Olfactory mucosa-mesenchymal stem cells with overexpressed Nrf2 modulate angiogenesis and exert anti-inflammation effect in an in vitro traumatic brain injury model by Zigui Chen, Chunyuan Zhang, Yuhua Fang, He Zhang, Jiawei Luo, Changfeng Miao, Jiale Li, Jun Peng, Yingqi Qiu, Ying Xia, Qisheng Luo

“…Abstract Background Traumatic brain injury (TBI) is a major cause of disability and mortality among children and adults in developed countries. Transcription factor nuclear factor erythroid-derived 2-like 2 (Nrf2) has antioxidant, anti-inflammatory and neuroprotective effects and is closely related to TBI. …”
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Efficacy of an intervention to increase therapeutic adherence in patients with secondary prevention for cardiovascular disease: a study protocol for a randomized controlled trial by Francisco Manuel Lidón-Muñoz, José Antonio Quesada, José Antonio Quesada, José Antonio Quesada, Vicente Francisco Gil-Guillén, Vicente Francisco Gil-Guillén, Vicente Francisco Gil-Guillén, Domingo Orozco-Beltrán, Domingo Orozco-Beltrán, Domingo Orozco-Beltrán

“…Moreover, this is particularly pertinent for high-risk patients, such as those in secondary prevention, given that cardiovascular disease remains the leading cause of mortality in developed countries. This trial has been registered at clinicalTrials.gov, https://clinicaltrials.gov/study/NCT06510946.…”
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Clinicodemographic profile and predictors of poor outcome in hospitalised COVID-19 patients: a single-centre, retrospective cohort study from India by Prashant K Singh, Lokesh Tiwari, Alok Ranjan, Prakriti Gupta, Prabhat Kumar Singh, Yogesh Kumar, Yankappa N, Amrita Banerjee, C M Singh

“…A strong predictor of mortality was disease progression on days 3–5 of admission (adjusted OR 13.66 95% CI 3.47 to 53.68).Conclusion COVID-19 related mortality in hospitalised adult patients at our center was similar to the developed countries. Progression in disease severity on days 3–5 of admission or days 6–13 of illness onset acts as ‘turning point’ for timely referral or treatment intensification for optimum use of resources.…”
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Oncological outcomes following extreme oncoplastic breast conserving surgery (eOPBCS) for locally advanced breast cancer (LABC): A systematic review and meta-analysis by Megan Chua Wern Ee, Ashley Lee Shi Hui, Wong Hung Chew, Emmeline Elaine Cua-Delos Santos, Sean Li Siwei, Sng Ming Xian, Qin Xiang Ng, Serene Goh Si Ning

“…Introduction: Locally advanced breast cancer (LABC) accounts for 5 % of new breast cancer diagnoses in developed countries and 30–60 % in developing regions. Historically, treatment relied on mastectomy guided by the Halstedian theory. …”
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Epidemiology of neonatal disorders attributable to low birthweight-global burden of disease research, 1990–2021 by Qi Zhang, Lan Luo, Lai-lai Yan, Lai-lai Yan, Jing Guo, Hui-jun Wu, Zi-wei Zhang, Yu-hua Zhu, Rui Qiao, Rui Qiao

“…Notably, absolute health inequality related to the Socio-demographic Index (SDI) has decreased, as indicated by a reduction in DALY disparities between the most and least developed countries from −4,216.49 (95% CI: −4,558.27 to −3,874.71) in 1990 to −2,635.35 (95% CI: −2,868.40 to −2,402.30) in 2021. …”
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Workplace Health Promotion as a good solution to the negative impact of the financial crisis on healthcare systems by Francesco Chirico

“…Primary care, especially preventive medicine, has been one of the sectors most affected by the deterioration of healthcare standards, which is in turn the most effective strategies against some of the deadliest conditions affecting developed countries, such as cancer and cardiovascular diseases. …”
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Hospital Prevalence of Colorectal Cancer among Colonoscopy Recipients Attending a Tertiary Hospital in Oman: A Cross-Sectional Study by Alanoud F. Alsumait, Yahya M. Al-Farsi, Mostafa I. Waly, Issa S. Al-Qarshoobi, Samir Al-Adawi, Nawaf H. Albali, Mansour S. Al-Moundhri

“…Evidence from industrialized/developed countries showed that colorectal cancer (CRC) incidence rates have significantly dropped due to the widespread use of colonoscopy. …”
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Effects of Therapeutic Hypothermia and Minimal Enteral Nutrition on Short-Term Outcomes in Neonates with Hypoxic–Ischemic Encephalopathy: A 10-Year Experience from Oman by Manoj Malviya, Sathiya Murthi, Dhanya Jayaraj, Vidya Ramdas, Fadia Nazir Malik, Valsala Nair, Nusrabegam Marikkar, Mukesh Talreja, Tariq Sial, Prakash Manikoth, Renjan Varghese, Khalsa Ali Al Ramadhani, Salima Al Aisry, Said Al Kindi, Ahmed Al Habsi, Ranjit Torgalkar, Munawwar Ahmed, Mohammed Al Yahmadi

“…Background: Therapeutic hypothermia (TH) is the standard treatment for moderate to severe hypoxic–ischemic encephalopathy (HIE) in developed countries, but data on its safety and efficacy in low-middle-income countries are limited and often conflicting. …”
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Designing and explaining the improvement model of women's employability capacity with emphasis on the 7th development plan by Mahsa Vahidpour, Akbar Etebarian Khorasgani, Mehrban Hadi Peykani, Saeed Daei-Karimzadeh

“…The human development index for women in developed countries is 80%, in underdeveloped countries it is 60% for men, and in Iran, the index is 61% for men. …”
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The role of smell in medical and psychological disorders: An interdisciplinary approach by Giuseppe Riva

