Efficacy and safety of 5-aminolevulinic acid photodynamic therapy in refractory genital lichen sclerosus by Weiwei Shi, Fang Wang, Liangliang Chen, Ruzhi Zhang

“…Lesion pretreatment was performed to enhance photosensitizer penetration, and fluorescence diagnosis was used for precise point-to-point treatment. …”
Get full text

Understanding the Impact of Urinary Incontinence in Persons with Dementia: Development of an Interdisciplinary Service Model by Patrick Juliebø-Jones, Elizabeth Coulthard, Elizabeth Mallam, Hilary Archer, Marcus J. Drake

“…Majority of persons had a diagnosis of Alzheimer’s disease (n = 43, 57%). Average score for how much urine leakage interferes with everyday life was 7.7/10 (range 2–10). 58.7% (n = 44) revealed some degree of sleep disturbance due to UI. 83% (n = 62) stated daily activities were limited due to UI. …”
Get full text

Lipodystrophy among HIV-Infected Patients Attending Care and Treatment Clinics in Dar es Salaam by Marina Njelekela, Rose Mpembeni, Alfa Muhihi, Nzovu Ulenga, Eric Aris, Deodatus Kakoko

“…Study protocol involved administration of structured questionnaire to collect sociodemographic and clinical information. Diagnosis of lipodystrophy was based on physician clinical assessment. …”
Get full text

Association between the Hypertriglyceridemic Waist Phenotype and Prediabetes in Chinese Adults Aged 40 Years and Older by Kun Zhao, Shan-Shan Yang, Hai-Bin Wang, Kang Chen, Zhao-Hui Lu, Yi-Ming Mu

“…The HTGW phenotype was a useful risk indicator and a practical screening tool to benefit in the early diagnosis and intervention for prediabetes, particularly for IGT and the combined IFG and IGT.…”
Get full text

A Retrospective Claims-Based Study Evaluating Clinical and Economic Burden Among Patients With Moderate to Severe Osteoarthritis Pain in the United States by Patricia B. Schepman, Sheena Thakkar, Rebecca L. Robinson, Craig G. Beck, Deepa Malhotra, Birol Emir, Ryan N. Hansen

“…Eligible patients were aged ≥45 years with ≥12 months pre-index (baseline) and ≥24 months (follow-up) of continuous enrollment; index date was defined as a physician diagnosis of hip or knee OA. An algorithm was employed to identify MTS OA pain patients, who were propensity score matched with patients having non-MTS OA pain. …”
Get full text

Herpes Simplex Virus Hepatitis in an Immunocompetent Host Resembling Hepatic Pyogenic Abscesses by Carrie Down, Amit Mehta, Gayle Salama, Erika Hissong, Russell Rosenblatt, Michael Cantor, David Helfgott, Kristen Marks

“…Though initially treated with broad-spectrum antibiotics, following histologic diagnosis of HSV hepatitis, the patient was transitioned to intravenous acyclovir for four weeks and he achieved full clinical recovery. …”
Get full text

Association of Autoimmune Thyroid Disease with Anti-GAD Antibody ELISA Test Positivity and Risk for Insulin Deficiency in Slowly Progressive Type 1 Diabetes by Masahito Katahira, Hidetada Ogata, Takahiro Ito, Tsutomu Miwata, Megumi Goto, Shizuka Nakamura, Hiromi Takashima

“…The presence of antiglutamic acid decarboxylase antibody (GADA) is required for the diagnosis of slowly progressive type 1 diabetes (SPT1D). …”
Get full text

Efficacy of Topical Mesenchymal Stem Cell Therapy in the Treatment of Experimental Dry Eye Syndrome Model by Emrullah Beyazyıldız, Ferda Alpaslan Pınarlı, Özlem Beyazyıldız, Emine Rümeysa Hekimoğlu, Uğur Acar, Muhammed Necati Demir, Aynur Albayrak, Figen Kaymaz, Güngör Sobacı, Tuncay Delibaşı

Get full text

Targeted therapy for cisplatin‐resistant lung cancer via aptamer‐guided nano‐zinc carriers containing USP14 siRNA by Xinmin Zhao, Xianghua Wu, Huijie Wang, Songtao Lai, Jialei Wang

“…Therefore, identifying novel biomarkers to improve the diagnosis and treatment of NSCLC is important. Ubiquitin‐specific protease (USP14) is involved in various pathological conditions including cancer; however, the role of USP14 in NSCLC remains elusive. …”
Get full text

Opinions and Treatment Decisions for Dental Erosive Wear: A Questionnaire Survey among Icelandic Dentists by Aida Mulic, Inga B. Árnadòttir, Torbjòrg Jensdottir, Simen E. Kopperud

“…Icelandic dentists seem to be well educated for diagnosis and treatment of dental erosion, and dentists are aware of a minimally invasive approach. …”
Get full text

Diagnostic performance of contrast-enhanced T2-FLAIR MRI in the detection of meningitis by Sanjay P., Vittal Manohar, Sushmita Balol, Yashwanth Naik M.B.

