Simultaneous Quantification of Pioglitazone and Omarigliptin in Rat Plasma by UHPLC-MS/MS and Its Application to Pharmacokinetic Study after Coadministration of the Two Drugs by Lin Wang, Jiaxi Wang, Chao Lin, Furong Wang, Xiangping Li, Wanhui Liu

“…A multiple reaction monitor (MRM) was used under positive ionization mode with electrospray ion source to detect pioglitazone (357.1 ⟶ 134.1), omarigliptin (399.2 ⟶ 153.0), and sitagliptin (408.2 ⟶ 235.0). …”
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The combination of kidney function variables with cell cycle arrest biomarkers identifies distinct subphenotypes of sepsis-associated acute kidney injury: a post-hoc analysis (the... by Dimitri Titeca-Beauport, Momar Diouf, Delphine Daubin, Ly Van Vong, Guillaume Belliard, Cédric Bruel, Yoann Zerbib, Christophe Vinsonneau, Kada Klouche, Julien Maizel

“…Background The severity and course of sepsis-associated acute kidney injury (SA-AKI) are correlated with the mortality rate. Early detection of SA-AKI subphenotypes might facilitate the rapid provision of individualized care.Patients and methods In this post-hoc analysis of a multicenter prospective study, we combined conventional kidney function variables with serial measurements of urine (tissue inhibitor of metalloproteinase-2 [TIMP-2])* (insulin-like growth factor-binding protein [IGFBP7]) at 0, 6, 12, and 24 h) and then using an unsupervised hierarchical clustering of principal components (HCPC) approach to identify different phenotypes of SA-AKI. …”
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Periplanta americana extract regulates the Th17/Treg cell balance via Notch1 in ulcerative colitis by Yanqiu Zheng, Yanqiu Zheng, Huibiao Li, Shiyu Qi, Fan Xiao, Jinbin Song, Shiyin Liu, Xinlin Chen, Yanwu Li, Muyuan Chen

“…The signal transduction was detected in vivo. In vitro, an activated Notch1-mediated Th17/Treg was modeled, and the effect of PAE on the epithelial cell barrier was examined.ResultsPAE mitigated colon inflammation and intestinal barrier damage in UC mice. …”
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Pathogenetic Treatment of Gastritis as a Basis for the Prevention of Gastric Cancer in the Countries of the Commonwealth of Independent States: Literature Review and the Resolution... by V. T. Ivashkin, I. V. Maev, J. V. Gorgun, K. S. Kaliaskarova, M. M. Karimov, A. V. Kononov, T. L. Lapina, N. A. Markaryan, M. S. Moldobaeva, S. I. Pimanov, A. A. Sheptulin

“…In every case of H. pylori detection, it is important to make a decision about the expediency of eradication therapy. …”
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Genome-wide identification and functional roles relating to anthocyanin biosynthesis analysis in maize by Xiaofang Wang, Huangai Li, Shuai Wang, Meiqi Ruan, Yiping Li, Lei Zhu, Zhenying Dong, Yan Long

“…Based on un-targeted metabolites detection in the silks of four maize representative inbred lines with different colors, two main differential anthocyanin components were identified. …”
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Efficacy of natural and synthetic inhibitors in the elimination of viruses in potato (<i>Solanum tuberosum</i> L.) by E. V. Shishchenko, I. V. Kim, E. N. Barsukova, I. M. Yermak, A. O. Kravchenko, A. G. Klykov

“…A highly sensitive PCR method was employed to detect viral infections in plant samples. Results. …”
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Severe pneumonia due to concurrent Legionella pneumophila and Acinetobacter baumannii infections: a case report by Xiaoming Yang, Zhongda Liu, Xiaojing Liu, Quan Li, Hui Huang, Yibo Wei, Tao Sun

“…Close clinical monitoring, early pathogen detection and antibiotic susceptability tests, and appropriate antibiotic regimen adjustments should be applied to these patients who failed initial antibiotic treatments.…”
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Unraveling the genetic mysteries of spinal muscular atrophy in Chinese families by Shanshan Gao, Duo Chen, Qianqian Li, Xuechao Zhao, Chen Chen, Lina Liu, Miao Jiang, Zhenhua Zhao, Yanhua Wang, Xiangdong Kong

“…Conclusions This study comprehensively analyzed the genetics of suspected familial SMA cases in the Chinese population, providing insights into the molecular genetic mechanisms of SMA and the utility of various detection techniques. The findings revealed important implications for genetic counseling, prenatal diagnosis, and targeted therapies in clinical practice.…”
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Nasal microbial diversity is associated with survival in piglets infected by a highly virulent PRRSV-1 strain by Pau Obregon-Gutierrez, Martí Cortey, Gerard E. Martín-Valls, Hepzibar Clilverd, Florencia Correa-Fiz, Virginia Aragón, Enric Mateu

“…Since the dysbiosis detected as an initial response to infection may be not specific for this virus, further investigations should explore this phenomenon in the context of other viral infections.…”
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The Modulation of Reward and Habit Systems by Acupuncture in Adolescents with Internet Addiction by Yang Wang, Yun Qin, Hui Li, Dezhong Yao, Bo Sun, Zhiliang Li, Xin Li, Yu Dai, Chao Wen, Lingrui Zhang, Chenchen Zhang, Tianmin Zhu, Cheng Luo

“…Seed-to-voxel and ROI-to-ROI analyses were applied to detect the rsFC alterations of the VS and related network in IA subjects and to investigate the modulation effect of acupuncture on the rsFC. …”
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Nutritional Properties, Antioxidant and Antihaemolytic Activities of the Dry Fruiting Bodies of Wild Edible Mushrooms Consumed by Ethnic Communities of Northeast India by Merilin Kakoti, Dibya Jyoti Hazarika, Assma Parveen, Samim Dullah, Alokesh Ghosh, Dipankar Saha, Madhumita Barooah, Robin Chandra Boro