“…Epidemiologic studies about smell disorders in developing countries are still lacking. Olfactory dysfunction could be conductive, sensorineural, or central. …”

Prevalence and determinants of post-neonatal mortality in East Africa: a multilevel analysis of the recent demographic and health survey by Alebachew Ferede Zegeye, Desale Bihonegn Asmamaw, Wubshet D. Negash, Wubshet D. Negash, Tadele Biresaw Belachew, Elsa Awoke Fentie, Atitegeb Abera Kidie, Tsegaw Amare Baykeda, Samrawit Mihret Fetene, Banchlay Addis, Sisay Maru Wubante, Abel Endawkie, Tadesse Tarik Tamir

“…Developing and developed countries still differ significantly in neonatal mortality rates. …”
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Stem cells for age-related macular degeneration by L.K. Moshetova, O.I. Abramova, I.N. Saburina, K.I. Turkina

“…Currently, this disorder is the leading cause of disability, blindness, and reduced quality of life in people aged over 50 in developed countries and is therefore important medical social issue. …”
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Diagnostics and treatment of gastroesophageal reflux disease: clinical guidelines of the Russian gastroenterological association by V. T. Ivashkin, I. V. Mayev, I. . A.s. Trukhmanov, Ye. K. Baranskaya, O. B. Dronova, O. V. Zayratyants, R. G. Sayfutdinov, A. A. Sheptulin, T. L. Lapina, S. S. Pirogov, Yu. A. Kucheryavy, O. A. Storonova, D. N. Andreyev

“…The heartburn that is a leading GERD symptom is present at 20-40% of the population of developed countries. The prevalence of GERD in Russia ranges 18­46%. …”
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Protocol, rationale and design of DAbigatran for Stroke PreVention In Atrial Fibrillation in MoDerate or Severe Mitral Stenosis (DAVID-MS): a randomised, open-label study by Andrew Ng, Esther W Chan, Duo Huang, Cheung Chi Lam, Ning Tan, Chung Wah Siu, Jo Jo Hai, Ji-yan Chen, Chun Ka Wong, Mi Zhou, Yuk Ming LAU, Chor Cheung Frankie Tam, Yiu Tung Anthony Wong, See Yue Arthur Yung, Ki Wan Kelvin Chan, Yingqing Feng, Chi Yui Yung, Kwok Lun Lee, Chun Wai Choi, Ho Lam, Katherine Fan, Man Hong Jim, Kai Hang Yiu, Bryan P. Yan

“…Nonetheless, the safety and effectiveness of NOACs have not been evaluated in patients with AF with underlying moderate or severe mitral stenosis (MS), hence the recommended stroke prevention strategy remains warfarin therapy.Method and analysis MS remains disproportionately prevalent in Asian countries compared with the developed countries. This prospective, randomised, open-label trial with blinded endpoint adjudication aims to evaluate the safety and efficacy of dabigatran for stroke prevention in AF patients with moderate or severe MS. …”
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Bridge Employment Model of Qualified Employees in Iran's Public Organizations by Seyedeh Sanaz Sadafi Mousavi, Mir ali Syed nagavi, Seyed Mehdi Alvani, Alireza Koushki Jahromi

“…It should be mentioned that the prerequisite for the correct implementation of Paul's employment in governmental and non-governmental organizations of the country is the formulation and implementation of appropriate human resources policies and strategies.Introduction Population aging is a global demographic trend, and developed countries are preparing to take advantage of its most positive effects. …”
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Presenting the model of portfolio management in investment funds based on behavioral financial variables by Seyed Mohammad Hadi Shahamat, Mahdi Mohammad Bagheri, Ali Raispour Rajabali, Mohsen Zayandeh Roudi

“…Investment funds On the other hand, in most of the developed countries, investment funds are considered as the central core of the capital market and they direct huge amounts of wandering capital to the productive and active sectors of the society every month. …”
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Presenting the entrepreneurial school model in Iran by tayebeh shahrostambeig, esmat Masoudi Nadushan, zahra taleb

“…On the one hand, according to the researches, entrepreneurial opportunities in developing countries such as Iran are seven times more than that of developed countries; and on the other hand, the inefficiency of formal education for reasons such as low quality and inflexibility of the country's education system according to the current needs of the community and the increase in unemployment of graduates due to the lack of skill-oriented empowerment, doubles the movement towards the generation of entrepreneurial schools (Fathy karkaragh et al, 2021). …”
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Investigating causal relationships between entrepreneurial education and sustainable employment generation in Islamic Azad Universities in Tehran by Sana Abdulali, Mohammad Naghi Imani GelepordesariI, Asghar Sharifi

“…Theoretical Framework Entrepreneurship education For years, the subject of entrepreneurship in developed countries has attracted the attention of scientists, officials and people, and it has become one of the most popular academic fields. …”
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Antecedents and consequences of professional competence of school administrators with emphasis on environmental sustainability and sustainable development by mohamadreza rasouli, ghafar tari, hossein Baghaei

“…With growing public concerns about the long-term consequences of environmental issues and climate change, and its negative impact on the growth and development of societies, particularly in less developed countries, proactive and innovative measures have been taken to embrace environmental responsibilities and professional competencies. …”
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Presenting the model of managerial competencies of women in the industry (case study: Sabah Food Company) by masoomeh samadi, mohammad mohammadi, Hamid Rezaei Far, hossein hakimpour

“…On the other hand, in many developing countries, following the example of developed countries, the isomorphic imitation approach has been used, which evidence shows that the use of this method is not very effective due to social, cultural and political differences (Adachi et al, 2020). …”
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