“…Objectives: To assess CE-T2-FLAIR compared to CE-T1W in the diagnosis of meningitis, using CSF analysis as the gold standard, using both qualitative and quantitative approaches for assessment. …”
Get full text

Comparing REM- and NREM-Related Obstructive Sleep Apnea in Jordan: A Cross-Sectional Study by K. Al Oweidat, S. A. AlRyalat, M. Al-Essa, N. Obeidat

“…We included patients with a diagnosis of OSA who had Apnea-Hypopnea Index (AHI) greater than or equal to five. …”
Get full text

Dampak Visual Dan Manifestasi Klinis Endoftalmitis Pasca Operasi Pada Rumah Sakit Mata Di Padang by Havriza Vitresia

“…Dampak visual yang didapatkan dimana visus akhir setelah tindakan dan follow up setelah 4 minggu adalah 20/400 sebanyak 55,6 % (10 orang) dan bahkan beberapa diantaranya mempunyai visus yang lebih baik dari 20/200 pada 70% (7 orang). Diagnosis dini dan penatalaksanaan yang tepat dan cepat maka kasus endoftalmitis eksogen pasca operasi penglihatan dapat diselamatkan.…”
Get full text

The Fatty Acid Profile in Patients with Newly Diagnosed Diabetes: Why It Could Be Unsuspected by C. Castro-Correia, S. Sousa, S. Norberto, C. Matos, V. F. Domingues, M. Fontoura, C. Calhau

“…To characterize and compare the fatty acids profiles in children with inaugural type 1 diabetes, diabetic children (at least 1 year after diagnosis), and healthy children. Design. Plasma fatty acids profiles in children with inaugural diabetes, children with noninaugural diabetes, and controls, all of whom were prepubescent with a BMI < 85th percentile, were evaluated. …”
Get full text

Cardiac Function in Long-Term Survivors of Childhood Lymphoma by Mark K. Friedberg, Ido Solt, Myriam Weyl-Ben-Arush, Yulia Braver, Avraham Lorber

“…Results. Mean age at diagnosis was 9.1 years. Mean followup duration was 10.9 years. …”
Get full text

Biomarker discovery and phytochemical interventions in Alzheimer's disease: A path to therapeutic advances by Mithila Debnath, Mahir Azmal, Rashid Taqui, Moshiul Alam Mishu, Ajit Ghosh

“…There is an urgent need to identify novel molecular markers for the diagnosis and treatment of AD. Genetic biomarkers hold promising potential in this regard. …”
Get full text

High Expression of Polo-Like Kinase 1 Is Associated with Early Development of Hepatocellular Carcinoma by Wei Sun, Qi Su, Xiankui Cao, Bin Shang, Aishan Chen, Hongzhuan Yin, Baolin Liu

“…Thus, we presume that the status of PLK1 expression might be an independent prognostic factor for HCC and targeting PLK1 might be a useful strategy for diagnosis and treatment of human HCC.…”
Get full text

Assessing the Role of Emergency Physicians in Medical Clearance: Predictors of Diagnosing Psychiatric Illness in the Emergency Department – A Retrospective Cross-sectional Study by Ibrahim Khamis Abdullah Almamari, Darpanarayan Hazra, Awatif K. Alsarrai Al-Alawi

“…Notable findings involved family history or previous psychiatric illness (OR: 2.32; 95% CI: 0.59–6.09; P < 0.01), absence of medical comorbidities (adjusted OR: 2.47; 95% CI: 1.05–5.86; P < 0.01), and no new medication initiation before illness (OR: 6.43; 95% CI: 1.52–27.18; P < 0.01), normal sensorium (adjusted OR: 2.84; 95% CI: 0.81–10.00; P < 0.01) and intact orientation (adjusted OR: 6.73; 95% CI: 1.24–36.42; P < 0.01) demonstrated statistically significant predictors of an initial psychiatric diagnosis in the ED. Conclusion: Significant predictors of initial psychiatric illness included abnormal behavior, substance abuse, family psychiatric history, absence of major medical conditions, no recent medication changes before illness onset, normal sensorium and orientation, and normal laboratory markers at presentation.…”
Get full text

Macular Changes in a Mucopolysaccharidosis Type I Patient with Earlier Systemic Therapies by Augusto Magalhães, Ana Maria Cunha, Rodrigo Vilares-Morgado, Elisa Leão-Teles, Esmeralda Rodrigues, Manuel Falcão, Ângela Carneiro, Jorge Breda, Fernando Falcão-Reis

“…We describe a case of a 12-year-old female with a biochemical and genetic diagnosis of MPS I. She underwent HSCT and ERT on the first year of life. …”
Get full text

Design and Development of a Wayside AI‐Assisted Vision System for Online Train Wheel Inspection by Muhammad Zakir Shaikh, Sanaullah Mehran, Enrique Nava Baro, Agata Manolova, Mohammad Aslam Uqaili, Tanweer Hussain, Bhawani Shankar Chowdhry

“…Visual inspection from wayside provides the opportunity to gain high‐resolution data, which can help in the early diagnosis of potential faults. It is rarely explored due to complexities associated with calibration, moving and rotating targets, and difficulties associated with data acquisition. …”
Get full text