“…Other compounds viz. citric acid, caffeic acid, riboflavin, vanillic acid, pyruvic acid, and p -coumaric acid were detected with variations. This study established the nutritional and health-promoting benefits of wild edible mushrooms of Northeast India region for consumption as functional foods in the human diet.…”
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Newly identified single-nucleotide polymorphism associated with the transition from nonalcoholic fatty liver disease to liver fibrosis: results from a nested case-control study in... by Yitong Ling, Yu Xuan Yang, Yan Chun Chen, Jing Hao Wang, Dong Ge Feng, Shi Jian Xiang, Xiaoyu Zhang, Jun Lyu, Sha Sha Li

“…To quantify gene expression, we used real-time PCR with fluorescence detection.Results The study analyzed data from 5467 participants (1094 cases and 4373 controls). …”
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Potential Research Tool of Stem Cells from Human Exfoliated Deciduous Teeth: Lentiviral Bmi-1 Immortalization with EGFP Marker by Siqi Yao, Lingping Tan, Huan Chen, Xiaojun Huang, Wei Zhao, Yan Wang

“…The expression of Bmi-1 was detected with Western blot. Replicative lifespan determination and colony-forming efficiency assessment were using to assay proliferation capability. …”
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JAK/STAT3 signaling promotes pain and depression-like behaviors in rats with bone cancer pain by regulating Th17 cell differentiation by Shuyan Wu, Jundan Jiang, Danfeng Wang, Daoyi Lin, Mingxue Lin, Pinzhong Chen, Jianghu Chen, Honghong Zhang, Ying Wang, Xiaohui Chen, Xiaochun Zheng

“…Changes in inflammatory factors and related protein expression levels in the amygdala were detected using western blotting, immunofluorescence, and reverse transcription-quantitative polymerase chain reaction (RT-qPCR). …”
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Celastrol boosts fluconazole efficacy against vaginal candidiasis: in vitro and in vivo evidence by Fatma Al-zahraa A. Yehia, Hisham A Abbas, Tarek M. Ibrahim, Basem Mansour, Zuhier A. Awan, Mohammed W. Al-Rabia, Wesam H. Abdulaal, Mustafa Adnan Zeyadi, Solomon Z. Okbazghi, Tarek S. Ibrahim, Wael A. H. Hegazy, Salwa E. Gomaa

“…Upon celastrol treatment, a significant decline in ABC transporters transcript levels were detected. Moreover, molecular docking demonstrated that celastrol is a potential ABC efflux transporters blocker that successfully fits into target binding pockets. …”
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Thermal Response and Degressive Reaction Study of Oxo-Biodegradable Plastic Products Exposed to Various Degradation Media by S. M. Al-Salem, A. Y. Al-Nasser, M. H. Behbehani, H. H. Sultan, H. J. Karam, M. H. Al-Wadi, A. T. Al-Dhafeeri, Z. Rasheed, M. Al-Foudaree

“…A shift in the degradation mechanism was also detected after studying the kinetic parameters which showed a range of Ea between 86.64 and 226.90 kJ mol-1 depending on the type of specimens and exposure media. …”
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Is The SARS-CoV2 Evolved in Human Being: A prospective Genetic Analysis by Salvatore Dimonte, Paywast Jamal Jalal, Hiwa Abdulrahman Ahmad, Safa Bakr Karim, Taib Ahmed Hama Soor, Salar Ibrahim Ali, Muhammed Babakir-Mina, Francesco Greco

“…The evolutionary changes observed in the inserted 23 amino acids in the RNA binding domain (RBD) of the coronvirus spike glycoprotein which cannot be detected in any other human coronavirus. Moreover, the 2019-nCoV is not closely related to other alpha, beta and gamma human Coronavirus, including MERS-CoV. …”
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Synthetic Data Generation and Evaluation Techniques for Classifiers in Data Starved Medical Applications by Wan D. Bae, Shayma Alkobaisi, Matthew Horak, Siddheshwari Bankar, Sartaj Bhuvaji, Sungroul Kim, Choon-Sik Park

“…This leads to a training dataset where healthy cases outnumber unhealthy ones, resulting in biased prediction models that struggle to detect the minority, unhealthy cases effectively. …”
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Integrative deep immune profiling of the elderly reveals systems-level signatures of aging, sex, smoking, and clinical traitsResearch in context by Lennart Riemann, Rodrigo Gutierrez, Ivan Odak, Joana Barros-Martins, Lennart M. Roesner, Ximena Leon Lara, Christine Falk, Thomas F. Schulz, Gesine Hansen, Thomas Werfel, Reinhold Förster, Berislav Bošnjak, Felix Jenniches, Norman Klopp, Till Robin Lesker, Martin Stangel

“…Our large sample size allowed detection of even subtle changes in cytokines and immune cell clusters. …”
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Pacific sailfish (Istiophorus platypterus) in the Eastern Pacific Ocean, association with ocean currents and seasonal effects of upwelling using real-time Argos locations by Chelsea E. Clyde-Brockway, Chelsea E. Clyde-Brockway, Samir Harshad Patel, Gabriela Blanco, Samuel J. Friederichk, Stephen Morreale, Frank V. Paladino, Frank V. Paladino

“…The two location recording methods produced similar tracking intervals—deployment date until the final location date—(Argos: 33.0 ± 13.5 d; GPE: 32.0 ± 11.2 d), and detection days—number of days the transmitter recorded a location—(Argos: 7.8 ± 6.0 d; GPE: 12.3 ± 8.5 d). …”
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