Chronic cannabis use differentially modulates neural oscillations serving the manipulate versus maintain components of working memory processing by Peihan J. Huang, Jake J. Son, Yasra Arif, Jason A. John, Lucy K. Horne, Mikki Schantell, Seth D. Springer, Maggie P. Rempe, Hannah J. Okelberry, Abraham D. Killanin, Ryan Glesinger, Anna T. Coutant, Thomas W. Ward, Madelyn P. Willett, Hallie J. Johnson, Elizabeth Heinrichs-Graham, Tony W. Wilson

“…Neurobehavioral relationships were also detected in the prefrontal cortices of nonusers, but not cannabis users. …”
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A novel TGFBR2 mutation causes Loeys-Dietz syndrome in a Chinese infant: A case report by Xin Liu, Kaiqing Liu, Lifu Hu, Zixiao Liu, Xinhua Liu, Jiantao Wang

“…The diagnosis of this disease is mainly based on clinical features combined with the detection of pathogenic gene mutations, mainly mutations in the transforming growth factor-beta (TGF-β) signaling pathway. …”
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Prognostic Role of Monocytic Myeloid-Derived Suppressor Cells in Advanced Non-Small-Cell Lung Cancer: Relation to Different Hematologic Indices by Asmaa M. Zahran, Helal F. Hetta, Zeinab Albadry M. Zahran, Alaa Rashad, Amal Rayan, Dalia O. Mohamed, Zeinab Ahmed Abd Elhameed, Salah M. Khallaf, Gaber El-Saber Batiha, Yasir Waheed, Khalid Muhammad, Hanaa Nafady-Hego

“…We recruited 40 cases of advanced NSCLC, stages III and IV, aged>18–<70 years old, and eligible to receive chemotherapy with or without radiotherapy, along with 20 healthy controls of comparable age and sex; after diagnosis and staging of patients, blood samples were collected for flow cytometric detection of Mo-MDSCs. Results. Significant accumulation of Mo-MDSCs in patients compared to their controls (p<0.0001). …”
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Polymorphisms in immunosuppression-related genes are associated with AML by Mingying Li, Mingying Li, Jingjing Ye, Jingjing Ye, Mengyuan Chang, Mengyuan Chang, Lei Feng, Lei Feng, Tingting Liu, Tingting Liu, Di Zhang, Di Zhang, Yuyan Wu, Yuyan Wu, Yuechan Ma, Yuechan Ma, Guangqiang Meng, Guangqiang Meng, Chunyan Ji, Chunyan Ji, Tao Sun, Tao Sun

“…Multi-omics analyses, such as single-cell transcriptomics, have revealed many potential new targets to improve AML prognosis from an immunological perspective.MethodsDNA from 307 AML patients and 316 healthy individuals were extracted. We detected nine single nucleotide polymorphisms (SNPs) in five immunosuppression-related genes (CIITA, CD200, CD163, MRC1 and LILRB4) in these samples. …”
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Working memory and the need for explainable AI – Scenarios from healthcare, social media and insurance by M. Liebherr, E. Gößwein, C. Kannen, A. Babiker, S. Al-Shakhsi, V. Staab, B.J. Li, R. Ali, C. Montag

“…Further, all participants were presented three AI systems scenarios of relatively different degrees of (personal) relevance and, hence, personal investment: skin cancer detection (i), the personalization of social media feeds (ii), and the amount to pay for a car insurance (iii). …”
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Simultaneous Quantification of Six Bioactive Components in Decoction of Ziziphi spinosae Semen Using Ultrahigh Performance Liquid Chromatography Coupled with Triple-Quadrupole Mass... by Xiao Liu, Xiaochai Zhu, Hui Zhu, Li Xie, Jia Ma, Yinghui Xu, Qigang Zhou, Zejun Wu, Baochang Cai

“…Multiple-reaction monitoring scanning detection was employed for quantification with an electrospray ion source in the negative ion mode. …”
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A multi-stage deep learning network toward multi-classification of polyps in colorectal images by Shilong Chang, Kun Yang, Yucheng Wang, Yufeng Sun, Chaoyi Qi, Wenlong Fan, Ying Zhang, Shuang Liu, Wenshan Gao, Jie Meng, Linyan Xue

