Human soft tissue sarcomas harbor an intratumoral viral microbiome which is linked with natural killer cell infiltrate and prognosis by William J Murphy, Robert J Canter, Nikhil Joshi, Sean J Judge, Morgan A Darrow, Steve W Thorpe, Alicia A Gingrich, Lauren M Perry, Sylvia M Cruz, Kara T Kleber, Louis B Jones, Ugur N Basmaci, Matthew L Settles, Blythe P Durbin-Johnson, Arta Monir Monjazeb, Janai Carr-Ascher, Jonathan A Eisen

“…Despite overwhelming human DNA (>99%) intratumorally, we detected a small but consistent proportion of bacterial DNA (0.02–0.03%) in all tumors, including Proteobacteria, Bacteroidetes, and Firmicutes, as well as viral species. …”
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Effect of Drying Methods on the Phenolic Profile and Antioxidant Capacity of <i>Pithecellobium dulce</i> (Roxb.) Benth. Aril and Its Inhibitory Properties on Human SW480 Colon Aden... by Ángel Félix Vargas-Madriz, Aarón Kuri-García, Ivan Luzardo-Ocampo, Roberto Augusto Ferriz-Martínez, Teresa García-Gasca, Carlos Saldaña, Haidel Vargas-Madriz, Salvador Horacio Guzmán-Maldonado, Jorge Luis Chávez-Servín

“…Up to 14 polyphenolic compounds were detected in oven-dried samples. For in vitro assays in SW480 cells, the 50% <i>v</i>/<i>v</i> methanolic extract was used. …”
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Meckel’s Diverticulum Diagnosed by Balloon-Assisted Enteroscopy: A Multicenter Report from the Taiwan Association for the Study of Small Intestinal Diseases (TASSID) by Jen-Wei Chou, Chen-Shuan Chung, Tien-Yu Huang, Chia-Hung Tu, Chen-Wang Chang, Chung-Hsin Chang, Yen-Po Wang, Wen-Hung Hsu, Hsu-Heng Yen, Chia-Jung Kuo, Chiao-Hsiung Chuang, Ching-Pin Lin, Tzung-Jiun Tsai, Ming-Yao Su, Horng-Yuan Wang, Deng-Chyang Wu, Cheng-Tang Chiu

“…The current study showed BAE is a very useful modality for detecting MD compared with other conventional modalities.…”
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Arbovirus exposure and subclinical myocardial dysfunction in an Indigenous population in Northeast Brazil: a cross-sectional study by Jandir Mendonça Nicacio, Carlos Dornels Freire de Souza, Ricardo Khouri, Vanessa Cardoso Pereira, Rodrigo Feliciano do Carmo, Pedro Vinícius Amorim de Medeiros Patriota, Sávio Luiz Pereira Nunes, Jeová Cordeiro de Morais Júnior, Manoel Barral-Netto, João Augusto Costa Lima, Anderson da Costa Armstrong

“…GLS abnormalities were detected in nearly half (48.3%) of the cohort. However, no significant association was found between arbovirus serology and GLS. …”
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Sources of PM2.5 exposure and health benefits of clean air actions in Shanghai by Yixuan Gu, Daven K. Henze, Hong Liao

“…A negative response of the PM2.5 exposure to local nitrogen oxides (NOx) emission changes is detected in winter. Even so, controlling NOx emissions is still justified since the negative impacts decrease as anthropogenic emissions decline and NOx emission reductions benefit the public health on average. …”
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The prognostic significance of tertiary lymphoid structures in oral squamous cell carcinomas: a systematic review by V. Ribeiro, J-L. Teillaud, J-L. Teillaud, J-L. Teillaud, M-C. Dieu-Nosjean, M-C. Dieu-Nosjean, M-C. Dieu-Nosjean, G. Lescaille, G. Lescaille, G. Lescaille, G. Lescaille, G. Lescaille, J. Rochefort, J. Rochefort, J. Rochefort, J. Rochefort, J. Rochefort

“…Our review shows that the presence of TLS is associated with improved survival in OSCC.DiscussionHowever, variations in TLS detection and classification methods across studies introduce potential biases, hindering direct comparisons between findings. …”
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Quantitative assessment of colour fundus photography in hyperopia children based on artificial intelligence by Yuan Zhang, Yingting Zhu, Zhirong Wang, Yue Xiao, Yehong Zhuo, Zhidong Li, Guitong Ye, Jianqi Chen, Ruiyu Luo, Rui Xie, Jinan Zhan

