Antenatal Corticosteroids: A Risk Factor for the Development of Chronic Disease by Elizabeth Asztalos

“…However, exogenous ACS reduces birth weight which, in turn, is associated with adverse adult outcomes such as coronary heart disease, stroke, hypertension, and type 2 diabetes. The long-term effects of ACS exposure on HPA axis activity and neurological function are well documented in animal studies, and it appears that ACS, regardless of dose exposure, is capable of affecting fetal HPA axis development causing permanent changes in the HPA axis that persists through life and is manifested by chronic illness and behavioral changes. …”
Get full text

Adropin: a key player in immune cell homeostasis and regulation of inflammation in several diseases by Junmin Wang, Ning Ding, Chong Chen, Simin Gu, Jing Liu, Yanping Wang, Liubing Lin, Yiyuan Zheng, Yong Li

“…To enhance the understanding of adropin’s immune-modulating and anti-inflammatory mechanisms, this review synthesizes recent findings on its effects in conditions such as atherosclerosis, diabetes, fatty liver, non-alcoholic hepatitis, and inflammation. …”
Get full text

Selective Modulators of PPAR-γ Activity: Molecular Aspects Related to Obesity and Side-Effects by Fang Zhang, Brian E. Lavan, Francine M. Gregoire

“…Based on this concept, new and improved antidiabetic agents for the treatment of diabetes are in development. This review summarizes the current knowledge on the mechanism of action and biological effects of recently characterized SPPARγMs, including metaglidasen/halofenate, PA-082, and the angiotensin receptor antagonists, recently characterized as a new class of SPPARγMs.…”
Get full text

Clinical Aspects of Trace Elements: Zinc in Human Nutrition – Zinc Deficiency and Toxicity by Michelle M Pluhator, Alan Br Thomson, Richard N Fedorak

“…Conditioned deficiencies have been reported to result from malabsorption syndromes, acrodermatitis enteropathica, alcoholism, gastrointestinal disease, thermal injury, chronic diseases (eg, diabetes, sickle cell anemia), and in total parenteral nutrition therapy. …”
Get full text

Las dos caras del veganismo: beneficios y riesgos en la salud de una dieta vegana by José Alfredo González-Ortiz

“…Múltiples estudios evidencian efectos benéficos de la dieta vegana como un menor riesgo de presentar enfermedades cardiovasculares, obesidad o diabetes mellitus tipo 2. En contraste, se le asocia con un incremento en el riesgo de fracturas, trastornos ortoréxicos, anemia megaloblástica, entre otros. …”
Get full text

Abnormal Decrease of Macrophage ALKBH5 Expression Causes Abnormal Polarization and Inhibits Osteoblast Differentiation by Junquan Weng, Haidong Fan, Huijuan Liu, Su Tang, Yuyan Zheng

“…RNA sequencing revealed that ALKBH5 expression was abnormally reduced in diabetic peri-implantitis. Further mechanism study showed that ALKBH5 and its mediated m6A can influence osteogenic differentiation, which in turn influences the persistence of diabetic peri-implantitis. …”
Get full text

Exercise as a Mean to Control Low-Grade Systemic Inflammation by Neha Mathur, Bente Klarlund Pedersen

“…Chronic noncommunicable diseases (CNCDs), which include cardiovascular disease, some cancers, for example, colon cancer, breast cancer, and type 2 diabetes, are reaching epidemic proportions worldwide. …”
Get full text

Primary Carcinoma in Squamous Cells of the Gallbladder by Javier Martínez Navarro, Virgen Yazmín Martínez Navarro, Lisanka Fumero Roldán

“…A case of an 81 year old patient is presented, with antecedents of type II diabetes mellitus and high blood pressure on permanent drug treatment. …”
Get full text

Mediation model with a categorical exposure and a censored mediator with application to a genetic study. by Jian Wang, Jing Ning, Sanjay Shete

“…We assessed the empirical performance of the proposed overall measures via simulation studies and applied the measures to evaluate the mediating effect of a women's age at menopause on the association between genetic variants and type 2 diabetes.…”
Get full text

The impact of obesity on disease activity and other health outcome measures in rheumatoid arthritis by Ankur Dalal, Rizwan Rajak

“…Obesity is a common risk factor for noncommunicable diseases such as hypertension and diabetes. It is believed to be a state of low-grade inflammation. …”
Get full text

Emerging Stem Cell Therapies: Treatment, Safety, and Biology by Joel Sng, Thomas Lufkin