“…In convolution, our approach not only demonstrates a significant improvement over existing methods by effectively emulating the step-by-step diagnostic process of endoscopists, but also promises to greatly enhance early detection and treatment strategies for CRC, ultimately improving patient outcomes.…”
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Pixel-wise navigation line extraction of cross-growth-stage seedlings in complex sugarcane fields and extension to corn and rice by Hongwei Li, Hongwei Li, Xindong Lai, Yongmei Mo, Deqiang He, Tao Wu, Tao Wu

“…Then, optimal region detection is applied to identify the fitting area. …”
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Flow Cytometry Evaluation of Blood-Cell-Bound Surface FVIII in Hemophilia A and Thrombosis by Anjud Al-Mohannadi, Reem Mohammed Yahia, Hani Bibawi, Che-Ann Lachica, Watfa Ahmed, Igor Pavlovski, Giusy Gentilcore, Elkhansa Elbukhari Elgaali, Anila Ejaz, Areeg Ahmed, Mohammed Elanbari, Zainab Awada, Mohammed J. Al-Kubaisi, Muhammad Elnaggar, Ayman Saleh, Chiara Cugno, Sara Deola

“…We developed a reliable flow cytometry (FC) method for FVIII detection that can be utilized for assessing surface-bound FVIII on leukocytes in different coagulation/clinical states; we analyzed 49 pediatric subjects, encompassing patients with HA, other coagulopathies, venous thrombosis, and normal coagulation. …”
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Anaerobic metabolism promotes breast cancer survival via Histone-3 Lysine-18 lactylation mediating PPARD axis by Ying Xu, Weiwei Meng, Yingqi Dai, Lin Xu, Ning Ding, Jinqing Zhang, Xuewei Zhuang

“…We utilized chromatin immunoprecipitation sequencing with H3K18la antibodies, transcriptomics of clinical BC samples, and proteomics and ATAC-seq analyses of in vivo tumors to identify the genes regulated by H3K18la and the transcription factor PPARD. qPCR and Western blot assays were used to detect expressions of molecules. We discovered that H3K18la levels were higher in BC tissues compared to adjacent non-cancerous tissues. …”
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Extensive Admixture Among Karst‐Obligate Salamanders Reveals Evidence of Recent Divergence and Gene Exchange Through Aquifers by Chris C. Nice, Katherine L. Bell, Zachariah Gompert, Lauren K. Lucas, James R. Ott, Ruben U. Tovar, Paul Crump, Peter H. Diaz

“…These results also highlight the applicability of population genomics data as a powerful lever for investigating connectivity among populations in systems where direct detection of dispersal paths is difficult, as in underground, aquatic systems.…”
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Three local plants adapt to ecological restoration of abandoned lead-zinc mines through assembly of rhizosphere bacterial communities by Wei Gao, Shuyi Chen, Xin Yu, Sumin Chen, Caijing Wan, Ying Wang, Peng Wu, Qiang Li

“…IntroductionThe plant restoration and ecological restoration of lead-zinc mines are very important.MethodsIn this study, we used three local plants to carry out ecological restoration of abandoned lead–zinc mining areas and detected the adaptive mechanisms of soil bacterial diversity and function during the ecological restoration of lead–zinc mines through 16S rRNA sequencing.ResultsThe results revealed that lead-zinc mining significantly reduced the soil bacterial diversity, including the Shannon, Simpson, and observed species indices, whereas the planting of the three ecological restoration plants restored the soil microbial diversity to a certain extent, leading to increases in the Shannon index and Observed species indices. …”
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CD34 evaluation of microvasculature in lung adenocarcinoma and its microvascular density predicts postoperative tumor recurrence by Zijian Qiu, Jiaji Wu, Guanchao Pang, Xia Xu, Jun Lin, Pingli Wang

