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34621
A novel ddPCR™ assay for eDNA detection and quantification of Greater Amberjack Seriola dumerilli and three congeners in US waters: challenges and application to fisheries independ...
Published 2025-01-01“…The study presented here is part of a fisheries-independent project initiated to determine an absolute abundance of S. dumerili, to expand biological knowledge of the species and to develop novel tools for fisheries management. …”
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34622
Association of clinical signs of possible serious bacterial infections identified by community health workers with mortality of young infants in South Asia: a prospective, observat...
Published 2025-02-01“…Methods: We conducted a population-based, prospective observational cohort study at five sites in Bangladesh (Sylhet, November 01, 2011–December 31, 2013), India (Vellore and Odisha, September 01, 2013–February 28, 2015), and Pakistan (Karachi, January 01, 2012–December 31, 2013; Matiari, March 01, 2012–December 31, 2013) to identify newborn infants who were followed-up by CHWs through 10 scheduled home visits over the first 60 completed days after birth to identify signs of possible serious bacterial infection (PSBI). We determined the frequency of signs and conducted Cox regression to investigate the association of signs with mortality risk within 7 days of identification of the signs. …”
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34623
Assessing the quality of life among African medical and health science students using the WHOQOL-BREF tool
Published 2025-02-01“…Data were collected using the WHOQOL-BREF tool, and analyzed using descriptive statistics, chi-square test and multiple linear regression to determine the predictors of QoL among students. Results The overall QoL among 349 African medical and health science students was moderate, with a mean score of 67.5% ± 10.8%. …”
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34624
Evaluation of circulating tumor DNA as a prognostic and predictive biomarker in BRAF V600E mutated colorectal cancer—results from the FIRE‐4.5 study
Published 2025-02-01“…Digital droplet PCR (ddPCR) technology was applied for determination of BRAF mutations and the in vitro diagnostics (IVD)‐certified ONCOBEAM RAS procedure for analysis of RAS mutations. …”
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34625
Spatiotemporal analysis of Plasmodium falciparum erythrocyte binding antigen-175 gene dimorphism in Ghana
Published 2025-01-01“…The prevalence ratio (wet/dry) for C, F and F/C were determined to be 1.0, 1.1 and 1.4, respectively. Between 2019 and 2022, the prevalence of the alleles changed significantly (χ2 = 6.5427, p = 0.03). …”
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34626
Response of high-yielding soybean varieties to water-saturated and drought stress
Published 2024-10-01“…The objective of this study was to determine how various soybean varieties react to waterlogging and drought in order to identify soybean cultivars that exhibit tolerance to both types of stressors.METHODS: The study was conducted at the greenhouse of the Indonesian Legumes and Tuber Crops Research Institute, spanning from June to August 2022. …”
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34627
Sustainability index analysis for environmentally low-input integrated farming
Published 2024-01-01“…Therefore, this study aimed to evaluate the level of sustainability of low-input integrated agricultural farming by determining and analyzing the sustainability index.METHODS: Experts and business operators engaged in the integrated production of organic fertilizer, corn, and laying hen farming conducted scientific assessments to gather primary and secondary data. …”
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34628
The transcription factor combination MEF2 and KLF7 promotes axonal sprouting in the injured spinal cord with functional improvement and regeneration-associated gene expression
Published 2025-02-01“…Next, adeno-associated viral vectors were used to express these TF combinations in vivo in L4/L5 dorsal root ganglia to test whether they would promote regeneration in a spinal cord injury model (dorsal column lesion) in female rats. To determine whether they could activate the RAG program we carried out gene expression profiling on laser-dissected dorsal root ganglion neurons specifically expressing these TF combinations, and of DRG neurons that had been axotomized. …”
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34629
Estimation of mangrove carbon stocks using unmanned aerial vehicle over coastal vegetation
Published 2024-07-01“…Field surveys were conducted to determine the species composition of each mangrove stand and measure their diameter at breast height. …”
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34630
Immunogenicity and safety of a COVID-19 DNA vaccine in healthy adults and elderly: A randomized, observer-blind, placebo-controlled phase 2 trial
Published 2025-12-01“…The primary immunogenicity endpoints focused on determining the geometric mean titers (GMTs) of spike-binding antibodies and live SARS-CoV-2 neutralizing antibody at day 30 after the second dose. …”
