A quantitative amplitude of vagus nerve obtained by intraoperative neuromonitoring predicts postoperative vocal cord paralysis among patients in thyroid/parathyroid surgery as a se... by Hiroshi Katoh, MD, FACS, Riku Okamoto, MD, Kanako Naito, MD, Tomoya Mitsuma, MD, Mariko Kikuchi, MD, Takaaki Tokito, MD, Takeshi Naitoh, MD, FACS, Naoki Hiki, MD, Yusuke Kumamoto, MD, Takafumi Sangai, MD

“…The optimal cut-offs of amplitudes or ratios of amplitude decrease on VCP were determined and evaluated. An independent recent cohort (177 RLNs) was analyzed for validation. …”
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Chloroquine and Rapamycin Augment Interleukin-37 Expression via the LC3, ERK, and AP-1 Axis in the Presence of Lipopolysaccharides by Xiaoyi Shi, Chunhui Lai, Lianyu Zhao, Mingying Zhang, Xi Liu, Shanqin Peng, Weizhong Guo, Qiuying Xu, Song Chen, Guang-xing Chen

“…Thereafter, IL-37 expression and autophagic markers (Beclin1, P62/SQSTM1, and LC3) were determined. For regulatory signal pathways, phosphorylated proteins of NF-κB (p65 and IκBα), AP-1 (c-Fos/c-Jun), and MAPK signal pathways (Erk1/2 and p38 MAPK) were quantified, and the agonists and antagonists of MAPK and NF-κB pathways were also used. …”
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Beneficial Effect of Multidomain Cognitive Training on the Neuropsychological Performance of Patients with Early-Stage Alzheimer’s Disease by Anastasia Nousia, Vasileios Siokas, Eleni Aretouli, Lambros Messinis, Athina-Maria Aloizou, Maria Martzoukou, Maria Karala, Charalampos Koumpoulis, Grigorios Nasios, Efthimios Dardiotis

“…The objective of the present study is to determine the benefits of a structured, multidomain, mostly computer-based, cognitive training (MCT) οn the cognitive performance of patients with early-stage AD. …”
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Wastewater-based analysis of antimicrobial resistance at UK airports: Evaluating the potential opportunities and challenges by Margaret E. Knight, Kata Farkas, Matthew Wade, Gordon Webster, Daniel A. Pass, William Perry, Peter Kille, Andrew Singer, Davey L. Jones

“…Edinburgh terminal and pumping station wastewater had compositionally comparable resistomes to that of the connected urban wastewater treatment plant, though further research is needed to determine the relative contributions of the local population and international travellers. …”
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Exploring cognitive and neuroimaging profiles of dementia subtypes of individuals with dementia in the Democratic Republic of Congo by Jean Ikanga, Jean Ikanga, Saranya Sundaram Patel, Saranya Sundaram Patel, Megan Schwinne, Caterina Obenauf, Caterina Obenauf, Emmanuel Epenge, Guy Gikelekele, Nathan Tshengele, Immaculee Kavugho, Samuel Mampunza, Lelo Mananga, Charlotte E. Teunissen, Julio C. Rojas, Brandon Chan, Argentina Lario Lago, Joel H. Kramer, Adam L. Boxer, Andreas Jeromin, Emile Omba, Alvaro Alonso, Alden L. Gross

“…Dementia subtypes were determined based on plasma biomarker pathology and vascular markers. …”
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Save a trip: Clinical outcomes of cardiac allografts recovered by local surgeons compared to recipient center surgeons. by Awab Ahmad, MD, Timothy R. Harris, MD, Aaron Williams, MD, Alexandra DeBose-Scarlett, MD, Rubayet Kamal, BS, Enock Atta Adjei, MD, Hasan K. Siddiqi, MD, Chen Chia Wang, Mark Petrovic, Clifton D. Keck, Shelley R. Scholl, RN, Ashish S. Shah, MD, Swaroop Bommareddi, MD, Brian Lima, MD MBA, John M. Trahanas, MD

“…Primary graft dysfunction (PGD) was determined based on 2014 ISHLT guidelines. Results: 218 recovery attempts were included, 25 conducted by local surgeons. …”
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Characterization of the Occult Hepatitis B Virus Variants Circulating among the Blood Donors from Eastern India by Avik Biswas, Rajesh Panigrahi, Partha Kumar Chandra, Arup Banerjee, Sibnarayan Datta, Manisha Pal, Subhashish Chakraborty, Prasun Bhattacharya, Sekhar Chakrabarti, Runu Chakravarty

