Exploring Core Genes Associated with Sepsis and Systemic Inflammatory Response Syndrome Using Single-Cell Sequencing Technology by Shen Y, Leng L, Hu Y

“…The frequency of occurrence is on the rise, but there is a lack of certain indicators for the timely detection and recognition of illnesses.Methods: By virtue of scRNA-seq, this research has analyzed single-cell transcriptome data from samples taken from groups with septic death and systemic inflammatory response syndrome so as to identify the unique markers and patterns in immune response.Results: By revealing the status of twelve cell clusters of four major cell types in blood samples through UMAP cell clustering and the differences of major cell populations between the dead and SIRS patients, the results have elucidated the components of different cells and their marker genes in two disease states, and the response mechanism beneficial to disease diagnosis in blood samples.Conclusion: By establishing a theoretical framework centered on cellular and molecular regulation, the study has introduced a novel approach for diagnosing and treating sepsis death group and SIRS patients early, as well as differentiating and preventing these conditions.Keywords: sepsis, SIRS, single cell sequencing, biomarkers, single cell transcriptome…”
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Photodynamic therapy for the precise treatment of localized prostate cancer by Youcheng Xu, Qinyuan Tan, Chong Sun, Yuefeng Jia, Shengxian Li, Xuecheng Yang

“…Over the past 20 years, early diagnosis of prostate cancer has become increasingly prevalent due to the promotion of prostate-specific antigens, and its treatment has become a focal point. …”
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A pathogenic COL7A1 variant highlights semi-dominant inheritance in dystrophic epidermolysis bullosa by Saira Sattar, Thashi Bharadwaj, Umm-e- Kalsoom, Anushree Acharya, Saadullah Khan, Suzanne M. Leal, Isabelle Schrauwen

“…This study highlights the importance of considering semi-dominant inheritance models for dystrophic epidermolysis bullosa and other Mendelian diseases with an autosomal recessive mode of inheritance, as it can significantly impact diagnosis and genetic counseling.…”
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Clinical Features and Outcomes of Adrenal Cavernous Hemangioma: A Study of 8 Cases from a Single Center by Henghai Huang, Xiaoyun Wu, Xiaocao Lin, Delin Li, Jingjing Zeng

“…ACH was asymptomatic in most cases, and diagnosis could be challenging. Adrenalectomy is a safe treatment modality for ACH, and it ensures favorable outcomes.…”
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Characterization of Type 2 Diabetic Patients Admitted to the Diabetes Care Center of Cienfuegos by Gisela Zerquera Trujillo, Belkis Vicente Sánchez, Elodia Rivas Alpizar, Miriam Costa Cruz

“…<br /><strong>Conclusion:</strong> diabetis mellitus is appearing at ages every time earlier a dat the moment of the diagnosis there are established already macro and microvascular complications.…”
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Synchronous HPV-Related Cancer of Bilateral Tonsils Detected Using Transoral Endoscopic Examination with Narrow-Band Imaging by Fukuko Shimizu, Kenji Okami, Koji Ebisumoto, Daisuke Maki, Akihiro Sakai, Go Ogura, Naoya Nakamura, Masahiro Iida

“…To our knowledge, this is the first report of a synchronous bilateral tonsillar carcinoma detected using transoral NBI in the outpatient setting. Early diagnosis without the inspection under general anesthesia is beneficial for the patients with lymph node metastasis from unknown primary lesion.…”
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Persistent effects of legal status on healthcare access and outcomes: findings from a state-wide representative cross-sectional survey in California by Lei Chen, Michelle Kao Nakphong, May Sudhinaraset, Nadereh Pourat, Maria-Elena De Trinidad Young

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Characterization of Pregnant Women treated at the Center for Assisted Reproduction by Linett León Díaz, Aimé María Reyes Pérez, Práxedes Rojas Quintana, Aida María Reyes Pérez, Neysi Matilde Chávez González

“…However, it represents a crisis for couples whose life projects are threatened, suffering not only at the time of diagnosis and during treatment, but also in many everyday situations.…”
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Characterization of High Grade Intraepithelial Cervical Lesion among Adolescents and Young Women by Carlos Eric Daudinot Cos, Albania Rodríguez Spinola, Viviana de la Caridad Sáez Cantero, Ana Isabel de la Torre Jiménez

