Myelofibrosis-Associated Lymphoproliferative Disease: Retrospective Study of 16 Cases and Literature Review by A. Etienne, B. Gruson, D. Chatelain, R. Garidi, B. Royer, H. Sevestre, J. P. Marolleau, G. Damaj

“…B-symptoms are more frequent at diagnosis and more patients presented with an elevated LDH level. …”
Get full text

Impact of Preoperative Three-Dimensional Computed Tomography Cholangiography on Postoperative Resection Margin Status in Patients Operated due to Hilar Cholangiocarcinoma by A. Andert, P. Bruners, C. Heidenhain, F. Ulmer, C. D. Klink, P. H. Alizai, C. Kuhl, U. P. Neumann, M. Binnebösel

“…The purpose of this study was to analyse the value of 3-dimensional computed tomography cholangiography (3D-ERC) compared to conventional retrograde cholangiography in the preoperative diagnosis of hilar cholangiocarcinoma (HC) with special regard to the resection margin status (R0/R1). …”
Get full text

Gastric Precancerous Lesions: From Progenitor Cell and Microsatellite Instability to Clinical Interpretation of Gastric Cancer Risk by A. V. Kononov, V. A. Rubtsov, M. N. Parygina, A. G. Shimanskaya, S. I. Mozgovoi, E. G. Pomorgailo, M. V. Markelova, Yu. A. Fedotova

“…Aim: to evaluate the possibility of the MMR-system status, microsatellite instability (MSI) usage in the differential diagnosis of gastric mucosa dysplasia, determination of the gastric adenocarcinoma development risk.   …”
Get full text

Community Perception on Trypanosomosis, Parasitological, and Entomological Studies in Two Selected Districts of South Omo Zone, Ethiopia by Solomon Mekuria, Tesfu K. Mekonnen, Nigatu Kebede

“…Hence regular control measures and molecular diagnosis need to be conducted.…”
Get full text

A recurrence model for non-puerperal mastitis patients based on machine learning. by Gaosha Li, Qian Yu, Feng Dong, Zhaoxia Wu, Xijing Fan, Lingling Zhang, Ying Yu

“…Accurate prediction of its recurrence is crucial for personalized adjuvant therapy, and pathological examination is the primary basis for the classification, diagnosis, and confirmation of non-puerperal mastitis. …”
Get full text

Costs and Outcomes of Clostridioides difficile Infections in Germany: A Retrospective Health Claims Data Analysis by Katharina Schley, Kirstin Heinrich, Jennifer C. Moïsi, Dennis Häckl, Dominik Obermüller, Gordon Brestrich, Christof von Eiff, Thomas Weinke

“…Overall excess costs for CDI cases were estimated at approximately €1.6 billion within 1 year after diagnosis. Conclusions CDI in Germany is associated with a high clinical and economic burden, including significantly higher mortality, costs, and healthcare resource utilization, in patients with CDI versus their matched patients without CDI. …”
Get full text

Fish Tank Granuloma Presenting as a Nasal Cavity Mass by Motoki Sekine, Fumiyuki Goto, Kosuke Saito, Shoji Kaneda, Hikaru Yamamoto, Tomoaki Murakami, Takahide Hamano, Kenji Okami

“…IGRA and the mycobacterial tissue culture test are useful for diagnosis. As in this case, the nasal lesion may be excised as an inflammatory nasal granuloma, and therefore, there may be many more “hidden” cases of M. marinum infection. …”
Get full text

Transient Elastography in Alcoholic Liver Disease and Nonalcoholic Fatty Liver Disease: A Systemic Review and Meta-Analysis by Changzhou Cai, Xin Song, Xueyang Chen, Weihua Zhou, Qi Jin, Shenghui Chen, Feng Ji

“…We included studies regarding the diagnosis or staging of steatosis or fibrosis by using controlled attenuation parameter (CAP) or liver stiffness measurement (LSM) measured by TE in patients with ALD or NAFLD. …”
Get full text

Digital cognitive training in children with attention-deficit/hyperactivity disorder: a study protocol of a randomised controlled trial by Sally Richmond, Hannah Kirk, Kim Cornish, Mark A Bellgrove, Tori Gaunson, Meg Bennett

“…Participants will comprise 104 children with a diagnosis of ADHD aged 5–8 years 11 months. Participants will be randomly allocated to either an adaptive, digital game-based (1) attention training programme (intervention) or (2) a numeracy programme (control). …”
Get full text

Cost-effectiveness Analysis of Hypoallergenic Milk Formulas for the Management of Cow’s Milk Protein Allergy in the United Kingdom by Rui Martins, Mark P. Connolly, Eleanor Minshall

“…**Conclusions:** Compared to AAF, SF, and EHWF hypoallergenic formulas, EHCF+LGG was the most cost-effective, associated with lower total costs and contributing to a higher proportion of children being symptom-free and developing immune tolerance 3-years after diagnosis.…”
Get full text

