Retrospective evaluation of risk factors for worsening renal function after angiotensin‐converting enzyme inhibitor treatment in dogs by Yelim Lee, Minju Baek, Dongseop Lee, Jinyeong Park, Yeon Chae, Byeong‐Teck Kang, Taesik Yun, Hakhyun Kim

“…Methods Serum creatinine concentration was determined at the initial presentation and first reevaluation to detect and grade WRF (increase in sCr ≥ 0.3 mg/dL). …”
Get full text

Changes in PD-1 expression on T lymphocyte subsets and related immune indicators before and after definitive chemoradiotherapy for esophageal squamous cell carcinoma by Xueling Shi, Hongyu Zhao, Jiaqi Yu, Peng Cai, Shixiang Zhou, Ning Yang, Duojie Li

“…Before and after CRT, flow cytometry was used to detect thePD-1 expression in the peripheral blood and related immune indicators. …”
Get full text

Exploring the Underlying Mechanism of Weiling Decoction Alleviates Cold-Dampness Diarrhea Based on Network Pharmacology, Transcriptomics, Molecular Docking and Experimental Validat... by Yannan Zhang, Shuai Zhang, Yimeng Fan, Sijuan Huang, Shimin Wang, Zhihui Hao, Jianzhong Shen

“…<b>Results</b>: A total of 223 chemical components were detected in WLD, and 49 absorption components were identified in the plasma of WLD-treated rats by UPLC-HRMS/MS. …”
Get full text

Endogenous 17β-estradiol regulates sexually dimorphic anxiety responses in zebrafish via the HPI axis and 5-HT/DA pathways by Hong Tao, Hong Tao, Ying–Ying Zhang, Ying–Ying Zhang, Yan–Jun Shen, Yan–Jun Shen, Qi–Liang Chen, Qi–Liang Chen, Zhi–Hao Liu, Zhi–Hao Liu

“…To elucidate the role of E2 in mediating sexually dimorphic anxiety responses, male zebrafish (Danio rerio) were administered E2 (E2-M), while females were treated with letrozole (LET, an aromatase inhibitor that reduces E2 synthesis, LET-F) for 60 days, and plasma and brain levels of E2 were detected and anxiety response was evaluated by a novel tank diving test. …”
Get full text

Genetic Variants Flanking the FGF21 Gene Were Associated with Renal Function in Chinese Patients with Type 2 Diabetes by Weihui Yu, Hong Zhu, Xiong Chen, Xuejiang Gu, Xingxing Zhang, Feixia Shen, Weiping Jia, Cheng Hu

“…However, a significant association with estimated glomerular filtration rate (eGFR) was detected: in the non-DKD group, rs838136 was significantly associated with eGFR under an additive model (β=0.013±0.006, P=0.0295, β was calculated for log10eGFR) as well as a recessive model (P=0.0385) and rs499765 was associated with eGFR under a dominant model (P=0.0411) and in the DKD group, rs499765 showed a trend toward association with eGFR under an additive model (β=−0.022±0.012, P=0.0820, β was calculated for log10eGFR) and showed a significant association with eGFR under a dominant model (P=0.0182). …”
Get full text

Morphological features of autoimmune gastritis by Ye. A. Losik, L. S. Selivanova, M. Yu. Konkov, T. L. Lapina, A. S. Tertychnyi, V. T. Ivashkin

“…In 4 patients Helicobacter pylori infection has been detected. According to guidelines of the Russian Society of Pathologists in all cases multiple biopsies have been taken at esophagogastroduodenoscopy. …”
Get full text

Los olvidados: Non-BRCA variants associated with Hereditary breast cancer in Mexican population by Dione Aguilar, María Lourdes Garza-Rodríguez, Carolina Elizabeth Muñiz-Garza, Fernando Alcorta Nuñez, Cynthia Mayte Villarreal-Garza, Oscar Vidal-Gutiérrez, Diana Cristina Pérez-Ibave, Carlos Horacio Burciaga-Flores

