Comparing the Efficacy and Safety of Glucagon-Like Peptide 1 Receptor Agonists with Sodium-Glucose Cotransporter 2 Inhibitors for Obese Type 2 Diabetes Patients Uncontrolled on Met... by Lu Ding, Bang Sun, Xinhua Xiao

“…No significant difference was detected between GLP-1RAs and SGLT-2is in overall adverse events (RR: 1.03; 95% CI: 0.98, 1.09; p=0.76), but gastrointestinal events showed higher occurrence in GLP-1RAs groups compared with SGLT-2is (RR: 1.62; 95% CI: 1.37, 1.93; p<0.00001). …”
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Sequence-based GWAS in 180,000 German Holstein cattle reveals new candidate variants for milk production traits by Ana-Marija Križanac, Christian Reimer, Johannes Heise, Zengting Liu, Jennie E. Pryce, Jörn Bennewitz, Georg Thaller, Clemens Falker-Gieske, Jens Tetens

“…Conclusions Our findings proved the power of large samples and sequence-based GWAS in detecting new association signals. In order to fully exploit the power of GWAS, one should aim at very large samples combined with whole-genome sequence data. …”
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Burden of Anemia among Human Immunodeficiency Virus-Positive Adults on Highly Active Antiretroviral Therapy at Hawassa University Compressive Specialized Hospital, Hawassa, Ethiopi... by Sisay Tesfaye, Melaku Hirigo, Dawit Jember, Mekdes Shifeta, Worku Ketema

“…Multivariable logistic regression was carried out to detect elements associated with anemia. A P value of <0.05 was used as a cutoff point to announce statistical significance. …”
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Effects of ruminal short-chain fatty acid concentration and pH on histology, hematology, and inflammation in cannulated Holstein dairy calves by A.R. Wolfe, M.H.P.M. Narciso, R.R.E. Uwiera, A.H. Laarman

“…No differences were detected in red blood cells or platelet numbers. Total white blood cell numbers decreased in the LS-LP group from wk 5 to 7 but increased in the HS-LP group along with hemoglobin and the hematocrit during the same period. …”
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Estimating the Prevalence of Schizophrenia in the General Population of Japan Using an Artificial Neural Network–Based Schizophrenia Classifier: Web-Based Cross-Sectional Survey by Pichsinee Choomung, Yupeng He, Masaaki Matsunaga, Kenji Sakuma, Taro Kishi, Yuanying Li, Shinichi Tanihara, Nakao Iwata, Atsuhiko Ota

“…The crude prevalence of schizophrenia was calculated through the proportion of positive cases detected by the SZ classifier. The crude estimate was further refined by excluding false-positive cases and including false-negative cases to determine the actual prevalence of schizophrenia. …”
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Malignant transformation of proliferative Verrucous Leukoplakia—systematic review & meta-analysis by Khadijah Mohideen, Snehashish Ghosh, Chandrasekaran Krithika, Mutaz Ali-Hassan, Revant Chole, Safal Dhungel

“…Understanding its etiology could aid early detection and management.…”
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Phylogenomic analysis reveals exceptions to the co-evolution of ZAR1 and ZRK immune gene families in plants by Li Yang, Shengyi Liu, M. Eric Schranz, Klaas Bouwmeester

“…Co-occurrence of ZAR1-A and ZRKs was found in various plant species belonging to different angiosperm orders, but both genes were found to be absent in chlorophyta, bryophytes, lycophytes, ferns, and gymnosperms. We also detected a large number of concerted gene losses in angiosperms, especially within the orders Fabales, Cucurbitales, Asterales, and Apiales. …”
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Marker-assisted selection in the development of advanced apple-tree forms and donors combining scab resistance with increased fruit storability by I. I. Suprun, E. A. Egorov, A. I. Nasonov, E. V. Lobodina, S. V. Tokmakov, I. V. Stepanov

“…The Md-ACS1 gene alleles were detected with a known SCAR DNA marker. The chi-square test was applied for statistical confirmation of the data.Results. …”
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TAK-242 improves sepsis-associated acute kidney injury in rats by inhibiting the TLR4/NF-κB signaling pathway by Yan-mei Xia, Yu-qian Guan, Ji-fang Liang, Wei-dong Wu

“…After 24 h, the indicators related to kidney injury in blood samples were detected. The pathological changes in the kidneys were observed by hematoxylin-eosin staining, and tubular damage was scored. …”
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Isolation and Characterization of Coronavirus and Rotavirus Associated with Calves in Central Part of Oromia, Ethiopia by Umer Seid, Fufa Dawo, Asamino Tesfaye, Munera Ahmednur

“…The four study areas were purposively selected and faecal samples were collected by simple random sampling for diagnosis of coronavirus and rotavirus infection by using the antigen detection enzyme-linked immunosorbent assay (Ag-ELISA) kit. …”
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Phenotypic Characterization and Antibiotic Resistance Patterns of Extended-Spectrum β-Lactamase- and AmpC β-Lactamase-Producing Gram-Negative Bacteria in a Referral Hospital, Saudi... by Mutasim E. Ibrahim, Mohammed Abbas, Abdullah M. Al-Shahrai, Bahaeldin K. Elamin

