Targeted drug delivery in neurodegenerative diseases: the role of nanotechnology by Rupal Dhariwal, Rupal Dhariwal, Mukul Jain, Mukul Jain, Yaser Rafiq Mir, Abhayveer Singh, Bhavik Jain, Pankaj Kumar, Mohd Tariq, Mohd Tariq, Devvret Verma, Khemraj Deshmukh, Virendra Kumar Yadav, Tabarak Malik, Tabarak Malik

“…By employing nanoparticles, this research aims to address critical challenges in the diagnosis and treatment of conditions such as Alzheimer’s, Parkinson’s, and Huntington’s diseases. …”
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The Swallowing Clinical Assessment Score in Parkinson’s Disease (SCAS-PD) Is a Valid and Low-Cost Tool for Evaluation of Dysphagia: A Gold-Standard Comparison Study by Larissa L. Branco, Sheila Trentin, Carla Helena Augustin Schwanke, Irenio Gomes, Fernanda Loureiro

“…The Swallowing Clinical Assessment Score in Parkinson’s Disease (SCAS-PD) is an alternative and low-cost tool for diagnosis of dysphagia, but had not been properly validated in comparison to the gold-standard method. …”
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Incidental Prostate Cancer in Transurethral Resection of the Prostate Specimens in the Modern Era by Brandon Otto, Christopher Barbieri, Richard Lee, Alexis E. Te, Steven A. Kaplan, Brian Robinson, Bilal Chughtai

“…A retrospective review was performed on all transurethral resections of the prostate (TURP) regardless of technique from 2006 to 2011 at a single tertiary care institution. 793 men (ages 45–90) were identified by pathology specimen. Those with a known diagnosis of prostate cancer prior to TURP were excluded (n=22) from the analysis. …”
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Characterization of Stroke Patients in an Intensive Care Unit by Marianela Planes Fajardo, Georgia Díaz-Perera Fernández, Maylín Isabel Alonso Martínez, Aurora Calzada Fajardo

“…<br /><strong>Method:</strong> a retrospective research was carried out that included 30 patients admitted with a diagnosis of stroke, in the Neurology and Neurosurgery Institute´s intensive care unit from January to December 2020. …”
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Spectral Imaging of Multi-Color Chromogenic Dyes in Pathological Specimens by Merryn V. E. Macville, Jeroen A. W. M. Van der Laak, Ernst J. M. Speel, Nir Katzir, Yuval Garini, Dirk Soenksen, George McNamara, Peter C. M. de Wilde, Antonius G. J. M. Hanselaar, Anton H.N. Hopman, Thomas Ried

“…Our data further indicate that the use of spectral imaging (a) may increase the number of parameters studied simultaneously in pathological diagnosis, (b) may provide quantitative data (such as positive labeling indices) more accurately, and (c) may solve segmentation problems currently faced in automated screening of cell‐ and tissue specimens. …”
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Prediction of the Clinical Outcomes of Sigmoid Volvulus by Abdominal X-Ray: AXIS Classification System by Rei Ishibashi, Ryota Niikura, Nobuya Obana, Sho Fukuda, Mayo Tsuboi, Tomonori Aoki, Shuntaro Yoshida, Atsuo Yamada, Yoshihiro Hirata, Kazuhiko Koike

“…Aim. Early diagnosis and evaluation of the severity of sigmoid volvulus are necessary for management and early intervention. …”
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Robotic-Assisted Transperitoneal Aortic Lymphadenectomy as Part of Staging Procedure for Gynaecological Malignancies: Single Institution Experience by V. Zanagnolo, D. Rollo, T. Tomaselli, P. G. Rosenberg, L. Bocciolone, F. Landoni, G. Aletti, M. Peiretti, F. Sanguineti, A. Maggioni

“…Results. The primary diagnosis was as follows: 6 cases of endometrial cancer, 31 epithelial ovarian cancer, 9 nonepithelial ovarian cancer, 4 tubal cancer, and 1 cervical cancer. …”
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An Atypical Presentation of Childhood Paraganglioma with Seizures: A Case Report and Review of the Literature by Elizabeth Eberechi Oyenusi, Uzoamaka Felicia Nwigbo, Oluwadamilola Moromoke Oladipo, Blessing Ebele Kene-Udemezue, Kasarachi Pauline Akowundu, Khadijah Omobusola Oleolo-Ayodeji, Oluwaseun Adunni Afoke, Funmilayo Oluwatoyin Babatunde, Felix Makinde Alakaloko, Gabriel Kolawole Asiyanbi, Ezekiel Olayiwola Ogunleye, Abiola Olufunmilayo Oduwole, Foluso Ebun Afolabi Lesi

“…Cardiovascular manifestations predominate but neurological symptoms like seizures can occur requiring a high index of suspicion for prompt diagnosis and treatment. Case Description. A 14-year-old girl was referred to the paediatric neurology unit for recurrent headaches of one-year duration, vomiting of 2 months duration, and an episode of generalized tonic-clonic seizures, 2 weeks prior to presentation. …”
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Liver cystic echinococcosis: A retrospective study on the demographics and clinical profile of patients managed at a single tertiary institution in central Eastern Cape Province, S... by A Govindasamy, P R Bhattarai, J van Niekerk, J John

“…The disease often has a nonspecific clinical presentation, necessitating imaging for the diagnosis. We observed good short-term outcomes in patients managed with combined partial cystectomy and medical therapy, although there is a risk of perioperative bile leak. …”
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Effectiveness and Safety of Using Standardized Treatment Protocols for Hypertension Compared to Usual Care: A Meta‐Analysis of Randomized Clinical Trials by Gautam Satheesh, Rupasvi Dhurjati, Vivekanand Jha, Aletta E. Schutte, Bolanle Banigbe, Dorairaj Prabhakaran, Andrew E. Moran, Abdul Salam

