Assessment of Bowel Preparation Using Low-Volume Sulphate-Based Preparations in Comparison with Macrogols: A Multicenter, Randomized, Comparative Clinical Study of the 3rd Phase by E. D. Fedorov, V. V. Veselov, S. V. Kashin, E. V. Tikhomirova, A. V. Veselov, D. V. Zavyalov, A. Kornowski, T. E. Gorskaya, M. Volteau, T. Ponchon

“…The differences in terms of secondary endpoints were not identified, including BBPS assessment for different sections of the colon, the level of polyp detection, the duration and completeness of colonoscopy, and the investigator’s satisfaction with the procedure. …”
Get full text

Inter-pregnancy interval and uterine rupture during a trial of labour after one previous caesarean delivery and no previous vaginal births: a retrospective population-based cohort... by Pejman Adily, Travis Bettison, Mark Lauer, Rajit Narayan, Adam Mackie, Hala Phipps, Vincenzo Berghella, Marjan M. Haghighi, Katelyn Perren, George Johnson, Bradley de Vries

“…The odds ratio (OR) of uterine rupture per three months interpregnancy interval was 0.91 (95% CI 0.88–0.94) between zero and 21 months after adjusting for confounders, with no further change in risk detected beyond 21 months. The OR was 2.51 (95% CI 2.27–2.78) for induced or augmented labours compared with spontaneous labours. …”
Get full text

Electroacupuncture Relieves Suppression of Autophagy in Interstitial Cells of Cajal of Diabetic Gastroparesis Rats by Xing Wei, Yaping Lin, Dongfeng Zhao, Xiaojuan Xiao, Qiao Chen, Siyi Chen, Yan Peng

“…When the intervention was completed, blood glucose was measured by ONE TOUCH glucometer and gastrointestinal propulsive rate was detected through measuring optical density. Autophagosomes were observed under transmission electron microscope (TEM). …”
Get full text

Renal dysfunction contributes to deteriorated survival outcomes in patients with upper and lower gastrointestinal bleeding: insights from a cohort study of 1160 cases by Orsolya Anna Simon, Levente Frim, Nelli Farkas, Zoltán Sipos, Nóra Vörhendi, Eszter Boros, Dániel Pálinkás, Brigitta Teutsch, Patrícia Kalló, Vivien Vass, Andrea Szentesi, Roland Hágendorn, Péter Hegyi, Bálint Erőss, Imre Szabó

“…Numerous primary (in-hospital mortality, discharge, need for endoscopic intervention, in-hospital rebleeding, length of hospitalisation, need for emergency surgery, need for endoscopic examination and need for intensive care unit) and secondary (detection of Helicobacter pylori (H. pylori), recognition of cancer as the source of bleeding, need for any kind of transfusion or clotting factor, anticoagulation therapy) outcomes were observed. …”
Get full text

Convergent construct validity and test-retest reliability of both German versions of the original and the revised Niigata PPPD Questionnaire: NPQ and NPQ-R by Sarah Chételat, Sarah Chételat, Eve-Yaël Gerber, Eve-Yaël Gerber, Sarah El Khadlaoui, Frank Behrendt, Frank Behrendt, Michaela Stark, Michaela Stark, Stefan Schädler, Stefan Schädler, Maximilian Maywald, Lena Fabritius, Johannes Gerb, Johannes Gerb, Denis Grabova, Wiebke Trost, Andreas Zwergal, Andreas Zwergal, Ralf Strobl, Ralf Strobl, Katrin Parmar, Katrin Parmar, Hans Ulrich Gerth, Hans Ulrich Gerth, Leo H. Bonati, Leo H. Bonati, Leo H. Bonati, Sandra Becker-Bense, Corina Schuster-Amft, Corina Schuster-Amft, Corina Schuster-Amft

“…The study's aim was to evaluate the concurrent construct validity and reliability [including test-retest reliability, internal consistency, standard error of measurement (SEM), and minimal detectable change (MDC)] of the German version of the NPQ (12 items) and its revised version, NPQ-R, which contains 19 items addressing additional symptoms and symptom behavior.MethodsThe Swiss Reha Rheinfelden and the German Center for Vertigo and Balance Disorders included 265 PPPD patients (mean age 50.2 ± 16.8 years, disease duration 46.3 ± 76.6 months). …”
Get full text

The added value of coupling anti-dsDNA and anti-chromatin antibodies in follow-up monitoring of systemic lupus erythematosus patients by Caroline Carlé, Françoise Fortenfant, Chloé Bost, Julie Belliere, Stanislas Faguer, Dominique Chauveau, Antoine Huart, David Ribes, Laurent Alric, Gregory Pugnet, Laurent Sailler, Yves Renaudineau

“…Conclusion: coupling anti-dsDNA with anti-Chr Ab detection at disease initiation/flare allows definition of endotypes, which is useful to follow disease activity, predict lupus nephritis/serositis, and anticipate therapeutic response in the DP + group.…”
Get full text

