Serum NLR combined with CA125 and HE4 improves the diagnostic and prognostic efficiency in patients with ovarian cancer by Yun Tian, Yun Tian, Xiabing Li, Xiabing Li, Hongjian Zhang, Hongjian Zhang, Yaping Wang, Yaping Wang, Hongyu Li, Hongyu Li, Qiaohong Qin, Qiaohong Qin

“…The prognosis for patients diagnosed at advanced stages is unfavorable, primarily attributable to the absence of reliable screening markers for early detection. An elevated neutrophil-to-lymphocyte ratio (NLR) serves as an indicator of host inflammatory response and has been linked to poorer overall survival (OS) across various cancer types; however, its examination in OC remains limited. …”
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Associations of combined exposure to selected metal mixtures with thyroid hormones in children: a cross-sectional study in China by Yuhan Cao, Shiting Xiang, Yuwei Du, Meiling Chen, Rumeng Xue, Qi Li, Jun Qiu, Yanying Duan

“…The concentrations of lead (Pb), iron (Fe), calcium (Ca), copper (Cu), zinc (Zn) and magnesium (Mg) in blood were detected via atomic absorption spectrometry (AAS). …”
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Early risk assessment in paediatric and adult household contacts of confirmed tuberculosis cases by novel diagnostic tests (ERASE-TB): protocol for a prospective, non-interventiona... by Ursula Panzner, Katharina Kranzer, Tsitsi Bandason, Kuda Mutasa, Sandra Rukobo, Charles Sandy, Bariki Mtafya, Andrea Rachow, Norbert Heinrich, Michael Hoelscher, Judith Bruchfeld, Olena Ivanova, Nyanda Elias Ntinginya, Doreen Pamba, Laura Olbrich, Issa Sabi, Simeon Mwanyonga, Elmar Saathoff, Willyhelmina Olomi, Junior Mutsvangwa, Hazel M Dockrell, Edson Tawanda Marambire, Denise Banze, Alfred Mfinanga, Theodora D Mbunda, Khosa Celso, Gunilla Kallenius, Claire J Calderwood, Christof Geldmacher, Kathrin Held, Tejaswi Appalarowthu, Friedrich Rieß, Anna Shepherd, Christopher Sundling, Mishelle Mugava, Martha Chipinduro, Lwitiho Sudi, Antelmo Haule, Emmanuel Sichone, Paschal Qwaray, Harrieth Mwambola, Lilian Minja, Peter Edwin, Dogo Ngalison, Stella Luswema, Celina Nhamuave, António Machiana, Carla Madeira, Emelva Manhiça, Nádia Sitoe, Jorge Ribeiro

“…Introduction The WHO End-TB Strategy calls for the development of novel diagnostics to detect tuberculosis (TB) earlier and more accurately. …”
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Analysis of the sensitization activity of Moringa oleifera leaves protein by Juan Lu, Juan Lu, Xiaoxue Liu, Xiaoxue Liu, Wenjie Li, Wenjie Li, Chuyu Xi, Chuyu Xi, Dan Feng, Dan Feng, Shuang Song, Shuang Song

“…The hemagglutination-related properties of Moringa oleifera leaves protein, such as (thermal, acid–base) stability, sugar binding specificity, ion binding characteristics, and hemolytic activity, were detected. The optimal combination of extraction process was: extraction time of 6 h, material-liquid ratio of 1:8, and ammonium sulfate saturation of 60%. …”
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Microbes on the Mobile Phones of Healthcare Workers in Palestine: Identification, Characterization, and Comparison by Mohammad Qadi, Rasha Khayyat, Mohammed A. AlHajhamad, Yazan I. Naji, Beesan Maraqa, Kais Abuzaitoun, Ahmed Mousa, Maysa Daqqa

“…No MRSA or Gram-negative species were detected in this group. Antibiotic resistance percentage of staphylococci was nearly half of that yielded in the HCW group against each antibiotic. …”
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Screening potential diagnostic biomarkers for PLA2R‑associated idiopathic membranous nephropathy by WGCNA analysis and LASSO algorithm by Jinxu Huang, Yaqing Huang, Xiaoling Zeng, Yuhong Zhang, Junneng Zhang, Qingchu Hong, Yongtiao Peng

“…Validation was performed in the GSE133288 dataset. IHC and qRT-PCR detected characteristic gene expression in PLA2R-positive patients. …”
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Interaction between walkability and fine particulate matter on ischemic heart disease: A prospective cohort study in China by Jiayun Zhang, Peng Shen, Yixing Wang, Zihan Li, Lisha Xu, Jie Qiu, Jingjing Hu, Zongming Yang, Yonghao Wu, Zhanghang Zhu, Hongbo Lin, Zhiqin Jiang, Liming Shui, Mengling Tang, Mingjuan Jin, Feng Tong, Kun Chen, Jianbing Wang

