid factor (RF) are used for diagnosis, but their predictive power for treatment outcomes remains unclear. …”
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Mapping Chilean clinical research: a protocol for a scoping review and multiple evidence gap maps by Sergio R Muñoz, Nicolás Meza, Eva Madrid, Juan Victor Ariel Franco, Gerard Urrútia, Camila Micaela Escobar Liquitay, Javier Bracchiglione

“…In Chile, there is no local diagnosis regarding recent clinical research that might inform prioritisation for future research funding. …”
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The Use of Machine Learning to Create a Risk Score to Predict Survival in Patients with Hepatocellular Carcinoma: A TCGA Cohort Analysis by Samer Tohme, Hamza O Yazdani, Amaan Rahman, Sanah Handu, Sidrah Khan, Tanner Wilson, David A Geller, Richard L Simmons, Michele Molinari, Christof Kaltenmeier

“…It is important to develop ways to help stratify patients upon initial diagnosis to provide optimal treatment modalities and follow-up plans. …”
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Precision fetal cardiology detects cyanotic congenital heart disease using maternal saliva metabolome and artificial intelligence by Ray Bahado-Singh, Nadia Ashrafi, Amin Ibrahim, Buket Aydas, Ali Yilmaz, Perry Friedman, Stewart F. Graham, Onur Turkoglu

“…Abstract Prenatal sonographic diagnosis of congenital heart disease (CHD) can lead to improved morbidity and mortality. …”
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Characterization of Cannabis usage in individuals with non-cancer chronic pain in the state of Maine using the Behavioral Risk Factor Surveillance System (BRFSS) by Rachel Bordonaro, Elizabeth N. Bean, Ling Cao

“…Methods We identified individuals with chronic pain as those that reported having a rheumatoid condition diagnosis, and controls as those who reported no such conditions. …”
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Occult Renal Calcifications in Patients with Normocalcemic Primary Hyperparathyroidism and Their Association with the Parathyroid Hormone-Vitamin D Axis by Fernanda Victor, Alyne Layane Pereira Lemos, Anna Mirella de Holanda Ribas, Leonardo Bandeira, José Henrique Pimentel, Luiz Otávio de Andrade Damázio, Francisco Bandeira

“…Cross-sectional analysis of 34 patients with no history of urolithiasis and/or nephrocalcinosis. The diagnosis of NPHPT was as follows: elevated serum PTH (reference range: 15–65 pg/mL), normal albumin-corrected serum calcium, normal urinary calcium excretion, serum 25(OH)D >30 ng/mL, eGFR (CKD-EPI) > 60 mL/min/1.73 m2, without intestinal disease, and not on medications such as thiazide diuretics, lithium, bisphosphonates, or denosumab. …”
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Clinical Features and Risk Factors of Active Tuberculosis in Patients with Behçet’s Disease by Yaxu Liu, Lifan Zhang, Ziyue Zhou, Luxi Sun, Baotong Zhou, Xiaoqing Liu, Wenjie Zheng

“…Our study suggested that when BD patients have systemic symptoms with significantly elevated TB-SPOT, the diagnosis of ATB should be considered.…”
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Serum KL-6 levels reflect the severity of interstitial lung disease caused by immune checkpoint inhibitors by Xiaoping Li, Dan Xue, Qiongying Wei, Xuexue Tan

“…The lack of clear correlations with dosage, duration, or drug efficacy, coupled with nonspecific clinical manifestations, poses challenges in timely diagnosis and effective management. This study examined the association between ICIs-related ILD and serum levels of KL-6 and inflammatory markers in NSCLC patients. …”
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Is There a Mild Form of Pediatric Appendicitis? An Eight-Year Single-Center Retrospective Review by Eric Scheier, Khaled Khalilia, Pavel Peslin, Stav Amir, Luba Pasherstnik Bizer

“…To confirm the accuracy of the initial sonographic diagnosis of appendicitis in children with spontaneous resolution, two study radiologists, blinded to clinical data, reviewed the images for signs of appendiceal inflammation. …”
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