Case Report - Severe hypospadias in 46, XY karyotype patients: is third level genetic testing always mandatory? by Giorgia Romano, Giovanni Rollo, Lorna Spagnol, Mafalda Mucciolo, Ottavio Adorisio, Massimiliano Silveri

“…Too commonly, surgeons tend to attach importance to malformation repair and disregard the genetic diagnoses, but we believe that precise genetic diagnosis improves the accuracy of DSD management in terms of prognostic predictions, the development of an individualized management plan and the determination of treatment options.…”
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Incidence of Typhoid Fever in Nineveh Province from 2018-2022 by Ali Adel Dawood

“…The count of infected individuals belonging to the sick group was authenticated based on the clinical diagnosis and laboratory investigation. Ultimately, we used a statistical analysis tool with SPSS version 25. …”
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Spontaneous Thrombosis in Giant Aneurysm of the Anterior Communicating Artery Complex in Pediatric Age: Five-Year Follow-Up by Vítor M. Gonçalves, N. Cristino, M. Cunha e Sá

“…Noninvasive and radiation-free imagiological studies play an important role in the diagnosis and follow-up of these young patients. We present the case of a 3-month-old boy with an intracranial hemorrhage secondary to the rupture of a giant aneurysm of the anterior communicating artery complex, with spontaneous thrombosis, which is a rare situation due to its location. …”
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Promotion Mechanisms of Stromal Cell-Mediated Lung Cancer Development Within Tumor Microenvironment by Wu S, Hu Y, Sui B

“…The goal is to provide new insights and potential strategies for the diagnosis and treatment of lung cancer.Keywords: tumor microenvironment, lung cancer, stromal cells, immune cells, cancer-associated fibroblasts, endothelial cells…”
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Dentinogenic Ghost Cell Tumor of the Peripheral Variant Mimicking Epulis by Uddipan Kumar, Hitesh Vij, Ruchieka Vij, Jitin Kharbanda, IN Aparna, Raghu Radhakrishnan

“…Microscopic appearance of odontogenic epithelium admixed with focal areas of dentinoid formation and sheets of ghost cells giving the definitive diagnosis of dentinogenic ghost cell tumor imply that microscopic examination is compulsory for any gingival mass. …”
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Benzocaine-Induced Methemoglobinemia in a Postoperative Bariatric Patient following Esophagogastroduodenoscopy by Khuram Khan, Irwin White-Gittens, Saqib Saeed, Leaque Ahmed

“…Differentials of aspiration and pulmonary embolism were plausible; stat blood gas analysis clinched the diagnosis and managed with intravenous methylene blue.…”
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A Rare Cause of the Cough: Primary Small Cell Carcinoma of Esophagus—Case Report by Erdal Yekeler, Timur Koca, Semra Vural

“…Most of the cases are in extensive stage at the time of diagnosis. Surgery is the treatment of choice in limited stages, but treatment must be multimodal in primary small cell carcinoma of the esophagus. …”
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Pancreatic Perivascular Epithelioid Cell Tumour Presenting with Upper Gastrointestinal Bleeding by Christos Petrides, Kyriakos Neofytou, Aamir Z. Khan

“…Multiple biopsies taken showed extensive ulceration with granulation tissue formation and underlying large macrophages without being able to establish a definite diagnosis. We proceeded with pylorus-preserving pancreaticoduodenectomy. …”
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Conservative Management of Muscle Invasive Bladder Cancer in Kidney-Pancreas Transplant Patient by Logan D. Glosser, Brandon S. Zakeri, Conner V. Lombardi, Obi O. Ekwenna

“…This report demonstrates a unique case of a patient with kidney-pancreas transplant diagnosed with MIBC treated with TMT that has no evidence of gross tumorigenesis at 3.5 years after diagnosis. Our findings suggest that trimodal therapy should be considered for treatment of MIBC in patients with kidney-pancreatic transplants to preserve the donated allografts.…”
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Signal Feature Extraction and Quantitative Evaluation of Metal Magnetic Memory Testing for Oil Well Casing Based on Data Preprocessing Technique by Zhilin Liu, Lutao Liu, Jun Zhang