“…BackgroundAngiogenesis is closely associated with tumor growth and metastasis, and microvascular density (MVD) is currently the clinical standard for evaluating tumor angiogenesis. Thus, the detection of intratumoral MVD is of great significance for understanding disease progression and predicting patient prognosis.MethodsTumor tissue sections of 238 patients with lung adenocarcinoma (LUAD) who underwent radical surgery were retrospectively analyzed. …”
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Intercropping of Saccharum spp. with Dictyophora indusiata: effects on microbial communities and metabolite profiles during bagasse degradation by Mingzheng Duan, Mingzheng Duan, Xiaojian Wu, Shengfeng Long, Hairong Huang, Xiang Li, Yijie Li, Changning Li, Bin Feng, Jiafu Chen, Defa Zhong, Zhendong Chen, Zeping Wang

“…In addition, unique metabolites such as L-alanine, serine, and oxaloacetate were detected in the DIBA treatment, suggesting more efficient bagasse degradation compared with natural processes.ConclusionThe use of macrofungi such as D. indusiata can play a pivotal role in circular agriculture by transforming agricultural waste into valuable soil amendments. …”
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Biochemical analysis of miR-217 and miR-532 in patients with fibromyalgia by Shymaa E. Ayoub, Azza M. Ahmed, Mostafa Y. Abdelwahed, Abeer A. Khalefa, Aeshah A. Awaji, Samer S. Zekry, Enas G. Ibrahim, Hana M. Eid, Shimaa M. Elasmer, Reham Fares

“…The miR-217 and miR-532 serum expressions were detected using quantitative real-time PCR (qRT-PCR). …”
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Induction of annexin-1 at transcriptional and post-transcriptional level in rat brain by methylprednisolone and the 21-aminosteroid U74389F by P. H. Voermans, K. G. Go, G. J. Ter Horst, M. H. J. Ruiters, E. Solito, L. Parente

“…In ependyma, choroid plexus, meninges, and vascular walls there was no Anx-1 mRNA transcription detectable. An opposite profile was shown by the Anx-1 immunoreactivity, the protein was present in control animals as well as the steroid-pretreated animals, suggesting that here the protein was either from systemic origin, or has diffused from adjacent structures. …”
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Palm Tocotrienol Activates the Wnt3a/β-Catenin Signaling Pathway, Protecting MC3T3-E1 Osteoblasts from Cellular Damage Caused by Dexamethasone and Promoting Bone Formation by Norfarahin Abdullah Sani, Nur Aqilah Kamaruddin, Ima Nirwana Soelaiman, Kok-Lun Pang, Kok-Yong Chin, Elvy Suhana Mohd Ramli

“…Alizarin Red staining was performed to detect calcium deposits. Cellular alkaline phosphatase activity was measured to evaluate osteogenic activity. …”
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Non-stationarity analysis of flood extremes under climate change and human activities in the Yuan River Basin, China by Ting Wang, Dehua Mao, Meirong Deng, Chang Feng, Guangwei Hu, Jingya Zhang, Yang Zou

“…Temporal variations were detected and non-stationary models were developed by incorporating physically-based covariates under climate change and human activities using the Mann-Kendall test, Pettitt test, and the Generalized Additive Models for Location, Scale, and Shape (GAMLSS) framework. …”
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Phenotypic divergence across populations does not affect habitat selection in an Amazonian poison frog by Martin Mayer, Lia Schlippe Justicia, Bibiana Rojas

“…We found little variation in habitat selection among populations or between disturbed and pristine areas but detected strong general patterns across populations. …”
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Prospective evaluation of the impact of repeated whole prison testing for hepatitis C by Stuart McPherson, Naw April Phaw, Manoj Valappil, Carolyn Miller, Craig Thompson, Francesca McCullough, Caroline Allsop, Kate McQue, Ryan Jelley, Jenna Kerry, Jodi Aldridge, Tony Jefferson, Colin Lawton, Lee Christensen, Aung Min Thant

“…Universal reception HCV testing is recommended, but acceptance can be suboptimal. To detect and treat missed HCV infections, a high-intensity test and treat (HITT) programme was introduced to rapidly test entire prisons. …”
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