Predictors of infliximab efficacy in patients with severe attack of ulcerative colitis by A. O. Golovenko, I. L. Khalif, O. V. Golovenko, V. V. Veselov

“…High cost of such treatment and risk of adverse events related to it requires definition of strict indications for application of this drug. It was necessary to detect factors due to which at early stage of biological therapy it is possible to decide whether infliximab will allow to achieve long-term clinical remission, and also to avoid operative treatment.Material and methods. …”
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Hippocampal Regulation of Postsynaptic Density Homer1 by Associative Learning by Nicholas E. Clifton, Darren Cameron, Simon Trent, Lucy H. Sykes, Kerrie L. Thomas, Jeremy Hall

“…Homer1a and Ania-3, but not long Homer1, were regulated by contextual fear learning or novelty detection, although their precise patterns of expression in hippocampal subregions were dependent on the isoform. …”
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Grouting Reinforcement of Large Building Foundation over Old Gob Areas: A Case Study in Huaibei Mining Area, China by Wenyan Guo, Shiqi Liu, Bingnan Hu, Yanchun Xu, Yaqi Luo

“…And the grouting effect was examined using borehole TV observation and the water injection test, where the detection results of boreholes TV observation showed that the filling ratio of the stratum fracture was over 85%, and the stability of the foundation was obviously enhanced. …”
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Colorectal Carcinoma with Extremely Low CA19-9 by Yutaka J. Kawamura, Aika Tokumitsu, Junichi Sasaki, Shingo Tsujinaka, Takafumi Maeda, Ken Mizogami, Fumio Konishi

“…In patients with extremely low CA19-9, who consist of 9.8% of colorectal carcinoma cases, postoperative sequential measurement of serum level of CA19-9 contributed neither to assessment of curability of surgical resection nor to detection of recurrence.…”
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Correlation between Serum IL-35 Levels and Bone Loss in Postmenopausal Women with Rheumatoid Arthritis by Yuxuan Li, Lutian Yao, Siyan Liu, JishengWu, Liping Xia, Hui Shen, Jing Lu

“…Serum IL-35 levels were detected by enzyme-linked immunosorbent assay. Bone mineral density (BMD) at lumbar spine 1-4 and at total hip was measured using dual-energy X-ray absorptiometry. …”
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Adeno-associated virus-based gene therapy for hemophilia–addressing the gaps by Wolfgang Miesbach, Paul Batty, Pratima Chowdary, Sylvia Fong, Radoslaw Kaczmarek, Frank W.G. Leebeek, Brian Long, Johnny Mahlangu, Mike Makris, Glenn F. Pierce, Steven W. Pipe, Alok Srivastava, Jan Voorberg, Flora Peyvandi

“…This manuscript follows literature reviews and structured discussions by the International Society on Thrombosis and Haemostasis Scientific and Standardization Committee Working Group on Gene Therapy that identified specific areas requiring standardization of methods, including viral vector production, liver function assessment, quantification of factor (F)VIII and FIX expression levels, assessment of antiadeno-associated viral antibodies, and genomic integration detection methods. Standardization strategies aim to achieve consistent vector quality, effective patient selection, and uniform assessment methods by implementing advanced laboratory techniques and standardized protocols. …”
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Immunogenicity and safety of a live attenuated varicella vaccine in healthy subjects aged between 13 to 55 years: a double-blind, randomized, active-controlled phase iii clinical t... by Yang Zhang, Shiyuan Wang, Guifan Li, Jinhui Shi, Xianyun Chang, Hao Zhang, Fengcai Zhu, Jingxin Li, Hongxing Pan, Jinfang Sun

