The causal effects between low back pain and cerebrospinal fluid metabolites: a two-sample Mendelian randomization study by Run Peng, Xiaoxin Wang, Wei Wang, Zeqin Li, Yuze Sun, Mingliang Yang

“…No significant estimates of heterogeneity or pleiotropy were detected. Conclusion Our study emphasizes the causal relationship between CSF metabolites and LBP risk, providing reference for clinical treatment and prognosis of LBP.…”
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Development and Validation of an HPLC Method for Simultaneous Quantification of Clopidogrel Bisulfate, Its Carboxylic Acid Metabolite, and Atorvastatin in Human Plasma: Application... by Octavian Croitoru, Adela-Maria Spiridon, Ionela Belu, Adina Turcu-Ştiolică, Johny Neamţu

“…Chromatographic separation was performed on an BDS Hypersil C18 column (250 × 4.6 mm; 5 μm) via gradient elution with mobile phase consisting of 10 mM phosphoric acid (sodium) buffer solution (pH = 2.6 adjusted with 85% orthophosphoric acid) : acetonitrile : methanol with flow rate of 1 mL·min−1. Detection was achieved with PDA detector at 220 nm. …”
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The added role of Doppler ultrasound evaluation of sickle cell disease vasculopathy as a state of arterial stiffness and decreased nitric oxide bioavailability by Marwa Mohammed Mohammed Onsy, Sonia Ali El-Saiedi, Douaa Mohammed Mohammed Elsheshtawy, Marwa Abd-Elhady Abd-Elsamad

“…Conclusion Doppler assessment of brachial and carotid elastic properties may be helpful for early detection of sickle cell vasculopathy and sickle-related complications.…”
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Oxidative Stress Level as a Predictor of Anastomotic Leakage after Rectal Surgery by Jiajun Luo, Hongxue Wu, Yu Yang, Yue Jiang, Jingwen Yuan, Qiang Tong

“…Most of the oxidative stress indicators we detected are of considerable significance in the diagnosis of anastomotic leakage. …”
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Th1 and Th2 cytokine profile in patients with early onset periodontitis and their healthy siblings by Jiřina Bártová, Zuzana Krátká-Opatrná, Jarmila Procházková, Otakar Krejsa, Jana Dušková, Lubor Mrklas, Helena Tlaskalová, Božena Cukrowská

“….), a bacterium typical for EOP, was detected in all people studied. Th1 and Th2 cytokine production was measured after in vitro stimulation. …”
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The Effect of PVP Molecular Weight on Dissolution Behavior and Physicochemical Characterization of Glycyrrhetinic Acid Solid Dispersions by Xiaoyu Sui, Yan Chu, Jie Zhang, Honglian Zhang, Huiyu Wang, Tingting Liu, Cuiyan Han

“…Based on FTIR and Raman detection, a hydrogen-bond between PVP and drug molecules is formed. …”
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Early Diagnosis of Alzheimer’s Disease Using Adaptive Neuro K-Means Clustering Technique by Karan Kumar, Shweta Agrawal, Isha Suwalka, Celestine Iwendi, Cresantus N. Biamba

“…Implemented in MATLAB, this method provides a robust, efficient framework for early AD detection, surpassing existing approaches in precision and reliability.…”
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Synaptic enrichment and dynamic regulation of the two opposing dopamine receptors within the same neurons by Shun Hiramatsu, Kokoro Saito, Shu Kondo, Hidetaka Katow, Nobuhiro Yamagata, Chun-Fang Wu, Hiromu Tanimoto

“…For cell-type-specific visualization of endogenous proteins, we employed reconstitution of split-GFP tagged to the receptor proteins. We detected dopamine receptors at both presynaptic and postsynaptic sites in multiple cell types. …”
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Circle of Willis Variants: Fetal PCA by Amir Shaban, Karen C. Albright, Amelia K. Boehme, Sheryl Martin-Schild

“…Patients with complete fPCA were older and more often female than partial fPCA and no fPCA patients, and significant variation in TOAST classification was detected across groups (). Patients with complete fPCA had less small vessel and more large vessel strokes than patients with no fPCA and partial fPCA. …”
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Guidelines for the Management of Complications of Diabetes in Saudi Arabia Using Delphi Technique for Consensus Among National Experts by Raed Aldahash, Mohammed A. Batais, Ashraf El-Metwally, Saja Alhosan, Mohammed Alharbi, Mohammed Almutairi, Abdulghani Alsaeed, Mohammed Alsofiani, Mohammed AlMehthel, Mohammed Aldubayee, Khaled Aldossari, Sulieman Alshehri

“…The guidelines offer useful insights into diabetes care, especially by prioritizing early detection and proactive management of complications. …”
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Variants in the 3′ End of SLC6A3 in Northwest Han Population with Parkinson’s by Peiye Chang, Yongwang Fu, Ping Zhao, Chunmei Wang, Mingfang Jiang, Rui Li, Yulin He

“…The significant difference of gene type and allele frequencies between the PD and control groups was detected only in rs40184 (P = 0.013 and 0.004, respectively; odds ratio 2.529, 95% confidence interval 1.325–4.827). …”
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Analysis of Biomolecular Changes in HeLa Cervical Cancer Cell Line Induced by Interaction with [Pd(dach)Cl₂] by Vanja Ralić, Maja D. Nešić, Tanja Dučić, Milutin Stepić, Lela Korićanac, Katarina Davalieva, Marijana Petković