“…Fundus parameters, such as optic disc area and mean vessel diameter, were automatically and quantitatively detected using AI. Significant variables (p&lt;0.05) in the univariate analysis were included in a stepwise multiple linear regression.Results Overall, 324 children were included, 172 with low and 152 with moderate-to-high hyperopia. …”
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Knockdown of PDPN in astrocytes reduces hippocampal inflammation in T2DM mice by Xiaohang Wang, Xiaohang Wang, Xiaohang Wang, Qianqian Wang, Zhensheng Cai, Chengming Ni, Huan Wang, Hui Liu, Yusong Zhao, Jinbang Wang, Subo Liu, Xueying Wang

“…After the cognition assessment, the mice were euthanized, and the inflammatory factors associated to the VaD were detected by immunofluorescence. We showed that the fluorescence intensities of IL-1β, IL-6, TNF-α, and TGF-β1 in hippocampus were decreased after the Pdpn knocking down in astrocytes of T2DM mice.ConclusionIn summary, this study demonstrates that Pdpn exerts a novel player in T2DM-induced neuroinflammation and cognitive decline. …”
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Ophthalmologists’ and patients’ perspectives on treatments for diabetic retinopathy and maculopathy in Vietnam: a descriptive qualitative study by Tunde Peto, Nathan Congdon, Lynne Lohfeld, Hoang Tran, Katie Curran, Van Thu Nguyen, Tung Thanh Hoang, Hue Thi Nguyen, Quan Nhu Nguyen, Catherine Dardis, Hoang Huy Tran, Anh Tuan Vu, Mai Quoc Tung

“…Introduction Globally, diabetic retinopathy (DR) is the leading cause of blindness in working-aged adults. Early detection and treatment of DR is essential for preventing sight loss. …”
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Domestication of different varieties in the cheese-making fungus Geotrichum candidum by Bennetot, Bastien, Vernadet, Jean-Philippe, Perkins, Vincent, Hautefeuille, Sophie, Rodríguez de la Vega, Ricardo C., O’Donnell, Samuel, Snirc, Alodie, Grondin, Cécile, Lessard, Marie-Hélène, Peron, Anne-Claire, Labrie, Steve, Landaud, Sophie, Giraud, Tatiana, Ropars, Jeanne

“…Within the cheese clade, we identified three genetically differentiated populations and we detected footprints of recombination and admixture. …”
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Exploring the CD3/CD56/TNF-α/Caspase3 pathway in pyrethroid-induced immune dysregulation: curcumin-loaded chitosan nanoparticle intervention by Nawal Alsubaie, Yasmina M. Abd-Elhakim, Amany Abdel-Rahman Mohamed, Tarek Khamis, Tarek Khamis, Mohamed M. M. Metwally, Mohamed M. M. Metwally, Nawal Helmi, Afnan M. Alnajeebi, Badriyah S. Alotaibi, Amirah Albaqami, Wedad Mawkili, Mai A. Samak, Mai A. Samak, Samar A. Eissa

“…Furthermore, a substantial upregulation of mRNA expression of splenic CD20, CD56, CD8, CD4, CD3, IL-6, and TNF-α, but downregulation of CD8 was detected in FTN-exposed rats. FTN exposure significantly upregulated splenic Caspase-3 and increased its immunohistochemical expression, along with elevated TNF-α immunoexpression. …”
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The Increased Ratio of Blood CD56bright NK to CD56dim NK Is a Distinguishing Feature of Primary Sjögren’s Syndrome by Bingxia Ming, Tong Wu, Shaozhe Cai, Peng Hu, Jungen Tang, Fang Zheng, Cong Ye, Lingli Dong

“…The frequency and absolute number of NK cells and CD56 NK cell subsets in peripheral blood samples were detected by flow cytometry. Other laboratory parameters such as the IgG level and complement protein levels were extracted from the clinical system. …”
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Investigating the feasibility of developing a collective action for biological control of fall armyworm among smallholder farmers in rural communities of Zambia by Léna Durocher-Granger, Sara Fiorito, Sibajene Kambanja Mudenda, Milimo Mildred Chiboola, Monica K. Kansiime, David Ludwig, Cees Leeuwis