“…Quality control practice and routine detection of β-lactamase producers before deciding on antibiotic therapy are advocated.…”
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Predictors of Neurological and Functional Recovery in Patients with Moderate to Severe Ischemic Stroke: The EPICA Study by Manuel Murie-Fernández, Mercedes Molleda Marzo

“…Apart from demonstrating traditional “non-modifiable” predictors of outcome after stroke, like age, sex, and stroke severity, we also detected association between the use of dietary supplement MLC901 and recovery.…”
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Role of the serum levels of the inter-organs messenger fibroblast growth factor 21 (FGF21) in the diagnosis and prognosis of breast cancer patients by Stella Maris Ranuncolo, Eduardo Armanasco, Myriam Nuñez, Laura Yuan, Sujhrob Makhkamov, Mariana S. De Lorenzo

“…Circulating FGF21 levels could be useful as a highly sensitive diagnosis biomarker for early breast cancer detection. We did not find any significant association between the serum FGF21 levels, and many clinical-pathological or metabolic parameters determined at the diagnosis of the primary disease. …”
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Synthesis and characteristics of Fe/Ni/Cr oxide nanoparticles/PLA hybrid composite coatings on Mg–Zn–Ca alloy by Prakash Kumar, Aditya Kudva S, AnilKumar T, Ramesh S, M.R. Ramesh, Ashwini Prabhu, Gajanan Anne

“…Furthermore, cytocompatibility of the PLA hybrid composites on osteoblast cells and apoptosis detection using acridine orange-ethidium bromide. Our developed coating showed ratings of 5B and 4B were obtained for FeNiCr/PLA NC- ball burnished (BB) Mg and FeNiCr/PLA nano composite (NC)–Mg samples, respectively, demonstrating the exceptional coating strength and the substrate. …”
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Superplastic Forming/Diffusion Bonding of TA15 Titanium Alloy for Manufacturing Integrated Solid/Hollow Four-Layer Grid Lightweight Structure Components by Zheng Han, Yuhan Xing, Taiying Liu, Ning Zhang, Shaosong Jiang, Zhen Lu

“…The quality of the components was evaluated using X-ray and ultrasonic C-scan detection methods. The results show that the maximum elongation of the alloy is 1340% at 900 °C/0.001 s⁻¹. …”
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Network pharmacology and experimental verification to investigate the mechanism of isoliquiritigenin for the treatment of Alzheimer’s disease by Waimao Gao, Guang Yang, Xinjuan Liu, Kaifan Hu, Jie Pan, Xingyu Wang, Yan Zhao, Ying Xu

“…The protein-protein interaction (PPI) network was constructed and clusters were obtained using the Molecular Complex Detection (MCODE) and the Cytohubba plugins. Further, molecular docking study was performed for these core targets. …”
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Association between mixed exposure of non-persistent pesticides and liver fibrosis in the general US population: NHANES 2013–2016 by Shuge Shu, Yuan Li, Xiangyu Yu, Xinting Chen, Ummara Abdullah, Yongquan Yu

“…Survey-weighted linear/logistic regression and Bayesian kernel machine regression (BKMR) were used to detected the independent and combined associations between non-persistent pesticides and liver fibrosis, respectively. …”
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GelMA@LNP/AST Promotes eNOS-Dependent Angiogenesis Through Autophagy Activation for the Treatment of Hind Limb Ischemia by Lai L, Wu H, Peng L, Zhang Z, Wu X, Zheng S, Su Z, Chu H

“…The changes in angiogenesis markers, autophagy markers, and eNOS levels were detected using qPCR and Western blotting. 3-MA was used to assess the role of autophagy in the activation of eNOS mediated by AST and its subsequent angiogenic effects.Results: GelMA@LNP/AST significantly promoted blood flow recovery in mice with hind limb ischemia. …”
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Improving timing resolution of BGO for TOF-PET: a comparative analysis with and without deep learning by Francis Loignon-Houle, Nicolaus Kratochwil, Maxime Toussaint, Carsten Lowis, Gerard Ariño-Estrada, Antonio J. Gonzalez, Etiennette Auffray, Roger Lecomte

“…Abstract Background The renewed interest in BGO scintillators for TOF-PET is driven by the improved Cherenkov photon detection with new blue-sensitive SiPMs. However, the slower scintillation light from BGO causes significant time walk with leading edge discrimination (LED), which degrades the coincidence time resolution (CTR). …”
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HEDDI-Net: heterogeneous network embedding for drug-disease association prediction and drug repurposing, with application to Alzheimer’s disease by Yin-Yuan Su, Hsuan-Cheng Huang, Yu-Ting Lin, Yi-Fang Chuang, Sheh-Yi Sheu, Chen-Ching Lin

“…Methods To address the limitations of traditional methods, we developed HEDDI-Net, a heterogeneous embedding architecture designed to accurately detect drug-disease associations while preserving the interpretability of biological mechanisms. …”
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