“…Varicella-zoster virus (VZV) antibody was detected before vaccination and 42 days after two doses of vaccination.Results The lower limits of the 95% CI for the differences in seroconversion rates and geometric mean titer (GMT) ratios between the two groups were greater than their respective pre-set non-inferiority margins. …”
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Genetic Testing Distinguishes Multiple Chondroid Chordomas with Neuraxial Bone Metastases from Multicentric Tumors by Hiroshi Kobayashi, Masahiro Shin, Naohiro Makise, Aya Shinozaki-Ushiku, Masachika Ikegami, Yuki Taniguchi, Yusuke Shinoda, Shinji Kohsaka, Tetsuo Ushiku, Katsutoshi Oda, Kiyoshi Miyagawa, Hiroyuki Aburatani, Hiroyuki Mano, Sakae Tanaka

“…Subsequent multiple metastases to the lung and appendicular and axial bones were detected 15 months after the initial surgery. Recurrent lesions at the clivus progressed despite EGFR-targeted therapy, surgery, and radiotherapy. …”
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Sufentanil enhances the cortical neurogenesis of rats with traumatic brain injury via PI3K/AKT signal pathway by Wei Gu, Mimi Wu, Ruocui Zhang, Peiyu Liu, Yang Jiao, Hui Rong

“…The oxidative stress, inflammation, nerve cell damage, melatonin, brain-derived neurotrophic factor (BDNF), neuron regeneration and p-AKT protein level in the cortex were detected with ELISA, TUNEL, qRT-PCR, immunofluorescence and Western blot. …”
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Case Report: Craniofacial deafness hand syndrome with unusual cardiovascular symptoms and lack of holistic care by Samantha Saenz Hinojosa, Carlos Reyes-Silva, Kazuyoshi Hosomichi, Vanessa I. Romero

“…This case highlights the importance of a holistic approach to patient care, encompassing timely detection and comprehensive evaluation of clinical features.MethodsWe report the case of a 21-year-old Ecuadorian male with facial and hand dysmorphias, cardiomegaly, pulmonary hypertension, and patent ductus arteriosus (PDA). …”
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Traumatic Brain Injury Promotes Neurogenesis and Oligodendrogenesis in Subcortical Brain Regions of Mice by Olga Astakhova, Anna Ivanova, Ilia Komoltsev, Natalia Gulyaeva, Grigori Enikolopov, Alexander Lazutkin

“…In addition to active astro- and microgliosis, we detected oligodendrogenesis in the striatum and optic tract. …”
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The Assessment of Selected Bone and Cartilage Biomarkers in Psoriatic Patients from Poland by Joanna Bartosińska, Anna Michalak-Stoma, Maria Juszkiewicz-Borowiec, Małgorzata Kowal, Grażyna Chodorowska

“…Psoriasis is an inflammatory disease in which joints involvement may be insidious and difficult to detect. Bone and cartilage biomarkers may be helpful in screening patients with psoriasis for psoriatic arthritis (PsA). …”
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Integrative determination of atomic structure of mutant huntingtin exon 1 fibrils implicated in Huntington disease by Mahdi Bagherpoor Helabad, Irina Matlahov, Raj Kumar, Jan O. Daldrop, Greeshma Jain, Markus Weingarth, Patrick C. A. van der Wel, Markus S. Miettinen

“…The obtained data are discussed in context of their implications for understanding the detection of such aggregates (diagnostics) as well as known biological properties of the fibrils.…”
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Intelligent IoT-Based Network Clustering and Camera Distribution Algorithm Using Reinforcement Learning by Islam T. Almalkawi, Rami Halloush, Mohammad F. Al-Hammouri, Alaa Alghazo, Loiy Al-Abed, Mohammad Amra, Ayooub Alsarhan, Sami Aziz Alshammari

“…However, existing surveillance systems are often based on traditional camera distribution and come with additional communication costs and redundancy in the detection range. Thus, we propose a smart and efficient camera distribution system based on machine learning using two Reinforcement Learning (RL) methods: Q-Learning and neural networks. …”
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Prepartum Dietary Supplementation of Potassium Humate Improves Postpartum Lactation Performance, Metabolic Profile of Multiparous Cows, and Immune Response of Their Calves by Cangir Uyarlar, Abdur Rahman, Eyup Eren Gultepe, İbrahim Sadi Cetingul, Muhammad Uzair Akhtar, Ismail Bayram