“…PCR amplification and sequencing were done to determine HBV genotypes, basal core promoter (BCP), and precore (Pre-C) mutations. …”
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The clinical evaluation of the triglyceride-glucose index as a risk factor for coronary artery disease and severity of coronary artery stenosis in patients with chronic kidney dise... by Dan Liu, Xiaoyang Guan, Ruoxin Chen, Ci Song, Shanhu Qiu, Shengchun Xu, Jingyuan Cao, Hong Liu

“…Logistic regression analysis was used to determine the related factors of CAD and severe CAS.Results A total of 943 patients were enrolled in this cross-sectional study and 720 (76.4%) of these patients were diagnosed with CAD. …”
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Retrospective evaluation of risk factors for worsening renal function after angiotensin‐converting enzyme inhibitor treatment in dogs by Yelim Lee, Minju Baek, Dongseop Lee, Jinyeong Park, Yeon Chae, Byeong‐Teck Kang, Taesik Yun, Hakhyun Kim

“…Methods Serum creatinine concentration was determined at the initial presentation and first reevaluation to detect and grade WRF (increase in sCr ≥ 0.3 mg/dL). …”
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Dicoumarol sensitizes hepatocellular carcinoma cells to ferroptosis induced by imidazole ketone erastin by Ziwei Yang, Ziwei Yang, Tixin Han, Ruibin Yang, Ruibin Yang, Yinuo Zhang, Yinuo Zhang, Yifei Qin, Yifei Qin, Yifei Qin, Jialu Hou, Jialu Hou, Fei Huo, Fei Huo, Zhuan Feng, Zhuan Feng, Yaxin Ding, Yaxin Ding, Jiali Yang, Jiali Yang, Gang Zhou, Gang Zhou, Shijie Wang, Shijie Wang, Xiaohang Xie, Xiaohang Xie, Peng Lin, Peng Lin, Zhi-Nan Chen, Zhi-Nan Chen, Jiao Wu, Jiao Wu

“…The intrinsic factors determining sensitivity to IKE-induced ferroptosis remain to be explored to improve its efficacy.MethodsBulk RNA-sequencing data from hepatocellular carcinoma (HCC) and normal liver tissues were collected from The Cancer Genome Atlas (TCGA) and the Genotype-Tissue Expression (GTEx) databases. …”
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Ellagic Acid from <i>Geranium thunbergii</i> and Antimalarial Activity of Korean Medicinal Plants by Hojong Jun, Joon-Hee Han, Min Hong, Fadhila Fitriana, Jadidan Hada Syahada, Wang-Jong Lee, Ernest Mazigo, Johnsy Mary Louis, Van-Truong Nguyen, Seok Ho Cha, Wanjoo Chun, Won Sun Park, Se Jin Lee, Sunghun Na, Soo-Ung Lee, Eun-Taek Han, Tae-Hyung Kwon, Jin-Hee Han

“…The plant extracts were fractionated using ethyl acetate, chloroform, and hot water, and their efficacy against <i>P. falciparum</i> was evaluated through IC₅₀ determination and microscopic analysis. The compounds evaluated included ellagic acid, gallic acid, afzelin, quercetin, and protocatechuic acid. …”
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International REACH forgiveness intervention: a multisite randomised controlled trial by Tyler J Vanderweele, Nicole Rodriguez, Richard G Cowden, Man Yee Ho, Everett L Worthington, Andrea Ortega Bechara, Zhuo Job Chen, Elly Yuliandari Gunatirin, Shaun Joynt, Viacheslav V Khalanskyi, Hennadii Korzhov, Ni Made Taganing Kurniati, Anastasiya Anastasiya Salnykova, Liudmyla Shtanko, Sergiy Tymchenko, Vitaliy L Voytenko, Anita Zulkaida, Maya B Mathur

“…Objectives To determine whether a brief self-directed forgiveness workbook intervention could alter forgiveness, depression symptoms, and anxiety symptoms.Design A multisite randomised waitlist-controlled trial was conducted among 4598 participants. …”
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Prognostic correlation analysis of multiple myeloma based on HALP score of peripheral blood before chemotherapy by CHEN Min, AN Liying, LIN Xiaojing, ZHAO Pan, ZOU Xingli, WEI Jin, NI Xun

“…The HALP score was calculated, and the optimal cutoff value for HALP was determined using X-tile software. Survival analysis was performed using Kaplan-Meier curves for high HALP and low HALP groups. …”
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Evaluation of the recombinant protein Sh-TSP-2 for the serological diagnosis of imported urogenital schistosomiasis and comparison with commercially available tests by María Pilar Luzón-García, Laura Navarro, Esther Rodríguez, Manuel Jesús Soriano-Pérez, José Vázquez-Villegas, María Isabel Cabeza-Barrera, Alex Loukas, Nerea Castillo-Fernández, María Jesús Perteguer, Javier Sotillo, Joaquín Salas-Coronas

