Soluble and cell-based markers of immune checkpoint inhibitor-associated nephritis by Sandra M Herrmann, Riley Fadden, Ryan J Sullivan, Kerry L Reynolds, Harish Seethapathy, Meghan E Sise, Shruti Gupta, Alexandra-Chloe Villani, Qiyu Wang, Daiana Moreno, Destiny Harden, R Neal Smith, Ivy A Rosales, Robert B Colvin, Sarah Chute, Lynn D Cornell, Nancy J Yang, Sara Barmettler, Sophia Wells, Jocelyn Farmer

“…Gene expressions for IL2RA, IL-2 signaling, and T cell receptor signaling in the kidney tissue with ICI-nephritis were significantly higher compared with controls.Conclusion Elevated sIL-2R level and flow cytometric markers of both B and T cell dysregulation may aid the diagnosis of ICI-nephritis.…”
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Differentiation of Early Sacroiliitis Using Machine-Learning- Supported Texture Analysis by Qingqing Zhu, Qi Wang, Xi Hu, Xin Dang, Xiaojing Yu, Liye Chen, Hongjie Hu

“…Patients were considered to have a confirmed diagnosis if their DR or CT grade was 4 for the sacroiliac joints and were thereby excluded. …”
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Transcriptomic Profiling and Tumor Microenvironment Classification Reveal Unique and Dynamic Immune Biology in HIV-Associated Kaposi Sarcoma by Jihua Yang, Ayse Ece Cali Daylan, Aleksei Shevkoplias, Ekaterina Postovalova, Meng Wang, Andrey Tyshevich, Matthew Lee, Hiba Narvel, Ksenia Zornikova, Nara Shin, Nikita Kotlov, Luca Paoluzzi, Changcheng Zhu, Balazs Halmos, Xingxing Zang, Haiying Cheng

“…Notably, HIV-negative KS samples showed alterations in NK cell-mediated immunity and cytotoxic response pathways, whereas HIV-positive samples exhibited changes in growth regulation and protein kinase activity pathways at the time of initial diagnosis. The gene expression of immune checkpoints, including CD274 (PD-L1) and PDCD1LC2 (PD-L2), was comparable between HIV-positive and HIV-negative KS samples at diagnosis. …”
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Clinicopathological and molecular characterization of astrocytoma by Xiaoyan Wu, Wenfeng Peng, Xu Zhang, Tao Tang, Ling Deng, Yuxia Xu, Xiaoyun Liu, Fang Wang, Wujian Peng, Jianrong Huang, Xiaoni Zhong

“…Identifying mutant genes can aid in reliable and early diagnosis, as well as provide insights for the development of targeted therapies.MethodsThis study aims to investigate the clinicopathologic and molecular characteristics of astroblastoma. …”
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Polymorphisms in immunosuppression-related genes are associated with AML by Mingying Li, Mingying Li, Jingjing Ye, Jingjing Ye, Mengyuan Chang, Mengyuan Chang, Lei Feng, Lei Feng, Tingting Liu, Tingting Liu, Di Zhang, Di Zhang, Yuyan Wu, Yuyan Wu, Yuechan Ma, Yuechan Ma, Guangqiang Meng, Guangqiang Meng, Chunyan Ji, Chunyan Ji, Tao Sun, Tao Sun

“…Additionally, rs4883263 in CD163 was related to low PLT count at diagnosis, while rs2272022 in CD200 was protective against low PLT count. rs4780335 in CIITA was associated with high WBC count at diagnosis and worse OS. …”
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Identification of strengths and weaknesses of the healthcare system for persons living with rare diseases in Catalonia (Spain), and recommendations to improve its comprehensive att... by José Hernández-Rodríguez, Fernando Martínez-Valle, Xènia Acebes, Carmen Alerany, Jordi Antón, Gonzalo Calvo, Marian Corral, Jordi Cruz, M. Antònia Mangues-Bafalluy, José Mateo, Josefa Rivera, Albert Salazar, Roser Francisco, Cristina Mallol, Rita Reig-Viader, Ariadna Tigri-Santiña, Assumpta Ricart, Francesc Palau

“…Abstract Background Rare diseases (RDs) are a heterogeneous group of complex and low-prevalence conditions in which the time to establish a definitive diagnosis is often too long. In addition, for most RDs, few to no treatments are available and it is often difficult to find a specialized care team. …”
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Wirelessly Powered Endoscopically Implantable Devices into the Submucosa as the Possible Treatment of Gastroesophageal Reflux Disease by J. Hajer, M. Novák, J. Rosina

“…The most specific symptoms which point to the diagnosis of GERD are feelings of heartburn and the regurgitation of acidic stomach contents into the esophagus. …”
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Idiopathic Generalized Epilepsy and Hypokalemic Periodic Paralysis in a Family of South Indian Descent by Muthiah Subramanian, N. Senthil, S. Sujatha

“…The understanding of mutations in ion-channel genes will lead to improved diagnosis and treatment of such inherited channelopathies.…”
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Colorectal Cancer in Patient with Functional Gastrointestinal Symptoms by Z. A. Mamieva, E. A. Poluektova, A. L. Kovaleva, O. S. Shifrin, V. P. Sobolev, V. M. Svistushkin, A. I. Ulyanin, A. S. Tertychnyy, V. T. Ivashkin

“…Colonoscopy was performed on admission, with diagnosis of rectal adenocarcinoma. The patient had a prompt surgical intervention, repeated courses of polychemotherapy and is currently followed by an oncologist and coloproctologist. …”
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Feasibility of Muscle Synergy Outcomes in Clinics, Robotics, and Sports: A Systematic Review by Juri Taborri, Valentina Agostini, Panagiotis K. Artemiadis, Marco Ghislieri, Daniel A. Jacobs, Jinsook Roh, Stefano Rossi