“…Conclusion Multi-gene testing implementation improves the detection of often overlooked genes related to HBOC pathogenesis and treatment. …”
Get full text

Identification and functional analysis of hub genes involved in deoxynivalenol-induced enterotoxicity in porcine (Sus scrofa) by Jinhua He, Geng Zhao, Mingxia Chen, Ximing Ren, Peizhi Zhu, Zhizhong Liu, Jiayi Zhou, Hanwei Chen, Chuqiao Xiao, Xiang-Guang Li

“…Subsequently, 6 hub genes (CXCR4, PTGS2, ICAM1, IL-1A, IL-1B, and IL-10) that played a central role in the response to DON were identified using cytohubba in conjunction with the Molecular Complex Detection. In summary, exposure to DON is more likely to result in increased rather than decreased gene expression. …”
Get full text

Randomised controlled trial comparing intraoperative cell salvage and autotransfusion with standard care in the treatment of hip fractures: a protocol for the WHITE 9 study by Mike Murphy, Nicholas Parsons, James Mason, Juul Achten, Duncan Appelbe, Edward Dickenson, Damian Griffin, Katy Mironov, Matthew Wyse, Amrita Athwal, Xavier Luke Griffin, Heather O'Connor

“…A minimum of 1128 patients will be recruited to obtain 90% power to detect a 0.075-point difference in the primary endpoint: EuroQol-5D-5L HRQoL at 4 months post injury. …”
Get full text

High CXCR3 on Leukemic Cells Distinguishes IgHVmut from IgHVunmut in Chronic Lymphocytic Leukemia: Evidence from CD5high and CD5low Clones by Gayane Manukyan, Tomas Papajik, Zuzana Mikulkova, Renata Urbanova, Veronika Smotkova Kraiczova, Jakub Savara, Milos Kudelka, Peter Turcsanyi, Eva Kriegova

“…Comparing IgHVmut and IgHVunmut patients, high levels of CXCR3 on CD5high and CD5low subpopulations were detected in the IgHVmut patients, with better discrimination in CD5low subpopulation. …”
Get full text

Polarization-independent high-sensitive metamaterial sensor for chemical sensing and EMI shielding application by Md Kutub Uddin, Shawon Hossen, Touhidul Alam, Mohammad Tariqul Islam, Saleh Albadran, Haitham Alsaif, Ahmed S. Alshammari, Ahmed Alzamil, Mohammad Lutful Hakim

“…Besides, the unit cell structure can be utilized as a sensor for detecting different liquid chemical substances. The sensor model achieves a high sensitivity of 18.87 as well as a high-quality Factor (Q-Factor) of 475. …”
Get full text

Ecological reef restoration: consumptive and nonconsumptive interactions among common North Sea predators and European oysters by Julius A. Ellrich, Clemens Kozian-Fleck, Markus Brand, Bérenger Colsoul, Bérenger Colsoul, Bernadette Pogoda, Bernadette Pogoda

“…Furthermore, they showed (ix) that the presence of brown crab conspecifics and (x) lobsters in natural abundances can nonconsumptively limit oyster consumption of brown crabs through intimidation mediated by (xi) brown crab- and (xii) lobster-released waterborne predator cues detected by brown crabs which indicates naturally underlying mechanisms regulating and limiting predation on oysters. …”
Get full text

Axonal regeneration and innervation ratio following supercharged end-to-side nerve transfer by Leopold Harnoncourt, Martin Schmoll, Christopher Festin, Laurenz Pflaum, Markus Breuss, Johanna Klepetko, Dominik C. Dotzauer, Florian J. Jaklin, Udo Maierhofer, Philipp Tratnig-Frankl, Oskar C. Aszmann, Oskar C. Aszmann