SLC31A1 promotes chemoresistance through inducing CPT1A-mediated fatty acid oxidation in ER-positive breast cancer by Xudong Li, Jingjing Ge, Mengdi Wan, Tongtong Feng, Xiaoqian Li, Haibo Zhang, Zhangyan Wang, Yongsheng Gao, Meiting Chen, Fei Pan

“…Conversely, promoting SLC31A1 significantly facilitated the proliferation and invasion of wild-type breast cancer cells. Subsequently, we detected reduced copper levels in TAM-resistant breast cancer cells with SLC31A1 depletion. …”
Get full text

Evaluation of long‐acting cabotegravir safety and pharmacokinetics in pregnant women in eastern and southern Africa: a secondary analysis of HPTN 084 by Sinead Delany‐Moretlwe, Brett Hanscom, Xu Guo, Clemensia Nkabiito, Patricia Mandima, Patricia Ntege Nahirya, Juliet Mpendo, Muchaneta Bhondai‐Mhuri, Nyaradzo Mgodi, Rebecca Berhanu, Jennifer Farrior, Estelle Piwowar‐Manning, Susan L. Ford, Craig W. Hendrix, Alex R. Rinehart, James F. Rooney, Adeola Adeyeye, Raphael J. Landovitz, Myron S. Cohen, Mina C. Hosseinipour, Mark A. Marzinke, the HPTN 084 Study Team

“…CAB‐LA group participants had a median 342 days (IQR 192, 497) of CAB‐LA exposure prior to pregnancy detection. Grade 2 or higher maternal AE incidence did not differ by study arm (CAB 157, 95% CI 91−271 per 100 py vs. …”
Get full text

A Predictive Model for Pulmonary Aspergillosis in ICU Patients: A Multicenter Retrospective Cohort Study by Li Y, Ren X, Wang Q, Shen S, Li Y, Qian X, Tang Y, Jia J, Zhang H, Ding J, Song Y, Zhang S, Wang S, Xu Y, Jiang Y, He X, Dai M, Zhong L, Xiong Y, Pan Y, Wang M, Shao H, Cai H, Huang L, Wang H

“…Nevertheless, the significance of other concurrently detected microorganisms in IPA patients is equally noteworthy. …”
Get full text

Normative Database of Spatiotemporal Gait Metrics Across Age Groups: An Observational Case–Control Study by Lianne Mobbs, Vinuja Fernando, R. Dineth Fonseka, Pragadesh Natarajan, Monish Maharaj, Ralph J. Mobbs

“…Our findings offer valuable reference points for clinicians to distinguish between healthy and pathological gait patterns, facilitating early detection and intervention for gait-related disorders. …”
Get full text

γ-亚麻酸对α-亚麻酸转化为DHA的影响 Effect of γ-linolenic acid on the conversion of α-linolenic acid to DHA by 谢婉菲1，姜珊1，王成成1，王玉明1,2，薛长湖1,2，张恬恬1 " XIE Wanfei1, JIANG Shan1, WANG Chengcheng1, WANG Yuming1,2, XUE Changhu1,2, ZHANG Tiantian1"

“…Compared with serum and liver, there were more fatty acid types in small intestinal wall of mice, and ALA was detected. Compared with ALA group, the DHA content in liver and small intestinal wall of mice in ALA+GLA group significantly decreased, and the DHA content in liver significantly decreased mainly reflected in the decrease of TG-type DHA, but the DHA content in brain of mice and the DHA concentration in serum of mice in the two groups was not significantly different. …”
Get full text

How can cervical screening meet the needs of vulnerable women? A qualitative comparative study with stakeholder perspectives from seven European countries by Partha Basu, Martin McKee, Adriana Băban, Marc Bardou, Ana Fernandes, Margarida Teixeira, Rebecca Moore, Nuno Lunet, David Ritchie, Romeu Mendes, Eric Lucas, Paolo Giorgi Rossi, Rosa Legood, Berit Andersen, Diana Taut, Keitly Mensah, João Firmino-Machado, Mariana Amorim, Mette Tranberg, Laura Bonvicini, Anneli Uusküla, Pia Kirkegaard, Paola Mantellini, Ines Baia, Liu Sun, Lise Rochaix, Camilla Fiorina, Luca Ghirotto, Anna Tisler, Firmino Machado, Rikke Buus Bøje, Raquel Rico Berrocal, Noemi Auzzi, Kerli Reintamm, Yulia Panayotova, Tatyana Kotzeva, Anna Foss, Rachel Greenley, Letizia Bartolini, Giusy Iorio, Cláudia Gouvinhas, Florian Nicula, Alexandra Tolnai, Vanessa Moore, Isabel Mosquera Metcalfe, Violette Delisle, Irina Todorova, Helena Ros Comesana, Meritxel Mallafré-Larrosa, Ginevra Papi, Nicoleta-Monica Pașca, Christiane Dascher-Nadel, Olivra Djuric

Get full text

Performance evaluation of four cascade impactors for airborne ultrafine-particle (UFP) collection: the influence of particle type, concentration, mass, and chemical nature by E. Eckenberger, A. Mittereder, N. Gawlitta, N. Gawlitta, J. Schnelle-Kreis, J. Schnelle-Kreis, M. Sklorz, D. Brüggemann, R. Zimmermann, R. Zimmermann, A. C. Nölscher

