An exceptionally rare case of a diffuse midline glioma with concomitant H3.1 K27M and G34R mutations in the HIST1H3C (H3C3) gene by Zita Reisz, Rita Pereira, Smitha Nevis, Alan Mackay, Leena Bhaw, Yura Grabovska, Ross Laxton, Valeria Molinari, Anna Burford, Barnaby Clark, Cristina Bleil, Bassel Zebian, Erika Pace, Annette Weiser, Fernando Carceller, Lynley Marshall, Andrew King, Istvan Bodi, Safa Al-Sarraj, Chris Jones, Matthew Clarke

“…Histology showed diffusely infiltrating pleomorphic astrocytes, multinucleated cells, and conspicuous mitotic activity; the diagnosis was DMG, H3 K27-altered (immunohistochemistry: H3K27me3 loss, H3K27M positivity). …”
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Coupling of an Au@AgPt nanozyme array with an micrococcal nuclease-specific responsiveness strategy for colorimetric/SERS sensing of Staphylococcus aureus in patients with sepsis by Xueqin Huang, Yingqi Yang, Hanlin Zhou, Liping Hu, Annan Yang, Hua Jin, Biying Zheng, Jiang Pi, Jun Xu, Pinghua Sun, Huai-Hong Cai, Xujing Liang, Bin Pan, Junxia Zheng, Haibo Zhou

“…Overall, benefiting from highly active and dense “hot spot” substrate, MNase-mediated cascade response strategy, and colorimetric/SERS dual-signal output, this methodology will offer a promising avenue for the early diagnosis of S. aureus infection.…”
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Targeted Next-Generation Sequencing in Pneumonia: Applications in the Detection of Responsible Pathogens, Antimicrobial Resistance, and Virulence by Liu B, Bao Z, Chen W, Xi X, Ge X, Zhou J, Zheng X, Zhang P, Deng W, Ding R, Zhou M, Fang J

“…And patients with virulence genes detected were of higher proportions of severe pneumonia (95.0% vs 42.9%, P = 0.009), acute respiratory distress syndrome (55.0% vs 0%, P = 0.022), and neutrophils (82.3% vs 62.2%, P = 0.026) than those not.Conclusion: In patients with pneumonia, tNGS could detect the responsible pathogens, AMR genes, and virulence genes simultaneously, serving as an efficient and cost-effective tool for the diagnosis, treatment, and severity indication of pneumonia.Keywords: targeted next-generation sequencing, pneumonia, pathogen, antimicrobial resistance, virulence…”
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Monitoring the Spread of Multidrug-Resistant <i>Escherichia coli</i> Throughout the Broiler Production Cycle by Victor Dellevedove Cruz, Danilo Henrique Rabaçal Alves, Jamile Kellen de Souza, Maísa Fabiana Menck-Costa, Bruno Henrique Dias de Oliva, Ana Angelita Sampaio Baptista, Alexandre Oba, Fabrizio Matté, Kácio Emílio Borges Baierle, Sérgio Paulo Dejato da Rocha, Kelly Cristina Tagliari de Brito, Benito Guimarães de Brito, Gerson Nakazato, Marcio Costa, Renata Katsuko Takayama Kobayashi

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Navigating Emergency Management of Cancer Patients: A Retrospective Study on First-Time, End-Stage, and Other Established Diagnoses in a High Turnover Emergency County Hospital by Mihaela Corlade-Andrei, Radu-Alexandru Iacobescu, Viorica Popa, Alexandra Hauta, Paul Nedelea, Gabriela Grigorasi, Monica Puticiu, Roxana Elena Ciuntu, Andreea Ivona Sova, Diana Cimpoesu

“…This study aims to determine the burden of end-stage and first-time diagnosis of cancer on emergency care in a high-turnover emergency care center. …”
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Acute phase responses in clinically healthy multiparous Holsteins with and without calcium dysregulation during the early postpartum period by J.A. Seminara, C.R. Seely, J.A.A. McArt

“…We hypothesized that dyscalcemic cows would experience more activated inflammation than eucalcemic cows and that inflammation would precede dyscalcemia diagnosis. Multiparous Holstein cows at 2 commercial dairy farms in central New York were enrolled from a parent study based on tCa at 4 DIM, at a 2:1 ratio of eucalcemic (tCa >2.3 mmol/L; n = 32) to dyscalcemic cows (tCa <2.2 mmol/L; n = 16). …”
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Pengaruh Hiperglikemia terhadap Gambaran Histopatologis Pulau Langerhans Mencit by Muhammad Farid, Eryati Darwin, Delmi Sulastri

“…Banyaknya teori patogenesis dan perjalanan penyakit yang melibatkan interaksi kompleks banyak faktor menyebabkan pendekatan terapi diabetes masih berpusat pada tindakan preventif dan diagnosis diabetes ditegakkan sepenuhnya dari ada atau tidaknya hiperglikemia. …”
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Profil Pasien Pneumonia Komunitas di Bagian Anak RSUP DR. M. Djamil Padang Sumatera Barat by Osharinanda Monita, Finny Fitry Yani, Yuniar Lestari