“…The present systematical review aims at providing an overview on the applications of muscle synergy theory in clinics, robotics, and sports; in particular, the review is focused on the papers that provide tangible information for (i) diagnosis or pathology assessment in clinics, (ii) robot-control design in robotics, and (iii) athletes’ performance assessment or training guidelines in sports.…”
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Multidimensional Analysis of PANoptosis-Related Molecule CASP8: Prognostic Significance, Immune Microenvironment Effect, and Therapeutic Implications in Hepatocellular Carcinoma by Fei Peng, Fang Zhu, Baodi Cao, Liang Peng

“…Hepatocellular carcinoma (HCC) presents significant challenges in diagnosis and treatment. Understanding the role of PANoptosis-related molecules in HCC is crucial for advancing therapeutic strategies. …”
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From skin to heart: The rare journey of pleomorphic dermal sarcoma metastasis by Maria Gabriela Matta, MD MSc, Dipesh Raniga, MD, Vinicius Carraro do Nascimento, MD, Gayle Therese Hill, BSc, Mohamed Nasser Essack, MD, Ian Agahari, MD

“…Advanced imaging revealed tumour invasion into the left atrium, leading to palliative chemotherapy and ultimately the patient's transition to palliative care 7 months after diagnosis. This case underscores the need for vigilance in monitoring potential metastasis in rare tumours like PDS.…”
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Autoimmune Conditions in 235 Hemochromatosis Probands with HFE C282Y Homozygosity and Their First-Degree Relatives by James C. Barton, J. Clayborn Barton

“…We performed a retrospective study of autoimmune conditions (ACs) in 235 hemochromatosis probands at diagnosis by analyzing age, sex, ACs, history of first-degree family members with ACs (FH), diabetes, heavy ethanol consumption, elevated serum ALT/AST, nonalcoholic fatty liver disease, viral hepatitis, cirrhosis, iron removed to achieve iron depletion (QFe), and positivity for human leukocyte antigen (HLA) haplotypes A∗01, B∗08; A∗02, B∗44; A∗03, B∗07; A∗03, B∗14; and A∗29, B∗44. …”
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Intrascrotal Dedifferentiated Leiomyosarcoma Originating from Dartos Muscle by Taro Teshima, Sayuri Takahashi, Shoichi Nagamoto, Hideyo Miyazaki, Tohru Nakagawa, Tetsuya Fujimura, Hiroshi Fukuhara, Haruki Kume, Yukio Homma

“…The tumor and the right testis were excised with the adhered right scrotal skin. The pathological diagnosis was pleomorphic leiomyosarcoma with dedifferentiation originating from the dartos muscle. …”
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Building m-health technology to promote breastfeeding by Jéssika Roberta Firme de Moura Santos, Maria Alzete de Lima, Ana Larissa Gomes Machado, Edina Araújo Rodrigues Oliveira, Adriele de Almeida Brito, Milena Leite Veloso, Luisa Helena de Oliveira Lima

“…The content was based on the precepts of Meaningful Learning, elaborated through a situational diagnosis and an integrative review, which guided the compilation of information and guidelines. …”
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Autoantibodies in a Three-Year-Old Girl with Visceral Leishmaniasis: A Potential Diagnostic Pitfall by Gholamreza Pouladfar, Zahra Jafarpour, Amir Hossein Babaei, Bahman Pourabbas, Bita Geramizadeh, Anahita Sanaei Dashti

“…Visceral leishmaniasis (VL), a life-threatening parasitic infection, is endemic in the Mediterranean region. Diagnosis of VL is based on epidemiologic, clinical, and laboratory findings. …”
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A Rare Sigmoid-Colon Schwannoma in a Premenopausal Woman: A Case Report by Aikaterini Selntigia, Benedetto Neri, Consuelo Russo, Francesco Giuseppe Martire, Giorgia Soreca, Dario Biasutto, Francesco Maria Di Matteo, Caterina Exacoustos

“…It could be challenging to make diagnosis in an early stage on asymptomatic patients. …”
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Causes and Intervention Strategies to Reduce Childhood Obesity in Ambato by Carlos David Castañeda Guillot, Diego Fernando Vaca Sánchez, María Augusta Reyes Pérez

“…The study was carried out in three phases; the first: for the diagnosis of knowledge patterns and gaps; the second: for the design and validation of the intervention program; and the third: to evaluate its effectiveness. …”
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Creating National Weights for a Patient-level Longitudinal Database by Onur Baser, Li Wang, Jon Maguire

“…**Results:** The following variables were used in the logistic regression: Age group, gender, race, location, income level and health status (Charlson Comorbidity Index scores and chronic condition diagnosis). Relative to MEPS data, patients included in the private insurance data were more likely to be male, older, to have a chronic condition, and to be white (p=0.0000). …”
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Toksigenitas Corynebacterium diphtheriae Pada Sampel Kejadian Luar Biasa Difteri Tahun 2010 – 2015 Menggunakan Elektes by Kambang Sariadji, Sunarno Sunarno

“…Jenis C.diphtheriae yang mampu memproduksi toksin disebut jenis toksigenik, sedangkan yang tidak memproduksi toksin disebut jenis non-toksigenik. Diagnosis laboratorium dalam mendeteksi C.diphtheriae dilakukan dengan cara kultur, isolasi dan identifikasi serta penentuan toksigenitas dari difteri. …”
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