“…We analyzed six markers representing typical UFP sources and various molecular<span id="page46"/> properties using HPLC-MS/FLD (high-performance liquid chromatography with mass spectrometry and fluorescence detection). These markers comprised benzo[a]pyrene (BaP), benzo[b]fluoranthene (BbF), levoglucosan (Levo), pinic acid (PA), terpenylic acid (TA), and N-(1,3-dimethylbutyl)-N'-phenyl-p-phenylenediamine (6PPD). …”
Get full text

homeRNA self-blood collection enables high-frequency temporal profiling of presymptomatic host immune kinetics to respiratory viral infection: a prospective cohort studyResearch in... by Fang Yun Lim, Hannah G. Lea, Ashley M. Dostie, Soo-Young Kim, Tammi L. van Neel, Grant W. Hassan, Meg G. Takezawa, Lea M. Starita, Karen N. Adams, Michael Boeckh, Joshua T. Schiffer, Ollivier Hyrien, Alpana Waghmare, Erwin Berthier, Ashleigh B. Theberge

“…Findings: Between June 2021 and April 2022, 68 participants across 26 U.S. states completed the study and self-collected a total of 691 and 466 longitudinal blood and nasal swab samples along with 688 symptom surveys. SARS-CoV-2 was detected in 17 out of 22 individuals with study-confirmed respiratory infection, of which five were still presymptomatic or pre-shedding, enabling us to profile detailed expression kinetics of the earliest blood transcriptional response to contemporaneous variants of concern. 51% of the genes assessed were found to be temporally dynamic during COVID-19 infection. …”
Get full text

Biosynthesis inhibition of miR-142-5p in a N 6-methyladenosine-dependent manner induces neuropathic pain through CDK5/TRPV1 signaling by Jinshi Li, Yang Guo, Chen Zhu, Dongxu Wang, Yuan Li, Xiaotong Hao, Linyan Cao, Yiting Fan, Bo Fang

“…The overall level of m6A was first determined by RNA m6A methylation assay, and subsequently the methylation level of pri-miR-142 was assessed using the meRIP assay to detect m6A modification. In addition, an in vivo rat chronic constriction injury (CCI) model was established, and miR-142-5p agomir or antagomir was injected intrathecally. …”
Get full text

STR profiling in a cohort of Saudi patients with acute leukemia by Husein A. Alhatim, PhD Student, Muhammad NH Abdullah, PhD, Suhaili A. Jamaludin, PhD, Armania B. Nurdin, PhD, Sayed A. Amer, PhD

“…Microsatellite instability (MSI) was detected in 22.2% of patients at TPOX, vWA, D19S433, D16S539, and D18S51. …”
Get full text

Phasic and periodic change of drought under greenhouse effect by Yang Li, Zhicheng Zheng, Yaochen Qin, Haifeng Tian, Zhixiang Xie, Peijun Rong

“…It also ignores the nonstationary nature of the hydrometeorological water process; therefore, it is prone to bias in drought detection and may overestimate the intensity and duration of droughts. …”
Get full text

PERKEMBANGAN ENZIM PENCERNAAN LARVA IKAN PATIN, Pangasius hypophthalmus sp. by Irzal Effendi, . Widanarni, D. Augustine

“…Protease and lipase activity were detected in digestive tract of  1 dAH larvae.   Digestive enzymes development have a similar pattern in larvae for all feeding schedules.  …”
Get full text

CO₂@C₈₄: DFT Calculations of Structure and Energetics by Zdeněk Slanina, Filip Uhlík, Takeshi Akasaka, Xing Lu, Ludwik Adamowicz

“…The calculated rotational constants and IR vibrational spectra are presented for possible use in detection. The stability of <inline-formula><math xmlns="http://www.w3.org/1998/Math/MathML" display="inline"><semantics><msub><mrow><mo>(</mo><msub><mi>CO</mi><mn>2</mn></msub><mo>)</mo></mrow><mn>2</mn></msub></semantics></math></inline-formula><inline-formula><math xmlns="http://www.w3.org/1998/Math/MathML" display="inline"><semantics><mrow><msub><mrow><mo>@</mo><mi mathvariant="normal">C</mi></mrow><mn>84</mn></msub></mrow></semantics></math></inline-formula> is also briefly discussed.…”
Get full text

Interplay between oxidative stress, neuroinflammatory cytokines and melatonin in Alzheimer's disease: Insights from cerebrospinal fluid analysis by Francisco Artime-Naveda, David Hevia, Rebeca Alonso-Arias, Carmen Martínez, Isabel Quirós-González, Rafael Cernuda-Cernuda, Alejando Alvarez-Artime, Iván Menéndez-Valle, Rosa M. Sainz, Juan C. Mayo

“…Qualitative analysis of the proinflammatory cytokines assayed showed a higher detection level in Aβ-positive patients. Regarding melatonin in the CSF, indolamine levels did not correlate with its major oxidative-derived metabolite, i.e., AFMK. …”
Get full text