“…The autologous transplantation of mesenchymal stem cells is increasingly employed to catalyze the repair of mesenchymal tissue and others, including the lung and heart, and utilized in treating various conditions such as stroke, multiple sclerosis, and diabetes. There is also increasing interest in the therapeutic potential of other adult stem cells such as neural, mammary, intestinal, inner ear, and testicular stem cells. …”
Get full text

The Role of PPARγ in the Transcriptional Control by Agonists and Antagonists by Tamotsu Tsukahara

“…In recent years, peroxisome proliferator-activated receptor gamma (PPARγ) has been reported to be a target for the treatment of type II diabetes. Furthermore, it has received attention for its therapeutic potential in many other human diseases, including atherosclerosis, obesity, and cancers. …”
Get full text

To Use or Not to Use Metformin in Cerebral Ischemia: A Review of the Application of Metformin in Stroke Rodents by Isaac Arbeláez-Quintero, Mauricio Palacios

“…Epidemiological reports indicate that metformin is an oral antidiabetic medication that can reduce the incidence of ischemic events in patients with diabetes mellitus. Its mechanism of action has not been elucidated, but metformin pleiotropic effects involve actions in addition to glycemic control. …”
Get full text

Gut Microbiome: An Intersection between Human Genome, Diet, and Epigenetics by Abdullahi Y. Muhammad, Malik Amonov, Atif A. Baig, Farrukh J. Alvi

“…Specific genetic variants in genes that are responsible for maintaining the composition of the gut commensal, such as genes of the immune system, are described to result in gut dysbiosis that can lead to the development of several autoimmune diseases such as inflammatory bowel disease and type-1 diabetes. Similarly, the diet of an individual shapes the gut microbiota by allowing the predominance of microbes that metabolize an abundant macromolecule in the diet. …”
Get full text

Metabolic dysfunction-associated steatotic liver disease by Chieh Chen, Da-Ming Liao

“…This study mainly searched for articles published in databases such as Cochrane Library, PubMed (Medline), UpToDate, and Google Scholar, using keywords related to digestive disease, metabolic syndrome, fatty liver, diabetes mellitus, and obesity. Case–control studies, systematic review, meta-analyses, and randomized controlled trials were also searched to explore the epidemiology and prevention of obesity or MASLD and to propose risk factors for MASLD, considering that early prevention keeps an unhealthy condition from progressing to serious chronic diseases.…”
Get full text

Insulin Resistance: A Proinflammatory State Mediated by Lipid-Induced Signaling Dysfunction and Involved in Atherosclerotic Plaque Instability by Fabrizio Montecucco, Sabine Steffens, François Mach

“…This condition characterizes several diseases, such as type 2 diabetes, impaired glucose tolerance (IGT), impaired fasting glucose (IFG), obesity, hypertension, dyslipidemia, and other endocrinopathies, but also cancer. …”
Get full text

Signaling Pathway Puts the Break on Fat Cell Formation by Ormond A. MacDougald

“…Unfortunately, excess fat or adipose tissue is associated with a wide array of health problems, including increased incidence of type II diabetes, cardiovascular disease, hypertension, sleep apnea, and skeletomuscular problems [4,5,6]. …”
Get full text

The Association of SGLT-2 inhibitors (Empagliflozin) with the development of hypernatremic dehydration: a case report by Diana Alegre-González, Sandra García-Guerreros, Sara Martínez-Hernández, Ana Yasmina Brito-Díaz, Marta Casañas-Martínez, Ramón Baeza-Trinidad

“…Due to their beneficial effects, they are currently used in treatment of both diabetes mellitus and heart failure, leading to widespread use in recent years. …”
Get full text

Cellular Stress Responses: Cell Survival and Cell Death by Simone Fulda, Adrienne M. Gorman, Osamu Hori, Afshin Samali

“…The implications of cellular stress responses to human physiology and diseases are manifold and will be discussed in this review in the context of some major world health issues such as diabetes, Parkinson's disease, myocardial infarction, and cancer.…”
Get full text

Successful Aging and Longevity in Older Old Women: The Role of Depression and Cognition by Daniel Paulson, Mary Elizabeth Bowen, Peter A. Lichtenberg

“…Mortality at 2, 6, and 8 year intervals was predicted using CVB (diabetes, heart disease, hypertension), depressive symptoms (Center for Epidemiological Studies Depression Scale), and cognitive decline (decline of 1 standard deviation or more on the 35-point Telephone Interview for Cognitive Status over 2 years). …”
Get full text