Molecular Monitoring in Adult Philadelphia Chromosome-Positive Acute Lymphoblastic Leukemia with the Variant e13a3 BCR-ABL1 Fusion by Mireille Crampe, Laura Kearney, David O’Brien, C. Larry Bacon, Derville O’Shea, Stephen E. Langabeer

“…Molecular monitoring reflected the disease response from diagnosis through allogeneic stem cell transplantation which resulted in undetectable e13a3 BCR-ABL1 transcripts. …”
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Very Elevated IgE, Atopy, and Severe Infection: A Genomics-Based Diagnostic Approach to a Spectrum of Diseases by A. Chin, S. Balasubramanyam, C. M. Davis

“…As treatment is predicated on early diagnosis, genomic testing is becoming a more commonly used diagnostic tool. …”
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Perforated Meckel diverticulitis: Diagnostic challenges and surgical outcomes by Imen Ben Ismail, MD, Mohamed Karim Tounsi, MD, Mohamed Boujemaa, MD, Hakim Zenaidi, MD, Saber Rebii, MD, Ayoub Zoghlami, MD

“…This case highlights the importance of including Meckel's diverticulum in the differential diagnosis of acute abdomen in young patients, emphasizing the utility of CT imaging and the need for prompt surgical intervention to achieve favorable outcomes.…”
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Experimental Biomechanics of Neonatal Brachial Plexus Avulsion Injuries Using a Piglet Model by Anita Singh, Kalyani Ghuge, Yashvy Patni, Sriram Balasubramanian

“…Despite being reported in 10–20% of brachial plexus birthing injuries, it remains poorly diagnosed during the acute stages of injury, leading to poor intervention approaches. The poor diagnosis of brachial plexus avulsion injury can be attributed to the currently unavailable biomechanics of brachial plexus avulsion. …”
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Two Brothers with Bardet-Biedl Syndrome Presenting with Chronic Renal Failure by Cem Sahin, Bulent Huddam, Gulhan Akbaba, Hasan Tunca, Emine Koca, Mustafa Levent

“…Therefore, as one of the major diagnostic criteria, renal damage is of great importance in early diagnosis. This paper presents the cases of two brothers with BBS who presented with chronic renal failure.…”
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Abdominal Cocoon Syndrome: Two Cases of an Anatomical Abnormality by Apostolos Sovatzidis, Eirini Nikolaidou, Anastasios Katsourakis, Iosif Chatzis, George Noussios

“…Preoperative clinical suspicion of this disease can help determine the diagnosis and protect surgeons from intraoperative “surprises”.…”
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Diegif: An efficient and secured DICOM to EGIF conversion framework for confidentiality in machine learning training by Abdullah Al Siam, Md Maruf Hassan, Md Atikur Rahaman, Masuk Abdullah

“…The framework comprises four key components: (1) converting DICOM files to GIF format with encryption, (2) decrypting EGIF files for processing, (3) enabling confidentiality-preserving machine learning training using EGIF data, and (4) facilitating physician diagnosis and report generation based on trained machine learning models. …”
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Prognostic Factors for Cancer-Specific Survival and Disease-Free Interval of Dogs with Mammary Carcinomas by Elaine da Silva Soares, Fabrício Luciani Valente, Carolina Camargos Rocha, Carlos Eduardo Real Pereira, Thaís Barroso Sarandy, Fabiano Luiz Dulce de Oliveira, Sabrina Loise de Morais Calado, Andréa Pacheco Batista Borges

“…Among the dogs diagnosed with malignant neoplasms, 86% had early clinical stages (I–III), while 14% had regional or distant metastasis at the time of diagnosis. Carcinoma in a mixed tumor was the most frequent histological type with 44% of the cases and had the best prognosis. …”
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Silent Neuroleptic Malignant Syndrome: A Case Report of Atypical Antipsychotic Induced Elevation of Creatinine Kinase and Altered Mental Status by Amber N. Edinoff, Hamza Mohammad-Amin, Amira S. Odisho

“…34-year-old African American male with a diagnosis of schizophrenia was placed on aripiprazole and risperidone for psychosis and mood stabilization. …”
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Prevalence of Middle Ear Infections and Associated Risk Factors in Children under 5 Years in Gasabo District of Kigali City, Rwanda by Kaitesi Batamuliza Mukara, Richard J. Lilford, Debara Lyn Tucci, Peter Waiswa

“…Middle ear infections are common in children, and delay in diagnosis and treatment may result in complications such as delays in speech and language development and deafness. …”
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Omadacycline for the Treatment of Severe Legionella Pneumonia Complicated with Multiple Organ Failure: A Case Report by Xu L, Xiong Y, Fang C