“…In terms of metabolic health and blood biochemistry, lymphocytes, neutrophils, monocytes, NEFAs, and BHBA were different among the treatment groups. No effects were detected on the blood physiology parameters of the calves. …”
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Convolutional Neural Decoder for Surface Codes by Hyunwoo Jung, Inayat Ali, Jeongseok Ha

“…To perform reliable information processing in quantum computers, quantum error correction (QEC) codes are essential for the detection and correction of errors in the qubits. Among QEC codes, topological QEC codes are designed to interact between the neighboring qubits, which is a promising property for easing the implementation requirements. …”
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Safety and efficacy of a feed additive consisting of Lactiplantibacillus plantarum NCIMB 41028 for all animal species (Genus Breeding Ltd.) by EFSA Panel on Additives and Products or Substances used in Animal Feed (FEEDAP), Roberto Edoardo Villa, Giovanna Azimonti, Eleftherios Bonos, Henrik Christensen, Mojca Durjava, Birgit Dusemund, Ronette Gehring, Boet Glandorf, Maryline Kouba, Marta López‐Alonso, Francesca Marcon, Carlo Nebbia, Alena Pechová, Miguel Prieto‐Maradona, Ilen Röhe, Katerina Theodoridou, Natalia Alija‐Novo, Montserrat Anguita, Nicole Bozzi Cionci, Matteo L. Innocenti, Fabiola Pizzo, Jordi Tarrés‐Call, Piera Valeri, Yolanda García‐Cazorla

“…The identity of the strain was established, and no antimicrobial resistance genes of concern were detected. Therefore, the EFSA Panel on Additives and Products or Substances used in Animal Feed (FEEDAP) concluded that the use of the strain as a silage additive is considered safe for all the animal species, for consumers of products from animals fed with the treated silage and for the environment. …”
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Predicting the Rate of Fast Radio Bursts in Globular Clusters from Binary Black Hole Observations by Aryamann Rao, Claire S. Ye, Maya Fishbach

“…GCs can also give rise to binary black hole (BBH) mergers detectable with gravitational waves, and the BWD coalescence rate from GCs is correlated with their BBH merger rate. …”
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Discordance between humoral and cellular immune responses to cytomegalovirus infection in CMV seropositive patients awaiting lung transplantation by Meritxell Boada-Pérez, Meritxell Boada-Pérez, Meritxell Boada-Pérez, Cristina Berastegui, Cristina Berastegui, Cristina Berastegui, Marta Erro, Marta Erro, Piedad Ussetti, Elena Crespo, Elena Crespo, Laura Donadeu, Laura Donadeu, Oriol Bestard, Oriol Bestard, Oriol Bestard, Gabriel Anguera, Amparo Solé, Ricardo Ponz Mir, Brian Molloy, Eva Revilla-López, Eva Revilla-López, Víctor Monforte, Víctor Monforte, Víctor Monforte, Susana Gómez-Ollés, Susana Gómez-Ollés, Susana Gómez-Ollés

“…All seronegative patients did not respond to either antigen.ConclusionsTherefore, over 20% of CMV seropositive LT candidates showed weak CMV-specific cellular immune responses despite detectable serological memory against CMV. This may be important in assessing the risk of developing a CMV infection after transplantation.…”
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Fine tuning enzyme activity assays for monitoring the enzymatic hydrolysis of PET by Krisztina Boros, Blanka Eszter Nagy, Raluca Bianca Tomoiagă, Róbert Tőtős, Monica Ioana Toșa, Csaba Paizs, László Csaba Bencze

“…The provided calibration curves cover a broad concentration range, from µM to low mM scale, facilitating assessment of both lower and higher PETase activities, with a limit of detection positioned below the reported PET-degrading activities. …”
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