“…It included 52 patients, all of them younger than 24 years old, who had been diagnosed with high-degree cervical pathology and were treated in the cervix pathology consultation of the "Ramón González Coro" Teaching Gynecologic and Obstetric Hospital from January 2007 to December 2008. Risk factors and diagnosis variables were studied and processed using the SPSS 11.5 system for Windows, through the determination of absolute and relative frequencies. …”
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Retinal Fundus Image Enhancement Using the Normalized Convolution and Noise Removing by Peishan Dai, Hanwei Sheng, Jianmei Zhang, Ling Li, Jing Wu, Min Fan

“…Retinal fundus image plays an important role in the diagnosis of retinal related diseases. The detailed information of the retinal fundus image such as small vessels, microaneurysms, and exudates may be in low contrast, and retinal image enhancement usually gives help to analyze diseases related to retinal fundus image. …”
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Lessons Learned from Experimental Human Model of Zinc Deficiency by Ananda S. Prasad

“…Development of sensitive immunological biomarkers may be more sensitive than an assay of zinc in plasma and peripheral blood cells for diagnosis of marginal zinc deficiency in human.…”
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Primary Cardiac Angiosarcoma: A Fatal Disease by L. Antonuzzo, V. Rotella, F. Mazzoni, L. Doni, D. Bianchini, F. Garbini, V. Maio, F. Di Costanzo

“…This paper confirms that cardiac angiosarcoma is a fatal disease, and the prognosis is usually 6–11 months from time of diagnosis.…”
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MDRN: Multi-distillation residual network for efficient MR image super-resolution by Liwei Deng, Jingyi Chen, Xin Yang, Sijuan Huang

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Usefulness of Immunological Detection of the Human Telomerase Reverse Transcriptase by Annalisa Volpi, Sara Bravaccini, Laura Medri, Serenella Cerasoli, Michele Gaudio, Dino Amadori

“…Objective: Recent years have seen a considerable wealth of studies conducted on the potential usefulness of telomerase determination in diagnosis, prognosis and targeted cancer therapy. The frequently used Telomeric Repeat Amplification Protocol assay suffers from some drawbacks, the most important being the rate of false positives. …”
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Proceedings of clinical trials on bile tract cancer by XIONG Yichen, YANG Ziyi, SANG Yuer, GONG Wei

“…So far, radical surgery is the main curative measure for BTC, most patients with BTC are already in progressive or advanced stage at the time of diagnosis. Even after radical surgical resection, the risk of tumor recurrence remains high, and the 5-year survival rate is low. …”
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Characterization of Type 2 Diabetics with Vascular Complications in Relation to Adherence to Treatment by Yadelaicy Ochoa González, Licet Utria Velázquez, Yousy Peña Escobar, Eizy Mastrapa Cruz, Zoraida de los Ángeles Cruz Paz

“…<strong><br />Conclusions:</strong> women over 50 years of age with psychosocial factors such as stress, anxiety and depression prevailed, mostly with more than 15 years of diagnosis and treatment. Non-adherent cases to treatment predominated.…”
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The Potential Diagnostic Value of Immune-Related Genes in Interstitial Fibrosis and Tubular Atrophy after Kidney Transplantation by Bin Yang, Dike Shi, Yahong Chen, Yi Zhu

“…This study identified 6 IF/TA-related genes, which might be used as a new diagnosis model in the clinical practice.…”
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Resilience and its relationship with disability in persons with bipolar disorder and schizophrenia: A comparative study by Arnab Datta, Dhrubajyoti Chetia

“…However, the type of disorder does not significantly affect the relationship between resilience and disability. Irrespective of diagnosis, higher resilience is associated with lower disability.…”
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Embolic risk management in infective endocarditis: predicting the ‘embolic roulette’ by Adela Mihaela Șerban, Diana Pepine, Andreea Inceu, Alexandra Dadarlat, Alexandru Achim

“…In this regard, embolic vascular dissemination—including asymptomatic cases detected through multimodality imaging—has been introduced as a new minor criterion for the diagnosis of IE.Depending on the location and severity of the embolism, the embolic risk can either escalate or alternatively, complicate and delay cardiac surgery. …”
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Delayed Cerebral Radiation Necrosis after Neutron Beam Radiation of a Parotid Adenocarcinoma: A Case Report and Review of the Literature by Christopher S. Hong, Hamza N. Gokozan, José J. Otero, Michael Guiou, J. Bradley Elder

“…Physicians should include the possible diagnosis of CRN in any patient with new neurologic signs or symptoms and a history of head and neck radiation that included planned fields extending to the base of the skull. …”
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