Complex and severe infection in a 67-year-old liver transplant recipient due to Cunninghamella elegans, Bordetella bronchiseptica, and Pneumocystis jirovecii by Muyun Wei, Kangyi Gu, Juanxiu Qin, Xinhua Lu, Junqi Feng, Shaowei Mao, Min Li, Zhilan Li, Changsheng Wang

“…B. bronchiseptica, P. jirovecii, Aspergillus fumigatus, and human alphaherpesvirus 1 (HSV1) were detected by clinical metagenomic next-generation sequencing (mNGS) of his bronchoalveolar lavage fluid (BLAF). …”
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High-resolution observation per 1.5 h revealed prominent time-dependent daily contamination variations of p-phenylenediamine (PPD) antioxidants and their quinone derivatives PPDQs... by Zifang Peng, Shijiao Hou, Qingyun He, Fangcheng Su, Lishun Ren, Congcong Pei, Dan Yin, Yanhao Zhang, Yanjie Huang, Shusheng Zhang, Zongwei Cai

“…p-Phenylenediamine (PPD) antioxidants and their quinone derivatives (PPDQs), as hot-spot novel contaminants in recent years, have been detected in air fine particulate matters (PM2.5) in multiple regions. …”
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Semaphorin 3A Inhibits Inflammation in Chondrocytes under Excessive Mechanical Stress by Chikako Sumi, Naoto Hirose, Makoto Yanoshita, Mami Takano, Sayuri Nishiyama, Yuki Okamoto, Yuki Asakawa, Kotaro Tanimoto

“…Furthermore, the phosphorylation of AKT, ERK, and NF-κB was detected by Western blot analysis. Results. Added Sema3A inhibited the gene expression of inflammatory cytokines upregulated by CTS in a dose-dependent manner. …”
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The burden of prostate cancer in the North Africa and Middle East Region from 1990 to 2021 by Saeid Safiri, Ali Shamekh, Kamaleddin Hassanzadeh, Asra Fazlollahi, Mark J. M. Sullman, Mortaza Raeisi, Ali-Asghar Kolahi

“…Further studies into the underlying causes of this increasing incidence are essential to devise effective strategies for the early detection and prevention of the disease.…”
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The Effect of Diabetes-Associated Autoantigens on Cell Processes in Human PBMCs and Their Relevance to Autoimmune Diabetes Development by Jana Vcelakova, Radek Blatny, Zbynek Halbhuber, Michal Kolar, Ales Neuwirth, Lenka Petruzelkova, Tereza Ulmannova, Stanislava Kolouskova, Zdenek Sumnik, Pavlina Pithova, Maria Krivjanska, Dominik Filipp, Katerina Stechova

“…Type 1 Diabetes (T1D) is considered to be a T-helper- (Th-) 1 autoimmune disease; however, T1D pathogenesis likely involves many factors, and sufficient tools for autoreactive T cell detection for the study of this disease are currently lacking. …”
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Bias in Discontinuous Elevational Transects for Tracking Species Range Shifts by Shixuan Li, Jiannan Yao, Yang Lin, Siyu Wu, Zhongjie Yang, Chao Jin, Yuhan Zhang, Zhen Wang, Jinliang Liu, Guochun Shen, Mingjian Yu

“…The results were striking: the widely used settings for discontinuous transects failed to detect 7.2% of species, inaccurately estimated shift distances for 78% of species, and produced an overall error rate of 86%. …”
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Proline isomerization modulates the bacterial IsdB/hemoglobin interaction: an atomic force spectroscopy study by Francesca Pancrazi, Omar De Bei, Francesco Lavecchia di Tocco, Marialaura Marchetti, Barbara Campanini, Salvatore Cannistraro, Stefano Bettati, Anna Rita Bizzarri

“…An increased bond strength under mechanical stress was also detected by Atomic Force Spectroscopy (AFS) for the interaction between IsdB and Hb. …”
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Antitumor effect of a pyrazolone-based-complex [Cu(PMPP-SAL)(EtOH)] against murine melanoma B16 cell in vitro and in vivo by Abula Ayipairi, Zhao Jing, Xu Guancheng, Li Yijie, Sun Surong

“…Moreover, the tumor growth was suppressed in mice due to the induction of apoptosis, as detected by the TUNEL assay (p < 0.001). In summary, [Cu(PMPP-SAL)(EtOH)] effectively inhibited the growth of B16 cells in vitro and in vivo due to the induction of apoptosis and the inhibition of intra-tumoral angiogenesis, demonstrating its therapeutic potential in melanoma treatment.…”
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High Concentrations of Tilmicosin Promote the Spread of Multidrug Resistance Gene <i>tol</i>C in the Pig Gut Microbiome Through Mobile Genetic Elements by Tao Chen, Minxing Zhao, Majian Chen, Xiaoyue Tang, Yuliang Qian, Xiaoting Li, Yan Wang, Xindi Liao, Yinbao Wu

“…Tilmicosin concentration in manure peaked on day 16 of dosing and dropped below detectable levels by day 13 of the withdrawal period. …”
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An effective vessel segmentation method using SLOA-HGC by Zerui Liu, Junliang Du, Weisi Dai, Wenke Zhu, Ziqing Ye, Lin Li, Zewei Liu, Linan Hu, Lin Chen, Lixiang Sun

“…Abstract Accurate segmentation of retinal blood vessels from retinal images is crucial for detecting and diagnosing a wide range of ophthalmic diseases. …”
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Lemongrass (Cymbopogon citratus) Essential Oil: Extraction, Composition, Bioactivity and Uses for Food Preservation – a Review by Ewa Majewska, Mariola Kozłowska, Eliza Gruczyńska-Sękowska, Dorota Kowalska, Katarzyna Tarnowska