“…Although a certain level of lipid peroxidation was detectable by SR FTIR spectroscopy and confirmed by an analysis of cellular lipids by matrix-assisted laser desorption and ionisation time-of-flight mass spectrometry, the oxidative stress is not a significant mechanism by which Pd(II) expresses the effect on the HeLa cells.…”
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Attraction and aversion of noctuid moths to fermented food sources coordinated by olfactory receptors from distinct gene families by Xiao-Qing Hou, Dan-Dan Zhang, Hanbo Zhao, Yang Liu, Christer Löfstedt, Guirong Wang

“…We deorphanized the olfactory receptors detecting these two compounds and found that they belonged to two distinct gene families and were functionally conserved across four noctuid subfamilies; HarmOR52 orthologues responded to the attractive isoamyl alcohol and HarmIR75q.1 orthologues responded to the aversive octanoic acid. …”
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Corneal Backscatters as an Objective Index for Assessing Fuchs’ Endothelial Corneal Dystrophy: A Pilot Study by Hsueh-Yen Chu, Ching-Hsi Hsiao, Phil Yeong-Fong Chen, David Hui-Kang Ma, Chee-Jen Chang, Hsin-Yuan Tan

“…It can assist ophthalmologists in detecting the early change and in monitoring disease progression of FECD. …”
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Young Cuban Patients with a Clinical and biochemical Diagnosis of Xeroderma Pigmentosum by Judith Beatriz Pupo Balboa, Mónica Marín García, Anamarys Pandolfi Blanco, Lucía Fariñas Rodríguez, Paulina Araceli Lantigua Cruz

“…In all four patients, expression of eta polymerase was detected by western blot; in the two who had normal repair, the protein band was weak, indicating that they might have the variant of the disease. …”
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Short Supply of High Levels of Guanidine Acetic Acid, Alters Ovarian Artery Flow and Improves Intraovarian Blood Perfusion Area Associated with Follicular Growth in Sheep by Marta da Costa Sousa, Camila Muniz Cavalcanti, Alfredo José Herrera Conde, Bruna Vitória de Freitas Alves, Larissa Fernandes Baia Cesar, Jhennyfe Nobre de Sena, Yohana Huicho Miguel, César Carneiro Linhares Fernandes, Juliana Paula Martins Alves, Dárcio Ítalo Alves Teixeira, Davide Rondina

“…Twenty adult sheep had their estrus synchronized using an MPA sponge, eCG, and PGF2α. After estrus detection ewes were mated. For 10 days until mating, ewes were grouped in groups of baseline diet (BSD; n = 10) and GAA diet (GAAD; n = 10), which was the BSD with daily 0.9 g/kg DM of GAA. …”
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mRNA Expression of EgCHI1, EgCHI2, and EgCHI3 in Oil Palm Leaves (Elaeis guineesis Jacq.) after Treatment with Ganoderma boninense Pat. and Trichoderma harzianum Rifai by Laila Naher, Soon Guan Tan, Chai Ling Ho, Umi Kalsom Yusuf, Siti Hazar Ahmad, Faridah Abdullah

“…Basal stem rot (BSR) disease caused by the fungus Ganoderma boninense is the most serious disease affecting the oil palm; this is because the disease escapes the early disease detection. The biocontrol agent Trichoderma harzianum can protect the disease only at the early stage of the disease. …”
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The anomalously thundery month of June 1925 in southwest Spain: description and synoptic analysis by F. J. Acero, M. Antón, A. J. P. Aparicio, A. J. P. Aparicio, N. Bravo-Paredes, V. M. S. Carrasco, M. C. Gallego, J. A. García, M. Núñez, I. Tovar, J. Vaquero-Martínez, J. M. Vaquero

“…<p>In a routine search for meteorological events with a great impact on society in the Extremadura region (southwest interior of the Iberian Peninsula) using newspapers, the month of June 1925 was detected as exceptional due to the large number of thunderstorms associated with significant losses of human lives and material resources. …”
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Assessment of changes in vitamin content and morphological characteristics in strawberries modified with a pulsed electric field using chromatography and optical coherence tomograp... by Ewa Korzeniewska, Ilona Gałązka-Czarnecka, Joanna Sekulska-Nalewajko, Jarosław Gocławski, Tomasz Dróźdż, Paweł Kiełbasa

“…Experiments have shown that PEF treatment with an intensity of 1 kV/cm and 10 pulses for 10 s resulted in a significant improvement in vitamin content and extraction efficiency of vitamin C by 22 %, folic acid by 24 %, thiamine by more than 50 % and riboflavin by more than 60 %.Optical coherence tomography imaging revealed texture changes in fruit pulp under the influence of PEF, related to the release of additional vitamins detected by chromatography methods.Additionally, PEF treatment offers significant benefits in fruit processing, including improved dehydration characteristics, reduced time and energy required for freeze-drying, increased extraction efficiency, and potential improvements in bioactive compound content and antioxidant properties.The research results may have practical applications in the analytical determination of vitamins C and B by improving the extraction efficiency. …”
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Downregulation of CD4+LAP+ and CD4+CD25+ Regulatory T Cells in Acute Coronary Syndromes by Ying-zhong Lin, Shan-he Lu, Zheng-de Lu, Ying Huang, Ying Shi, Ling Liu, Xiao-yan Wang, Qing-wei Ji

“…The frequencies of CD4+LAP+ and CD4+CD25+ Treg cells were detected using flow cytometric analysis, and the plasma IL-10 and TGF-β1 levels were measured using an ELISA in 29 stable angina (SA) patients, 30 NSTEACS patients, 27 STEAMI patients, and a control group (30 cases). …”
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