“…Due to the limitations of microscopy as a perfect reference method, a latent class analysis (LCA) and composite reference standard (CRS) approach was used to determine the sensitivity and specificity of each test. …”
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Sustainability index analysis of organic fertilizer production from paunch manure and rice straw waste by A.D. Santoso, F.D. Arianti, E.S. Rohaeni, B. Haryanto, M.D. Pertiwi, L.P. Panggabean, A. Prabowo, S. Sundari, S.P. Wijayanti, I.N. Djarot, F.D. Kurniawati, F.L. Sahwan, T. Prasetyo, A. Barkah, T.A. Adibroto, R. Ridlo, I. Febijanto, A.A. Wasil, S. Lusiana, R. Rosmeika, R.B. Heryanto

“…These include water use and raw material efficiency, potential business scale increase, market absorption, the potential for public unrest, the manager or worker level of expertise in the manufacture of organic fertilizer as well as the process used to determine its quality and output.CONCLUSION: The proposed inquiry conducted within the context of this study identified the pivotal factors that influenced organic fertilizer supply framework as the quality, quantity, and market absorption of organic production. …”
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Heat Re-process approach and thermally integrated renewable energy system for power, compressed hydrogen, and freshwater production; ANN boosted optimization and techno-enviro-econ... by Zhaoyang Zuo, Junhua Wang, Mohammed A. Alghassab, Nashwan Adnan Othman, Ahmad Almadhor, Fahad M. Alhomayani, Hind Albalawi, Samah G. Babiker, Barno Abdullaeva, Aboulbaba Eladeb

“…Under the optimal operating conditions derived from the multi-objective optimization, the levelized costs of the HTES's products were determined to be 12.63 cents/kWh for electricity, 4.75 $/kg for compressed hydrogen, and 20.59 cents/m3 for freshwater. …”
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D-mannose promotes diabetic wound healing through inhibiting advanced glycation end products formation in keratinocytes by Jialiang Luo, Tianxing Wu, Jing Zhang, Zhicheng Liang, Weijie Shao, Di Wang, Lei Li, Daming Zuo, Jia Zhou

“…The expression of the AMPK/Nrf2/HO-1 signaling-related molecules was determined by Western blotting. Results We first found that topical supplementation of D-mannose remarkably improved skin wound healing in diabetes mice. …”
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Expression Analysis of Fibronectin Type III Domain-Containing (FNDC) Genes in Inflammatory Bowel Disease and Colorectal Cancer by Tilo Wuensch, Jonas Wizenty, Janina Quint, Wolfgang Spitz, Madeleen Bosma, Olaf Becker, Andreas Adler, Wilfried Veltzke-Schlieker, Martin Stockmann, Sascha Weiss, Matthias Biebl, Johann Pratschke, Felix Aigner

“…Gene expression was determined by quantitative real-time PCR. In addition, FNDC expression data from publicly available Gene Expression Omnibus (GEO) data sets (GDS4296, GDS4515, and GDS5232) were analyzed. …”
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Standardization and validation of a novel reverse transcriptase polymerase chain reaction method for detecting virulent strains of the infectious bursal disease virus by Vladimir Longa-Bobadilla, Phillip Ormeño-Vásquez, Manuel Criollo-Orozco, Luis Tataje-Lavanda, Katherine Huamán-Gutierrez, Ángela Montalván, Mirko Zimic, Manolo Fernández-Sanchez, Manolo Fernández-Díaz

“…Finally, the conditions for this novel RT-PCR were evaluated using a commercial kit and the newly designed primers. Results: After determining the optimal RT-PCR conditions, the newly designed primers successfully amplified a 402-bp consensus sequence of the VP5 gene. …”
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Backtranslation of human RNA biosignatures of tuberculosis disease risk into the preclinical pipeline is condition dependent by Hannah Painter, Sasha E. Larsen, Brittany D. Williams, Hazem F. M. Abdelaal, Susan L. Baldwin, Helen A. Fletcher, Andrew Fiore-Gartland, Rhea N. Coler

“…Using a 3Rs (replacement, reduction, and refinement) approach we reanalyzed heterogeneous publicly available transcriptional data sets to determine whether a specific set of COR signatures are viable endpoints in the preclinical pipeline. …”
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