“…Abstract Background Fall armyworm, Spodoptera frugiperda, an alien invasive pest from the Americas, was detected in Zambia late 2016 and since has caused significant losses on maize threatening livelihood and food security. …”
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Depth-Dependent Cellular Response from Dental Bulk-Fill Resins in Human Dental Pulp Stem Cells by Su-Min Lee, Soo-Youn Kim, Jae-Heon Kim, Soo-Kyung Jun, Hae-Won Kim, Jung-Hwan Lee, Hae-Hyoung Lee

“…All bulk-fill resins except BBF revealed cytotoxicity from 4 to 6 or 2 to 4 mm, while ZFF was cytotoxic at over 2 mm. Depth of cure was detected from 3.55 to 4.02 mm in the bulk-fill resins (vs. ~2.25 mm in conventional resin), and 80% hardness compared with that of a fully polymerized top surface was determined from 4.2 to 6 mm in the bulk-fill resin (vs. 2.4 mm in conventional resin). …”
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Differences in Clinicopathological Characteristics of Papillary Thyroid Carcinoma between Symptomatic and Asymptomatic Patients with Primary Hyperparathyroidism by Yuan Liu, Siyi Guo, Shaowei Sang, Jinbo Liu, Lin Qi, Bin Lv, Xiaoli Zhang

“…Popularization of cervical ultrasound led to higher detection of papillary thyroid carcinoma (PTC) and primary hyperparathyroidism (PHPT), as well as increasing percentage of asymptomatic PHPT in China. …”
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Sustained Impairment in Cardiopulmonary Exercise Capacity Testing in Patients after COVID-19: A Single Center Experience by Georg Evers, Arik Bernard Schulze, Irina Osiaevi, Kimon Harmening, Richard Vollenberg, Rainer Wiewrodt, Rudin Pistulli, Matthias Boentert, Phil-Robin Tepasse, Juergen R. Sindermann, Ali Yilmaz, Michael Mohr

“…Limited relative EC was detected in 11/30 (36.7%) patients. Limitation correlated with reduced body weight-indexed peak oxygen (O2) uptake (peakV̇O2/kg) (mean 74.7 (±7.1) % vs. 103.6 (±14.9) %, p<0.001). …”
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Nailfold Capillaroscopy in Early Stages of Mixed Connective Tissue Disease in a Sample of Egyptian Patients by Yasser A Elmotaleb Gazar, Hesham Salah Hamoud, Sherif Mohamed Ismail

“…Nailfold capillaroscopy (NFC) is a noninvasive diagnostic tool for patients with different connective tissue diseases that permit detection of local microvascular changes that correlate with systemic vascular involvement. …”
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Rotation errors in path integration are associated with Alzheimer’s disease tau pathology: a cross-sectional study by Lise Colmant, Lisa Quenon, Lara Huyghe, Adrian Ivanoiu, Thomas Gérard, Renaud Lhommel, Pauline Coppens, Yasmine Salman, Vincent Malotaux, Laurence Dricot, Lukas Kunz, Nikolai Axmacher, Philippe Lefèvre, Bernard Hanseeuw

“…Spatial navigation assessment, in particular path integration, appears promising to detect preclinical symptoms, as the medial temporal lobe plays a key role in navigation and is the first cortical region affected by tau pathology. …”
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Patterns of failure and prognosis in nasopharyngeal carcinoma according to Epstein-Barr virus DNA status by Lin-Feng Guo, Guan-Zhong Lu, Zhen-Zhen Lu, Yi-Feng Yu, San-Gang Wu

“…Results This study involved 108 patients, including 105 (97.2%) who had EBV-DNA detectable at the initial diagnosis of NPC. Regarding progression patterns, 34 patients (31.5%) experienced only LRR, while 60 patients (55.6%) had only DM. …”
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Functional and effective EEG connectivity patterns in Alzheimer’s disease and mild cognitive impairment: a systematic review by Elizabeth R. Paitel, Christian B. D. Otteman, Mary C. Polking, Henry J. Licht, Kristy A. Nielson, Kristy A. Nielson

“…We address the need for including demographic and methodological details, using source space connectivity, and extending this work to cognitively healthy older adults with AD risk toward advancing early AD detection and intervention.…”
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