“…Penelitian ini bersifat deskriptif dengan menggunakan data rekam medik anak yang dirawat dengan diagnosis utama pneumonia periode 1 Januari 2010 sampai 31 Desember 2012 dan diperoleh jumlah sampel sebanyak 178 orang anak. …”
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Masquerade Syndrome of Multicentre Primary Central Nervous System Lymphoma by Silvana Guerriero, Ermete Giancipoli, Lorenza Ciracì, Giuseppe Ingravallo, Marcella Prete, Elisabetta Di Leo, Antonietta Cimmino, Nicola Cardascia

“…All ophthalmologists and clinicians must be aware of masquerade syndromes, in order to avoid delays in diagnosis.…”
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Different Clinical Features of Acral Abortive Hemangiomas by N. Vega Mata, J. C. López Gutiérrez, B. Vivanco Allende, M. S. Fernández García

“…Immunohistochemical Glut-1 was performed in all of them as a way to confirm the abortive hemangioma diagnosis. The most common appearance was a reticulated erythematous patch with multiple fine telangiectasias on the surface. …”
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Presentation and Surgical Management of Duodenal Duplication in Adults by Caroline C. Jadlowiec, Beata E. Lobel, Namita Akolkar, Michael D. Bourque, Thomas J. Devers, David W. McFadden

“…Duodenal duplications in adults are exceedingly rare and their diagnosis remains difficult as symptoms are largely nonspecific. …”
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Persistent CSF Rhinorrhoea, Pneumocephalus, and Recurrent Meningitis Following Misdiagnosis of Olfactory Neuroblastoma by Neil Barua, David A. Hilton, William Mukonoweshuro, Hisham Khalil, Louis Pobereskin

“…Histological examination of an endonasal transethmoidal biopsy suggested a diagnosis of olfactory neuroblastoma. A profuse CSF leak occurred and the patient developed coliform meningitis. …”
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An Unusual Presentation of Idiopathic Lymphatic Cyst of the Thigh by Chairat Burusapat, Sophilak Sringkarawat, Sineenard Thanapurirat, Rapeepat Sapruangthong, Chatchai Pruksapong, Kantang Satayasoontorn

“…Completed surgical resection was performed for definitive diagnosis and treatment. Immunohistochemical studies revealed the cell lining was positive for CD34, CD31, and D2-40 and negative for calretinin. …”
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Iron Deficiency Anemia in Adult Onset Still's Disease with a Serum Ferritin of 26,387 μg/L by Sheetal Patel, Seyed Monemian, Ayesha Khalid, Harvey Dosik

“…The combination has clinical relevance and allows deductions about the presence of serum ferritin at 26,387 μg/L despite obvious iron depletion. The diagnosis of iron deficiency anemia was delayed and became fully obvious when her Still's disease remitted and serum ferritin decreased to 6.5 μg/L. …”
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Adjuvant ozone therapy in necrotizing soft tissue infection. Presentation of a case by Isidro Lamote Matos, Jorge Enrique Rodríguez León, Maydelin Pérez Reina, Niuvys Valera Rodríguez

“…The case of a 73-year-old patient with a diagnosis of phlyctenular lymphangitis with a large area of necrosis in the right leg is presented. …”
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Management of a Complex Dentoalveolar Traumatic Injury with Multiple Avulsions by Anita Thakur, Seema Thakur

“…This case report includes proper history taking, diagnosis, and treatment of a complex dentoalveolar trauma along with short-term prosthetic rehabilitation for improvement of aesthetics, phonetics, and mastication of growing child.…”
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Bile Duct Adenoma with Oncocytic Features by E. J. Johannesen, Zihao Wu, Jason-Scott Holly

“…A 61-year-old male with a diagnosis of colorectal adenocarcinoma was undergoing surgery when a small white nodule was discovered on the surface of the right lobe of his liver. …”
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Peroneal Nerve Palsy Caused by Proximal Fibular Solitary Osteochondroma: Case Report and Literature Review by Takashi Kozu, Masayoshi Machida, Katsuaki Taira, Noboru Oikawa, Naho Nemoto, Kazuyoshi Nakanishi

“…Conventional wisdom states that surgery should be performed within 3 months, but we recommend that surgery be performed as soon as diagnosis is made even in cases with a long history, as it may improve patient symptoms and outcomes.…”
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Adenoid-Cystic Carcinoma of Nasal Septum and Pterygo-Palatine Fossa by Santanu Dutta, Sudipta Pal, Sirshak Dutta

“…The article is aimed to highlight the clinical features, diagnosis, endoscopic approach for surgical management and long term post operative follow up of this rare entity. …”
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An Atypical Porencephalic Cyst Manifesting as a Simple Partial Seizure: A Case Report and Literature Review by Abdulaziz Ibrahim Al Thafar, Abdullatif Sami Al Rashed, Bayan Abdullah Al Matar, Abdulaziz Mohammad Al-Sharydah, Abdulrahman Hamad Al-Abdulwahhab, Sari Saleh Al-Suhibani

“…We describe a case involving a 23-year-old male who presented with involuntary movements of the left upper limb of 6 months’ duration. A diagnosis of porencephaly was confirmed by magnetic resonance imaging (MRI). …”
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