“…ABSTRACT Large gaps persist in the diagnosis, awareness, treatment, and control of hypertension globally. …”
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Diagnostic and Prognostic Impact of Progesterone Receptor Immunohistochemistry: A Study Evaluating More Than 16,000 Tumors by Florian Viehweger, Lisa-Marie Tinger, David Dum, Natalia Gorbokon, Anne Menz, Ria Uhlig, Franziska Büscheck, Andreas M. Luebke, Claudia Hube-Magg, Andrea Hinsch, Doris Höflmayer, Christoph Fraune, Patrick Lebok, Sören Weidemann, Maximilian Lennartz, Frank Jacobsen, Till S. Clauditz, Rainer Krech, Till Krech, Andreas H. Marx, Ronald Simon, Eike Burandt, Stefan Steurer, Guido Sauter, Sarah Minner, Christian Bernreuther

“…In diagnostic pathology, positive PR immunostaining is used to support a diagnosis of breast or gynecologic origin in a tumor. …”
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Change in Antimicrobial Therapy Based on Bronchoalveolar Lavage Data Improves Outcomes in ICU Patients with Suspected Pneumonia by Bharti Chogtu, Vrinda Mariya Elenjickal, Dharma U. Shetty, Mahsheeba Asbin, Vasudeva Guddattu, Rahul Magazine

“…This study included a retrospective cohort of intensive care unit (ICU) patients who underwent FB for a diagnosis of suspected pneumonia. The study compared the outcome of patients in whom antimicrobial modification was carried out based on BAL reports versus those in whom it was not carried out. …”
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Burkitt’s Lymphoma Presented as Advanced Ovarian Cancer without Evidence of Lymphadenopathy: CT and MRI Findings by Lucia Manganaro, Silvia Bernardo, Maria Eleonora Sergi, Paolo Sollazzo, Valeria Vinci, Alessandra De Grazia, Anna Clerico, Maria Giovanna Mollace, Matteo Saldari

“…MRI is the most useful tool to characterize the ovarian lesions and suggest the diagnosis before the histopathological results.…”
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A Rare Case of Colonic Sarcoidosis Presenting as a Mass by Haozhe Sun, Jasbir Makker, Harish Patel, Nikhitha Mantri, Ali N. Hussain, Naeem Abbas

“…Histopathology is the key to diagnosis as it distinguishes malignancy from sarcoidosis. …”
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The Serum S100B Level as a Biomarker of Enteroglial Activation in Patients with Ulcerative Colitis by Asuman Celikbilek, Mehmet Celikbilek, Seda Sabah, Nermin Tanık, Elif Borekci, Serkan Dogan, Yavuz Akin, Suleyman Baldane, Kemal Deniz, Neziha Yilmaz, Omer Ozbakir, Mehmet Yucesoy

“…This clinical prospective study included 35 patients with UC and 40 age- and sex-matched controls. The diagnosis of UC was based on standard clinical, radiological, endoscopic, and histological criteria. …”
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Light-chain proximal tubulopathy: a retrospective study from a single Chinese nephrology referral center by Xin Wang, Xiao-juan Yu, Su-xia Wang, Fu-de Zhou, Ming-hui Zhao

“…Clinical data, kidney pathological type, treatment, and prognosis were analyzed.Results Nineteen patients were enrolled, the mean age at diagnosis was 57 ± 11 and the sex ratio was 6/13 (female/male). …”
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Enhancing cardiac diagnostics: a deep learning ensemble approach for precise ECG image classification by Ahmed Alsayat, Alshimaa Abdelraof Mahmoud, Saad Alanazi, Ayman Mohamed Mostafa, Nasser Alshammari, Majed Abdullah Alrowaily, Hosameldeen Shabana, Mohamed Ezz

“…The outcomes of this research highlight the synergistic benefit of ensembles in DL applications for medical imaging and suggest a promising approach for the early detection and diagnosis of cardiac diseases, potentially improving clinical outcomes and patient care.…”
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Reliability of Endoscopic Ultrasound Using Miniprobes and Grayscale Histogram Analysis in Diagnosing Upper Gastrointestinal Subepithelial Lesions by Samiullah Khan, Rui Zhang, Weili Fang, Tao Wang, Shu Li, Danna Wang, Yixiang Chang, Lanping Zhu, Bang-mao Wang, Wentian Liu

“…To assess the role of endoscopic ultrasound (EUS) in the diagnosis of upper gastrointestinal subepithelial lesions (SELs) and to investigate EUS combined with a grayscale histogram analysis for the differentiation of leiomyomas and gastrointestinal stromal tumors (GISTs). …”
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Improving predictability of IgE-high type 2 chronic sinusitis with nasal polyps in the biologic era by Austin Heffernan, Jobanjit Phulka, Andrew Thamboo

“…Conclusions IgE-high type-2 inflammation can be predicted by a model that includes eosinophil ≥ 300 cell/uL, CRSwNP, LM ≥ 17, asthma diagnosis and SNOT-22 ≥ 40. Patients meeting these parameters have a high pretest probability for elevated IgE and would benefit from IgE serology to determine qualification for omalizumab. …”
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Correlation of Platelet Indices with Severity of Gastroesophageal Varices in Patients of Liver Cirrhosis: A Research Protocol by Parav Tantia, Sourya Acharya

“…Patients fulfilling the selection criteria will be informed about the study procedure in their native language. The diagnosis of liver cirrhosis will be established based on the patient’s detailed history, physical examination, laboratory tests, and ultrasound scan. …”
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