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34631
Utilization of patient-reported outcomes to assess adherence to relugolix when combined with stereotactic body radiation therapy for intermediate to high-risk prostate cancer
Published 2025-01-01“…A p-value < 0.05 determined statistical significance.ResultsBetween August 2021 and December 2023, 78 men were treated at Georgetown with relugolix and prostate SBRT per an institutional protocol. …”
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34632
Predictive Immunological, Virological, and Routine Laboratory Markers for Critical COVID-19 on Admission
Published 2021-01-01“…RT-PCR cycle threshold (Ct) values from oropharyngeal or nasopharyngeal swabs were determined on the day of admission. Symptom severity was categorized as mild (grade 1), severe (grade 2), or critical (grade 3). …”
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34633
PD-L1/TLR7 dual-targeting nanobody-drug conjugate mediates potent tumor regression via elevating tumor immunogenicity in a host-expressed PD-L1 bias-dependent way
Published 2022-10-01“…Immunophenotyping, immune cell depletion, tumor rechallenge, RNA sequencing and PD-L1-deficient models were combined to determine the mechanism for NDCs function. The dynamics of the in vivo behaviors of NDCs were assessed based on multiorgan changes in PD-L1 levels.Results The screened PD-L1 nanobodies were characterized as tumor-targeting and alleviated T-cell immunosuppression. …”
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34634
The Importance of Dose Escalation in the Treatment of Pulmonary Arterial Hypertension with Treprostinil
Published 2025-01-01“…A number of factors determine how well patients respond to treatment. <b>Objectives</b>: The aim of this study was to identify factors that may influence the clinical response to the dose of treprostinil at 3 months after the start of therapy. …”
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34635
Virological Aspects of COVID-19 in Patients with Hematological Malignancies: Duration of Viral Shedding and Genetic Analysis
Published 2024-12-01“…In this prospective study, we aimed to determine the duration of excretion of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in 37 Tunisian patients with hematological malignancies (40.5% with lymphoma and 37.8% with leukemia). …”
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34636
Population of Merging Compact Binaries Inferred Using Gravitational Waves through GWTC-3
Published 2023-03-01“…Using both binary neutron star and neutron star–black hole binaries, we obtain a broad, relatively flat neutron star mass distribution extending from 1.2_{-0.2}^{+0.1} to 2.0_{-0.3}^{+0.3}M_{⊙}. We confidently determine that the merger rate as a function of mass sharply declines after the expected maximum neutron star mass, but cannot yet confirm or rule out the existence of a lower mass gap between neutron stars and black holes. …”
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34637
Central venous oxygen saturation changes as a reliable predictor of the change of CI in septic shock: To explore potential influencing factors
Published 2025-01-01“…This study aimed to determine the ability of the change in ScvO2 (ΔScvO2) to detect fluid responsiveness in ventilated septic shock patients and potential influencing factors. …”
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34638
A comparative analysis of autograft choices of anterior cruciate ligament reconstruction and their effects on muscle strength and joint biomechanics
Published 2025-01-01“…The BTB group also showed the largest deviation in H:Q ratios (Δ = −0.23, Cohen's d = 2.70), while the HT group showed a more balanced recovery with smaller significant deficits in H:Q ratios (Δ = −0.07, Cohen's d = 0.46).ConclusionThe BTB graft showed the most pronounced variations in QPT and HPT between healthy and injured legs in the short term, indicating the importance of longitudinally monitoring knee stability to determine the best autograft choice for ACLR. While all graft types contribute to muscle strength recovery, the HT graft may provide advantages in balancing muscle strength and potentially enhancing knee stability.…”
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34639
Overview: quasi-Lagrangian observations of Arctic air mass transformations – introduction and initial results of the HALO–(𝒜 𝒞)<sup>3</sup> aircraft campaign
Published 2024-08-01“…However, numerical models struggle to represent key processes that determine Arctic weather and climate. To collect data that help to constrain the models, the HALO–(<span class="inline-formula">𝒜𝒞</span>)<span class="inline-formula"><sup>3</sup></span> aircraft campaign was conducted over the Norwegian and Greenland seas, the Fram Strait, and the central Arctic Ocean in March and April 2022. …”
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34640
Transcriptomic Profiling and Tumor Microenvironment Classification Reveal Unique and Dynamic Immune Biology in HIV-Associated Kaposi Sarcoma
Published 2025-01-01“…The immune cellular composition was determined using deconvolution and compared to a cohort of non-KS patients. …”
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