“…Walkability and PM2.5 were positively correlated (rs = 0.12, P < 0.001), and a multiplicative interaction was detected (Pinteraction = 0.019). Conclusion: Walkability was inversely associated with risk of IHD, whereas exposure to PM2.5 was positively associated with IHD. …”
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Impacts of free-roaming dogs on spatiotemporal niches of native carnivores in Taiwan by Hsin-Cheng Ho, Tzung-Su Ding, Hsiao-Wei Yuan, Jo-Szu Tsai, Guo-Jing Weng, Yu-Hsiu Lin, Hsiang Ling Chen, Yu-Bo Huang, Shih-Ching Yen

“…., forests around freshwater environments). We did not detect changes in spatiotemporal niche overlap among native carnivores. …”
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Gastric Peroral Endoscopic Myotomy (G-POEM) as a Treatment for Refractory Gastroparesis: Long-Term Outcomes by Jiaxin Xu, Tianyin Chen, Shaimaa Elkholy, Meidong Xu, Yunshi Zhong, Yiqun Zhang, Weifeng Chen, Wenzheng Qin, Mingyan Cai, Pinghong Zhou

“…The secondary outcome parameter was the detection of possible predictive factors for success and the determination of cut-off values for such predictors. …”
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On the tracks of an uninvited guest, the Asian tiger mosquito, Aedes albopictus in Cyprus by Riccardo Piccinno, Giulia Fiorenza, Marlen Ines Vasquez, Jeremy Bouyer, Gregoris Notarides, Ludvik Marcus Gomulski, Soteris Meletiou, Mustafa Akiner, Antonios Michaelakis, Federico Forneris, Giovanni Maga, Giuliano Gasperi, Anna Rodolfa Malacrida

“…An ongoing mosquito dispersal within the Limassol district was detected, suggesting the presence of established, hidden adventive populations. …”
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Cohort profile: the potentially preventable burden of community-acquired pneumonia in South African adults in the era of widespread PCV13 immunisation and antiretroviral therapy ro... by Jo Southern, Kennedy Otwombe, Eileen Dunne, Khuthadzo Hlongwane, Bradford D Gessner, Michelle Wong, Cheryl Cohen, Anne von Gottberg, Elizabeth Begier, Sharon Gray, Ebrahim Variava, Tumelo Moloantoa, Neil Martinson, Firdaus Nabeemeeah, Nadia Sabet, Lebohang M Mlambo, Phetho Mangena, Pattamukkil Abraham, Floris Swanepoel, Fahima Moosa, Mark Fletcher, Bha Ndungane-Tlakula, Jerusha Naidoo, Minja Milovanovic

“…Among StART cohort, 18/950 (1.9%) died during follow-up.Future plans Planned analyses include incidence estimates of pneumococcal serotype-specific adult CAP and its recurrence, using Urinary Antigen Detection assay results to model the burden of pneumococcal CAP better and health economics analyses.…”
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Isolation and function of a human endothelial cell C1q receptor by M. R. Daha, L. Dunn, R. van den Berg, Y. Muizert-de Lange, A. Gerritsen, L. A. van Es

“…During isolation, C1qR was detected by its capacity to inhibit the lysis of EAC1q in C1q-deficient serum. …”
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Ecological security driving mechanisms and optimization of zoning in Chinese urban agglomerations: A case study of the central plains urban agglomeration by Jinyuan Zhang, Xuning Qiao, Yongju Yang, Liang Liu, Yalong Li, Shengnan Zhao

“…Spatial disparities in ecological security were relatively small, and counties with lower ecological security levels tended to show greater clustering; (2) The explanatory power of the driving factors is ranked as follows: human factors > natural factors > landscape factors. Interaction detection factors exhibit varying degrees of dual-factor or nonlinear enhancement, with the combined strength of positive effects being greater than that of negative effects; (3) The spatial distribution characteristics of ecological security zones in the CPUA align with those of ecological security conditions. …”
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Feasibility study to assess the delivery of a lifestyle intervention (TreatWELL) for patients with colorectal cancer undergoing potentially curative treatment by Annie S Anderson, Ronan E O’Carroll, Martine Stead, Robert J C Steele, Mary Wells, Maureen Macleod, Anna Campbell, Jacqui A Sugden, Jackie Rodger, Jennifer McKell