“…After Legionella infection was confirmed by metagenomic next-generation sequencing, the patient was switched to omadacycline antibiotic therapy and eventually discharged after recovery.Conclusion: The results of this study suggest that metagenomic next-generation sequencing can facilitate early diagnosis of Legionnaires’ disease, and omadacycline can be an alternative antibiotic treatment for severe Legionnaires’ disease, especially in patients experiencing multiple organ failure.Keywords: Legionella pneumonia, Legionnaires‘disease, metagenomic next-generation sequencing, omadacycline, antibiotic therapy…”
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The Expression of miR-34a in Gingival Crevicular Fluid of Chronic Periodontitis and Its Connection with the TLR/NF-κB Signaling Pathway by Jiaxin Pan, Jue Liu, Lu Zhao

“…Its expression is associated with the degree of periodontal inflammation, periodontal tissue damage, and the activation of the TLR/NF-κB signaling pathway and could be used as a potential index for auxiliary diagnosis and severity of the disease.…”
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Neuroleptic Malignant Syndrome (NMS) on Clozapine with a Potential Atypical Interaction with Paliperidone by Paras Agarwal, Adanegbe Omoruyi, Kiara Gascon Perai, Kerenza MacDaid, Andrea Burton

“…The evidence further suggests that the presentation of NMS for patients on this medication may be different to the classical presentation, and other criteria for diagnosis are suggested, which may lower the threshold for investigating NMS for patients on clozapine.…”
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Primary Candida guilliermondii Infection of the Knee in a Patient without Predisposing Factors by Gun Woo Lee, Tae-Hun Kim, Jung-Hwan Son

“…If left untreated, irreversible deformity and pain with severe osteoarticular destruction occur. Thus, early diagnosis and treatment are important. This paper presents a case of 72-year-old man with primary C. guilliermondii infection of knee joint without predisposing factors and previous traumatic procedures, who was misdiagnosed with advanced degenerative osteoarthritis. …”
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Laparotomy for Advanced Abdominal Ectopic Pregnancy by Dereje Tegene, Sultan Nesha, Befikadu Gizaw, Tadele Befikadu

“…High index of suspicion and correlation of patient’s sign and symptom is very important to make early diagnosis.…”
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Mixed Germ Cell Tumor with Extensive Yolk Sac Tumor Elements in the Frontal Lobe of an Adult by Toshihide Takahashi, Eiichi Ishikawa, Yosuke Masuda, Tetsuya Yamamoto, Taiki Sato, Makoto Shibuya, Akira Matsumura

“…Histological examination of specimens after subtotal removal revealed a primary mixed germ cell tumor with extensive yolk sac tumor elements, often referred to as an intracranial “yolk sac tumor.” The preoperative diagnosis of NGGCTs in unusual age and locations is extremely difficult. …”
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Olmsted Syndrome by Renata Elise Tonoli, Damiê De Villa, Renata Hübner Frainer, Luana Pizzarro Meneghello, Nelson Ricachnevsky, Maurício de Quadros

“…It was first described by Olmsted in 1927. The diagnosis of this rare disease depends on clinical features like symmetrical involvement of keratoderma of the palms and soles and the symmetrical hyperkeratotic plaques around the body orifices. …”
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A rare case of temporal arteritis in a young Indian male by Debaditya Roy, Susmita Rakshit, Azeez Pasha, Abhishek Patil

“…No necrosis or giant cells were seen. A diagnosis of temporal arteritis (TA) was, thus, made. …”
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Effect of Arginine Vasopressin on Intraoperative Hypotension Caused by Oral Administration of 5-Aminolevulinic Acid by Gen Owada, Hideo Nishizawa, Yuki Matoyama, Eri Watanabe, Keigo Mitsuda, Naoki Kaneko, Yasuhiro Kimura, Taikan Nanao, Junichi Fujimoto

“…5-Aminolevulinic acid (5-ALA) is used for the photodynamic diagnosis of malignant tumors and has been effectively utilized to improve the complete resection rate and reduce the risk of tumor recurrence. …”
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TRANSFORMATION OF THE CONCEPT "SUBJECT" IN THE CLINICAL DISCOURSE OF PHILOSOPHICAL ANTHROPOLOGY by V. M. Skyrtach

“…The logic of the research coincides with the paradigmatic understanding of the subject’s transformations and suggests a transition from diagnostic strategies of the analysis of individual being as the basis of the pathological nature of the subject to the study of therapeutic models of communication as the determinants of pathology and, finally, to the analytics of the subject in the horizon of polysubject sociality.Originality of the work consists in disclosing the basic anthropological models of the subject, corresponding to the functions of diagnosis and therapy. It is shown that, in spite of the revolutionary nature of certain projects, which allows them to be classified as postmetaphysical, they still have relapses of metaphysics existing in the image of the subject, which is conceived as the basis of authenticity. …”
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