“…It can provide an early diagnosis of microdamages for preventive protection. …”
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Premalignant Lesions of the Colon by Rodger C Haggitt

“…Cancer of the colon and rectum is the second most common cancer in men and women in North America. Early diagnosis results in detection of early stage tumours with a high probability of cure. …”
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Chiari I malformation with neurogenic hypertension underwent suboccipital decompression: A case report by Steven Okta Chandra, I Putu Pramana Suarjaya, Ida Bagus Krisna Jaya Sutawan, Tjokorda Gde Agung Senapathi, Tjokorda Gde Bagus Mahadewa

“…An uncommon symptom is neurogenic hypertension, which remains controversial from its origin, its clinical clues that suggest the diagnosis, and the intervention best suited for its treatment. …”
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“Spontaneous epidural hematoma in a pediatric patient following pansinusitis: a case report and review of the literature” by Shahin Nazarpour, Farid Qoorchi Moheb Seraj, Seyed Morteza Sharifzadeh Khavari, Mehran Seadghat, Mohammad Ali Abouei Mehrizi

“…However, consideration of surgery facilitates reaching a reliable diagnosis and treatment.…”
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Role of immunotherapy in the overall survival of gastrointestinal cancer patients with liver metastases by Taoyuan M Beninato, Saber A Amin, Michael J Baine, Chi Lin

“…Aim: To investigate the role of immunotherapy in the overall survival (OS) of gastrointestinal cancer patients who have liver metastases at the time of the primary site cancer diagnosis.Materials & methods: Survival outcome was compared between groups with immunotherapy and groups without immunotherapy.Results: Chemoimmunotherapy was associated with improved OS (hazard ratio [HR] 0.768; 95% CI 0.739–0.800; p < 0.001) compared with chemotherapy alone. …”
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Silicone-Induced Granuloma of Breast Implant Capsule (SIGBIC): Histopathology and Radiological Correlation by Eduardo de Faria Castro Fleury, Gabriel Salum D’Alessandro, Sheila Cristina Lordelo Wludarski

“…Our experience demonstrates histological-radiological correlation in SIGBIC diagnosis. Knowledge of these findings may demonstrate its real importance in terms of public health and patient management. …”
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Extraintestinal manifestations of inflammatory bowel diseases: arthropathy and arthritis by Gulustan Hamid Sadygova

“…Meditate analysis of extraintestinal IBD manifestations, in particular IBD-associated arthropathy and arthritis, expands potential of time the diagnosis and adequate drug treatment to decrease disability risk and to improve quality of life of IBD patients.…”
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Ganglioneuroma of the External Auditory Canal and Middle Ear by Hesham Saleh Almofada, Michael Steven Timms, M. Anas Dababo

“…Ganglioneuroma should be considered in the differential diagnosis of patients presenting with recurrent ear discharge and decreased hearing in treated cases of neuroblastoma with metastases to temporal bone.…”
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Severe Erosive Pill Esophagitis Induced by Crizotinib Therapy: A Case Report and Literature Review by Patrick Jung, Kyle J. Fortinsky, Zane R. Gallinger, Piero Tartaro

“…Future research may help to uncover additional risk factors for this exceedingly rare diagnosis in this patient population. Most importantly, this case highlights nonpharmacologic ways to improve tolerability and decrease adverse effects of a highly effective chemotherapeutic agent.…”
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Familial Pemphigus Vulgaris Occured in a Father and Son as the First Confirmed Cases by Ali Haydar Eskiocak, Birgul Ozkesici, Soner Uzun

“…PV in father and son, as presented here, has not been reported in the literature before, except an unconfirmed report. The diagnosis of PV was established by histologic, cytologic studies and enzyme linked immunosorbent assay (ELISA) in Case 1 and by ELISA and BIOCHIP indirect immunofluorescence test in Case 2. …”
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A Comprehensive Review of Zavegepant as Abortive Treatment for Migraine by Nazir Noor, Alexis Angelette, Abby Lawson, Anjana Patel, Ivan Urits, Omar Viswanath, Cyrus Yazdi, Alan D. Kaye

“…The International Headache Society has defined criteria for the diagnosis of migraine with and without aura. The pathophysiology of migraine headaches is multifactorial so there are a variety of treatment approaches. …”
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