Harnessing nanotechnology for cancer treatment by Jiajun Zhu, Jiajun Zhu, HaeJu Lee, HaeJu Lee, Ruotong Huang, Ruotong Huang, Jianming Zhou, Jingjun Zhang, Xiaoyi Yang, Wenhan Zhou, Wangqing Jiang, Shuying Chen

“…In addition to drug delivery, with the utilization of tools such as quantum dots and nanosensors that enables more precise identification of cancer biomarkers, nanotechnology is also playing a pivotal role in early cancer detection and diagnosis. Furthermore, nanotechnology-based therapeutic strategies, including photothermal therapy, gene therapy and immunotherapy are offering novel ways to combat cancer by selectively targeting tumor cells and enhancing the immune response. …”
Get full text

Identifying Primary Spontaneous Pneumothorax from Administrative Databases: A Validation Study by Eric Frechette, Keegan Guidolin, Ayman Seyam, Yun-Hee Choi, Sarah Jones, J. Andrew McClure, Jennifer Winick-Ng, Blayne Welk, Richard A. Malthaner

“…The charts of 150 patients who consulted the emergency room (ER) with a recorded main diagnosis of pneumothorax were reviewed to define the type of pneumothorax that occurred. …”
Get full text

Diabetes Increases Risk of Cardiovascular Events in Patients Receiving Permanent Pacemaker: A Propensity Score-Matched Cohort Study by Huang-Chung Chen, Wen-Hao Liu, Chien-Hao Tseng, Yung-Lung Chen, Wei-Chieh Lee, Yen-Nan Fang, Shaur-Zheng Chong, Mien-Cheng Chen

“…Between January 2003 and December 2017, 1742 patients receiving naïve PPM treatment comprised this retrospective cohort study and were categorized into two groups by the diagnosis of diabetes: group with diabetes (n=632, 36.3%) and group without diabetes (n=1110, 63.7%). …”
Get full text

Eye movement desensitisation and reprocessing for childbirth-related post-traumatic stress symptoms: effectiveness, duration and completion by A. Doherty, U. Nagle, J. Doyle, R. M. Duffy, R. M. Duffy

“…Pre-intervention, 64.7% (n = 22) of the sample met criteria for a provisional diagnosis of PTSD. The majority of women (61.8%) demonstrated a ≥ 10 point reduction on PCL-5 following EMDR. …”
Get full text

Revealing the critical state and identifying individualized dynamic network biomarker for type 2 diabetes through advanced analysis methods on individual basis by Peiyu Li, Shaowen Jing, Guo Tian, Jing Jiang

“…They can therefore not only help future studies of personalized disease diagnosis but also provide a better insight into clinical practice.…”
Get full text

Prescribed Minimum Benefits complaints: a five-year retrospective review by Lindelwa Mitchele Ngobeni, Lucky Moropeng, Evelyn Thsehla

“… Background: No matter which benefit option members have chosen, medical schemes are required by the Medical Schemes Act no. 131 of 1998 to pay costs associated with the diagnosis, treatment, or care of a specified set of benefits known as Prescribed Minimum Benefits (PMBs). …”
Get full text

Intraductal Papillary Neoplasms of the Bile Duct by Masayuki Ohtsuka, Hiroaki Shimizu, Atsushi Kato, Hideyuki Yoshitomi, Katsunori Furukawa, Toshio Tsuyuguchi, Yuji Sakai, Osamu Yokosuka, Masaru Miyazaki

“…However, pathologic diagnosis by preoperative biopsy cannot always reflect the maximum degree of atypia, because IPNBs are often composed of varying degrees of cytoarchitectural atypia. …”
Get full text

Is There a Relationship between the Staining Pattern of Classical Neuroendocrine Markers and Clinicopathological Findings in Neuroendocrine Tumors of the Appendix? by Merve CİN, Enver YARIKKAYA, Selçuk CİN, Özgecan GÜNDOĞAR

“…The findings suggest that it will create awareness in pathology practice in terms of both diagnosis and pathological prognostic parameters (tumor size, stage).…”
Get full text

Objective Clinical and Radiological Response under Sunitinib in a Case of Thigh Hidradenocarcinoma by S. Korbi, H. Rachdi, H. El Benna, N. Mejri, Y. Berrazaga, N. Daoud, S. Labidi, H. Boussen

“…A 2nd histology and immunohistochemistry exam showed a proliferation positive for CK, CK5, and p63 suggesting the diagnosis of hidradenocarcinoma. The patient was treated by 3 lines of chemotherapy, 1st by Adriamycin, 2nd by carboplatin-paclitaxel, and then 3rd by oral capecitabine, leading to a stable clinical disease but without a clinical benefit. …”
Get full text

Selective epithelial expression of KRASG12D in the Oncopig pancreas drives ductal proliferation and desmoplasia that is accompanied by an immune response by Carlos P. Jara, Al-Murtadha Al-Gahmi, Audrey Lazenby, Michael A. Hollingsworth, Mark A. Carlson

“…Abstract Pancreatic ductal adenocarcinoma (PDAC) remains a formidable challenge in oncology, characterized by a high mortality rate, largely attributable to delayed diagnosis and the intricacies of its tumor microenvironment. …”
Get full text