“…Physical activity data showed a positive trend towards increased activity overall, but no other changes in secondary outcomes were detected.Conclusions To make this intervention feasible for testing as a full trial, further research is required on (a) recruitment optimisation, (b) appropriate assessment tools, (c) protocols for phase 2 and 3, which can build in flexibility and (d) ways for NHS staff to facilitate the programme.Trial registration number ISRCTN52345929; Post-results.…”
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DNA hypomethylation-mediated upregulation of GADD45B facilitates airway inflammation and epithelial cell senescence in COPD by Yuan Zhan, Qian Huang, Zhesong Deng, Shanshan Chen, Ruonan Yang, Jiaheng Zhang, Yating Zhang, Maocuo Peng, Jixing Wu, Yiya Gu, Zhilin Zeng, Jungang Xie

“…Methods: Expressions of GADD45 family were evaluated by bioinformatic analysis combined with detections in clinical specimens. The effects of GADD45B on inflammation and senescence were investigated via constructing cell model with siRNA transfection or overexpression lentivirus infection and animal model with Gadd45b knockout. …”
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Hepatitis B Virus-KMT2B Integration Drives Hepatic Oncogenic Processes in a Human Gene-edited Induced Pluripotent Stem Cells-derived ModelSummary by Jun Tsuchiya, Masato Miyoshi, Sei Kakinuma, Fukiko Kawai-Kitahata, Akihide Kamiya, Taro Shimizu, Ayako Sato, Keiya Watakabe, Tomohiro Mochida, Kento Inada, Rion Kamimae, Shun Kaneko, Miyako Murakawa, Sayuri Nitta, Mina Nakagawa, Mamoru Watanabe, Yasuhiro Asahina, Ryuichi Okamoto

“…Long-read RNA-sequence detected the common KMT2B transcript variants in the HCC sample and HPCs. …”
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The Effect of Lipotoxicity on Renal Dysfunction in a Nonobese Rat Model of Metabolic Syndrome: A Urinary Proteomic Approach by Irena Markova, Denisa Miklankova, Martina Hüttl, Petr Kacer, Jelena Skibova, Jan Kucera, Radislav Sedlacek, Tereza Kacerova, Ludmila Kazdova, Hana Malinska

“…Assessing urinary secretion of proinflammatory cytokines and epidermal growth factor can help in detecting early development of metabolic syndrome-associated renal dysfunction.…”
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Solid and Gaseous Methane in IRAS 23385+6053 as Seen with Open JWST Data by Ruslan Nakibov, Varvara Karteyeva, Igor Petrashkevich, Maksim Ozhiganov, Mikhail Medvedev, Anton Vasyunin

“…The band at 7.58–7.8 μ m (1320–1280 cm ^−1 ) is interpreted as a wide solid absorption methane feature overlapped by the sharp features of the methane emission. We report the detection of gaseous methane and estimate its emitting area radius R , temperature T , and column density N as R = 2940 au, $T=10{3}_{-11}^{+13}$ K, and $N=0.7{8}_{+6.18}^{-0.64}\times 1{0}^{17}$ cm ^−2 , correspondingly. …”
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The Role of Atrial Fibrillation and Oral Anticoagulation Status in Health‐Related Quality of Life 12 Months After Ischemic Stroke or TIA by Manuel C. Olma, Lena Steindorf‐Sabath, Serdar Tütüncü, Claudia Kunze, Cornelia Fiessler, Paulus Kirchhof, Joanna Dietzel, Johannes Schurig, Patrick Oschmann, Ludwig Niehaus, Christian Urbanek, Götz Thomalla, Darius G. Nabavi, Joachim Röther, Ulrich Laufs, Roland Veltkamp, Peter U. Heuschmann, Karl Georg Haeusler, Matthias Endres, for the MonDAFIS Investigators

“…Results A first episode of AF was detected in 261/2927 (8.9%) patients within 12 months after the index stroke and 227/2920 (7.8%) patients had AF and were anticoagulated at 12 months. …”
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Generation and miRNA Characterization of Equine Induced Pluripotent Stem Cells Derived from Fetal and Adult Multipotent Tissues by Laís Vicari de Figueiredo Pessôa, Pedro Ratto Lisboa Pires, Maite del Collado, Naira Caroline Godoy Pieri, Kaiana Recchia, Aline Fernanda Souza, Felipe Perecin, Juliano Coelho da Silveira, André Furugen Cesar de Andrade, Carlos Eduardo Ambrosio, Fabiana Fernandes Bressan, Flavio Vieira Meirelles

“…The morphology and in vitro pluripotency maintenance potential (alkaline phosphatase detection, embryoid body formation, in vitro spontaneous differentiation, and expression of pluripotency markers) of the eiPSCs were characterized. …”
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