Characteristics of velopharyngeal dysfunction in 22q11.2 deletion syndrome: a retrospective case-control study by Sebastiano Failla, Peng You, Chandheeb Rajakumar, Anne Dworschak-Stokan, Philip C. Doyle, Murad Husein

“…Fifteen children with a definitive diagnosis of 22q11.2 deletion syndrome requiring surgical VPD repair were included in the 22q11.2 deletion syndrome group. …”
Get full text

[18F]FDG PET-Based Radiomics and Machine Learning for the Assessment of Gliomas and Glioblastomas: A Systematic Review by Francesco Dondi, Roberto Gatta, Maria Gazzilli, Pietro Bellini, Gian Luca Viganò, Cristina Ferrari, Antonio Rosario Pisani, Giuseppe Rubini, Francesco Bertagna

“…Signatures, including radiomics analysis and ML, generally demonstrated a possible diagnostic value to assess different characteristics of gliomas and GBMs, such as the methylation status of the O6-methylguanine-DNA methyltransferase (MGMT) promoter, the isocitrate dehydrogenase (IDH) genotype, alpha thalassemia/mental retardation X-linked (ATRX) mutation status, proliferative activity, differential diagnosis with solitary brain metastases or primary central nervous system lymphoma, and prognosis of these patients. …”
Get full text

Adrenal Disorders and the Paediatric Brain: Pathophysiological Considerations and Clinical Implications by Vincenzo Salpietro, Agata Polizzi, Gabriella Di Rosa, Anna Claudia Romeo, Valeria Dipasquale, Paolo Morabito, Valeria Chirico, Teresa Arrigo, Martino Ruggieri

“…Physicians should be aware of potential neurological manifestations in children with adrenal dysfunction to achieve better prevention and timely diagnosis and treatment of these disorders. Further studies are needed to explore the potential neurological, cognitive, and psychiatric long-term consequences of high doses of prolonged corticosteroid administration in childhood.…”
Get full text

Histological Ex Vivo Evaluation of the Suitability of a 976 nm Diode Laser in Oral Soft Tissue Biopsies by Gaspare Palaia, Federico Renzi, Daniele Pergolini, Alessandro Del Vecchio, Paolo Visca, Gianluca Tenore, Umberto Romeo

“…A 976 nm diode laser demonstrated good surgical effectiveness that provoked little peripheral damage in the cut edges and allowed a safe histological diagnosis. Clinical Relevance. In oral pathology, many times, there is fear in using the laser to remove some lesions due to its thermal effect on the tissues close to the lesion. …”
Get full text

Knowledge and Use of Caries Detection Methods among Dental Students and Dental Practitioners in Riyadh, Saudi Arabia by Waseem Radwan, Abeer A. AlNasser, Hesah Aloqab, Khalid Al-Saggaf, Nora A. Almuhtab, Bothinah Alnasyan

“…Accurate detection and diagnosis of dental caries is an integral part of achieving adequate comprehensive dental care. …”
Get full text

Prospective evaluation of the diagnostic accuracy of FDG-PET/CT for the detection of sternal wound infection post-sternotomy by Angela Cai, Mehrshad Bakhshi, Yoan Lamarche, Francois Harel, Matthieu Pelletier-Galarneau

“…Methods We conducted a single center prospective study of consecutive patients referred for suspected SWI post-median sternotomy. Gold standard diagnosis was established by chart review of clinical follow-up, surgical findings, and cultures. …”
Get full text

Anti-Tumor Necrosis Factor-α Use in Pediatric Inflammatory Bowel Disease—Reports from a Romanian Center by Roxana Matran, Andra-Mihaela Diaconu, Andreea Maria Iordache, Irina Dijmărescu, Alexandra Coroleucă, Daniela Păcurar, Cristina Becheanu

“…The median (IQR) age at diagnosis was 14.8 years [10.8–15.9]. IFX was used in 34 (85%) patients while 6 (15%) patients received either ADA or IFX/ADA sequential therapy. …”
Get full text

Combined alverine citrate and simeticonein preparation in the treatment of irritable bowel syndrome by Ye. A. Poluektova, S. Yu. Kuchumova, V. T. Ivashkin

“…Retrospective analysis of efficacy and safety of meteospasmyl in 30 patients with IBS diagnosis, confirmed by conformity of complaints to Rome-III criteria and absence of pathological changes at laboratory and instrumental investigations was carried out. …”
Get full text

Gaps in Study Design for Immune Parameter Research for Latent Tuberculosis Infection: A Systematic Review by Mariana Herrera, Cristian Vera, Yoav Keynan, Zulma Vanessa Rueda

“…It is mandatory to harmonize the study of immune parameters for LTBI diagnosis. This systematic review is registered with PROSPERO CRD42017073289.…”
Get full text

Biomechanics Parameters of Gait Analysis to Characterize Parkinson’s Disease: A Scoping Review by Michela Russo, Marianna Amboni, Noemi Pisani, Antonio Volzone, Danilo Calderone, Paolo Barone, Francesco Amato, Carlo Ricciardi, Maria Romano

“…Therefore, the use of quantitative information on the gait mechanisms of PD patients is a promising approach, particularly for monitoring gait disorders and potentially informing therapeutic interventions, though it is not yet a well-established tool for early diagnosis or direct assessment of disease progression. …”
Get full text

Use of complementary and alternative medicine among females with polycystic ovary syndrome in Jordan: a cross-sectional study by Oriana Awwad, Mais Saleh, Ali Alsamydai, Fatma U Afifi, Amal Akour, Renad Abu Tarboosh, Manar Hamdan, Asma Sa’d Basha, Sanaa K Bardaweel