“…Retrograde labeling demonstrated motor neuron regeneration of both the MCN and UN in a distal direction toward the muscle; however, tracer uptake of the UN motor neurons following intramuscular tracer application was detected only in Group C. In contrast, stained pseudounipolar cells in the dorsal root ganglia associated with the UN and MCN revealed afferent muscle innervations in Groups B and C.DiscussionThis novel SETS nerve transfer model enables isolated electrophysiological as well as histological evaluations of all nerve sections to determine the muscle innervation ratio exactly. …”
Get full text

Rare Taxa Are Key Links in Regional Antimicrobial Resistance Profiles in Dusts Across Diverse North American Regions by Paul B. L. George, Florent Rossi, Marc Veillette, Amélia Bélanger Cayouette, Samantha Leclerc, Cindy Dumais, Nathalie Turgeon, Caroline Duchaine

“…High‐throughput qPCR was used to detect and quantify a panel of 36 ARGs and 3 mobile genetic elements. …”
Get full text

Oral health and dental behaviour of patients with left ventricular assist device: a cross‐sectional study by Jens Garbade, Josephine Rast, Gerhard Schmalz, Mirjam Eisner, Justus Wagner, Tanja Kottmann, Andreas Oberbach, Sven Lehmann, Rainer Haak, Michael A. Borger, Christian Binner, Dirk Ziebolz

“…Further correlations between treatment need and disease specific factors were not detected. Conclusions Patients with LVAD suffer from a high periodontal treatment need and a lack in oral behaviour. …”
Get full text

Transcription Factor E2F-1 Is Upregulated in Human Gastric Cancer Tissues and Its Overexpression Suppresses Gastric Tumor Cell Proliferation by Qiang Xiao, Lei Li, Yubo Xie, Ning Tan, Changqing Wang, Junyi Xu, Keyi Xia, Kevin Gardner, Qingdi Q. Li

“…PCR-SSCP analysis demonstrated that mutations were not detected in any of the gastric cancer and normal tissue specimens. …”
Get full text

The cinnamyl alcohol dehydrogenase gene family is involved in the response to Fusarium oxysporum in resistant and susceptible flax genotypes by R. O. Novakovskiy, L. V. Povkhova, G. S. Krasnov, T. A. Rozhmina, A. A. Zhuchenko, L. P. Kudryavtseva, E. N. Pushkova, P. Kezimana, A. V. Kudryavtseva, A. A. Dmitriev, N. V. Melnikova

“…Expression alterations in response to the pathogen were detected for all 13 examined CAD genes. The most significant differences in expression between control and infected plants were observed for CAD1B, CAD4A, CAD5A, and CAD5B, with strong upregulation of CAD1B, CAD5A, and CAD5B and strong downregulation of CAD4A. …”
Get full text

Identifying the function of novel cross-species microRNAs from the excretory-secretory products of Angiostrongylus cantonensis fifth-stage larvae by Kuang-Yao Chen, Yi-Hsuan Lin, Chien-Ju Cheng, Yi-Hao Huang, Sheng-Yu Lin, Chyi-Liang Chen, Cheng-Hsun Chiu

“…Novel microRNAs were initially detected, and their expression was found. Moreover, the prediction results showed that these secreted microRNAs may regulate Wnt and mTOR signaling. …”
Get full text

Comparison of Tick Control and Antibiotic Use Practices at Farm Level in Regions of High and Low Acaricide Resistance in Uganda by Joseph Byaruhanga, Fred Odua, Yvette Ssebunya, Olivia Aketch, Dickson Stuart Tayebwa, Innocent B. Rwego, Patrick Vudriko

“…Delvotest SP-NT® test kit was used to detect antibiotic residues in milk. Half-body tick counts and acaricide efficacy tests were performed. …”
Get full text

LoSI: Large Scale Location Inference Through FM Signal Integration and Estimation by Tathagata Mukherjee, Piyush Kumar, Debdeep Pati, Erik Blasch, Eduardo Pasiliao, Liqin Xu

“…This system can be used for detecting GPS spoofing as well as for initial position estimation for input to other GPS free positioning and navigation systems like Terrain Contour Matching (TERCOM). …”
Get full text