“…The chemical constituents of the essential oil which have constantly been detected and determine its biological activity are aldehydes, hydrocarbon terpenes, alcohols, ketones, and esters. …”
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Psychological Safety in Saudi Arabian Healthcare: A Scoping Review by Yumna Ali, Roaya Alqurashi, Ahmed M. Asfahani, Mark Leonard, Catherine Elisa John, Yasuhiro Kotera

“…The aim of a scoping review is to detect potential research gaps. Presently, mindfulness-based programs relating to psychological safety are under-researched in the Saudi Arabian context, and a scoping review is a preliminary requirement before a formal systematic review is conducted. …”
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Interleukin-12p70 Expression by Dendritic Cells of HIV-1-Infected Patients Fails to Stimulate gag-Specific Immune Responses by Ellen Van Gulck, Nathalie Cools, Derek Atkinson, Lotte Bracke, Katleen Vereecken, Marc Vekemans, Viggo F. I. Van Tendeloo, Zwi N. Berneman, Guido Vanham

“…However, although most of the patients had detectable gag-specific CD8+ T cell responses, no significant differences in the level of expansion of functional CD8+ T cells could be demonstrated when comparing conventional or immune-modulated DCs expressing IL-12p70. …”
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Risk Factors for Mortality in Melioidosis: A Single-Centre, 10-Year Retrospective Cohort Study by Raviraj Menon, Poornima Baby, Anil Kumar V., Sandeep Surendran, Manu Pradeep, Aiswarya Rajendran, Gaayathri Suju, Arathy Ashok

“…Hypoalbuminemia is a novel mortality risk factor, detected in this study, and requires further investigation to validate its utility as a prognostic marker and reveal possible therapeutic benefits in clinical correction.…”
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Soil Microarthropods as Tools for Monitoring Soil Quality: The QBS-ar Index in Three European Agroecosystems by Filippo Gallese, Laura Gismero-Rodriguez, Anton Govednik, Laura Giagnoni, Erica Lumini, Marjetka Suhadolc, Francesco Primo Vaccari, Anita Maienza

“…Our results underlined that the QBS-ar is very sensitive for detecting soil quality and treatment effects. The results suggest that the choice of sampling season is a particularly vulnerable phase, especially for southern Mediterranean sites. …”
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The Molecular Diagnosis Protocols of New Coronavirus (COVID-19); Specificity and Sensitivity an Overview by Abdullah Ahmed Hama, Othman Abdulrahman Mohammed, Fatima Mahmud Ali, Osama Hamid Shareef, Sardar Muhammad Wli, Sabiha Sharif, Syamand Ahmed Qadir

“…The new outbreak of COVID-19 can be detected by different molecular protocols. Quantitative polymerase chain reaction (qPCR) is the recommended technique used with varied sensitivity due to primers variation and specimen type. …”
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Characterization of aroma compounds of Pu-erh ripen tea using solvent assisted flavor evaporation coupled with gas chromatography-mass spectrometry and gas chromatography-olfactome... by Bei Wang, Qing Meng, Lin Xiao, Ruili Li, Chunhai Peng, Xueli Liao, Jingna Yan, Honglin Liu, Guanhua Xie, Chi-Tang Ho, Huarong Tong

“…Linalool, α-terpineol, α-ionone, β-ionone, and benzeneacetaldehyde were responsible for the floral odor. Compared the odor detection threshold (ODT) among the 8 methoxyphenyl compounds in water, 1,2,3-trimethoxybenzene showed the highest ODT, followed by 3,4-dimethoxyphenol. 1,3-Dimethoxybenzene (105 μg/L) and 1,2,3-trimethoxy-5-methylbenzene (100 μg/L) were present at relatively low odor threshold values. …”
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Partial rejuvenation of the spermatogonial stem cell niche after gender-affirming hormone therapy in trans women by Emily Delgouffe, Samuel Madureira Silva, Frédéric Chalmel, Wilfried Cools, Camille Raets, Kelly Tilleman, Guy T'Sjoen, Yoni Baert, Ellen Goossens

“…The transcriptomic profile of transgender tissue confirmed a loss of mature characteristics - a partial rejuvenation - of the spermatogonial stem cell niche and, in addition, detected inflammation processes occurring in the samples. …”
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Mechanisms for upstream migration of firn aquifer drainage: preliminary observations from Helheim Glacier, Greenland by Jessica Z. Mejia, Kristin Poinar, Colin R. Meyer, Aleah N. Sommers, Winnie Chu

“…We infer inland expansion of crevasses over the firn aquifer from crevasse-nucleated whaleback dune formation and Global Navigation Satellite System-station detected crevasse opening extending 14 and 4 km, respectively, inland from the current, farthest-upstream drainage point. …”
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Complement classical and alternative pathway activation contributes to diabetic kidney disease progression: a glomerular proteomics on kidney biopsies by Yang Yang, Ying Zhang, Yuan Li, Xinjin Zhou, Kazuho Honda, Dedong Kang, Muxi Wang, Jing-Hua Yang, Zongping Xia, Yuan Wei, Lu Liu, Ruimin Hu, Takashi Takaki, Guolan Xing

“…Notably, none of the proteins unique to the lectin complement pathway, including mannose-binding lectin (MBL) and its associated proteins, were detected in DKD glomeruli. Furthermore, the glomerular complement proteins of CP and AP were positively correlated with glomerular pathological grades and proteinuria, and negatively correlated with eGFR in DKD patients. …”
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