“…The primary sources of information were family and friends (46.1%).Longer duration since diagnosis, having more PCOS signs/symptoms and a higher level of education were factors significantly associated with CAM use (β=1.257, 95% CI=1.018 to 2.552, p=0.034; β=1.146, 95% CI=1.052 to 1.250, p=0.002 and β=1.584, 95% CI=1.054 to 2.379, p=0.027, respectively). …”
Get full text

Awaking Blood Pressure Surge and Progression to Microalbuminuria in Type 2 Normotensive Diabetic Patients by Michelangela Barbieri, Maria Rosaria Rizzo, Ilaria Fava, Celestino Sardu, Nicola Angelico, Pasquale Paolisso, Angela Abbatecola, Giuseppe Paolisso, Raffaele Marfella

“…We investigated the predictive value of morning blood pressure surge (MBPS) on the development of microalbuminuria in normotensive adults with a recent diagnosis of type 2 diabetes. Methods. Prospective assessments of 24-hour ambulatory blood pressure monitoring and urinary albumin excretion were performed in 377 adult patients. …”
Get full text

Tuberculosis and COVID-19: Lessons from the Past Viral Outbreaks and Possible Future Outcomes by Radu Crisan-Dabija, Cristina Grigorescu, Cristina-Alice Pavel, Bogdan Artene, Iolanda Valentina Popa, Andrei Cernomaz, Alexandru Burlacu

“…How does the TB vaccine affect COVID-19? How does one diagnosis affect the other? Discussions. Few essential elements about TB and SARS-CoV coinfections were discussed. …”
Get full text

Sex-based differences in lung cancer susceptibility and molecular genetics in the 2020s by Berta Mosleh, Pavla Sarova, Sonja Zehetmayer, Felicitas Oberndorfer, Joachim Widder, Helmut Prosch, Marco Idzko, Clemens Aigner, Mir Alireza Hoda, Daniela Gompelmann

“…There were no significant differences in age at diagnosis, body mass index, lung function parameters, histological subtypes, PD-L1 protein expression, disease stage, and survival between men and women (all p > 0.05). …”
Get full text

Dynamic high resolution US as primary tool in comparison to MRI in evaluation of TMJ disk anterior displacement by Ahmed Y. Ashour, Abdalwhab M.A. Zwiri, Ahmed H. Ali, Ahmed M. Mostafa, Bahaa-Eldin A. Moustafa, Husseini F. EL boraey, Alshimaa Y. Ashour, Elsayed M. Abd El-Hamid

“…Methods: This study included forty patients with a clinical diagnosis of anterior disk displacement (ADD). The TMJ was imaged bilaterally using a 1.5 T MRI using a 2-mm slice width, in the sagittal and coronal planes 1–7 days after performing US. …”
Get full text

Giant Protruding Nodular Fasciitis of the Anterior Chest Wall Clinically Mimicking a Soft Tissue Sarcoma by Hideyuki Kinoshita, Tsukasa Yonemoto, Hiroto Kamoda, Yoko Hagiwara, Toshinori Tsukanishi, Sumihisa Orita, Kazuhide Inage, Naoya Hirosawa, Seiji Ohtori, Takeshi Ishii

“…Owing to its rapidly growing nature, a precise clinical diagnosis is difficult; it is frequently misdiagnosed as an aggressive or malignant tumor. …”
Get full text

Early detection of myocarditis caused by immune checkpoint inhibitor therapy with nivolumab and ipilimumab for advanced recurrent renal cell carcinoma by Maki Todo, Yodo Gatate, Shintaro Nakano, Go Kaneko, Masayuki Hagiwara, Takayuki Takahashi, Yuta Umezawa, Genji Ueda, Shiho Ishikawa, Yoshinori Makino, Masafumi Oyama, Suguru Shirotake

“…Our management strategy of care by a onco-cardiology team may contribute to the early diagnosis and treatment of myocarditis.…”
Get full text

Eosinophilia predicts poor clinical outcomes in recent-onset arthritis: results from the ESPOIR cohort by Sandrine Jousse-Joulin, Alain Saraux, Thierry Marhadour, Divi Cornec, Gilles Chiocchia, Valérie Devauchelle-Pensec, Gabriel J Tobón, Dewi Guellec, Morgane Milin, Olivier Vittecocq

“…Our data suggest that patients with mild eosinophilia at diagnosis could respond worse to the treatment than those without.…”
Get full text

Identification of Hepatocellular Carcinoma Subtypes Based on Global Gene Expression Profiling to Predict the Prognosis and Potential Therapeutic Drugs by Cunzhen Zhang, Jiyao Wang, Lin Jia, Qiang Wen, Na Gao, Hailing Qiao

“…<b>Background:</b> Hepatocellular carcinoma (HCC) is a highly heterogeneous tumor, and distinguishing its subtypes holds significant value for diagnosis, treatment, and the prognosis. <b>Methods:</b> Unsupervised clustering analysis was conducted to classify HCC subtypes. …”
Get full text

Outpatient chemotherapy drug costs and expensive chemotherapy drug use in 340B and Non-340B hospitals: an observational study by Jianhui Hu, David R. Nerenz

“…., B-cell), or had advanced-stage disease had a higher chance to use expensive chemotherapy treatment; patients who were older, survived the first 12 months upon diagnosis, had advanced-stage disease, or had more drug claims had higher drug costs. …”
Get full text